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Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model

Park Jung-Eun Lee Jiyoun Ok Soonhyuck Byun Seunghee Chang Eun-Ju Yoon Sung-Eun Kim Young-Joon Kang Min-Ji 2023년

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' Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model' 의 주제별 논문영향력
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주제
  • The endoplasmic reticulum (ER) is a subcellular organelle essential for cellular homeostasis. Perturbation of ER functions due to various conditions can induce apoptosis. Chronic ER stress has been implicated in a wide range of diseases
  • alleviating retinal degeneration in the Drosophila ADRP model. In contrast
  • including autosomal dominant retinitis pigmentosa (ADRP)
  • knocking down Erasp via RNAi suppressed apoptosis induced by mutant rhodopsin-1 (Rh-1P37H) toxicity
  • overexpression of Erasp resulted in enhanced caspase activity in Drosophila S2 cells treated with apoptotic inducers and the stabilization of the initiator caspase Dronc (Death regulator Nedd2-like caspase) by stimulating DIAP1 (Drosophila inhibitor of a
  • the signaling pathways that mediate apoptosis in response to ER stress remain poorly understood. In this study
  • was a downstream target of Wg/Wnt1 during ER stress. Furthermore
  • we performed an unbiased in vivo RNAi screen with a Drosophila ADRP model and found that Wg/Wnt1 mediated apoptosis. Subsequent transcriptome analysis revealed that ER stress-associated serine protease (Erasp)
  • which has been predicted to show serine-type endopeptidase activity
  • which is characterized by age-dependent retinal degeneration caused by mutant rhodopsin alleles. However
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