연구동향 분석

혈관과 섬유증의 평활근 및 세포외기질 조절에 대한 릴랙신의 다양한 작용기전

민계식 2022년

논문상세정보
인용/피인용
' 혈관과 섬유증의 평활근 및 세포외기질 조절에 대한 릴랙신의 다양한 작용기전' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Extracellular matrix remodeling
  • fibrosis
  • relaxin
  • signal transduction mechanisms
  • vasodilation
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
77 0

0.0%

' 혈관과 섬유증의 평활근 및 세포외기질 조절에 대한 릴랙신의 다양한 작용기전' 의 참고문헌

  • Vascular metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin
  • Vascular actions of relaxin : nitric oxide and beyond
    Leo, C. H. [2017]
  • Use of relaxin in the treatment of scleroderma
  • Unveiling the vasodilatory actions and mechanisms of relaxin
  • Type 2 immunity in tissue repair and fibrosis
  • Transforming growth factor beta(TGF-beta)mediates cardiac fibrosis and induces diabetic cardiomyopathy
    Yue, Y. [2017]
  • Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin).
    Leo, C. H. [2016]
  • The relaxin gene-knockout mouse : a model of progressive fibrosis
  • The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
    Heeg, M. H. [2005]
  • The anti-fibrotic actions of relaxin are mediated through a NO-sGC-cGMPdependent pathway in renal myofibroblasts in vitro and enhanced by the NO donor, diethylamine nonoate
    Wang, C. [2016]
  • TGFbeta pathway inhibition in the treatment of non-small cell lung cancer
    Eser, P. O. [2018]
  • TGF-beta signaling in liver and gastrointestinal cancers
    Katz, L. H. [2016]
  • TGF-beta : the master regulator of fibrosis
    Meng, X. M. [2016]
  • Serelaxin-mediated signal transduction in human vascular cells : bell-shaped concentrationresponse curves reflect differential coupling to G proteins
    Sarwar, M. [2015]
  • Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats
    Wang, D. [2017]
  • Serelaxin : a novel therapeutic for vascular diseases
    Leo, C. H. [2016]
  • Reperfusion therapy with recombinant human relaxin-2(serelaxin)attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism
  • Relaxin-induced increased coronary flow through stimulation of nitric oxide production
  • Relaxin-dependent adenosine 6’, 5’-monophosphate concentration changes in the mouse pubic symphysis
  • Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice
    Ikeda, Y. [2018]
  • Relaxin-1-deficient mice develop an age-related progression of renal fibrosis
  • Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist : attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK–1/2 and nuclear factor-kappaB
  • Relaxin(releasin)therapy in diffuse progressive scleroderma; a preliminary report
  • Relaxin stimulates myometrial calcium-activated potassium channel activity via protein kinase A
    Meera, P. [1995]
  • Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases : the additional involvement of iNOS
  • Relaxin reverses inflammatory and immune signals in aged hearts
    Martin, B. [2018]
  • Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
  • Relaxin remodels fibrotic healing following myocardial infarction
  • Relaxin regulates vascular wall remodeling and passive mechanical properties in mice
  • Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties
    Beiert, T. [2017]
  • Relaxin prevents cardiac fibroblast-myofibroblast transition via Notch-1-mediated inhibition of TGF-β/Smad3 signaling
    Sassoli, C. [2013]
  • Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
  • Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
  • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
  • Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats
  • Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow
  • Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats
  • Relaxin is essential for renal vasodilation during pregnancy in conscious rats
    Novak, J. [2001]
  • Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
  • Relaxin inhibits lipopolysaccharide-induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide-mediated mechanism
    Nistri, S. [2003]
  • Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway
    Zhou, X. [2015]
  • Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide
  • Relaxin induces an extracellular matrix degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
  • Relaxin increases calcium efflux from rat myometrial cells in culture
    Rao, M. R. [1986]
  • Relaxin family peptides and their receptors
  • Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms
  • Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease
  • Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
  • Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis
  • Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice
  • Relaxin decreases the severity of established hepatic fibrosis in mice
  • Relaxin decreases renal interstitial fibrosis and slows progression of renal disease
  • Relaxin counteracts myocardial damage induced by ischemia-reperfusion in isolated guinea pig hearts : evidence for an involvement of nitric oxide
    Masini, E. [1997]
  • Relaxin counteracts asthma-like reaction induced by inhaled antigen in sensitized guinea pigs
    Bani, D. [1997]
  • Relaxin and fibrosis : emerging targets, challenges, and future targets
  • Relaxin and extracellular matrix remodeling : mechanisms and signaling pathways
    Ng, H. H. [2019]
  • Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size
  • Relaxin ameliorates renal fibrosis and expression of endothelial cell transition markers in rats of isoproterenol-induced heart failure
    Zheng, G. [2017]
  • Relaxin activates the L-arginine nitric oxide pathway in vascular smooth muscle cells in culture
    Bani, D. [1998]
  • Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling
    Chen, L. [2017]
  • Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome
    강영미 [2017]
  • Relaxin s physiological roles and other diverse actions
    Sherwood OD [2004]
  • Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats
    Yoshida, T. [2014]
  • Protection from cigarette smoke-induced lung dysfunction and damage by H2 relaxin(serelaxin)
    Pini, A. [2016]
  • Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats
    Novak, J. [2002]
  • Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease
  • Mechanistic connection between inflammation and fibrosis
    Lee, S. B. [2010]
  • Maternal vasodilation during pregnancy : emerging role of relaxin
  • Mast cell inhibition and reduced ventricular arrhythmias in a swine model of acute myocardial infarction upon therapeutic administration of relaxin
    Nistri, S. [2008]
  • ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
    Kocan, M. [2017]
  • Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
    Jelinic, M. [2014]
  • Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?
    Fisher, C. [2002]
  • Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin
    Wetzl, V. [2016]
  • Inhibitory effects of relaxin on human basophils activated by stimulation of the Fc epsilon receptor. The role of nitric oxide
    Bani, D. [2002]
  • Inhibition of the TGFβ signaling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis
  • Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice
    Ng, H. H. [2015]
  • Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice : a gender-specific phenotype
    Du, X-J. [2003]
  • Inbibition of markers of hepatic stellate cell activation by the hormone relaxin
  • Impaired vascular responses to relaxin in diet-induced overweight female rats
  • Impaired nipple development and parturition in LGR7knockout mice
  • Impaired effect of relaxin on vasoconstrictor reactivity on spontaneous hypertensive rats
  • G-Protein-coupled receptors as potential drug candidates in preeclampsia : targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention
  • Experimental relaxation of the pubic ligament of the guinea pig
  • Evidence for local relaxin ligand-receptor expression and function in arteries
    Novak, J. [2006]
  • Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy
  • Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries
  • Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment
    Gooi, J. H. [2013]
  • Endogenous relaxin is a naturally occuring modulator of experimental renal tubulointerstitial fibrosis
  • Emerging role of relaxin in the maternal adaptations to normal pregnancy : implications for preeclampsia
  • Effects of relaxin on rat uterine myosin light chain kinase activity and myosin light chain phosphorylation
  • Effects of relaxin on mast cells : in vitro and in vivo studies in rats and guinea pigs
    Masini, E. [1994]
  • Effects of relaxin on arterial dilation, remodeling, and mechanical properties
  • Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy
  • Collagen studies in late pregnant relaxin null mice
    Zhao, L. [2000]
  • Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties
    Beiert, T. [2018]
  • Central role of dysregulation of TGF-beta/Smad in CKD progression and potential targets of its treatment
    Chen, L. [2018]
  • Cellular and molecular mechanisms of fibrosis
  • Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin
  • Antifibrotic properties of relaxin : in vivo mechanism of action in experimental renal tubulointerstitial fibrosis
  • Anti-fibrotic actions of relaxin
  • Anti-fibrosis effect of relaxin and spironolactone combined on isoprenaline-induced myocardial fibrosis in rats via inhibition of endothelial-mesenchymal transition
    Cai, J. [2017]
  • Angiotensin II AT(2)receptor decreases AT(1)receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats
    Yang, J. [2012]
  • Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans
  • Aging attenuates the vasodilator response to relaxin
  • Acute intravenous injection of serelaxin(recombinant human relaxin-2)causes rapid and sustained bradykinin-mediated vasorelaxation
    Leo, C. H. [2014]
  • Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature
    Li, Y. [2005]
  • Activation of orphan receptors by the hormone relaxin
    Hsu, S. Y. [2002]
  • A vasoactive role for endogenous relaxin in mesenteric arteries of male mice
    Leo, C. H. [2014]