연구동향 분석

Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Ji Hye Park Na Kyoung Lee Hye Ji Lim Seung Taek Ji 김연주 Woong Bi Jang Da Yeon Kim 강송화 Jisoo Yun Jongseong Ha Hyungtae Kim Dongjun Lee 백상홍 권상모 2020년

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' Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells' 의 참고문헌

  • mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells
    Zheng, B. [2017]
  • mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
    Zhou, J. [2009]
  • mTOR signaling in growth control and disease
  • mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
  • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    Noda, T. [1998]
  • The target of rapamycin (TOR)proteins
    Raught, B. [2001]
  • The serine/threonine kinase Pim-1
  • The regulation of autophagy-unanswered questions
    Chen, Y. [2011]
  • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    Hsu, P. P. [2011]
  • The limited in vitro lifetime of human diploid cell strains
  • The MEK/ERK cascade: from signaling specificity to diverse functions
  • TOR, a central controller of cell growth
  • TOR signaling in growth and metabolism
  • Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure
  • STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo
    Iwakura, T. [2011]
  • STAT3, a key regulator of cell-to-cell communication in the heart
  • SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
  • Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
    Torella, D [2006]
  • Replicating centromeric chromatin : spatial and temporal control of CENP-A assembly
  • Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice
  • Rejuvenation of human cardiac progenitor cells with Pim-1kinase
    Mohsin, S. [2013]
  • Regulation of mammalian autophagy in physiology and pathophysiology
  • Rapamycin: one drug, many effects
    Li, J. [2014]
  • Rapamycin efficiently promotes cardiac differentiation of mouse embryonic stem cells
    Lu, Q. [2017]
  • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    Choo, A. Y. [2008]
  • Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis
    Qiu, X. X. [2017]
  • Prolonged rapamycin treatment inhibits mTORC2assembly and Akt/PKB
  • Pim1 kinase overexpression enhances ckit(+)cardiac stem cell cardiac repair following myocardial infarction in swine
  • Pim-1 regulates cardiomyocyte survival downstream of Akt
  • Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    Yu, Y. [2011]
  • PIM1-minicircle as a therapeutic treatment for myocardial infarction
    Liu, N. [2017]
  • Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
  • Modulation of Human Cardiac Progenitors via Hypoxia-ERK Circuit Improves their Functional Bioactivities
    정석윤 [2013]
  • Mechanistic target of rapamycin(Mtor)is essential for murine embryonic heart development and growth
    Zhu, Y. [2013]
  • Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
  • Mammalian target of rapamycin signaling in cardiac physiology and disease
  • Keeping the senescence secretome under control : molecular reins on the senescence-associated secretory phenotype
  • Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
    Zheng, B. [2017]
  • Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling
    Katare, R. [2011]
  • Hypoxic/normoxic preconditioning increases endothelial differentiation potential of human bone marrow CD133+ cells
    Ong, L. L. [2010]
  • Hypoxic preconditioning of human mesenchymal stem cells overcomes hypoxia-induced inhibition of osteogenic differentiation
    Volkmer, E. [2010]
  • Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells
    Hung, S. P. [2012]
  • Human cardiac stem cells
    Bearzi, C. [2007]
  • Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction
  • Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair
    Li, T. S. [2011]
  • Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction
    Avolio, E. [2014]
  • Effects of age and heart failure on human cardiac stem cell function
  • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
  • Doxorubicin regulates autophagy signals via accumulation of cytosolic Ca(2+) in human cardiac progenitor cells
    Park, J. H. [2016]
  • Doxorubicin induces senescence and impairs function of human cardiac progenitor cells
    Piegari, E. [2013]
  • Doxorubicin : an update on anticancer molecular action, toxicity and novel drug delivery systems
    Tacar, O. [2013]
  • Differential gene and transcript expression analysis of RNAseq experiments with TopHat and Cufflinks
  • Cellular senescence, ageing and disease
  • Cellular senescence in aging and age-related disease : from mechanisms to therapy
    Childs BG [2015]
  • Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy
  • Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Urbanek, K. [2005]
  • Cardiac stem cell and myocyte aging, heart failure, and insulinlike growth factor-1 overexpression
    Torella, D. [2004]
  • Cardiac stem cell aging and heart failure
  • Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice
    Shende, P. [2011]
  • Cardiac cell senescence and redox signaling
  • CENP-A is essential for cardiac progenitor cell proliferation
  • Autophagy as a cell death and tumor suppressor mechanism
  • Adult cardiac stem cells are multipotent and support myocardial regeneration
  • 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase
    Qian, Q. [2012]