연구동향 분석

밀집 및 고삼투압 조건에서 세포내 액체-액체 상 분리 = Intracellular liquid-liquid phase separation under crowded and hyperosmotic conditions

베자알릭 2022년

논문상세정보
인용/피인용
' 밀집 및 고삼투압 조건에서 세포내 액체-액체 상 분리 = Intracellular liquid-liquid phase separation under crowded and hyperosmotic conditions' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Biomolecular condensates
  • liquid?liquid phase separation
  • macromolecular crowding
  • membraneless organelles
  • osmotic stress
  • statedependent reactions
  • 거대분자 밀집
  • 막 없는 소기관
  • 삼투압
  • 상태 의존적 반응
  • 생체 분자 응축물
  • 액체- 액체 상 분리
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
31 0

0.0%

' 밀집 및 고삼투압 조건에서 세포내 액체-액체 상 분리 = Intracellular liquid-liquid phase separation under crowded and hyperosmotic conditions' 의 참고문헌

  • Z. Nizami, S. Deryusheva, and J. G. Gall, The cajal body and histone locus body, Cold Spring Harbor Perspectives in Biology, vol. 2, no. 7, pp. a000 653–a000 653, may 2010.
    [2010]
  • Z. Hu, J. Jiang, and R. Rajagopalan, Effects of macromolecular crowding on biochemical reaction equilibria: A molecular thermodynamic perspective, Biophysical Journal, vol. 93, no. 5, pp. 1464–1473, sep 2007.
    [2007]
  • Y. Shin, J. Berry, N. Pannucci, M. P. Haataja, J. E. Toettcher, and C. P. Brangwynne, Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets, Cell, vol. 168, no. 1-2, pp. 159–171.e14, jan 2017.
    [2017]
  • Y. Fujioka, J. M. Alam, D. Noshiro, K. Mouri, T. Ando, Y. Okada, A. I. May, R. L. Knorr, K. Suzuki, Y. Ohsumi, and N. N. Noda, Phase separation organizes the site of autophagosome formation, Nature, vol. 578, no. 7794, pp. 301–305, feb 2020.
  • X. Zhang, S. Sridharan, I. Zagoriy, C. E. Oegema, C. Ching, T. Pflaesterer, H. K. H. Fung, I. Poser, C.W. MÃOEller, A. A. Hyman, M. M. Savitski, and J. Mahamid, Condensate-mediated reactivation of mumps virus infection under stress, bioRxiv, jul 2021.
    [2021]
  • X. Su, J. A. Ditlev, E. Hui, W. Xing, S. Banjade, J. Okrut, D. S. King, J. Taunton, M. K. Rosen, and R. D. Vale, Phase separation of signaling molecules promotes t cell receptor signal transduction, Science, vol. 352, no. 6285, pp. 595–599, apr 2016.
  • X. Chen, X. Wu, H. Wu, and M. Zhang, Phase separation at the synapse, Nature Neuroscience, vol. 23, no. 3, pp. 301–310, feb 2020.
    [2020]
  • W. M. Jacobs and D. Frenkel, Phase transitions in biological systems with many components, Biophysical Journal, vol. 112, no. 4, pp. 683–691, feb 2017.
    [2017]
  • W. M. Babinchak and W. K. Surewicz, Liquid–liquid phase separation and its mechanistic role in pathological protein aggregation, Journal of Molecular Biology, vol. 432, no. 7, pp. 1910–1925, mar 2020.
    [2020]
  • Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components
  • V. Pirrotta and H.-B. Li, A view of nuclear polycomb bodies, Current Opinion in Genetics & Development, vol. 22, no. 2, pp. 101–109, apr 2012.
    [2012]
  • V. Lallemand-Breitenbach and H. de The, PML nuclear bodies, Cold Spring Harbor Perspectives in Biology, vol. 2, no. 5, pp. a000 661– a000 661, apr 2010.
    [2010]
  • U. W. Gedde and M. S. Hedenqvist, Fundamental Polymer Science. Springer International Publishing, 2019.
    [2019]
  • T. Skóra, F. Vaghefikia, J. Fitter, and S. Kondrat, Macromolecular crowding: How shape and interactions affect diffusion, The Journal of Physical Chemistry B, vol. 124, no. 35, pp. 7537–7543, aug 2020.
    [2020]
  • T. M. Franzmann, M. Jahnel, A. Pozniakovsky, J. Mahamid, A. S. Holehouse, E. NÃOEske, D. Richter, W. Baumeister, S. W. Grill, R. V. Pappu, A. A. Hyman, and S. Alberti, Phase separation of a yeast prion protein promotes cellular fitness, Science, vol. 359, no. 6371, p. eaao5654, jan 2018.
  • T. J. Nott, E. Petsalaki, P. Farber, D. Jervis, E. Fussner, A. Plochowietz, T. D. Craggs, D. P. Bazett-Jones, T. Pawson, J. D. Forman-Kay, and A. J. Baldwin, Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles, Molecular Cell, vol. 57, no. 5, pp. 936–947, mar 2015.
  • T. J. Jentsch, VRACs and other ion channels and transporters in the regulation of cell volume and beyond, Nature Reviews Molecular Cell Biology, vol. 17, no. 5, pp. 293–307, apr 2016.
    [2016]
  • T. Hara, K. Nakamura, M. Matsui, A. Yamamoto, Y. Nakahara, R. Suzuki- Migishima, M. Yokoyama, K. Mishima, I. Saito, H. Okano, and N. Mizushima, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, vol. 441, no. 7095, pp. 885–889, apr 2006.
  • T. G. Kurtz, The relationship between stochastic and deterministic models for chemical reactions, The Journal of Chemical Physics, vol. 57, no. 7, pp. 2976–2978, oct 1972.
    [1972]
  • T. C. Qui, T. Nagaki, T. Nakagawa, O. Yano, and T. Soen, Immobilization of transient structures in polystyrene/poly(2-chlorostyrene) blends undergoing phase separation by using photocrosslinking, Macromolecules, vol. 22, no. 6, pp. 2720–2723, nov 1989.
    [1989]
  • Self-assembly of biomolecular condensates with shared components
    W. M. Jacobs vol . 126 , no . 25 , p. 258101 , [2021]
  • Scalar f4 field theory for active-particle phase separation ,
  • S.Wegmann, B. Eftekharzadeh, K. Tepper, K. M. Zoltowska, R. E. Bennett, S. Dujardin, P. R. Laskowski, D. MacKenzie, T. Kamath, C. Commins, C. Vanderburg, A. D. Roe, Z. Fan, A. M. Molliex, A. Hernandez-Vega, D. Muller, A. A. Hyman, E. Mandelkow, J. P. Taylor, and B. T. Hyman, Tau protein liquid–liquid phase separation can initiate tau aggregation, The EMBO Journal, vol. 37, no. 7, p. e98049, feb 2018.
  • S. Wang, T. Dai, Z. Qin, T. Pan, F. Chu, L. Lou, L. Zhang, B. Yang, H. Huang, H. Lu, and F. Zhou, Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity, Nature Cell Biology, vol. 23, no. 7, pp. 718–732, jul 2021.
  • S. U. Setru, B. Gouveia, R. Alfaro-Aco, J. W. Shaevitz, H. A. Stone, and S. Petry, A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches, Nature Physics, vol. 17, no. 4, pp. 493– 498, jan 2021.
    [2021]
  • S. Safran, Statistical Thermodynamics of Surfaces, Interfaces, and Membranes. Boulder, Co. Oxford: Westview Press, 2003.
    [2003]
  • S. S. Stadmiller, J. S. Aguilar, S. Parnham, and G. J. Pielak, Protein– peptide binding energetics under crowded conditions, The Journal of Physical Chemistry B, vol. 124, no. 42, pp. 9297–9309, sep 2020.
    [2020]
  • S. S. Stadmiller and G. J. Pielak, Protein-complex stability in cells and in vitro under crowded conditions, Current Opinion in Structural Biology, vol. 66, pp. 183–192, feb 2021.
    [2021]
  • S. S. Lee, S. Tashiro, A. Awazu, and R. Kobayashi, A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization, Journal of Mathematical Biology, vol. 74, no. 1-2, pp. 333–354, may 2016.
    [2016]
  • S. M. Gough, C. I. Slape, and P. D. Aplan, NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights, Blood, vol. 118, no. 24, pp. 6247–6257, dec 2011.
    [2011]
  • S. L. Speer, W. Zheng, X. Jiang, I.-T. Chu, A. J. Guseman, M. Liu, G. J. Pielak, and C. Li, The intracellular environment affects protein–protein interactions, Proceedings of the National Academy of Sciences, vol. 118, no. 11, p. e2019918118, mar 2021.
    [2021]
  • S. K. Powers, A. S. Holehouse, D. A. Korasick, K. H. Schreiber, N. M. Clark, H. Jing, R. Emenecker, S. Han, E. Tycksen, I. Hwang, R. Sozzani, J. M. Jez, R. V. Pappu, and L. C. Strader, Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in arabidopsis thaliana, Molecular Cell, vol. 76, no. 1, pp. 177–190.e5, oct 2019.
  • S. Ghosh, S. Shahid, N. Raina, F. Ahmad, M. I. Hassan, and A. Islam, Molecular and macromolecular crowding-induced stabilization of proteins: Effect of dextran and its building block alone and their mixtures on stability and structure of lysozyme, International Journal of Biological Macromolecules, vol. 150, pp. 1238–1248, may 2020.
    [2020]
  • S. F. Banani, H. O. Lee, A. A. Hyman, and M. K. Rosen, Biomolecular condensates: organizers of cellular biochemistry, Nature Reviews Molecular Cell Biology, vol. 18, no. 5, pp. 285–298, feb 2017.
    [2017]
  • S. F. Banani, A. M. Rice, W. B. Peeples, Y. Lin, S. Jain, R. Parker, and M. K. Rosen, Compositional control of phase-separated cellular bodies, Cell, vol. 166, no. 3, pp. 651–663, jul 2016.
    [2016]
  • S. Elbaum-Garfinkle, Y. Kim, K. Szczepaniak, C. C.-H. Chen, C. R. Eckmann, S. Myong, and C. P. Brangwynne, The disordered p granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics, Proceedings of the National Academy of Sciences, vol. 112, no. 23, pp. 7189–7194, may 2015.
  • S. C. Weber and C. P. Brangwynne, Getting RNA and protein in phase, Cell, vol. 149, no. 6, pp. 1188–1191, jun 2012.
    [2012]
  • S. C. Glotzer, Computer simulations of spinodal decomposition in polymer blends, in Annual Reviews of Computational Physics II. World Scientific, mar 1995, pp. 1–46.
    [1995]
  • S. Boeynaems, S. Alberti, N. L. Fawzi, T. Mittag, M. Polymenidou, F. Rousseau, J. Schymkowitz, J. Shorter, B. Wolozin, L. V. D. Bosch, P. Tompa, and M. Fuxreiter, Protein phase separation: A new phase in cell biology, Trends in Cell Biology, vol. 28, no. 6, pp. 420–435, jun 2018.
  • S. B. Zimmerman and A. P. Minton, Macromolecular crowding: Biochemical, biophysical, and physiological consequences, Annual Review of Biophysics and Biomolecular Structure, vol. 22, no. 1, pp. 27–65, jun 1993.
  • S. Alberti, A. Gladfelter, and T. Mittag, Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates, Cell, vol. 176, no. 3, pp. 419–434, jan 2019.
    [2019]
  • S. Alberti and D. Dormann, Liquid–liquid phase separation in disease, Annual Review of Genetics, vol. 53, no. 1, pp. 171–194, dec 2019.
    [2019]
  • S. Alberti and A. A. Hyman, Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing, Nature Reviews Molecular Cell Biology, vol. 22, no. 3, pp. 196–213, jan 2021.
    [2021]
  • S. Alberti and A. A. Hyman, Are aberrant phase transitions a driver of cellular aging? BioEssays, vol. 38, no. 10, pp. 959–968, aug 2016.
    [2016]
  • Reversible elastic phase field approach and application to cell monolayers
  • R. Milo and R. Phillips, Cell Biology by the Numbers. New York, NY: Garland Science, Taylor & Francis Group, 2016.
    [2016]
  • R. Livi and P. Politi, Nonequilibrium Statistical Physics. Cambridge University Press, Cambridge, UK, oct 2017.
    [2017]
  • R. Lefever, D. Carati, and N. Hassani, Comment on monte carlo simulations of phase separation in chemically reactive binary mixtures, Physical Review Letters, vol. 75, no. 8, pp. 1674–1674, aug 1995.
    [1995]
  • R. J. Duronio and W. F. Marzluff, Coordinating cell cycle-regulated histone gene expression through assembly and function of the histone locus body, RNA Biology, vol. 14, no. 6, pp. 726–738, jan 2017.
    [2017]
  • R. J. Cauchi, Gem formation upon constitutive gemin3 overexpression inDrosophila, Cell Biology International, vol. 35, no. 12, pp. 1233–1238, nov 2011.
    [2011]
  • R. Ellis, Macromolecular crowding: obvious but underappreciated, Trends in Biochemical Sciences, vol. 26, no. 10, pp. 597–604, oct 2001.
    [2001]
  • R. D. Travasso, M. Castro, and J. C. Oliveira, The phase-field model in tumor growth, Philosophical Magazine, vol. 91, no. 1, pp. 183–206, jan 2011.
    [2011]
  • R. C. Desai and R. Kapral, Dynamics of Self-Organized and Self-Assembled Structures. Cambridge University Press, Cambridge, UK, Mar. 2009.
    [2009]
  • Q. Bai, Q. Zhang, H. Jing, J. Chen, and D. Liang, Liquid–liquid phase separation of peptide/oligonucleotide complexes in crowded macromolecular media, The Journal of Physical Chemistry B, vol. 125, no. 1, pp. 49–57, dec 2020.
    [2020]
  • Physical principles of intracellular organization via active and passive phase transitions
    J. Berry , C. P. Brangwynne , and M. Haataja , vol . 81 , no . 4 , p. 046601 [2018]
  • Phase-field approach to threedimensional vesicle dynamics
    T. Biben , K. Kassner , and C. Misbah , vol . 72 , no . 4 , p. 041921 [2005]
  • Phase transitions of multivalent proteins can promote clustering of membrane receptors ,
  • Phase separation and nucleation in mixtures of particles with different temperatures
    E. Ilker and J.-F. Joanny vol . 2 , no . 2 , p. 023200 , [2020]
  • Partial demixing of RNA-protein complexes leads to intradroplet patterning in phase-separated biological condensates ,
  • P. Yang, C. Mathieu, R.-M. Kolaitis, P. Zhang, J. Messing, U. Yurtsever, Z. Yang, J. Wu, Y. Li, Q. Pan, J. Yu, E. W. Martin, T. Mittag, H. J. Kim, and J. P. Taylor, G3bp1 is a tunable switch that triggers phase separation to assemble stress granules, Cell, vol. 181, no. 2, pp. 325–345.e28, apr 2020.
  • P. Moin, Fundamentals of Engineering Numerical Analysis. Cambridge University Press, Cambridge, UK, 2009.
    [2009]
  • P. Li, S. Banjade, H.-C. Cheng, S. Kim, B. Chen, L. Guo, M. Llaguno, J. V. Hollingsworth, D. S. King, S. F. Banani, P. S. Russo, Q.-X. Jiang, B. T. Nixon, and M. K. Rosen, Phase transitions in the assembly of multivalent signalling proteins, Nature, vol. 483, no. 7389, pp. 336–340, mar 2012.
  • P. C. Hohenberg and B. I. Halperin, Theory of dynamic critical phenomena, Reviews of Modern Physics, vol. 49, no. 3, pp. 435–479, jul 1977.
  • Ordering kinetics in the activemodel B
    S. Pattanayak , S. Mishra , and S. Puri , vol . 104 , no . 1 , p. 014606 , [2021]
  • O. Beutel, R. Maraspini, K. Pombo-García, C. Martin-Lemaitre, and A. Honigmann, Phase separation of zonula occludens proteins drives formation of tight junctions, Cell, vol. 179, no. 4, pp. 923–936.e11, oct 2019.
    [2019]
  • NUP214 in leukemia : It ’ s more than transport
    A. Mendes and B. Fahrenkrog vol . 8 , no . 1 , p. 76 [2019]
  • N. N. Noda, Z. Wang, and H. Zhang, Liquid–liquid phase separation in autophagy, Journal of Cell Biology, vol. 219, no. 8, jun 2020.
    [2020]
  • N. Kedersha, M. D. Panas, C. A. Achorn, S. Lyons, S. Tisdale, T. Hickman, M. Thomas, J. Lieberman, G. M. McInerney, P. Ivanov, and P. Anderson, G3bp–caprin1–USP10 complexes mediate stress granule condensation and associate with 40s subunits, Journal of Cell Biology, vol. 212, no. 7, mar 2016.
  • N. Jones, I. M. Blasutig, V. Eremina, J. M. Ruston, F. Bladt, H. Li, H. Huang, L. Larose, S. S.-C. Li, T. Takano, S. E. Quaggin, and T. Pawson, Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes, Nature, vol. 440, no. 7085, pp. 818–823, mar 2006.
  • N. B. Nedelsky and J. P. Taylor, Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease, Nature Reviews Neurology, mar 2019.
    [2019]
  • Multiple scale model for cell migration in monolayers : Elastic mismatch between cells enhances motility
  • Molecular crowding tunes material states of ribonucleoprotein condensates
  • Mechanism for the stabilization of protein clusters above the solubility curve : the role of non-ideal chemical reactions
    J. F. Lutsko vol . 28 , no . 24 , p. 244020 [2016]
  • Macromolecular crowding effects on the kinetics of opposing reactions catalyzed by alcohol dehydrogenase
  • M. Zeng, Y. Shang, Y. Araki, T. Guo, R. L. Huganir, and M. Zhang, Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity, Cell, vol. 166, no. 5, pp. 1163–1175.e12, aug 2016.
    [2016]
  • M. Zeng, X. Chen, D. Guan, J. Xu, H. Wu, P. Tong, and M. Zhang, Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity, Cell, vol. 174, no. 5, pp. 1172–1187.e16, aug 2018.
    [2018]
  • M. Z. Bazant, Theory of chemical kinetics and charge transfer based on nonequilibrium thermodynamics, Accounts of Chemical Research, vol. 46, no. 5, pp. 1144–1160, mar 2013.
    [2013]
  • M. Shah, O. Galkin, and P. G. Vekilov, Smooth transition from metastability to instability in phase separating protein solutions, The Journal of Chemical Physics, vol. 121, no. 15, pp. 7505–7512, oct 2004.
    [2004]
  • M. Ramaswami, J. P. Taylor, and R. Parker, Altered ribostasis: RNAprotein granules in degenerative disorders, Cell, vol. 154, no. 4, pp. 727– 736, aug 2013.
    [2013]
  • M. Morimoto and C. Boerkoel, The role of nuclear bodies in gene expression and disease, Biology (Basel), vol. 2, no. 3, pp. 976–1033, jul 2013.
    [2013]
  • M. Komatsu, S. Waguri, T. Chiba, S. Murata, J. ichi Iwata, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami, and K. Tanaka, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, vol. 441, no. 7095, pp. 880–884, apr 2006.
  • M. K. Hazra and Y. Levy, Biophysics of phase separation of disordered proteins is governed by balance between short- and long-range interactions, The Journal of Physical Chemistry B, vol. 125, no. 9, pp. 2202– 2211, feb 2021.
    [2021]
  • M. Hofweber, S. Hutten, B. Bourgeois, E. Spreitzer, A. Niedner-Boblenz, M. Schifferer, M.-D. Ruepp, M. Simons, D. Niessing, T. Madl, and D. Dormann, Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation, Cell, vol. 173, no. 3, pp. 706–719.e13, apr 2018.
  • M. Du and Z. J. Chen, DNA-induced liquid phase condensation of cGAS activates innate immune signaling, Science, vol. 361, no. 6403, pp. 704– 709, aug 2018.
    [2018]
  • M. Doi, Soft Matter Physics. Oxford University Press, Oxford, UK, Aug. 2013.
    [2013]
  • M. Delarue, G. Brittingham, S. Pfeffer, I. Surovtsev, S. Pinglay, K. Kennedy, M. Schaffer, J. Gutierrez, D. Sang, G. Poterewicz, J. Chung, J. Plitzko, J. Groves, C. Jacobs-Wagner, B. Engel, and L. Holt, mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding, Cell, vol. 174, no. 2, pp. 338–349.e20, jul 2018.
  • M. C. Munder, D. Midtvedt, T. Franzmann, E. Nüske, O. Otto, M. Herbig, E. Ulbricht, P. Müller, A. Taubenberger, S. Maharana, L. Malinovska, D. Richter, J. Guck, V. Zaburdaev, and S. Alberti, A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy, eLife, vol. 5, mar 2016.
  • M. A. Mourão, J. B. Hakim, and S. Schnell, Connecting the dots: The effects of macromolecular crowding on cell physiology, Biophysical Journal, vol. 107, no. 12, pp. 2761–2766, dec 2014.
    [2014]
  • Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
  • Liquid-liquid phase separation induces pathogenic tau conformations in vitro
  • Liquid phase condensation in cell physiology and disease
    Y. Shin and C. P. Brangwynne vol . 357 , no . 6357 , p. eaaf4382 [2017]
  • L. Zhang, M. R. Tonks, D. Gaston, J. W. Peterson, D. Andrs, P. C. Millett, and B. S. Biner, A quantitative comparison between C0 and C1 elements for solving the Cahn-Hilliard equation, Journal of Computational Physics, vol. 236, pp. 74–80, mar 2013.
    [2013]
  • L. Stagg, S.-Q. Zhang, M. S. Cheung, and P. Wittung-Stafshede, Molecular crowding enhances native structure and stability of / protein flavodoxin, Proceedings of the National Academy of Sciences, vol. 104, no. 48, pp. 18 976–18 981, nov 2007.
    [2007]
  • L. Li, K. Roy, S. Katyal, X. Sun, S. Bléoo, and R. Godbout, Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, cajal bodies, and gems, Molecular Biology of the Cell, vol. 17, no. 3, pp. 1126–1140, mar 2006.
    [2006]
  • L. L. Latour, K. Svoboda, P. P. Mitra, and C. H. Sotak, Time-dependent diffusion of water in a biological model system. Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 4, pp. 1229–1233, feb 1994.
  • K. Watanabe, T. Umeda, K. Niwa, I. Naguro, and H. Ichijo, A PP6-ASK3 module coordinates the bidirectional cell volume regulation under osmotic stress, Cell Reports, vol. 22, no. 11, pp. 2809–2817, mar 2018.
    [2018]
  • K. Watanabe, K. Morishita, X. Zhou, S. Shiizaki, Y. Uchiyama, M. Koike, I. Naguro, and H. Ichijo, Cells recognize osmotic stress through liquid– liquid phase separation lubricated with poly(ADP-ribose), Nature Communications, vol. 12, no. 1, mar 2021.
    [2021]
  • K. Taniue and N. Akimitsu, Aberrant phase separation and cancer, The FEBS Journal, mar 2021.
  • K. Laaß, F. G. Quiroz, J. Hunold, S. Roberts, A. Chilkoti, and D. Hinderberger, Nanoscopic dynamics dictate the phase separation behavior of intrinsically disordered proteins, Biomacromolecules, vol. 22, no. 2, pp. 1015–1025, jan 2021.
    [2021]
  • K. Julius, J. Weine, M. Gao, J. Latarius, M. Elbers, M. Paulus, M. Tolan, and R. Winter, Impact of macromolecular crowding and compression on protein–protein interactions and liquid–liquid phase separation phenomena, Macromolecules, vol. 52, no. 4, pp. 1772–1784, feb 2019.
    [2019]
  • K. E. Handwerger, J. A. Cordero, and J. G. Gall, Cajal bodies, nucleoli, and speckles in the xenopus oocyte nucleus have a low-density, sponge-like structure, Molecular Biology of the Cell, vol. 16, no. 1, pp. 202–211, jan 2005.
    [2005]
  • J. W. Cahn, On spinodal decomposition, Acta Metallurgica, vol. 9, no. 9, pp. 795–801, sep 1961.
  • J. W. Cahn and J. E. Hilliard, Free energy of a nonuniform system. i. interfacial free energy, The Journal of Chemical Physics, vol. 28, no. 2, pp. 258–267, feb 1958.
  • J. W. Barrett, J. F. Blowey, and H. Garcke, Finite element approximation of the cahn–hilliard equation with degenerate mobility, SIAM Journal on Numerical Analysis, vol. 37, no. 1, pp. 286–318, jan 1999.
  • J. S. Vrentas and C. M. Vrentas, A new equation relating self-diffusion and mutual diffusion coefficients in polymer-solvent systems, Macromolecules, vol. 26, no. 22, pp. 6129–6131, oct 1993.
    [1993]
  • J. S. Schreck, J. Bridstrup, and J.-M. Yuan, Investigating the effects of molecular crowding on the kinetics of protein aggregation, The Journal of Physical Chemistry B, vol. 124, no. 44, pp. 9829–9839, oct 2020.
    [2020]
  • J. Risso-Ballester, M. Galloux, J. Cao, R. L. Goffic, F. Hontonnou, A. Jobart-Malfait, A. Desquesnes, S. M. Sake, S. Haid, M. Du, X. Zhang, H. Zhang, Z. Wang, V. Rincheval, Y. Zhang, T. Pietschmann, J.- F. Eléouët, M.-A. Rameix-Welti, and R. Altmeyer, A condensatehardening drug blocks RSV replication in vivo, Nature, vol. 595, no. 7868, pp. 596–599, jul 2021.
  • J. Ojalvo, Noise in Spatially Extended Systems. New York, USA: Springer, 1999.
    [1999]
  • J. Mittal and R. B. Best, Dependence of protein folding stability and dynamics on the density and composition of macromolecular crowders, Biophysical Journal, vol. 98, no. 2, pp. 315–320, jan 2010.
    [2010]
  • J. H. Ahn, E. S. Davis, T. A. Daugird, S. Zhao, I. Y. Quiroga, H. Uryu, J. Li, A. J. Storey, Y.-H. Tsai, D. P. Keeley, S. G. Mackintosh, R. D. Edmondson, S. D. Byrum, L. Cai, A. J. Tackett, D. Zheng,W. R. Legant, D. H. Phanstiel, and G. G. Wang, Phase separation drives aberrant chromatin looping and cancer development, Nature, jun 2021.
  • J. D. Finan, H. A. Leddy, and F. Guilak, Osmotic stress alters chromatin condensation and nucleocytoplasmic transport, Biochemical and Biophysical Research Communications, vol. 408, no. 2, pp. 230–235, may 2011.
    [2011]
  • J. Cubuk, J. J. Alston, J. J. Incicco, S. Singh, M. D. Stuchell-Brereton, M. D. Ward, M. I. Zimmerman, N. Vithani, D. Griffith, J. A. Wagoner, G. R. Bowman, K. B. Hall, A. Soranno, and A. S. Holehouse, The SARSCoV- 2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA, Nature Communications, vol. 12, no. 1, mar 2021.
  • J. Berry, S. C.Weber, N. Vaidya, M. Haataja, and C. P. Brangwynne, RNA transcription modulates phase transition-driven nuclear body assembly, Proceedings of the National Academy of Sciences, vol. 112, no. 38, pp. E5237–E5245, sep 2015.
    [2015]
  • J. A. Harrigan, R. Belotserkovskaya, J. Coates, D. S. Dimitrova, S. E. Polo, C. R. Bradshaw, P. Fraser, and S. P. Jackson, Replication stress induces 53bp1-containing OPT domains in g1 cells, Journal of Cell Biology, vol. 193, no. 1, pp. 97–108, mar 2011.
    [2011]
  • Intrinsically disordered proteins in chronic diseases
    P. Kulkarni and V. Uversky vol . 9 , no . 4 , p. 147 [2019]
  • I. Chiolo, A. Minoda, S. U. Colmenares, A. Polyzos, S. V. Costes, and G. H. Karpen, Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair, Cell, vol. 144, no. 5, pp. 732–744, mar 2011.
    [2011]
  • H. Wu and M. Fuxreiter, The structure and dynamics of higher-order assemblies: Amyloids, signalosomes, and granules, Cell, vol. 165, no. 5, pp. 1055–1066, may 2016.
    [2016]
  • H. Nojima, S. RothhÃCmel, T. Shimizu, C.-H. Kim, S. Yonemura, F. L. Marlow, and M. Hibi, Syntabulin, a motor protein linker, controls dorsal determination, Development, vol. 137, no. 6, pp. 923–933, mar 2010.
    [2010]
  • H. Falahati and A. Haji-Akbari, Thermodynamically driven assemblies and liquid–liquid phase separations in biology, Soft Matter, 2019.
    [2019]
  • G. Rivas and A. P. Minton, Macromolecular crowding in vitro , in vivo , and in between, Trends in Biochemical Sciences, vol. 41, no. 11, pp. 970–981, nov 2016.
    [2016]
  • G. Guigas, C. Kalla, and M.Weiss, The degree of macromolecular crowding in the cytoplasm and nucleoplasm of mammalian cells is conserved, FEBS Letters, vol. 581, no. 26, pp. 5094–5098, oct 2007.
    [2007]
  • G. Boulay, G. J. Sandoval, N. Riggi, S. Iyer, R. Buisson, B. Naigles, M. E. Awad, S. Rengarajan, A. Volorio, M. J. McBride, L. C. Broye, L. Zou, I. Stamenkovic, C. Kadoch, and M. N. Rivera, Cancer-specific retargeting of BAF complexes by a prion-like domain, Cell, vol. 171, no. 1, pp. 163– 178.e19, sep 2017.
  • F. Geiger, J. Acker, G. Papa, X. Wang, W. E. Arter, K. L. Saar, N. A. Erkamp, R. Qi, J. P. Bravo, S. Strauss, G. Krainer, O. R. Burrone, R. Jungmann, T. P. Knowles, H. Engelke, and A. Borodavka, Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses, The EMBO Journal, vol. 40, no. 21, sep 2021.
  • F. Frottin, F. Schueder, S. Tiwary, R. Gupta, R. Körner, T. Schlichthaerle, J. Cox, R. Jungmann, F. U. Hartl, and M. S. Hipp, The nucleolus functions as a phase-separated protein quality control compartment, Science, vol. 365, no. 6451, pp. 342–347, jul 2019.
    [2019]
  • Effects of surfaces and macromolecular crowding on bimolecular reaction rates ,
    S. S. Andrews vol . 17 , no . 4 , p. 045001 , [2020]
  • E. S. F. Rosenzweig, B. Xu, L. K. Cuellar, A. Martinez-Sanchez, M. Schaffer, M. Strauss, H. N. Cartwright, P. Ronceray, J. M. Plitzko, F. Förster, N. S.Wingreen, B. D. Engel, L. C. Mackinder, and M. C. Jonikas, The eukaryotic CO2-concentrating organelle is liquid-like and exhibits dynamic reorganization, Cell, vol. 171, no. 1, pp. 148–162.e19, sep 2017.
  • Dehydration entropy drives liquid-liquid phase separation by molecular crowding ,
  • D. Milovanovic, Y. Wu, X. Bian, and P. D. Camilli, A liquid phase of synapsin and lipid vesicles, Science, vol. 361, no. 6402, pp. 604–607, jul 2018.
    [2018]
  • D. Milovanovic and P. D. Camilli, Synaptic vesicle clusters at synapses: A distinct liquid phase? Neuron, vol. 93, no. 5, pp. 995–1002, mar 2017.
    [2017]
  • D. L. Spector, Nuclear domains, Journal of Cell Science, vol. 114, no. 16, pp. 2891–2893, aug 2001.
    [2001]
  • D. L. Spector and A. I. Lamond, Nuclear speckles, Cold Spring Harbor Perspectives in Biology, vol. 3, no. 2, pp. a000 646–a000 646, oct 2010.
    [2010]
  • D. Eisenberg and M. Jucker, The amyloid state of proteins in human diseases, Cell, vol. 148, no. 6, pp. 1188–1203, mar 2012.
    [2012]
  • D. Carati and R. Lefever, Chemical freezing of phase separation in immiscible binary mixtures, Physical Review E, vol. 56, no. 3, pp. 3127–3136, sep 1997.
  • Chemical-reaction-controlled phase separated drops : Formation , size selection , and coarsening
    J. D. Wurtz and C. F. Lee vol . 120 , no . 7 , p. 078102 [2018]
  • C. Schwayer, S. Shamipour, K. Pranjic-Ferscha, A. Schauer, M. Balda, M. Tada, K. Matter, and C.-P. Heisenberg, Mechanosensation of tight junctions depends on ZO-1 phase separation and flow, Cell, vol. 179, no. 4, pp. 937–952.e18, oct 2019.
    [2019]
  • C. Pollock and S. Huang, The perinucleolar compartment, Cold Spring Harbor Perspectives in Biology, vol. 2, no. 2, pp. a000 679–a000 679, jan 2010.
    [2010]
  • C. P. Brangwynne, T. J. Mitchison, and A. A. Hyman, Active liquidlike behavior of nucleoli determines their size and shape in xenopus laevis oocytes, Proceedings of the National Academy of Sciences, vol. 108, no. 11, pp. 4334–4339, feb 2011.
    [2011]
  • C. P. Brangwynne, P. Tompa, and R. V. Pappu, Polymer physics of intracellular phase transitions, Nature Physics, vol. 11, no. 11, pp. 899–904, nov 2015.
    [2015]
  • C. P. Brangwynne, C. R. Eckmann, D. S. Courson, A. Rybarska, C. Hoege, J. Gharakhani, F. Julicher, and A. A. Hyman, Germline p granules are liquid droplets that localize by controlled dissolution/condensation, Science, vol. 324, no. 5935, pp. 1729–1732, may 2009.
    [2009]
  • C. J. Decker and R. Parker, P-bodies and stress granules: Possible roles in the control of translation and mRNA degradation, Cold Spring Harbor Perspectives in Biology, vol. 4, no. 9, pp. a012 286–a012 286, jul 2012.
    [2012]
  • C. Ferreira, M. F. Pinto, S. Macedo-Ribeiro, P. J. B. Pereira, F. A. Rocha, and P. M. Martins, Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions, Physical Chemistry Chemical Physics, vol. 22, no. 28, pp. 16 143–16 149, 2020.
    [2020]
  • Basal condensation of numb and pon complex via phase transition during drosophila neuroblast asymmetric division ,
  • B. van den Berg, Effects of macromolecular crowding on protein folding and aggregation, The EMBO Journal, vol. 18, no. 24, pp. 6927–6933, dec 1999.
    [1999]
  • B. Wang, L. Zhang, T. Dai, Z. Qin, H. Lu, L. Zhang, and F. Zhou, Liquid– liquid phase separation in human health and diseases, Signal Transduction and Targeted Therapy, vol. 6, no. 1, aug 2021.
    [2021]
  • B. R. Parry, I. V. Surovtsev, M. T. Cabeen, C. S. O’Hern, E. R. Dufresne, and C. Jacobs-Wagner, The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity, Cell, vol. 156, no. 1-2, pp. 183–194, jan 2014.
    [2014]
  • B. L. Goode, J. A. Eskin, and B. Wendland, Actin and endocytosis in budding yeast, Genetics, vol. 199, no. 2, pp. 315–358, feb 2015.
    [2015]
  • B. A. Gibson, L. K. Doolittle, M. W. Schneider, L. E. Jensen, N. Gamarra, L. Henry, D. W. Gerlich, S. Redding, and M. K. Rosen, Organization of chromatin by intrinsic and regulated phase separation, Cell, vol. 179, no. 2, pp. 470–484.e21, oct 2019.
    [2019]
  • A.-O. Vweza, C.-G. Song, and K.-T. Chong, Liquid–liquid phase separation in the presence of macromolecular crowding and state-dependent kinetics, International Journal of Molecular Sciences, vol. 22, no. 13, p. 6675, jun 2021.
    [2021]
  • A. Steven, Molecular biology of assemblies and machines. New York: Garland Science, Taylor & Francis Group, 2016.
    [2016]
  • A. S. Lyon, W. B. Peeples, and M. K. Rosen, A framework for understanding the functions of biomolecular condensates across scales, Nature Reviews Molecular Cell Biology, vol. 22, no. 3, pp. 215–235, nov 2020.
    [2020]
  • A. R. Strom, A. V. Emelyanov, M. Mir, D. V. Fyodorov, X. Darzacq, and G. H. Karpen, Phase separation drives heterochromatin domain formation, Nature, vol. 547, no. 7662, pp. 241–245, jun 2017.
    [2017]
  • A. Patel, H. O. Lee, L. Jawerth, S. Maharana, M. Jahnel, M. Y. Hein, S. Stoynov, J. Mahamid, S. Saha, T. M. Franzmann, A. Pozniakovski, I. Poser, N. Maghelli, L. A. Royer, M. Weigert, E. W. Myers, S. Grill, D. Drechsel, A. A. Hyman, and S. Alberti, A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation, Cell, vol. 162, no. 5, pp. 1066–1077, aug 2015.
  • A. P. Minton, The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences, Molecular and Cellular Biochemistry, vol. 55, no. 2, pp. 119–140, 1983.
    [1983]
  • A. P. Minton, Excluded volume as a determinant of macromolecular structure and reactivity, Biopolymers, vol. 20, no. 10, pp. 2093–2120, oct 1981.
    [1981]
  • A. P. Jalihal, S. Pitchiaya, L. Xiao, P. Bawa, X. Jiang, K. Bedi, A. Parolia, M. Cieslik, M. Ljungman, A. M. Chinnaiyan, and N. G. Walter, Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change, Molecular Cell, vol. 79, no. 6, pp. 978–990.e5, sep 2020.
  • A. Moure and H. Gomez, Phase-field modeling of individual and collective cell migration, Archives of Computational Methods in Engineering, vol. 28, no. 2, pp. 311–344, dec 2019.
    [2019]
  • A. Molliex, J. Temirov, J. Lee, M. Coughlin, A. P. Kanagaraj, H. J. Kim, T. Mittag, and J. P. Taylor, Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization, Cell, vol. 163, no. 1, pp. 123–133, sep 2015.
    [2015]
  • A. M. Berezhkovskii and A. Szabo, Theory of crowding effects on bimolecular reaction rates, The Journal of Physical Chemistry B, vol. 120, no. 26, pp. 5998–6002, may 2016.
    [2016]
  • A. Klosin, F. Oltsch, T. Harmon, A. Honigmann, F. JÃOElicher, A. A. Hyman, and C. Zechner, Phase separation provides a mechanism to reduce noise in cells, Science, vol. 367, no. 6476, pp. 464–468, jan 2020.
    [2020]
  • A. K. Doolittle, Studies in newtonian flow. III. the dependence of the viscosity of liquids on molecular weight and free space (in homologous series), Journal of Applied Physics, vol. 23, no. 2, pp. 236–239, feb 1952.
  • A. G. Larson, D. Elnatan, M. M. Keenen, M. J. Trnka, J. B. Johnston, A. L. Burlingame, D. A. Agard, S. Redding, and G. J. Narlikar, Liquid droplet formation by HP1a suggests a role for phase separation in heterochromatin, Nature, vol. 547, no. 7662, pp. 236–240, jun 2017.
  • A. B. Singer and J. G. Gall, An inducible nuclear body in theDrosophilagerminal vesicle, Nucleus, vol. 2, no. 5, pp. 403–409, sep 2011.
    [2011]
  • A. A. M. André and E. Spruijt, Liquid–liquid phase separation in crowded environments, International Journal of Molecular Sciences, vol. 21, no. 16, p. 5908, aug 2020.
    [2020]
  • A. A. Hyman, C. A.Weber, and F. Jülicher, Liquid-liquid phase separation in biology, Annual Review of Cell and Developmental Biology, vol. 30, no. 1, pp. 39–58, oct 2014.
    [2014]
  • A. A. Hyman and C. P. Brangwynne, Beyond stereospecificity: Liquids and mesoscale organization of cytoplasm, Developmental Cell, vol. 21, no. 1, pp. 14–16, jul 2011.
    [2011]
  • A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels