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알츠하이머병의 치료 타깃과 잠재적 치료법의 탐색 = Searching for therapeutic targets and potential treatments of Alzheimers disease

전성각 2020년

논문상세정보
인용/피인용
' 알츠하이머병의 치료 타깃과 잠재적 치료법의 탐색 = Searching for therapeutic targets and potential treatments of Alzheimers disease' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • GV-971
  • Nurr1
  • aducanumab
  • alzheimer’s disease
  • th2
  • the treatment of Alzheimer’s disease
  • 면역체계
  • 시냅스 단백질
  • 신약
  • 알츠하이머 병
  • 잠재적 치료법
  • 천연물
  • 핵수용체
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
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' 알츠하이머병의 치료 타깃과 잠재적 치료법의 탐색 = Searching for therapeutic targets and potential treatments of Alzheimers disease' 의 참고문헌

  • van Praag H. When neurogenesis encounters aging and disease
    33:569-79 [2010]
  • neuron loss , and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer 's disease .
    33:196 e29-40 [2012]
  • microRNA regulation of neural stem cells and neurogenesis .
    30:14931-6 [2010]
  • amyloidogenesis and Alzheimer disease
    120:4081-91 [2007]
  • a postsynaptic calpacitin for setting the response threshold to calcium influxes
    15:131-63 [1997]
  • Zhong K. Alzheimer 's disease drug-development pipeline : few candidates , frequent failures
    6:37 [2014]
  • Zhong K. Alzheimer 's disease drug development pipeline : 2018
    4:195-214 [2018]
  • Zhong K. Alzheimer 's disease drug development pipeline : 2017
    3:367-84 [2017]
  • Zaidi M. A possible new role for vitamin D-binding protein in osteoclast control : inhibition of extracellular Ca2+ sensing at low physiological concentrations
    249:668-71 [1998]
  • Yu-Wai-Man P. Disturbed mitochondrial dynamics and neurodegenerative disorders
    11:11-24 [2015]
  • Youdim M. From single target to multitarget/network therapeutics in Alzheimer 's therapy
    7:113-35 [2014]
  • Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat
    0.5173611111 [2013]
  • Yokukansan , a traditional Japanese medicine , ameliorates memory disturbance and abnormal social interaction with antiaggregation effect of cerebral amyloid beta proteins in amyloid precursor protein transgenic mice
    180:305-13 [2011]
  • Y. Phenol red interacts with the protofibrillike oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts .
    91:3664-72 . [2006]
  • Y. Neuroprotection Against MPP ( + ) Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3beta/MEF2D Signaling Pathway by Rhynchophylline , the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla .
    0.9083333333 [2018]
  • Xu W. Experience-Dependent Equilibration of AMPARMediated Synaptic Transmission during the Critical Period
    18:892-904 [2017]
  • Wiedemann N. Mitochondrial proteins : from biogenesis to functional networks
    20:267-84 [2019]
  • Whole plant extracts versus single compounds for the treatment of malaria : synergy and positive interactions
    10 Suppl 1 : S4 . [2011]
  • Watanabe W. Physical and chemical stability of drug nanoparticles
    63:456-69 [2011]
  • Wang Y. Herbal therapy : a new pathway for the treatment of Alzheimer 's disease
    2:30 [2010]
  • Wang X. Vitamin D Binding Protein and 25Hydroxyvitamin D Levels : Emerging Clinical Applications .
    23:605-13 [2017]
  • Vitamin D-binding protein interacts with Abeta and suppresses Abeta-mediated pathology .
    20:630-8 . [2013]
  • Vitamin D-binding protein directs monocyte responses to 25-hydroxyand 1,25-dihydroxyvitamin D.
    95:3368-76 [2010]
  • Vitamin D binding protein ( Gc-globulin )
    10:294-307 [1989]
  • Vitamin D and multiple sclerosis
    9:599-612 [2010]
  • Verkhratsky A. Neurogenesis in Alzheimer 's disease .
    219:78-89 [2011]
  • Ventral tegmental area and substantia nigra neural correlates of spatial learning
    18:260-71 [2011]
  • Using confocal laser scanning microscopy to investigate the organization and development of neuronal projections labeled with DiI
    38:325-44 [1993]
  • Uptake and degradation of vitamin D binding protein and vitamin D binding protein-actin complex in vivo in the rat
    267:721-5 [1990]
  • Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients
    8:587-600 [1995]
  • Understanding cognitive deficits in Alzheimer 's disease based on neuroimaging findings
    17:510-6 [2013]
  • Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats
    37:351- 60 . [2009]
  • Uncaria rhynchophylla Ameliorates Parkinson 's Disease by Inhibiting HSP90 Expression : Insights from Quantitative Proteomics
    47:1453-64 [2018]
  • Uncaria rhynchophylla , a Chinese medicinal herb , has potent antiaggregation effects on Alzheimer 's beta-amyloid proteins .
    84:427-33 [2006]
  • Uncaria rhynchophylla ( miq ) Jack plays a role in neuronal protection in kainic acid-treated rats
    38:251-63 [2010]
  • Transthyretin protects Alzheimer 's mice from the behavioral and biochemical effects of Abeta toxicity
    105:2681-6 [2008]
  • Traditional Oriental Medicines and Alzheimer 's Disease
  • Toth K. Serotonergic control of the hippocampus via local inhibitory interneurons .
    87:8501-5 [1990]
  • Total Lignans of Schisandra chinensis Ameliorates Abeta1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells
    11 : e0152772 [2016]
  • Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    87:1327-38 [1996]
  • Therapeutic potential of vitamin D-binding protein
    22:340-5 [2004]
  • The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis .
    115:97-105 [2002]
  • The toxic Abeta oligomer and Alzheimer 's disease : an emperor in need of clothes .
    15:349-57 [2012]
  • The synaptic Abeta hypothesis of Alzheimer disease
    8:977-9 [2005]
  • The role of calmodulin as a signal integrator for synaptic plasticity
    6:267-76 [2005]
  • The role of astrocytes in amyloid beta-protein toxicity and clearance .
    236:1-5 [2012]
  • The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
    0.6118055556 [2014]
  • The road to restoring neural circuits for the treatment of Alzheimer 's disease
    539:187-96 [2016]
  • The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs
    64:1397- 403 [2005]
  • The pRb/E2F cell-cycle pathway mediates cell death in Parkinson 's disease
    104:3585-90 [2007]
  • The nature and staging of attention dysfunction in early ( minimal and mild ) Alzheimer 's disease : relationship to episodic and semantic memory impairment .
    38:252-71 [2000]
  • The molecular pathology of Alzheimer 's disease
  • The intersection of amyloid beta and tau at synapses in Alzheimer 's disease .
    82:756-71 [2014]
  • The human hippocampus and spatial and episodic memory
    35:625-41 [2002]
  • The hippocampal-VTA loop : controlling the entry of information into long-term memory
    46:703-13 [2005]
  • The glutamatergic system and Alzheimer 's disease : therapeutic implications
    17:641-52 [2003]
  • The effects on Jowiseungchungtang of patients with early DAT using auditory ERP and K-DRS
    14:43-59 [2003]
  • The effects of jowiseungchungtang versus fluoxetine in the chronic mild stress model of depression in rats
    15:27-41 [2004]
  • The effects of Jowiseungchungtang on Learning and Memory of AD Rats using Morris water maze and Radial arm maze paradigm
    21:479- 501 [1998]
  • The effect of lauryl capping group on protein release and degradation of poly ( D , L-lactic-co-glycolic acid ) particles
    172:436-43 [2013]
  • The dorsal raphe nucleus and serotonin : implications for neuroplasticity linked to major depression and Alzheimer 's disease
    172:233-64 [2008]
  • The cholinergic system in old age and Alzheimer 's disease
    9:1-8 [1980]
  • The cholinergic limbic system : projections to hippocampal formation , medial cortex , nuclei of the ascending cholinergic reticular system , and the subfornical organ and supra-optic crest
    90:521-40 [1967]
  • The cholinergic hypothesis of Alzheimer 's disease : a review of progress
    66:137-47 [1999]
  • The amyloid hypothesis of Alzheimer 's disease at 25 years
    8:595-608 [2016]
  • The action of norepinephrine in the rat hippocampus . II . Activation of the input pathway
    72:99-114 [1974]
  • The Locus Coeruleus : Essential for Maintaining Cognitive Function and the Aging Brain
    20:214-26 [2016]
  • The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer 's Disease
  • Thanos S. Current concepts in neuroanatomical tracing .
    62:327-51 . [2000]
  • Temple S. Fine control : microRNA regulation of adult neurogenesis .
    12:369-70 [2009]
  • Tau suppression in a neurodegenerative mouse model improves memory function
    309:476-81 [2005]
  • Tau pathology in Alzheimer disease and other tauopathies .
    1739:198-210 [2005]
  • Tau and Abeta imaging , CSF measures , and cognition in Alzheimer 's disease
    8:338ra66 [2016]
  • Takeshi Y. Polygalae radix extract ameliorates behavioral and neuromorphological abnormalities in chronic corticosteronetreated mice
    0 .
  • Taghipour B. PLGA micro and nanoparticles in delivery of peptides and proteins
    20:385-93 [2015]
  • Synthesis and characterization of PLGA nanoparticles
    17:247-89 [2006]
  • Synaptic proteins predict cognitive decline in Alzheimer 's disease and Lewy body dementia
    12:1149-58 [2016]
  • Synaptic markers of cognitive decline in neurodegenerative diseases : a proteomic approach
    141:582-95 [2018]
  • Synapsespecific regulation of AMPA receptor function by PSD-95
    103:19535-40 [2006]
  • Sung H. Colorimetric determination of acidic polysaccharide from Panax ginseng , its extraction condition and stability
    17:139-44 [1993]
  • Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
    423:555-60 [2003]
  • Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice : correlation with Th1/Th2 balance after stress exposure
    218:12-20 [2010]
  • Spillantini MG. ACentury of Alzheimer 's disease .
    314:777-81 [2006]
  • Spatial memory , recognition memory , and the hippocampus .
    101:14515-20 [2004]
  • Soluble protein oligomers in neurodegeneration : lessons from the Alzheimer 's amyloid beta-peptide .
    8:101-12 [2007]
  • Solanezumab for the treatment of mildto-moderate Alzheimer ’ s disease
    8:135-49 [2012]
  • Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotionrelated behaviors in juvenile mice
    105:921-32 [2008]
  • Smoking and increased Alzheimer 's disease risk : a review of potential mechanisms
    10 : S122-45 . [2014]
  • Sleegers K. The genetic landscape of Alzheimer disease :Clinical implications and perspectives
    18:421-30 [2016]
  • Site-specific inhibitory mechanism for amyloid beta42 aggregation byCatechol-type flavonoids targeting the Lys residues
    288:23212-24 [2013]
  • Single Oral Dose Toxicity Test ofChoweseuncheng-tang , a Polyherbal Formula in ICR Mice
    28:53-8 [2014]
  • Simultaneous determination of 30 ginsenosides in Panax ginseng preparations using ultra performance liquidChromatography .
    37:457-67 [2013]
  • Sharma M. Differential effects on spatial navigation of immunotoxin-inducedCholinergic lesions of the medial septal area and nucleus basalis magnocellularis
    14:4507-19 . [1994]
  • Sesaki H. Mitochondrial dynamics in neurodegeneration
    23:64-71 [2013]
  • Serum-derived immunoglobulins alter amyloid beta transport across a blood-brain barrier in vitro model .
    65:267-73 [2010]
  • Serotonin in aging , late-life depression , and Alzheimer 's disease : the emerging role of functional imaging
    18:407-30 [1998]
  • Semisynthesis and Structure-Activity Studies of Uncarinic AcidC Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid beta42 Aggregation .
    79:2521-9 [2016]
  • Selective loss of noradrenaline exacerbates earlyCognitive dysfunction and synaptic deficits in APP/PS1 mice
    73:454-63 [2013]
  • Selective immunolesioning of the basal forebrainCholinergic system disrupts short-term memory in rats
    8:1535-44 [1996]
  • Schwartz M. TCell deficiency leads toCognitive dysfunction : implications for therapeutic vaccination for schizophrenia and other psychiatricConditions
    101:8180-5 [2004]
  • Schisandrin enhances dendrite outgrowth and synaptogenesis in primaryCultured hippocampal neurons
    91:694-702 [2011]
  • Schisandrin A and B affect subventricular zone neurogenesis in mouse
    740:552-9 [2014]
  • Scheff SW. Synapse loss in frontalCortex biopsies in Alzheimer 's disease :Correlation withCognitive severity
    27:457-64 [1990]
  • Scarpini E. Disease-modifying treatments for Alzheimer 's disease .
    4:203-16 [2011]
  • Sarmento B. Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications
    7 [2018]
  • Sabatino M. Substantia nigra-mediated anticonvulsant action : a possible role of a dopaminergicComponent
    515:87-93 [1990]
  • S. Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stemCells
    218:49-59 [2013]
  • S. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice
    0.6631944444 [2018]
  • Royall DR. Vitamin D binding protein as a serum biomarker of Alzheimer 's disease .
    43:37-45 [2015]
  • Role of the neurograninConcentrated in spines in the induction of long-term potentiation
    26:7337-47 [2006]
  • Role of neuroinflammation in neurodegenerative diseases ( Review )
    13:3391-6 [2016]
  • Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from StemCells
    17:17 [2015]
  • Rivett K.Constitutive expression of interleukin ( IL ) -4 in vivoCauses autoimmune-type disorders in mice
    185:329-39 [1997]
  • Risk factors for Alzheimer 's disease : a prospective analysis from theCanadian Study of Health and Aging
    156:445-53 [2002]
  • Rhynchophylline suppresses soluble Abeta1-42-induced impairment of spatialCognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors
    135:100-12 [2018]
  • Rhynchophylline Protects Against the Amyloid betaInduced Increase of Spontaneous Discharges in the HippocampalCA1 Region of Rats
    40:2365-73 [2015]
  • Rhim H. Ginsenosides : are any of themCandidates for drugs acting on theCentral nervous system ?
    13:381-404 [2007]
  • Review : adult neurogenesisContributes to hippocampal plasticity
    373:693-709 [2018]
  • Revealing the Inhibitory Effect of Ginseng on Mitochondrial Respiration through Synaptosomal Proteomics
    18 : e1700354 [2018]
  • Rendu F. Pro-atherogenic effect of interleukin-4 in endothelialCells : modulation of oxidative stress , nitric oxide and monocyteChemoattractant protein-1 expression
    187:285-91 [2006]
  • Relative frequencies of Alzheimer disease , Lewy body , vascular and frontotemporal dementia , and hippocampal sclerosis
    16:203-12 [2002]
  • Relationships Between Mitochondria and Neuroinflammation : Implications for Alzheimer 's Disease .
    16:849-57 [2016]
  • Relationship between plaques , tangles , and loss ofCorticalCholinergic fibers in Alzheimer disease
    57:63-75 [1998]
  • Relationship between asthma andCognition : theCooperCenter Longitudinal Study
    68:545- 8 [2013]
  • Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide
    37:1139- 52 [2009]
  • Regulation of learning and memory by meningeal immunity : a key role for IL-4 .
    207:1067-80 [2010]
  • Regulation of NMDA receptor trafficking by amyloid-beta
    8:1051-8 [2005]
  • Reduced hippocampal functionalConnectivity in Alzheimer disease
    64:1482-7 [2007]
  • Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophreniaCan be rescued by IGF2
    33:9408-19 [2013]
  • Red notoginseng : higher ginsenosideContent and stronger anticancer potential than Asian and American ginseng
    125:1299-305 [2011]
  • Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway
    0.5861111111 [2013]
  • Reale M. Neuroinflammation and Alzheimer 's Disease : Implications for Microglial Activation
    14:1140-8 [2017]
  • Rausell E. RC3/neurogranin is expressed in pyramidal neurons of motor and somatosensoryCortex in normal and denervated monkeys
    493:554-70 [2005]
  • RamponC. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis
    27:6771-80 [2007]
  • Pulte I. Memantine andCholinesterase Inhibitors :Complementary Mechanisms in the Treatment of Alzheimer ’ s Disease
    24:358-69 [2013]
  • Proteomics analysis of the expression of neurogranin in murine neuroblastoma ( Neuro-2a )Cells reveals its involvement forCell differentiation
    3:263-73 [2007]
  • Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
    280:23802-14 [2005]
  • Protein encapsulation in biodegradable polymeric nanoparticles : morphology , fluorescence behaviour and stemCell uptake
    13:1204-12 [2013]
  • Protective effects of ginsenoside Rd against okadaic acidinduced neurotoxicity in vivo and in vitro
    138:135-41 [2011]
  • Proneural bHLH neurogenin 2 differentially regulates Nurr1induced dopamine neuron differentiation in rat and mouse neural precursorCells in vitro .
    582:537-42 [2008]
  • Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitorCells
    149:2191-9 [2008]
  • Proliferative Neural StemCells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/AktDependant Manner .
    8:59-71 [2011]
  • ProliferatingCell nuclear antigen binds DNA polymerase-beta and mediates 1-methyl-4-phenylpyridinium-induced neuronal death .
    9 . [2014]
  • ProliferatingCell nuclear antigen ( PCNA ) : ringmaster of the genome
    77:1007-21 [2001]
  • Processing emotional information in Alzheimer 's disease : effects on memory performance and neurophysiologicalCorrelates
    14:104-12 [2002]
  • Pro-cognitive properties of TCells
    12:663-9 [2012]
  • Precautionary effects of Red Liriope platyphylla on NGF secretion and Abeta42 deposition under the preclinical stage of Alzheimer 's disease in Tg2576 mice
    29:212-20 [2013]
  • Polymeric systems forControlled drug release
    99:3181-98 [1999]
  • Poly lactic-co-glycolic acidControlled delivery of disulfiram to target liverCancer stem-likeCells
    13:641-57 [2017]
  • Poly Lactic-co-Glycolic Acid ( PLGA ) as BiodegradableControlled Drug DeliveryCarrier
    3:1377-97 [2011]
  • Poly ( lactic-co-glycolic ) acid-controlled-release systems : experimental and modeling insights
    30:257-76 [2013]
  • Poly ( lactic acid ) and poly ( lactic-coglycolic acid ) particles as versatileCarrier platforms for vaccine delivery
    9:2703-18 [2014]
  • Physical basis ofCognitive alterations in Alzheimer 's disease : synapse loss is the majorCorrelate ofCognitive impairment
    30:572-80 [1991]
  • Physical and meiotic mapping of the region of humanChromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigeneCluster .
    9:581-7 . [1999]
  • Pharmacological actions of Uncaria alkaloids , rhynchophylline and isorhynchophylline .
    [2003]
  • Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease
    1:07 [2009]
  • Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice
    276:248-50 [1997]
  • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer 's disease .
    98:8850-5 [2001]
  • Peretto P. Neurogenesis in the caudate nucleus of the adult rabbit
    26:609-21 [2006]
  • Patterson K. Is semantic memory consistently impaired early in the course of Alzheimer 's disease ? Neuroanatomical and diagnostic implications
    33:441-59 [1995]
  • Pathogenesis of Alzheimer ’ s disease
    2:347-59 [2007]
  • Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    1:24 [2004]
  • Panax ginseng as an adjuvant treatment for Alzheimer 's disease
    42:401-11 [2018]
  • Pacitti C. Anterograde and retrograde tracing of projections from the ventral tegmental area to the hippocampal formation in the rat
    33:445-52 . [1994]
  • PI3K/Akt andCREB regulate adult neural hippocampal progenitor proliferation and differentiation
    67:1348-61 [2007]
  • Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism
    583:1505-10 [2009]
  • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta , interleukin 4 , and prostaglandin E expression in the brain
    176:1355-64 [1992]
  • Ono T. Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats
    69:511-25 [2000]
  • One for All ? Hitting Multiple Alzheimer 's Disease Targets with One Drug
    0.5395833333 [2016]
  • Olson L. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system .
    41:111-20 [1996]
  • Olfactory thresholds are associated with degree of dementia in Alzheimer 's disease
    11:465-9 [1990]
  • Olfactory dysfunction in Alzheimer 's disease .
    12:869-75 [2016]
  • Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community
    84:182-9 [2015]
  • Olfactory centres in Alzheimer 's disease : olfactory bulb is involved in early Braak 's stages
    12:285-8 [2001]
  • Ohno M. Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
    33:229-35 [2009]
  • Ohno M. Genetic reductions of beta-site amyloid precursor proteincleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer 's disease model mice
    31:110-8 [2010]
  • Oh S. Administration of red ginseng ameliorates memory decline in aged mice
    39:250-6 [2015]
  • Oh MS. Cistanches Herba enhances learning and memory by inducing nerve growth factor
    216:652-8 [2011]
  • Object recognition memory and the rodent hippocampus .
    17:5-11 [2009]
  • Object recognition in rats and mice : a one-trial nonmatching-to-sample learning task to study 'recognition memory
    1:1306-11 [2006]
  • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    95:4013-8 [1998]
  • Nurr1 expression and its modulation in microglia .
    16:162-70 [2009]
  • Nurr1 blocks the mitogenic effect of FGF-2 and EGF , inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes
    75:823-41 [2015]
  • Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress
    288:5506-17 [2013]
  • Novelty-evoked elevations of nucleus accumbens dopamine : dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission in the ventral tegmental area
    13:819-28 [2001]
  • Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
    25:3900-11 [2006]
  • New neurons and new memories : how does adult hippocampal neurogenesis affect learning and memory ?
    11:339-50 [2010]
  • Neurotrophins enhance CaMKII activity and rescue amyloid-beta-induced deficits in hippocampal synaptic plasticity
    21:823-31 [2010]
  • Neurotoxicity of amyloid beta-protein : synaptic and network dysfunction
    2 : a006338 . [2012]
  • Neuroprotective effect of a ginseng ( Panax ginseng ) root extract on astrocytes primary culture
    112:262-70 [2007]
  • Neuroprotective and Cognition-Enhancing Effects of Compound K Isolated from Red Ginseng
    64:2855-64 [2016]
  • Neuroprotective Effect of Uncaria rhynchophylla in Kainic Acid-Induced Epileptic Seizures by Modulating Hippocampal Mossy Fiber Sprouting , Neuron Survival , Astrocyte Proliferation , and S100B Expression
  • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    60:337-41 [2003]
  • Neuroinflammatory cytokine signaling and Alzheimer 's disease
    368:770-1 [2013]
  • Neuroinflammation in Alzheimer 's disease and mild cognitive impairment : a field in its infancy
    19:355-61 [2010]
  • Neuroinflammation in Alzheimer 's disease .
    14:388-405 [2015]
  • Neuroinflammation and neuronal loss precede Abeta plaque deposition in the hAPP-J20 mouse model of Alzheimer 's disease
    8 : e59586 . [2013]
  • Neurogranin restores amyloid beta-mediated synaptic transmission and long-term potentiation deficits
    277:115-23 [2016]
  • Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components
  • Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer 's disease
    1362:13-22 [2010]
  • Neurogranin enhances synaptic strength through its interaction with calmodulin
    28:3027-39 [2009]
  • Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease
    72:1275-80 [2015]
  • Neurogenesis in the dentate gyrus : carrying the message or dictating the tone
    7 [2013]
  • Neurogenesis and Alzheimer 's disease : Biology and pathophysiology in mice and men
    7:113-25 [2010]
  • Neurochemical correlates of dementia severity in Alzheimer 's disease : relative importance of the cholinergic deficits
    64:749-60 [1995]
  • Neurobehavioral changes resulting from recombinase activation gene 1 deletion .
    10:13- 8 . [2003]
  • Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington 's Disease Mouse Model
    53:2276- 86 [2016]
  • Neural stem and progenitor cells shorten Sphase on commitment to neuron production .
    0.1902777778 [2011]
  • Navarrete L. The revitalized tau hypothesis on Alzheimer 's disease .
    41:226-31 [2010]
  • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway .
    27:2866-75 [2007]
  • Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer 's Disease
    14:5576-86 [2013]
  • Naive human T cells can be a source of IL-4 during primary immune responses
    118:384- 91 [1999]
  • NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors
    122:3593-602 [2012]
  • N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer 's toxic amyloid-beta peptide oligomers
    115:1520-9 [2010]
  • Myelin basic protein-specific T helper 2 ( Th2 ) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    186:307-12 [1997]
  • Multipotent natural agents to combat Alzheimer 's disease . Functional spectrum and structural features
    29:143-51 [2008]
  • Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model .
    1822:286-92 [2012]
  • Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer 's Disease
    0.7076388889 [2017]
  • Mucke L. Inflammation in neurodegenerative disease -- a doubleedged sword
    [2002]
  • Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer 's disease : from synapses toward neural networks .
    13:812-8 [2010]
  • Mucke L. Alzheimer mechanisms and therapeutic strategies
    148:1204-22 [2012]
  • Mucke L. A network dysfunction perspective on neurodegenerative diseases
    443:768-73 [2006]
  • Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers
    21:373-82 [2012]
  • Moon M. Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer 's Disease
    55:7886-99 [2018]
  • Mook-Jung I. Disruption of blood-brain barrier in Alzheimer disease pathogenesis .
    1 : e23993 . [2013]
  • Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis .
    24:6590-9 [2004]
  • Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer 's disease
    17:304-11 [2014]
  • Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs .
    461:402-6 [2009]
  • Mizoguchi K. Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients .
    166:84-95 [2016]
  • Mitochondrial dysfunction in sporadic and genetic Alzheimer 's disease
    41:668-73 [2006]
  • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    443:787-95 [2006]
  • Mitochondrial dynamics and inheritance during cell division , development and disease
    15:634-46 [2014]
  • Mitochondrial abnormalities in Alzheimer 's disease .
    21:3017-23 [2001]
  • Mitochondrial Abeta : a potential focal point for neuronal metabolic dysfunction in Alzheimer 's disease
    19:2040-1 [2005]
  • Mitochondria dysfunction of Alzheimer 's disease cybrids enhances Abeta toxicity
    89:1417-26 [2004]
  • Mitochondria as central regulators of neural stem cell fate and cognitive function .
    20:34-48 [2019]
  • Mitochondria and Mitochondrial Cascades in Alzheimer 's Disease
    62:1403-16 [2018]
  • Mishkin M. Differential effects of early hippocampal pathology on episodic and semantic memory
    277:376-80 [1997]
  • Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    23:601-6 [2005]
  • Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer 's disease
    13:411-3 [2010]
  • Microglia-mediated neurotoxicity : Uncovering the molecular mechanisms
    8:57-69 [2007]
  • Microglia enhance betaamyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species
    83:973-83 [2002]
  • Microglia as neuroprotective , immunocompetent cells of the CNS .
    [2002]
  • Microglia , neuroinflammation , and beta-amyloid protein in Alzheimer 's disease .
    124:307-21 [2014]
  • Mechanisms underlying inflammation in neurodegeneration
    140:918-34 [2010]
  • Mechanisms of neuronal death in Alzheimer 's disease
    [1996]
  • Mechanisms and functional implications of adult neurogenesis .
    132:645-60 [2008]
  • Mattes H. Identification of a potent agonist of the orphan nuclear receptor Nurr1
    1:955-8 [2006]
  • Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the tripleknockout 3xTg Alzheimer mouse model
    [2017]
  • Martinowich K. Suppression of Adult Neurogenesis Leads to an Increased HPA Axis Response
    20:553-7 [2009]
  • Malinow R. PSD-95 is required for activity-driven synapse stabilization
    104:4176-81 [2007]
  • Maletic-Savatic M. Adult human neurogenesis : from microscopy to magnetic resonance imaging
    5 . [2011]
  • Major dissociation between medial and lateral entorhinal input to dorsal hippocampus
    308:1792-4 [2005]
  • Macroautophagy -- a novel Beta-amyloid peptide-generating pathway activated in Alzheimer 's disease
    171:87-98 [2005]
  • Ma S. Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-kappaB signaling pathways in primary microglia
  • Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type
    10:576-96 [1988]
  • Long-term efficacy and toxicity of cholinesterase inhibitors in the treatment of Alzheimer disease
    59:618-23 [2014]
  • Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating
    10:15 [2019]
  • Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
    26:1343-54 [2006]
  • Locus ceruleus controls Alzheimer 's disease pathology by modulating microglial functions through norepinephrine .
    107:6058-63 [2010]
  • Lefebvre P. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1
    34:5515-27 [2006]
  • Lee TH , Oh MS. Heat stress-induced memory impairment is associated with neuroinflammation in mice
    12:015-0324 [2015]
  • Learning and memory ... and the immune system
    [2013]
  • Lazarov O. Alzheimer 's Disease and Hippocampal Adult Neurogenesis ; Exploring Shared Mechanisms
    0.5402777778 [2016]
  • Lavenex P. An analysis of entorhinal cortex projections to the dentate gyrus , hippocampus , and subiculum of the neonatal macaque monkey
    522:1485-505 [2014]
  • Laroche S. Long-term potentiation enhances neurogenesis in the adult dentate gyrus
    26:5888-93 [2006]
  • Laroche S. Adult hippocampal neurogenesis , synaptic plasticity and memory : facts and hypotheses
    18:93-114 [2007]
  • Landis S. Afferents to the hippocampus of the rat studied with the method of retrograde transport of horseradish peroxidase
    78:1-15 [1974]
  • LRP-1 , and amyloid-beta protein in Alzheimer 's disease .
    112:405-15 [2006]
  • Korean Red Ginseng Protects Against Mitochondrial Damage and Intracellular Inflammation in an Animal Model of Type 2 Diabetes Mellitus
    21:544-50 [2018]
  • Knockdown of Nurr1 in the rat hippocampus : Implications to spatial discrimination learning and memory
    13:734-44 [2006]
  • Kivipelto M. Alzheimer 's disease : clinical trials and drug development
    9:702-16 [2010]
  • Kipnis J. Dynamics of the meningeal CD4 ( + ) Tcell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice
    19:531-3 [2014]
  • Kipnis J. Adaptive immunity affects learning behavior in mice
    22:861-9 [2008]
  • Kim Y. Uncaria rhynchophylla inhibits the production of nitric oxide and interleukin-1beta through blocking nuclear factor kappaB , Akt , and mitogen-activated protein kinase activation in macrophages
    13:1133-40 [2010]
  • Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease .
    22:222-6 [2008]
  • Kim L. Effects of Korean Red Ginseng on Cognitive and Motor Function : A Double-blind , Randomized , Placebo-controlled Trial
    36:190-7 [2012]
  • Kempermann G. Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus .
    23:3121-8 [2009]
  • Kee N. BrdU assay for neurogenesis in rodents .
    1:1399-405 . [2006]
  • Kayed R. The Role of Amyloid-beta Oligomers in Toxicity , Propagation , and Immunotherapy
    [2016]
  • K. Physicochemical characterisation of PLGA nanoparticles after freeze-drying and storage
    [2009]
  • Jr. OT-II TCR transgenic mice fail to produce anti-ovalbumin antibodies upon vaccination .
    282:79-84 [2013]
  • Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
    25:1468-75 [2007]
  • Iqbal K. Multifactorial Hypothesis and Multi-Targets for Alzheimer 's Disease .
    64 : S107-s17 . [2018]
  • Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II , synaptic plasticity , and spatial learning : a study with knockout mice
    97:11232-7 [2000]
  • Intraneuronal beta-amyloid aggregates , neurodegeneration , and neuron loss in transgenic mice with five familial Alzheimer 's disease mutations : potential factors in amyloid plaque formation
    26:10129-40 [2006]
  • Intraneuronal Abeta accumulation and neurodegeneration : lessons from transgenic models
    91:1148-52 [2012]
  • Intrahippocampal injection of a lentiviral vector expressing neurogranin enhances cognitive function in 5XFAD mice
    50 : e461 . [2018]
  • Intracellular amyloid-beta accumulation in calcium-binding protein-deficient neurons leads to amyloid-beta plaque formation in animal model of Alzheimer 's disease .
    29:615-28 [2012]
  • Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
    200:95-9 [2009]
  • Interleukin-4-induced oxidative stress via microglial NADPH oxidase contributes to the death of hippocampal neurons in vivo
    1:192-201 [2008]
  • Interleukin-4 receptor signaling pathways in asthma pathogenesis
    10:493-9 [2004]
  • Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment
    7:43 [2015]
  • Insulin transiently increases tau phosphorylation : involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase
    72:576-84 [1999]
  • Inhibition of MAPK/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats .
    265:497-509 [2015]
  • Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation
    0.7375 [2017]
  • Inflammation and Alzheimer 's disease .
    21:383-421 [2000]
  • Induction of cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus by aqueous extract from Platycodon grandiflorum in middle-aged mice
    444:97-101 [2008]
  • Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
    17:653-9 [1999]
  • Inducible expression of Tau repeat domain in cell models of tauopathy : aggregation is toxic to cells but can be reversed by inhibitor drugs .
    281:1205-14 [2006]
  • Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits
    57:375-82 [2010]
  • Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    472:466-70 [2011]
  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning .
    35:7503-8 [2015]
  • Increased hippocampal neurogenesis in Alzheimer 's disease .
    101:343-7 [2004]
  • Increased CSF neurogranin concentration is specific to Alzheimer disease .
    86:829-35 [2016]
  • In situ analysis of chemical components induced by steaming between fresh ginseng , steamed ginseng , and red ginseng
    41:361-9 [2017]
  • Improvement of cognitive deficit in Alzheimer 's disease patients by long term treatment with korean red ginseng
    35:457- 61 [2011]
  • Impaired social recognition memory in recombination activating gene 1-deficient mice
    1383:187-95 [2011]
  • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells .
    491:769-73 [2012]
  • Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice
    [2014]
  • Impaired balance of mitochondrial fission and fusion in Alzheimer 's disease
    29:9090-103 [2009]
  • Immunotherapy for Alzheimer 's disease : from anti-beta-amyloid to tau-based immunization strategies .
    [2012]
  • Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease .
    103:234-9 . [1989]
  • Immune modulation of learning , memory , neural plasticity and neurogenesis .
    [2011]
  • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    9:268-75 [2006]
  • Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance
    121:441-9 [2015]
  • Identifying transcription factor NURR1 expression-level specific pathways with gene signaling networks
    8:102-14 [2014]
  • Identification of a new brainspecific transcription factor , NURR1
    6:2129-35 [1992]
  • IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation .
    32:1428-33 [2002]
  • IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro , but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    47:1914-22 [2010]
  • How do immune cells support and shape the brain in health , disease , and aging ?
    33:17587-96 [2013]
  • Hodges JR. Advances in the early detection of Alzheimer 's disease
    10 Suppl : S34-41 . [2004]
  • Hippocampal synaptic plasticity , spatial memory and anxiety
    15:181-92 [2014]
  • Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodentsLaurberg S. Commissural and intrinsic connections of the rat hippocampus .
    35:702-10 . 410184:685-708
  • Highly enantioselective catalytic synthesis of neurite growth-promoting secoyohimbanes
    20:500-9 . [2013]
  • Heuschling P. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions : Effects of oligomeric and fibrillar amyloid-beta
    210:3-12 . [2009]
  • Handunnetthi L. The emerging role of vitamin D binding protein in multiple sclerosis
    258:353-8 [2011]
  • HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein .
    8 : e77972 . [2013]
  • H. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer 's Disease
    36:577- 89 [2016]
  • H. Adult neurogenesis in the mammalian central nervous system
    28:223-50 [2005]
  • Gyenis J. Optimization of protein encapsulation in PLGA nanoparticles
    50:757-65 [2011]
  • Guo Z. Thioflavin T as an amyloid dye : fibril quantification , optimal concentration and effect on aggregation
    4:160696 [2017]
  • Guan F. Effect of Huanglian Jiedu Decoction on pitavastatin treatment of Alzheimer 's disease .
    22:71-4 [2016]
  • Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
    40:425-35 [2014]
  • Gregor T. Presence of both odor identification and detection deficits in Alzheimer 's disease
    18:597-600 [1987]
  • Gradual alteration of mitochondrial structure and function by beta-amyloids : importance of membrane viscosity changes , energy deprivation , reactive oxygen species production , and cytochrome c release
    37:207-25 [2005]
  • Glaser E. Mitochondrial import and degradation of amyloid-beta peptide
    1837:1069-74 [2014]
  • Gintonin , newly identified compounds from ginseng , is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity
    33:151-62 [2012]
  • Gintonin , a ginseng-derived lysophosphatidic acid receptor ligand , attenuates Alzheimer 's disease-related neuropathies : involvement of non-amyloidogenic processing .
    31:207-23 [2012]
  • Ginsenoside Rg3 improves cardiac mitochondrial population quality : mimetic exercise training
    441:169-74 [2013]
  • Ginsenoside Rg1 attenuates oligomeric Abeta ( 1- 42 ) -induced mitochondrial dysfunction .
    9:388-95 [2012]
  • Ginsenoside Re reduces Abeta production by activating PPARgamma to inhibit BACE1 in N2a/APP695 cells
    793:101-8 [2016]
  • Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha
    168:16-23 [2017]
  • Ginsenoside Rd attenuates mitochondrial permeability transition and cytochrome C release in isolated spinal cord mitochondria : involvement of kinase-mediated pathways
    15:9859-77 [2014]
  • Ginseng ginsenoside pharmacology in the nervous system : involvement in the regulation of ion channels and receptors
    0.2763888889 [2014]
  • Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts : a functional comparison of different extraction solvents
    [2018]
  • Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons
    33:1165-9 [2010]
  • Ghrelin directly stimulates adult hippocampal neurogenesis : implications for learning and memory
    60:781-9 [2013]
  • Ghrelin ameliorates cognitive dysfunction and neurodegeneration in intrahippocampal amyloid-beta1-42 oligomer-injected mice
    23:147-59 [2011]
  • Geula C. Abnormalities of neural circuitry in Alzheimer 's disease : hippocampus and cortical cholinergic innervation
    51 : S18-29 ; discussion S65-7 [1998]
  • Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    16:1829-38 [2002]
  • Genetic aspects of Alzheimer disease
    10:231-9 [2008]
  • Genes involved in cerebrospinal fluid production as candidate genes for late-onset Alzheimer 's disease : a hypothesis
    25:195-200 [2011]
  • Generation of functional dopamine neurons from neural precursor cells isolated from the subventricular zone and white matter of the adult rat brain using Nurr1 overexpression
    25:1252-62 [2007]
  • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice : up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer 's disease
    13:1225-40 [2004]
  • Gc-globulin : roles in response to injury
    52:1247-53 [2006]
  • Gasparini L. Resting microglia react to Abeta42 fibrils but do not detect oligomers or oligomer-induced neuronal damage
    35:2444-57 [2014]
  • GA. Alzheimer 's disease : the amyloid cascade hypothesis .
    256:184-5 [1992]
  • Functional significance of adult neurogenesis .
    14:186-91 [2004]
  • Functional roles of Nurr1 , Pitx3 , and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells
    23:477-87 [2014]
  • Fukunaga K. Role of Akt and ERK signaling in the neurogenesis following brain ischemia .
    85:375-87 [2009]
  • Frisen J. Neural stem cells and neurogenesis in the adult .
    10:657-9 [2012]
  • Fluoro-Gold : a new fluorescent retrograde axonal tracer with numerous unique properties .
    377:147-54 [1986]
  • Fluorescent stains , with special reference to amyloid and connective tissues
    68:487-98 [1959]
  • Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures
    103:171-87 [1986]
  • Fedele E. The Amyloid Cascade Hypothesis in Alzheimer 's Disease : It 's Time to Change Our Mind .
    15:926-35 [2017]
  • Fate of patients with questionable ( very mild ) Alzheimer 's disease : longitudinal profiles of individual subjects
    11:342-9 [2000]
  • Exercise enhances learning and hippocampal neurogenesis in aged mice
    25:8680-5 [2005]
  • Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system
    79:236-42 [2003]
  • Evidence for stroke-induced neurogenesis in the human brain
    103:13198-202 [2006]
  • Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer 's disease
    33:781-96 [2013]
  • Episodic and declarative memory : role of the hippocampus .
    [1998]
  • Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1knockout mice
    3:238-44 . [2000]
  • Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity .
    552:187-93 [2017]
  • Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus .
    429:184-7 [2004]
  • Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus
    86:322-9 [2006]
  • Enhanced neurogenesis in Alzheimer 's disease transgenic ( PDGF-APPSw , Ind ) mice
    101:13363-7 [2004]
  • Engineering poly ( lactic-coglycolic acid ) ( PLGA ) microand nano-carriers for Controlled Delivery of 17beta-Estradiol
    45:1697-709 [2017]
  • Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells
    109:19380-5 [2012]
  • Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer 's disease : an updated meta-analysis
    116:457-65 [2009]
  • Efficacy and safety of anti-amyloid-beta immunotherapy for Alzheimer 's disease : a systematic review and network meta-analysis .
    4:931-42 [2017]
  • Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells .
    31:41-9 [2018]
  • Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson 's disease
    126:361-5 [2009]
  • Effects of jowiseungcheung-tang extract on the lipid metabolism , anti-oxidation and inflammatory reflex high fat diet obese rats
    34 [2013]
  • Effects of fermented ginseng on memory impairment and beta-amyloid reduction in Alzheimer 's disease experimental models
    37:100-7 [2013]
  • Effects of extrusion cooking on physicochemical properties of white and red ginseng ( powder )
    38:146-53 [2014]
  • Effects of different fractions of Acori graminei rhizoma extracts on learning and memory abilities in Aβ-induced Alzheimer disease mice
    28:159-62 [2012]
  • Effects of Chongmyung-tang , Polygalae Radix and Acori Graminei Rhizoma on Aβ Toxicity and Memory Dysfunction in Mice
    29:608-20 [2008]
  • Effector TCell interactions with meningeal vascular structures in nascent autoimmuneCNS lesions .
    [2009]
  • Effect of intermittent preventive treatment of malaria on health and education in schoolchildren : a cluster-randomised , double-blind , placebo-controlled trial
    372:127-38 [2008]
  • Effect of Korean Red Ginseng on Cognitive Function and Quantitative EEG in Patients with Alzheimer 's Disease : A Preliminary Study
    22:280-5 [2016]
  • Effect of Korean Red Ginseng extraction conditions on antioxidant activity , extraction yield , and ginsenoside Rg1 and phenolic content : optimization using response surface methodology
    40:229-36 [2016]
  • Edison P. Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer 's disease
    138:3685-98 [2015]
  • Eckert A. Amyloid-Beta interaction with mitochondria .
    2011:925050 [2011]
  • Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice
    146:98-107 [2007]
  • Ear2 deletion causes early memory and learning deficits in APP/PS1 mice
    34:8845-54 [2014]
  • EGCG redirects amyloidogenic polypeptides into unstructured , off-pathway oligomers
    15:558-66 [2008]
  • Dudchenko PA. Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points
    27:9769-79 [2007]
  • Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
    522:216-20 [2015]
  • Dragunow M. Brain-derived neurotrophic factor is reduced in Alzheimer 's disease .
    49:71- 81 . [1997]
  • Doublecortin expression levels in adult brain reflect neurogenesis .
    21:1-14 [2005]
  • Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression
    85:1443-54 [2003]
  • Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson 's disease
    418:50-6 [2002]
  • Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer 's disease
    8:14727 [2017]
  • Dopamine depletion impairs precursor cell proliferation in Parkinson disease .
    7:726-35 [2004]
  • Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    11:36-46 [1998]
  • Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer 's disease ?
    98:654-60 [2006]
  • Diversity of astrocyte functions and phenotypes in neural circuits .
    18:942-52 [2015]
  • Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 ( NGFI-B ) in adult rat brain using in situ hybridization
    75:221-30 [1996]
  • Distribution and cytokine production of CD4 and CD8 T-lymphocyte subsets in patients with acute asthma attacks .
    86:659-64 [2001]
  • Disease-specific patterns of locus coeruleus cell loss
    32:667-76 [1992]
  • Dioscin relieves endotoxemia induced acute neuroinflammation and protect neurogenesis via improving 5-HT metabolism
    7:40035 [2017]
  • Dil and diO : versatile fluorescent dyes for neuronal labelling and pathway tracing .
    12:333-5 , 40-1 . [1989]
  • Differential regulation of dual NADPH oxidases/peroxidases , Duox1 and Duox2 , by Th1 and Th2 cytokines in respiratory tract epithelium .
    579:4911-7 [2005]
  • Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells
    31:560-73 [2006]
  • Differential loss of synaptic proteins in Alzheimer 's disease : implications for synaptic dysfunction
  • Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease .
    73:561-71 [2016]
  • Developmental vitamin D deficiency alters brain protein expression in the adult rat : implications for neuropsychiatric disorders
    7:769-80 [2007]
  • Determination of key aspects of precursor cell proliferation , cell cycle length and kinetics in the adult mouse subgranular zone
    146:108-22 [2007]
  • Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    16:147-54 [2009]
  • Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation .
    35:6836-48 [2015]
  • Dendritic translocation of RC3/neurogranin mRNA in normal aging , Alzheimer disease and frontotemporal dementia
    56:1105-18 [1997]
  • Dendritic cells and the control of immunity
    392:245-52 [1998]
  • Deisseroth K. Communication in Neural Circuits : Tools , Opportunities , and Challenges
    164:1136-50 [2016]
  • Deierborg T. Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer 's disease mouse model 5xFAD .
    1.409722222 [2018]
  • Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
    76:34-40 [1998]
  • Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer 's Disease
    0.4916666667
  • Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer 's disease .
    495:70-83 [2006]
  • DAcquisto F. CD4 ( + ) but not CD8 ( + ) T cells revert the impaired emotional behavior of immunocompromised RAG-1- deficient mice
    3 : e280 . [2013]
  • Current and future treatments for Alzheimer 's disease
    6:19-33 [2013]
  • Current advances in research and clinical applications of PLGA-based nanotechnology
    9:325-41 [2009]
  • Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice , an animal model of Alzheimer 's disease
    132:254-62 [2015]
  • Cooke N. The multifunctional properties and characteristics of vitamin Dbinding protein .
    11:320-7 [2000]
  • Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1 .
    203:394-405 [2007]
  • Contribution of glial cells to the development of amyloid plaques in Alzheimer 's disease .
    25:663-74 [2004]
  • Computational modeling and empirical studies of hippocampal neurogenesis-dependent memory : Effects of interference , stress and depression
    24:45-54 [2009]
  • Comparison of Clinical Manifestation in Familial Alzheimer 's disease and Dementia with Lewy Bodies
    65:1634-9 [2008]
  • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    300:486-9 [2003]
  • Combination therapy in a transgenic model of Alzheimer 's disease
    250:228-38 [2013]
  • Collin F. Oxidative stress and the amyloid beta peptide in Alzheimer 's disease
    14:450-64 [2018]
  • Clinical effects of Abeta immunization ( AN1792 ) in patients with AD in an interrupted trial
    64:1553-62 [2005]
  • Chronic intestinal inflammation alters hippocampal neurogenesis
    0.5451388889 [2015]
  • Chronic exposure to sub-lethal beta-amyloid ( Abeta ) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells
    103:1989-2003 [2007]
  • Choquet D. The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
    53:719-34 [2007]
  • Choquet D. Regulation of AMPA receptor surface diffusion by PSD-95 slots
    22:453-60 [2012]
  • Cholinesterase inhibitors in the treatment of Alzheimer 's disease : a comparison of tolerability and pharmacology
    19:465- 80 . [1998]
  • Cholinesterase inhibitors for the treatment of Alzheimer 's disease : : getting on and staying on
    64:216-35 [2003]
  • Chinese herbal medicine for Alzheimer 's disease : Clinical evidence and possible mechanism of neurogenesis
    141:143-55 [2017]
  • Changing Paradigm from one Target one Ligand Towards Multi-target Directed Ligand Design for Key Drug Targets of Alzheimer Disease : An Important Role of In Silico Methods in Multi-target Directed Ligands Design .
    16:726-39 [2018]
  • Changes in hippocampal connectivity in the early stages of Alzheimer 's disease : evidence from resting state fMRI
    31:496- 504 [2006]
  • Cerebrospinal fluid tau , neurogranin , and neurofilament light in Alzheimer 's disease .
    8:1184-96 [2016]
  • Cerebrospinal fluid proteomic biomarkers for Alzheimer 's disease .
    61:120-9 [2007]
  • Cerebrospinal fluid neurogranin : relation to cognition and neurodegeneration in Alzheimer 's disease .
    138:3373-85 [2015]
  • Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer 's disease
    11:1180- 90 [2015]
  • Carrasquillo Y. Hippocampal expression of the orphan nuclear receptor gene hzf-3/nurr1 during spatial discrimination learning .
    74:161-78 [2000]
  • Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    34:300-7 [2009]
  • Cammarota M. Dopamine controls persistence of long-term memory storage
    325:1017-20 [2009]
  • Calabresi P. Mitochondria and the link between neuroinflammation and neurodegeneration .
    20 Suppl 2 : S369-79 . [2010]
  • CST , an Herbal Formula , Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice
    21 [2016]
  • CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    129:526-9 [2008]
  • CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis
    [1950]
  • C. Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease .
    487:70-2 . [2011]
  • Bridging physiology and pathology in AD
    137:997- 1000 [2009]
  • Brand M. Proliferation , neurogenesis and regeneration in the nonmammalian vertebrate brain
    363:101-22 [2008]
  • Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    13:717-28 [2008]
  • Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire
    35:58-63 [2014]
  • Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD
    58:1791-800 [2002]
  • Boucheron C. Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice
    26:6230-7 [2006]
  • Botanical characteristics , pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer
    29:1109-18 [2008]
  • Bonhoeffer F. A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue
    101:697-713 [1987]
  • Blood-derived amyloid-beta protein induces Alzheimer 's disease pathologies .
    [2017]
  • Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer 's disease
    111:9959-64 [2014]
  • Blennow K. Neurogranin Levels in Cerebrospinal Fluid : A New Addition to the Alzheimer Disease Diagnostic Toolbox .
    72:1237-8 [2015]
  • Blennow K. Neurochemical dissection of synaptic pathology in Alzheimer 's disease
  • Biological and clinical aspects of the vitamin D binding protein ( Gc-globulin ) and its polymorphism
    372:33-42 [2006]
  • Bioassay-Guided Isolation of Neuroprotective Compounds from Uncaria rhynchophylla against Beta-Amyloid-Induced Neurotoxicity .
    2012:802625 [2012]
  • Biala G. The novel object recognition memory : neurobiology , test procedure , and its modifications .
    13:93-110 [2012]
  • Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo : involvement of the p38MAPK pathway
    11:257-74 [2002]
  • Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
    80:91- 100 [2002]
  • Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases : past findings and future directions
    42:239-47 [2018]
  • Baudier J. Neurogranin : immunocytochemical localization of a brain-specific protein kinase C substrate
    10:3782-92 [1990]
  • Basal forebrain-lesioned monkeys are severely impaired in tasks of association and recognition memory
    22:735-43 [1987]
  • Bapineuzumab : anti-beta-amyloid monoclonal antibodies for the treatment of Alzheimer 's disease .
    2:767- 82 . [2010]
  • Balschun D. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling
    24:10660- 9 [2004]
  • BACE1 molecular docking and anti-Alzheimer 's disease activities of ginsenosides
    190:219-30 [2016]
  • B. Autophagy in neurodegenerative disorders : pathogenic roles and therapeutic implications
    33:541-9 [2010]
  • Avital A. Poly-lacticglycolic acid microspheres : a biodegradable marker for the diagnosis of aspiration in hamsters
    58:537-41 [2005]
  • Autosomal-dominant Alzheimer 's disease : a review and proposal for the prevention of Alzheimer 's disease
    0.1256944444 [2011]
  • Autophagy failure in Alzheimer 's disease and the role of defective lysosomal acidification .
    37:1949-61 [2013]
  • Attenuation of allergic airway inflammation in IL-4 deficient mice
    24:73-80 [1994]
  • Association of the expression of IL-4 and IL-13 genes , IL-4 and IgE serum levels with allergic asthma
    6:67-72 [2007]
  • Assessment of proliferating cell nuclear antigen and its relationship with proinflammatory cytokines and parameters of disease activity in multiple myeloma patients
    2.310416667 [2011]
  • Arias C. beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine
    68:89-96 [2002]
  • Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons
    7:819-22 [1995]
  • Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism
    9:1549-54 [2009]
  • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action .
    26:143-9 . [2005]
  • An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer 's disease
    15:865-8 [2008]
  • An olfacto-hippocampal network is dynamically involved in odor-discrimination learning
    98:2196-205 [2007]
  • An experimental study of driental medicine on cure for dementia : the effect of Jowiseungcheongtang and Hyungbangjihwangtang on cure for aged rats
    9:19-35 [1998]
  • An effector-reduced anti-beta-amyloid ( Abeta ) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta .
    32:9677-89 [2012]
  • An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat
    240:37-59 [1985]
  • An Experimental Study on the Effects of Jowiseungchungtang on Learning and Memory of Rats in the Radial - Arm Maze
    8:69-79 [1997]
  • Amyloid-beta/Fyn-induced synaptic , network , and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer 's disease
    31:700-11 [2011]
  • Amyloid-beta vaccination , but not nitro-nonsteroidal anti-inflammatory drug treatment , increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
    144:950-60 [2007]
  • Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer 's disease mice
    106:20057-62 [2009]
  • Amyloid beta , mitochondrial dysfunction and synaptic damage : implications for cognitive decline in aging and Alzheimer 's disease
    14:45-53 [2008]
  • Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer 's disease
    102:113-24 [2017]
  • Alzheimer Disease : Pharmacologic and Nonpharmacologic Therapies for Cognitive and Functional Symptoms
    95:771-8 [2017]
  • Alzheimer 's disease prevention : from risk factors to early intervention
    0.4243055556 [2017]
  • Alzheimer 's disease is a synaptic failure
    298:789-91 [2002]
  • Alzheimer 's disease : the challenge of the second century
    3:77sr1 [2011]
  • Alzheimer 's disease : synaptic dysfunction and Abeta
    0.2 [2009]
  • Alzheimer 's disease .
    388:505-17 [2016]
  • Alzheimer 's disease
    362:329-44 [2010]
  • Alzheimer 's Disease
    351:56-67 [2004]
  • Altered expression of synaptic proteins occurs early during progression of Alzheimer 's disease
    56:127-9 [2001]
  • Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities : implications for Alzheimer 's disease
    24:2401-11 [2004]
  • Advancing research diagnostic criteria for Alzheimer 's disease : the IWG-2 criteria .
    13:614-29 [2014]
  • Adult-born hippocampal neurons are more numerous , faster maturing , and more involved in behavior in rats than in mice
    29:14484-95 [2009]
  • Adult neurogenesis in mammals
    364:827-8 [2019]
  • Adult mice with reduced Nurr1 expression : an animal model for schizophrenia
    12:756-66 [2007]
  • Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer 's disease .
    25:554-60 . [2019]
  • Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    476:458-61 [2011]
  • Adult hippocampal neurogenesis and its role in cognition
    5:573-87 [2014]
  • Adult hippocampal neurogenesis and its role in Alzheimer 's disease
    0.3090277778 [2011]
  • Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons
    20:2553-5 [2006]
  • Acetylcholinesterase inhibitors in Alzheimer ’ s disease
    48:471-80 [1999]
  • Abeta peptide secretion is reduced by Radix Polygalae-induced autophagy via activation of the AMPK/mTOR pathway
    12:2771-6 [2015]
  • Abel T. The role of NR4A transcription factors in memory formation
    85:21-9 [2011]
  • ATP as a biological hydrotrope
    356:753-6 [2017]
  • APOE epsilon4 carriers may undergo synaptic damage conferring risk of Alzheimer 's disease
    12:1159-66 [2016]
  • AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
    52:831-43 [2006]
  • A systemic view of Alzheimer disease - insights from amyloid-beta metabolism beyond the brain
    13:612-23 [2017]
  • A serial analysis of gene expression profile of the Alzheimer 's disease Tg2576 mouse model
    17:360-79 [2010]
  • A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies
    86:35-47 . [2013]
  • A review on Alzheimer 's disease pathophysiology and its management : an update
    67:195-203 [2015]
  • A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer 's disease
    78:151-64 [1987]
  • A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts
    [2018]
  • A mesoscale connectome of the mouse brain
    508:207-14 [2014]
  • A Study of Jowiseungchungtang in patients with mild Dementia of Alzheimer type
    14:17-26 [2003]
  • A Nurr1 point mutant , implicated in Parkinson ’ s disease , uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
    29:117-22 [2008]
  • 99. Kintner C. Neurogenesis in embryos and in adult neural stem cells. J Neurosci 2002;22:639-43.
  • 53. Avila J. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS Lett 2006;580:2922-7.
  • 481. Jahn H. Memory loss in Alzheimer's disease. Dialogues in clinical neuroscience 2013;15:445-54.
  • 452. Taupin P. Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells. International journal of medical sciences 2008;5:127-32.
  • 449. Carlesimo GA, Piras F, Orfei MD, Iorio M, Caltagirone C, Spalletta G. Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands) 2015;1:24-32.
  • 448. Jawhar S, Trawicka A, Jenneckens C, Bayer TA, Wirths O. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiology of aging 2012;33:196.e29-40.
  • 414. Ho TY, Tang NY, Hsiang CY, Hsieh CL. Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1beta and brainderived neurotrophic factor. Phytomedicine : international journal of phytotherapy and phytopharmacology 2014;21:893-900.
  • 342. Tulving E, Markowitsch HJ. Episodic and declarative memory: role of the hippocampus. Hippocampus 1998;8:198-204.
  • 331. Kook SY, Hong HS, Moon M, Ha CM, Chang S, Mook-Jung I. Abeta(1)(-)(4)(2)- RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling. J Neurosci 2012;32:8845-54.
  • 316. Bhan I. Vitamin d binding protein and bone health. Int J Endocrinol 2014;2014:561214.
  • 29. Malpass K. Alzheimer disease: Plaque-specific anti-A[beta] antibody shows promise in model of AD. Nat Rev Neurol 2013;9:61-.
  • 272. Alzheimer disease: Elevated neurogranin levels reveal early synaptic damage in APOE* varepsilon4 carriers. Nature reviews Neurology 2016;12:430.
  • 252. Fyfe I. Alzheimer disease: neurogranin in the CSF signals early Alzheimer disease and predicts disease progression. Nat Rev Neurol 2015;11:609.
  • 24. Birks J. Cholinesterase inhibitors for Alzheimer's disease. The Cochrane database of systematic reviews 2006:Cd005593.
  • 19. Forstl H. Alzheimer's disease: the size of the problem, clinical manifestation and heterogeneity. Journal of neural transmission Supplementum 1998;54:1-8.
  • 149. Noben-Trauth N, Hu-Li J, Paul WE. Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. Journal of immunology (Baltimore, Md : 1950) 2000;165:3620-5.
  • 116. Gadani SP, Cronk JC, Norris GT, Kipnis J. IL-4 in the brain: a cytokine to remember. Journal of immunology (Baltimore, Md : 1950) 2012;189:4213-9.
  • 113. Bartholomaus I, Kawakami N, Odoardi F, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009;462:94-8.