박사

간 손상 마우스 모델에서 Toll-like Receptor 5와 TBK1/IKKε의 병리학적 역할

주자웅 2020년
논문상세정보
' 간 손상 마우스 모델에서 Toll-like Receptor 5와 TBK1/IKKε의 병리학적 역할' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Acetaminophen
  • Liver fibrosis
  • TBK1/IKKε
  • acute liver injury
  • tlr5
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
137 0

0.0%

' 간 손상 마우스 모델에서 Toll-like Receptor 5와 TBK1/IKKε의 병리학적 역할' 의 참고문헌

  • β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
    52 ( 1 ) : p. 102-110 [2003]
  • al. , LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
    290 ( 6 ) : p. G1318-G1328 . [2006]
  • al. , Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity
    290 ( 6 ) : p. G1269-G1279 . [2006]
  • al. , Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites
    26 ( 6 ) : p. 1372-1378 . [1997]
  • al. , Immunological orchestration of liver fibrosis
    43 ( 3 ) : p. 220-229 . [2012]
  • al. , Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution
    50 ( 4 ) : p. 48 . 10.1038/s12276-018-0074-5 [2018]
  • a key parameter of cytokine-driven tissue protection during sterile inflammation–the case of experimental acetaminophen ( Paracetamol ) - induced liver damage
    7 : p. 163 . [2016]
  • a Toll-like receptor 5 agonist , offers protection against radiation-induced male reproductive system damage in mice†
    100 ( 1 ) : p. 281-291 . [2018]
  • Worldwide mortality from cirrhosis : an update to 2002
    46 ( 5 ) : p. 827-39 . 10.1016/j.jhep.2007.01.025 [2007]
  • Type I interferons protect from toll-like receptor 9–associated liver injury and regulate IL-1 receptor antagonist in mice
    140 ( 2 ) : p. 697-708. e4 [2011]
  • Type I interferon inhibits interleukin-1 production and inflammasome activation
    34 ( 2 ) : p. 213-223 . [2011]
  • Type 1 Diabetic Mice Are Protected from Acetaminophen Hepatotoxicity .
    73 ( 2 ) : p. 220-234 . [2003]
  • Trolline ameliorates liver fibrosis by inhibiting the NF-κB pathway
    44 ( 2 ) : p. 436-446 . [2017]
  • Triggering the interferon antiviral response through an IKKrelated pathway .
    300 ( 5622 ) : p. 1148-51 . 10.1126/science.1081315 [2003]
  • Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced lipotoxicity and steatohepatitis in vitro
    52 : p. 33-40 . [2018]
  • Transforming growth factor-β ( TGF-β ) directly activates the JAK1-STAT3 axis to induce hepatic fibrosis in coordination with the SMAD pathway
    292 ( 10 ) : p. 4302-4312 . [2017]
  • Toll‐like receptor‐induced innate immune responses in non‐ parenchymal liver cells are cell type‐specific
    129 ( 3 ) : p. 363-374 . [2010]
  • Toll‐like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    37 ( 5 ) : p. 1043-1055 [2003]
  • Toll-like receptors in systemic autoimmune disease
    6 ( 11 ) : p. 823 [2006]
  • Toll-like receptors in liver fibrosis : cellular crosstalk and mechanisms
    3 : p. 138 . [2012]
  • Toll-like receptor-induced innate immune responses in nonparenchymal liver cells are cell type-specific
    129 ( 3 ) : p. 363-374 . [2010]
  • Toll-like receptor-5 agonist , entolimod , suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis
    113 ( 7 ) : p. E874-E883 . [2016]
  • Toll-like receptor signalling
    4 ( 7 ) : p. 499-511 . [2004]
  • Toll-like receptor signaling in the liver
    130 ( 6 ) : p. 1886-1900 . [2006]
  • Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication
    51 ( 6 ) : p. 1037-1045 [2009]
  • Toll-like receptor 9 , CpG DNA and innate immunity
    2 ( 6 ) : p. 545-556 . [2002]
  • Toll-like receptor 7-mediated type I interferon signaling prevents cholestasisand hepatotoxin-induced liver fibrosis
    60 ( 1 ) : p. 237-249 . [2014]
  • Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin
    44 ( 10 ) : p. 4247-4254 . [2003]
  • Toll-like receptor 5 signaling restrains T-cell/natural killer T-cell activation and protects against concanavalin A–induced hepatic injury
    65 ( 6 ) : p. 2059-2073 . [2017]
  • Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis .
    13 ( 9 ) : p. 4763-4767 . [2012]
  • Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis
    3 ( 1 ) : p. 21 . [2010]
  • Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice
    188 ( 11 ) : p. 2574-2588 [2018]
  • Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity .
    8 ( 6 ) : p. e65899 . [2013]
  • Tissue Repair : An Important Determinant of Final Outcome of Toxicant-Induced Injury
    33 ( 1 ) : p. 41-51 . [2005]
  • The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis
    2 ( 1 ) : p. 16-25 . [2009]
  • The role of pattern-recognition receptors in innate immunity : update on Toll-like receptors
    11 ( 5 ) : p. 373 [2010]
  • The protein kinase IKKɛ regulates energy balance in obese mice
    138 ( 5 ) : p. 961-975 [2009]
  • The protein kinase IKKepsilon regulates energy balance in obese mice
    138 ( 5 ) : p. 961-75 . 10.1016/j.cell.2009.06.046 [2009]
  • The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
    122 ( 4 ) : p. 1574-1583 [2012]
  • The gut–liver axis and the intersection with the microbiome
    p. 1 [2018]
  • The function of the soluble interleukin 6 ( IL-6 ) receptor in vivo : sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
    183 ( 4 ) : p. 1399-1406 . [1996]
  • The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis
    98 ( 12 ) : p. 1600-1613 [2018]
  • The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury
    115 ( 4 ) : p. 860-869 [2005]
  • The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis
    67 ( 9 ) : p. 1704-1715 [2018]
  • TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-kappaB/STAT3 pathways
    87 : p. 67- 75 . 10.1016/j.molimm.2017.04.003 [2017]
  • TLR5 activation induces secretory interleukin-1 receptor antagonist ( sIL-1Ra ) and reduces inflammasome-associated tissue damage .
    4 ( 1 ) : p. 102 . [2011]
  • TLR4 enhances TGF-β signaling and hepatic fibrosis
    13 ( 11 ) : p. 1324 [2007]
  • TGF-β/Smad signaling in the injured liver
    44 ( 01 ) : p. 57-66 . [2006]
  • TBK1 mediates crosstalk between the innate immune response and autophagy
    4 ( 187 ) : p. pe39-pe39 [2011]
  • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes : indirect evidence for islet regeneration ?
    48 ( 11 ) : p. 2221- 2228 [2005]
  • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
    128 ( 1 ) : p. 138-146 [2005]
  • Studies on the use of flagellin as an immunostimulant and vaccine adjuvant in fish aquaculture
    9 : p. 3054 [2018]
  • Structure and ubiquitination-dependent activation of TANKbinding kinase 1 .
    3 ( 3 ) : p. 747-758 . [2013]
  • Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta : implication for a pathogenetic role in alcoholic liver fibrogenesis
    11 ( 4 ) : p. 599-605 . [1990]
  • Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-β .
    180 ( 3 ) : p. 1382-1389 . [2008]
  • Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice
    295 ( 1 ) : p. G45-G53 [2008]
  • Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis
    1842 ( 11 ) : p. 2237-2245 . [2014]
  • Stat3 signaling activation crosslinking of TGF-beta1 in hepatic stellate cell exacerbates liver injury and fibrosis
    1842 ( 11 ) : p. 2237-45 . 10.1016/j.bbadis.2014.07.025 [2014]
  • Starring role of toll-like receptor-4 activation in the gut-liver axis
    6 ( 4 ) : p. 99 . [2015]
  • Spliceosome-Associated Protein 130 Exacerbates AlcoholInduced Liver Injury by Inducing NLRP3 Inflammasome–Mediated IL-1β in Mice
    188 ( 4 ) : p. 967-980 . [2018]
  • Spliceosome-Associated Protein 130 Exacerbates AlcoholInduced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1beta in Mice
    188 ( 4 ) : p. 967-980 . 10.1016/j.ajpath.2017.12.010 [2018]
  • Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition
    112 ( 23 ) : p. 7243-8 . 10.1073/pnas.1507499112 [2015]
  • Smart , Transcriptional regulation of hepatic stellateCell activation
    50 ( 6 ) : p. 891-896 . [2002]
  • Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosingCholangitis
    138 ( 7 ) : p. 2499-508 . 10.1053/j.gastro.2010.02.049 [2010]
  • Signal transducer and activator of transcription 3 in liver diseases : a novel therapeutic target
    7 ( 5 ) : p. 536-50 [2011]
  • Senescence of activated stellateCells limits liver fibrosis
    134 ( 4 ) : p. 657-667 . [2008]
  • Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice
    307 ( 1 ) : p. 67-73 [2003]
  • Safety and efficacy of intravenous N‐ acetylcysteine for acetaminophen overdose : analysis of the Hunter Area Toxicology Service ( HATS ) database
    23 ( 10 ) : p. 2359- 2368 [2007]
  • STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity
    44 ( 6 ) : p. 1441-1451 . [2006]
  • Roles for the IKK-Related Kinases TBK1 and IKKε inCancer
    7 ( 9 ) : p. 139 . [2018]
  • Role of toll-like receptors in immune activation and tolerance in the liver
    5 : p. 221-221 [2014]
  • Role of interleukin-1 and its antagonism of hepatic stellateCell proliferation and liver fibrosis in the Abcb4-/-mouse model
    8 ( 8 ) : p. 401 [2016]
  • Role of TLR9 in hepatic stellateCells and experimental liver fibrosis
    376 ( 2 ) : p. 271- 276 . [2008]
  • Role of KupfferCells in the pathogenesis of liver disease
    12 ( 46 ) : p. 7413-20 . [2006]
  • Role of KupfferCells and toll-like receptor 4 in acetaminopheninduced acute liver failure
    180 ( 1 ) : p. 147-155 . [2013]
  • Resistin mediates the hepatic stellateCell phenotype
    19 ( 28 ) : p. 4475 . [2013]
  • Regulation of wound healing and organ fibrosis by toll-like receptors
    1832 ( 7 ) : p. 1005-1017 . [2013]
  • Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity
    29 ( 2 ) : p. 242-249 . [2001]
  • Protection against RNA‐induced liver damage by myeloidCells requires type I interferon and IL‐1 receptor antagonist in mice
    59 ( 4 ) : p. 1555-1563 . [2014]
  • Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model
    184 ( 11 ) : p. 3013-3025 [2014]
  • Polyinosinic‐polycytidylic acid suppresses acetaminophen‐ induced hepatotoxicity independent of type I interferons and toll‐like receptor 3
    53 ( 6 ) : p. 2042-2052 . [2011]
  • Polyinosinic-polycytidylic acid suppresses acetaminopheninduced hepatotoxicity independent of type I interferons and toll-like receptor 3
    53 ( 6 ) : p. 2042-2052 . [2011]
  • Pathogen recognition and innate immunity
    124 ( 4 ) : p. 783-801 . [2006]
  • Oxidative-stress and IL-6 mediate the fibrogenic effects of Kupffer cells on stellate cells
    44 ( 6 ) : p. 1487-501 . 10.1002/hep.21427 [2006]
  • Oxidative stress during acetaminophen hepatotoxicity : Sources , pathophysiological role and therapeutic potential
    10 : p. 148-156 [2016]
  • Overexpression of miR‐483‐5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF‐β stimulated HSC s in transgenic mice
    18 ( 6 ) : p. 966-974 . [2014]
  • Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice
    12 ( 6 ) : p. 729 . [2015]
  • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus .
    202 ( 8 ) : p. 1131-1139 . [2005]
  • Nuclear factor κB in proliferation , activation , and apoptosis in rat hepatic stellate cells
    33 ( 1 ) : p. 49-58 . [2000]
  • Non-alcoholic fatty liver and the gut microbiota
    5 ( 9 ) : p. 782-794 [2016]
  • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in nkg2d-dependent and tumor necrosis factor–related apoptosis-inducing ligand–dependent manners
    130 ( 2 ) : p. 435-452 . [2006]
  • NF-κB in the liver—linking injury , fibrosis and hepatocellular carcinoma
    8 ( 2 ) : p. 108 . [2011]
  • NAK is an IκB kinase-activating kinase .
    404 ( 6779 ) : p. 778 . [2000]
  • Mucosal interplay among commensal and pathogenic bacteria : Lessons from flagellin and Toll-like receptor 5
    580 ( 12 ) : p. 2976-2984 [2006]
  • Molecular regulation of hepatic fibrosis , an integrated cellular response to tissue injury
    275 ( 4 ) : p. 2247-50 [2000]
  • Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
    193 ( 3 ) : p. 225-31 . 10.1016/j.cbi.2011.07.001 [2011]
  • Molecular interplays in hepatic stellate cells : apoptosis , senescence , and phenotype reversion as cellular connections that modulate liver fibrosis
    41 ( 9 ) : p. 946- 959 [2017]
  • Mobilan : a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy
    37 ( 4 ) : p. 439 . [2018]
  • Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation .
    187 ( 5 ) : p. 570-580 . [2017]
  • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    328 : 228-231 .56 ( 3 ) : p. 209 [2010]
  • Mechanisms of spontaneous resolution of rat liver fibrosis . Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    102 ( 3 ) : p. 538-549 . [1998]
  • Mechanisms of hepatic fibrogenesis
    25 ( 2 ) : p. 195-206 . 10.1016/j.bpg.2011.02.005 [2011]
  • Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
    17 : p. 274-283 [2018]
  • Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6
    44 : p. 49-60 . [2013]
  • Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction .
    16 : p. 139-149 . 10.1016/j.molmet.2018.06.007 [2018]
  • Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production
    25 ( 17 ) : p. 2520 . [2006]
  • Leading causes of death in England and Wales -- how should we group causes ?
    28 ) : p. 6-17 [2005]
  • Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis
    176 ( 5 ) : p. 2236-46 . 10.2353/ajpath.2010.090469 [2010]
  • Kupffer cell activation by lipopolysaccharide in rats : role for lipopolysaccharide binding protein and toll‐like receptor 4
    31 ( 4 ) : p. 932-936 . [2000]
  • IκB kinase ɛ ( IKKɛ ) : a therapeutic target in inflammation and cancer
    85 ( 7 ) : p. 873-880 . [2013]
  • Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice
    147 ( 6 ) : p. 1363-1377. e17 [2014]
  • Interleukin-11 links oxidative stress and compensatory proliferation
    5 ( 207 ) : p. ra5-ra5 . [2012]
  • Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse .
    309 ( 4 ) : p. 857-863 . [2003]
  • Interleukin 22 ( IL‐22 ) plays a protective role in T cell‐ mediated murine hepatitis : IL‐22 is a survival factor for hepatocytes via STAT3 activation
    39 ( 5 ) : p. 1332-1342 [2004]
  • Interferon‐β reduces the mouse liver fibrosis induced by repeated administration of concanavalin A via the direct and indirect effects
    122 ( 4 ) : p. 562-570 [2007]
  • Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model
    35 ( 6 ) : p. 464- 473 [2015]
  • Interferon regulatory factors : at the crossroads of immunity , metabolism , and disease . Biochimica et Biophysica Acta ( BBA ) - Molecular Basis of Disease
    1852 ( 2 ) : p. 365-378 . [2015]
  • Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
    65 ( 3 ) : p. 719-731 . [2016]
  • Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    128 ( 1 ) : p. 108-120 [2005]
  • Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    128 ( 1 ) : p. 108-20 [2005]
  • Inhibition of MAPK and NF-κB signaling pathways alleviate carbon tetrachloride ( CCl4 ) -induced liver fibrosis in Toll-like receptor 5 ( TLR5 ) deficiency mice
    471 ( 1 ) : p. 233-239 . [2016]
  • Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes
    26 ( 1 ) : p. 157-170.e7 [2017]
  • Inflammatory links between obesity and metabolic disease
    121 ( 6 ) : p. 2111-2117 [2011]
  • Induction of macrophage nitric oxide production by Gramnegative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes
    170 ( 12 ) : p. 6217-6223 . [2003]
  • Increased intestinal permeability in obese mice : new evidence in the pathogenesis of nonalcoholic steatohepatitis
    292 ( 2 ) : p. G518-G525 [2007]
  • Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence
    18 ( 5 ) : p. 700-708 . [2012]
  • In vitro and in vivo association of transforming growth factorbeta 1 with hepatic fibrosis
    108 ( 6 ) : p. 2477-2482 . [1989]
  • In liver fibrosis , dendritic cells govern hepatic inflammation in mice via TNF-α
    119 ( 11 ) : p. 3213-3225 [2009]
  • Immunology in the liver—from homeostasis to disease
    13 ( 2 ) : p. 88 . [2016]
  • IkappaB kinase-beta inhibitor attenuates hepatic fibrosis in mice
    17 ( 47 ) : p. 5203-13 . 10.3748/wjg.v17.i47.5203 [2011]
  • Identification of TBK1 and IKKepsilon , the non-canonical IkappaB kinases , as crucial pro-survival factors in HTLV-1-transformed T lymphocytes
    46 : p. 37-44 . 10.1016/j.leukres.2016.04.012 [2016]
  • IL-11 prevents IFN-γ-induced hepatocyte death through selective downregulation of IFN-γ/STAT1 signaling and ROS scavenging
    14 ( 2 ) : p. e0211123 [2019]
  • IKKε is part of a novel PMAinducible IκB kinase complex
    5 ( 3 ) : p. 513-522 . [2000]
  • IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex .
    5 ( 3 ) : p. 513-522 . [2000]
  • IKK-i/IKKϵ Controls Constitutive , Cancer Cellassociated NF-κB Activity via Regulation of Ser-536 p65/RelA Phosphorylation
    281 ( 37 ) : p. 26976-26984 . [2006]
  • Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity
    334 ( 1 ) : p. 33-43 . [2010]
  • Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration
    285 ( 5 ) : p. G949-G958 . [2003]
  • Human CD4+T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+T Regulatory Cells
    175 ( 12 ) : p. 8051-8059 . [2005]
  • High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK
    8 ( 5 ) : p. e64373 [2013]
  • Hepatocytes : a key cell type for innate immunity
    13 ( 3 ) : p. 301-315 . [2016]
  • Hepatocyte free cholesterol lipotoxicity results from JNK1- mediated mitochondrial injury and is HMGB1 and TLR4-dependent
    61 ( 6 ) : p. 1376-1384 . [2014]
  • Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease
    2 ( 5 ) : p. 584- 604 [2016]
  • Hepatic stellate cells in liver development , regeneration , and cancer
    123 ( 5 ) : p. 1902-1910 . [2013]
  • Hepatic inflammation and fibrosis : functional links and key pathways
    61 ( 3 ) : p. 1066-1079 [2015]
  • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    121 ( 3 ) : p. 685-698 [2001]
  • Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis
    76 ( 1 ) : p. 89-96 [2008]
  • Flagellin promotes myeloid differentiation factor 88- dependent development of Th2-type response
    172 ( 11 ) : p. 6922-6930 . [2004]
  • Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury
    187 ( 5 ) : p. 2626-2631 [1950]
  • Endothelial cell toll‐like receptor 4 regulates fibrosis‐ associated angiogenesis in the liver
    52 ( 2 ) : p. 590-601 [2010]
  • Emerging insights into transforming growth factor β Smad signal in hepatic fibrogenesis
    56 ( 2 ) : p. 284-292 . [2007]
  • Effects of melittin treatment in cholangitis and biliary fibrosis in a model of xenobiotic-induced cholestasis in mice
    7 ( 9 ) : p. 3372-3387 . [2015]
  • Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway
    5 : p. 18038 [2015]
  • Differential expression of toll-like receptors 2 and 4 in patients with liver cirrhosis
    15 ( 3 ) : p. 275-282 [2003]
  • Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells
    5 ( 2 ) : p. 95-105 . [2013]
  • Detrimental effects of nicotine on thioacetamide-induced liver injury in mice
    27 ( 7 ) : p. 501-510 . 10.1080/15376516.2017.1323256 [2017]
  • Deletion of TLR5 results in spontaneous colitis in mice
    117 ( 12 ) : p. 3909-3921 . [2007]
  • Current status of novel antifibrotic therapies in patients with chronic liver disease
    4 ( 6 ) : p. 391-417 [2011]
  • Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist
    110 ( 20 [2013]
  • Cellular and molecular mechanisms of fibrosis
    214 ( 2 ) : p. 199-210 . 10.1002/path.2277 [2008]
  • Carbon tetrachloride-induced lipid peroxidation : eicosanoid formation and their regulation by antioxidant nutrients . 2003 . 189 ( 1-2 ) : p. 113-127
  • CBLB502 administration protects gut mucosal tissue in ulcerative colitis by inhibiting inflammation
    4 ( 16 ) . [2016]
  • Biological significance of local TGF-β activation in liver diseases
    3 : p. 12 . [2012]
  • Bile duct ligation in mice : induction of inflammatory liver injury and fibrosis by obstructive cholestasis
    96 ) : p. e52438 . [2015]
  • Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury
    175 ( 3 ) : p. 1056-1065 [2009]
  • Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
    10 ( 6 ) : p. 587-594 [2009]
  • Bacterial flagellin—a potent immunomodulatory agent
    49 ( 9 ) : p. e373 . [2017]
  • Bacterial flagellin stimulates toll-like receptor 5— dependent defense against vancomycin-resistant Enterococcus infection
    201 ( 4 ) : p. 534-543 . [2010]
  • Bacterial flagellin elicits widespread innate immune defense mechanisms , apoptotic signaling , and a sepsis-like systemic inflammatory response in mice
    14 ( 4 ) : p. R160 [2010]
  • Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis
    47 ( 3 ) : p. 978-985 . [2008]
  • Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9 .
    207 ( 13 ) : p. 2931-2942 . [2010]
  • Association of the Adaptor TANK with the IκB Kinase ( IKK ) Regulator NEMO Connects IKK Complexes with IKKε and TBK1 Kinases
    277 ( 40 ) : p. 37029-37036 . [2002]
  • Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll‐like receptor 9p. 1509-1518
    46 ( 5 [2007]
  • Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll‐like receptor 9
    46 ( 5 ) : p. 1509-1518 [2007]
  • Apoptosis and necrosis in the liver : a tale of two deaths ? 2006
    43 ( S1 ) : p. S31-S44 .
  • Animal models of chronic liver diseasesp. G449- G468
    304 ( 5 [2012]
  • An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
    19 ( 3 ) : p. 313 . [2013]
  • An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice
    19 ( 3 ) : p. 313- 21 . 10.1038/nm.3082 . [2013]
  • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    320 ( 5873 ) : p. 226-230 [2008]
  • Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury
    41 ( 1 ) : p. 26-31 [2005]
  • Adapting to obesity with adipose tissue inflammation
    13 : p. 633 [2017]
  • Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth .
    71 ( 7 ) : p. 2466-2475 . [2011]
  • Activation of TGF-β1 promoter by hepatitis C virus-induced AP-1 and Sp1 : role of TGF-β1 in hepatic stellate cell activation and invasion
    8 ( 2 ) : p. e56367 . [2013]
  • Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes : protection by N-acetyl cysteine
    80 ( 2 ) : p. 343-349 [2004]
  • Acetaminophen-induced liver injury in rats and mice : comparison of protein adducts , mitochondrial dysfunction , and oxidative stress in the mechanism of toxicity
    264 ( 3 ) : p. 387-394 [2012]
  • Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    119 ( 2 ) : p. 305-314 . [2009]
  • Acetaminophen and the U.S. acute liver failure study group : Lowering the risks of hepatic failure
    40 ( 1 ) : p. 6-9 . [2004]
  • Abrogation of the antifibrotic effects of natural killer cells/interferon-γ contributes to alcohol acceleration of liver fibrosis
    134 ( 1 ) : p. 248-258 . [2008]
  • A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts .
    278 ( 35 ) : p. 32861-71 . 10.1074/jbc.M211439200 . [2003]
  • A phase I trial of recombinant human interleukin-11 ( neumega rhIL-11 growth factor ) in women with breast cancer receiving chemotherapy
    87 ( 9 ) : p. 3615-3624 . [1996]
  • A novel model of CCl4-induced cirrhosis with ascites in the mouse
    51 ( 6 ) : p. 991-999 . [2009]
  • A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis . 2007
    171 ( 2 ) : p. 525-536 .
  • A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts
    278 ( 35 ) : p. 32861- 32871 . [2003]
  • 74. Athersuch, T.J., et al., Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective. Toxicology Research, 2018. 7(3): p. 347-357.
  • 61. Hotamisligil, G.S., Inflammation and metabolic disorders. Nature, 2006. 444(7121): p. 860-867.
  • 6. Gunawan, B.K. and N.J.C.i.l.d. Kaplowitz, Mechanisms of drug-induced liver disease. 2007. 11(3): p. 459-475.
  • 5. Kaplowitz, N.J.C.I.D., Drug-induced liver injury. 2004. 38(Supplement_2): p. S44-S48.
  • 5. Friedman, S.L.J.G., Mechanisms of hepatic fibrogenesis. 2008. 134(6): p. 1655- 1669.
  • 4. Schuppan, D. and Y.O. Kim, Evolving therapies for liver fibrosis. J Clin Invest, 2013. 123(5): p. 1887-901. 10.1172/jci66028.
    123 ( 5 ) : p. 1887-901 . 10.1172/jci66028 [2013]
  • 4. Schuppan, D. and N.H.J.T.L. Afdhal, Liver cirrhosis. 2008. 371(9615): p. 838- 851.
  • 35. Garbers, C. and J.J.B.c. Scheller, Interleukin-6 and interleukin-11: same same but different. 2013. 394(9): p. 1145-1161.
  • 3. Lee, W.M., et al., Acute liver failure: summary of a workshop. 2008. 47(4): p. 1401-1415.
    47 ( 4 ) : p. 1401-1415 . [2008]
  • 3. Hernandez-Gea, V. and S.L.J.A.r.o.p.m.o.d. Friedman, Pathogenesis of liver fibrosis. 2011. 6: p. 425-456.
  • 28. Jenne, C.N. and P.J.N.i. Kubes, Immune surveillance by the liver. 2013. 14(10): p. 996.
  • 22. Yang, J., H.J.C. Yan, and m. immunology, TLR5: beyond the recognition of flagellin. 2017. 14(12): p. 1017.
    14 ( 12 ) : p. 1017 . [2017]
  • 2. Zimmerman, H.J. and W.C.J.H. Maddrey, Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. 1995. 22(3): p. 767-773.
  • 2. Bataller, R. and D.A. Brenner, Liver fibrosis. The Journal of clinical investigation, 2005. 115(2): p. 209-218.
    115 ( 2 ) : p. 209-218 . [2005]
  • 19. Wernke, M.J., J.D.J.C.i.o. Schell, and e. medicine, Solvents and malignancy. 2004. 4(3): p. 513-27, vii.
    4 ( 3 ) : p. 513-27 , vii . [2004]
  • 19. Akira, S. and K.J.N.r.i. Takeda, Toll-like receptor signalling. 2004. 4(7): p. 499.
  • 14. Yang, J., H.J.C. Yan, and m. immunology, TLR5: beyond the recognition of flagellin. 2017. 14(12): p. 1017.
    14 ( 12 ) : p. 1017 [2017]
  • 12. Karin, M. and F.R.J.N.r.i. Greten, NF-κB: linking inflammation and immunity to cancer development and progression. 2005. 5(10): p. 749.
  • 1. Larson, A.M.J.C.i.l.d., Acetaminophen hepatotoxicity. 2007. 11(3): p. 525-548.
  • 1. Bataller, R. and D.A.J.T.J.o.c.i. Brenner, Liver fibrosis. 2005. 115(2): p. 209-218.
  • 1. Bataller, R. and D.A. Brenner, Liver fibrosis. The Journal of clinical investigation, 2005. 115(2): p. 209-218.
    115 ( 2 ) : p. 209-218 . [2005]