박사

Neuroprotective Effects of Angelica gigas Roots on Mice Models of Ischemic Stroke and Vascular Dementia = 생쥐의 허혈성 뇌졸중 및 혈관성 치매 모델에 대한 당귀의 신경 보호 효과

이세은 2019년
논문상세정보
' Neuroprotective Effects of Angelica gigas Roots on Mice Models of Ischemic Stroke and Vascular Dementia = 생쥐의 허혈성 뇌졸중 및 혈관성 치매 모델에 대한 당귀의 신경 보호 효과' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Angelica gigas Roots
  • Ischemic stroke
  • Vascular dementia
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
93 0

0.0%

' Neuroprotective Effects of Angelica gigas Roots on Mice Models of Ischemic Stroke and Vascular Dementia = 생쥐의 허혈성 뇌졸중 및 혈관성 치매 모델에 대한 당귀의 신경 보호 효과' 의 참고문헌

  • Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ: Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia. Brain Pathology 2000, 10(1):95-112.
  • Zhao Q, Wang X, Chen A, Cheng X, Zhang G, Sun J, Zhao Y, Huang Y, Zhu Y: Rhein protects against cerebral ischemic-/reperfusion-induced oxidative stress and apoptosis in rats. International journal of molecular medicine 2018, 41(5):2802-2812.
  • Zhao P, Zhou R, Zhu XY, Hao YJ, Li N, Wang J, Niu Y, Sun T, Li YX, Yu JQ: Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice. International journal of molecular medicine 2015, 36(3):633- 644.
  • Zhang S, Zis O, Ly PT, Wu Y, Zhang S, Zhang M, Cai F, Bucala R, Shyu WC, Song W: Down-regulation of MIF by NFkappaB under hypoxia accelerated neuronal loss during stroke. The FASEB journal 2014, 28(10):4394-4407.
  • Zhang RL, Chopp M, Li Y, Zaloga C, Jiang N, Jones ML, Miyasaka M, Ward PA: Anti‐ ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology 1994, 44(9):1747-1747.
  • Zekry D, Epperson TK, Krause KH: A role for NOX NADPH oxidases in Alzheimer's disease and other types of dementia? IUBMB life 2003, 55(6):307-313.
  • Younglimsa: Herbology Association of Korea's Colleges of Oriental Medicine.: Younglimsa; 2000.
  • Yoon M-Y, Kim YS, Ryu SY, Choi GJ, Choi YH, Jang KS, Cha B, Han S-S, Kim J-C: In vitro and in vivo antifungal activities of decursin and decursinol angelate isolated from Angelica gigas against Magnaporthe oryzae, the causal agent of rice blast. Pesticide biochemistry and physiology 2011, 101(2):118-124.
  • Yoo AJ, Chaudhry ZA, Nogueira RG, Lev MH, Schaefer PW, Schwamm LH, Hirsch JA, Gonzalez RG: Infarct volume is a pivotal biomarker after intra-arterial stroke therapy. Stroke 2012, 43(5):1323-1330.
  • Yong-Joon S, Yong-Ki P: Effects of different parts of Angelica gigas Nakai on brain damages and neuronal death in transient middle artery occlusion/reperfusion-induced ischemic rats. The Korea Journal of Herbology 2014, 29(6):85-93.
  • Yim N-H, Lee JH, Cho W-K, Yang MC, Kwak DH, Ma JY: Decursin and decursinol angelate from Angelica gigas Nakai induce apoptosis via induction of TRAIL expression on cervical cancer cells. European Journal of Integrative Medicine 2011, 3(4):e299-e307.
  • Yang Y, Rosenberg GA: Blood-Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease. Stroke; a journal of cerebral circulation 2011, 42(11):3323-3328.
  • Yan J-J, Kim D-H, Moon Y-S, Jung J-S, Ahn E-M, Baek N-I, Song D-K: Protection against β-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2004, 28(1):25-30.
  • Wu Y, Wang X, Zhou X, Cheng B, Li G, Bai B: Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential. Frontiers in Molecular Neuroscience 2017, 10:1.
  • Willmot M, Leonardi-Bee J, Bath PMW: High Blood Pressure in Acute Stroke and Subsequent Outcome. A Systematic Review 2004, 43(1):18-24.
  • Widimsky P, Hopkins LN: Catheter-based interventions for acute ischaemic stroke. European Heart Journal 2016, 37(40):3081-3089.
  • Whittington MA, Traub RD, Jefferys JGR: Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature 1995, 373:612.
  • Welsh TJ, Gladman JR, Gordon AL: The treatment of hypertension in people with dementia: a systematic review of observational studies. BMC Geriatrics 2014, 14:19-19.
  • Wang T, Li Y, Wang Y, Zhou R, Ma L, Hao Y, Jin S, Du J, Zhao C, Sun T et al: Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice. PloS one 2014, 9(3):e90780.
  • Virley D, Hadingham SJ, Roberts JC, Farnfield B, Elliott H, Whelan G, Golder J, David C, Parsons AA, Hunter AJ: A new primate model of focal stroke: endothelin-1-induced middle cerebral artery occlusion and reperfusion in the common marmoset. Journal of cerebral blood flow and metabolism 2004, 24(1):24-41.
  • Vila N, Castillo J, Davalos A, Chamorro A: Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke 2000, 31(10):2325-2329.
  • Vijayan M, Reddy PH: Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links. Journal of Alzheimer's disease : JAD 2016, 54(2):427-443.
  • Venkat P, Chopp M, Chen J: Models and Mechanisms of Vascular Dementia. Experimental neurology 2015, 272:97-108.
  • Tomas E, Stanojevic V, Habener JF: GLP-1-derived nonapeptide GLP-1(28–36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes. Regulatory Peptides 2011, 167(2):177-184.
  • Thundyil J, Manzanero S, Pavlovski D, Cully TR, Lok KZ, Widiapradja A, Chunduri P, Jo DG, Naruse C, Asano M et al: Evidence that the EphA2 receptor exacerbates ischemic brain injury. PloS one 2013, 8(1):e53528.
  • Su P, Zhang J, Wang D, Zhao F, Cao Z, Aschner M, Luo W: The role of autophagy in modulation of neuroinflammation in microglia. Neuroscience 2016, 319:155-167.
  • Song B-K, Jeon Y-C, Kim S-A, Shim A-N, Seong K-M, Lee E-J: The Effect of Intravenous Injection of the Water Extract of Angelica gigas Nakai on Gliosis in the Middle Cerebral Artery Occlusion Rats. Journal of Pharmacopuncture 2011, 14(3):5-17.
  • Sims NR, Muyderman H: Mitochondria, oxidative metabolism and cell death in stroke. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2010, 1802(1):80-91.
  • Shimokawa A, Yatomi N, Anamizu S, Torii S, Isono H, Sugai Y, Kohno M: Influence of Deteriorating Ability of Emotional Comprehension on Interpersonal Behavior in Alzheimer-Type Dementia. Brain and Cognition 2001, 47(3):423-433.
  • Shibata M, Ohtani R, Ihara M, Tomimoto H: White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion. Stroke 2004, 35(11):2598- 2603.
  • Shah B, Bartaula B, Adhikari J, Neupane HS, Shah BP, Poudel G: Predictors of In-hospital Mortality of Acute Ischemic Stroke in Adult Population. Journal of neurosciences in rural practice 2017, 8(4):591-594.
  • Sembi S, Tarrier N, O'Neill P, Burns A, Faragher B: Does post‐traumatic stress disorder occur after stroke: a preliminary study. International Journal of Geriatric Psychiatry 1998, 13(5):315-322.
  • Saito K, Suyama K, Nishida K, Sei Y, Basile AS: Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. Neuroscience letters 1996, 206(2):149-152.
  • Sahathevan R, Brodtmann A, Donnan GA: Dementia, stroke, and vascular risk factors; a review. International Journal of Stroke 2012, 7(1):61-73.
  • Rogers SL, Friedman RB: The underlying mechanisms of semantic memory loss in Alzheimer's disease and semantic dementia. Neuropsychologia 2008, 46(1):12-21.
  • Ramirez L, Kim-Tenser MA, Sanossian N, Cen S, Wen G, He S, Mack WJ, Towfighi A: Trends in Acute Ischemic Stroke Hospitalizations in the United States. Journal of the American Heart Association 2016, 5(5):e003233.
  • Prasad SS, Russell M, Nowakowska M: Neuroprotection Induced In Vitro by Ischemic Preconditioning and Postconditioning: Modulation of Apoptosis and PI3K–Akt Pathways. Journal of Molecular Neuroscience 2011, 43(3):428-442.
  • Plotnikov A, Zehorai E, Procaccia S, Seger R: The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011, 1813(9):1619-1633.
  • Pirozzolo F, Hansch E: Oculomotor reaction time in dementia reflects degree of cerebral dysfunction. Science 1981, 214(4518):349-351.
  • Pieper AA, Verma A, Zhang J, Snyder SH: Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends in Pharmacological Sciences 1999, 20(4):171-181.
  • Peterson BW, Pellionisz AJ, Baker JF, Keshner EA: Functional Morphology and Neural Control of Neck Muscles in Mammals1. American Zoologist 1989, 29(1):139-149.
  • Penfield W, Milner B: Memory deficit produced by bilateral lesions in the hippocampal zone. AMA Archives of Neurology & Psychiatry 1958, 79(5):475-497.
  • Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH: Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 2004, 35(10):2412- 2417.
  • Papadopoulos MC, Krishna S, Verkman AS: Aquaporin water channels and brain edema. The Mount Sinai journal of medicine, New York 2002, 69(4):242-248.
  • Orset C, Macrez R, Young AR, Panthou D, Angles-Cano E, Maubert E, Agin V, Vivien D: Mouse Model of In Situ Thromboembolic Stroke and Reperfusion. Stroke 2007, 38(10):2771-2778.
  • Ohwaki K, Yano E, Nagashima H, Hirata M, Nakagomi T, Tamura A: Blood Pressure Management in Acute Intracerebral Hemorrhage. Relationship Between Elevated Blood Pressure and Hematoma Enlargement 2004, 35(6):1364-1367.
  • Oh TW, Park KH, Jung HW, Park YK: Neuroprotective effect of the hairy root extract of Angelica gigas NAKAI on transient focal cerebral ischemia in rats through the regulation of angiogenesis. BMC complementary and alternative medicine 2015, 15:101.
  • Nishio K, Ihara M, Yamasaki N, Kalaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T et al: A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke 2010, 41(6):1278-1284.
  • Mukaetova-Ladinska EB, Li M, Kalaria RN: tau protein, ischemic injury and vascular dementia. Future Neurology 2015, 10(6):559-575.
  • Moskowitz MA, Lo EH, Iadecola C: The science of stroke: mechanisms in search of treatments. Neuron 2010, 67(2):181-198.
  • Moretti R, Torre P, Antonello RM, Cazzato G, Bava A: Use of galantamine to treat vascular dementia. Lancet (London, England) 2002, 360(9344):1512-1513; author reply 1513.
  • Mittal SH, Goel D: Mortality in ischemic stroke score: A predictive score of mortality for acute ischemic stroke. Brain circulation 2017, 3(1):29-34.
  • Misner DL, Sullivan JM: Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons. The Journal of neuroscience 1999, 19(16):6795-6805.
  • Miossec P, Kolls JK: Targeting IL-17 and TH17 cells in chronic inflammation. Nature Reviews Drug Discovery 2012, 11:763.
  • Metcalfe MJ, Figueiredo-Pereira ME: Relationship between tau pathology and neuroinflammation in Alzheimer's disease. The Mount Sinai journal of medicine 2010, 77(1):50-58.
  • Merrill JE, Benveniste EN: Cytokines in inflammatory brain lesions: helpful and harmful. Trends in Neurosciences 1996, 19(8):331-338.
  • Meneses G, Bautista M, Florentino A, D az G, Acero G, Besedovsky H, Meneses D, Fleury A, Del Rey A, Gevorkian G et al: Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide. Journal of Inflammation (London, England) 2016, 13:33.
  • McShane R, Areosa Sastre A, Minakaran N: Memantine for dementia. The Cochrane database of systematic reviews 2006(2):Cd003154.
  • Matsuda T, Takuma K, Nishiguchi E, Asano S, Hashimoto H, Azuma J, Baba A: Involvement of Na+–Ca2+ Exchanger in Reperfusion-induced Delayed Cell Death of Cultured Rat Astrocytes. European Journal of Neuroscience 1996, 8(5):951-958.
  • Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS: Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Medicine 2000, 6:159.
  • Manaenko A, Chen H, Kammer J, Zhang JH, Tang J: Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood–brain barrier in a mice hemorrhage model. Journal of Neuroscience Methods 2011, 195(2):206-210.
  • Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, Williams GR: Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004, 110(10):1245-1250.
  • MacDonald JF, Xiong Z-G, Jackson MF: Paradox of Ca2+ signaling, cell death and stroke. Trends in Neurosciences 2006, 29(2):75-81.
  • Ma J, Peng C, Guo W, Dong YF, Dong XH, Sun X, Xie HH: A Modified Model of Middle Cerebral Artery Electrocoagulation in Mice. CNS Neuroscience & Therapeutics 2012, 18(9):796-798.
  • Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R: Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 2005, 65(4):545-551.
  • Lu J, Moochhala S, Kaur C, Ling E-A: Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. Neuroscience letters 2000, 290(2):89-92.
  • Lozano JD, Abulafia DP, Danton GH, Watson BD, Dietrich WD: Characterization of a thromboembolic photochemical model of repeated stroke in mice. Journal of Neuroscience Methods 2007, 162(1):244-254.
  • Lopez M, Dempsey RJ, Vemuganti R: Resveratrol Neuroprotection in Stroke and Traumatic CNS injury. Neurochemistry international 2015, 89:75-82.
  • Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM et al: NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience 2007, 27(11):2846-2857.
  • Lindwall G, Cole RD: Phosphorylation affects the ability of tau protein to promote microtubule assembly. The Journal of biological chemistry 1984, 259(8):5301-5305.
  • Lindsberg PJ, Carpen O, Paetau A, Karjalainen-Lindsberg ML, Kaste M: Endothelial ICAM- 1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 1996, 94(5):939-945.
  • Li Y, Mei Z, Liu S, Wang T, Li H, Li X-X, Han S, Yang Y, Li J, Xu Z-QD: Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1. Aging and disease 2017, 8(1):85-100.
  • Li L, Du JK, Zou LY, Wu T, Lee YW, Kim YH: Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid beta-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK. Evidencebased complementary and alternative medicine : eCAM 2013, 2013:467245.
  • Li L, Du J, Zou L, Xia H, Wu T, Kim Y, Lee Y: The Neuroprotective Effects of Decursin Isolated from Angelica gigas Nakai Against Amyloid β-Protein-Induced Apoptosis in PC 12 Cells via a Mitochondria-Related Caspase Pathway. Neurochemical research 2015, 40(8):1555-1562.
  • Li JH, Lu J, Zhang H: Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats: A Pilot Study with (18) F-Fluorodeoxyglucose MicroPET. Evidence-based complementary and alternative medicine : eCAM 2013, 2013:507091.
  • Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG: Blood Pressure and Clinical Outcomes in the International Stroke Trial. Stroke 2002, 33(5):1315-1320.
  • Lee YY, Lee S, Jin JL, Yun-Choi HS: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of pharmacal research 2003, 26(9):723-726.
  • Lee S, Lee M, Hong Y, Won J, Lee Y, Kang S-G, Chang K-T, Hong Y: Middle cerebral artery occlusion methods in rat versus mouse models of transient focal cerebral ischemic stroke. Neural Regeneration Research 2014, 9(7):757-758.
  • Labat-gest V, Tomasi S: Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies. Journal of Visualized Experiments : JoVE 2013(76):50370.
  • Koroshetz WJ, Ropper AH: Artery‐to‐artery embolism causing stroke in the posterior circulation. Neurology 1987, 37(2):292-292.
  • Kontush A: Amyloid-β: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer’s disease. Free Radical Biology and Medicine 2001, 31(9):1120- 1131.
  • Kimura R, Okouchi M, Fujioka H, Ichiyanagi A, Ryuge F, Mizuno T, Imaeda K, Okayama N, Kamiya Y, Asai K et al: Glucagon-like peptide-1 (GLP-1) protects against methylglyoxalinduced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience 2009, 162(4):1212-1219.
  • Khouri RK, Cooley BC, Kenna DM, Edstrom LE: Thrombosis of microvascular anastomoses in traumatized vessels: fibrin versus platelets. Plastic and reconstructive surgery 1990, 86(1):110-117.
  • Kessler W, Diedrich S, Menges P, Ebker T, Nielson M, Partecke LI, Traeger T, Cziupka K, van der Linde J, Puls R et al: The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis. Mediators of inflammation 2012, 2012:467620.
  • Kennelly SP, Lawlor BA, Kenny RA: Blood Pressure and Dementia – a Comprehensive Review. Therapeutic Advances in Neurological Disorders 2009, 2(4):241-260.
  • Kang SY, Lee KY, Sung SH, Kim YC: Four new neuroprotective dihydropyranocoumarins from Angelica gigas. Journal of natural products 2005, 68(1):56- 59.
  • Kang SY, Kim YC: Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Archives of pharmacal research 2007, 30(11):1368-1373.
  • Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2005, 1754(1):253-262.
  • Kalaria RN, Akinyemi R, Ihara M: Stroke injury, cognitive impairment and vascular dementia(). Biochimica et Biophysica Acta 2016, 1862(5):915-925.
  • Kaasik A, Vassiljev V, Poldoja E, Kalda A, Zharkovsky A: Do nuclear condensation or fragmentation and DNA fragmentation reflect the mode of neuronal death? Neuroreport 1999, 10(9):1937-1942.
  • Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier J-P: IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages. The Journal of Immunology 1998, 160(7):3513-3521.
  • Jeong SY, Kim HM, Lee KH, Kim KY, Huang DS, Kim JH, Seong RS: Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD. Chemical & pharmaceutical bulletin 2015, 63(7):504-511.
  • Ingall T: Stroke--incidence, mortality, morbidity and risk. Journal of insurance medicine (New York, NY) 2004, 36(2):143-152.
  • Huang J, Upadhyay UM, Tamargo RJ: Inflammation in stroke and focal cerebral ischemia. Surgical Neurology 2006, 66(3):232-245.
  • Horie N, Maag A-L, Hamilton SA, Shichinohe H, Bliss TM, Steinberg GK: Mouse model of focal cerebral ischemia using endothelin-1. Journal of neuroscience methods 2008, 173(2):286-290.
  • Herceg Z, Wang Z-Q: Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2001, 477(1):97-110.
  • Heo JH, Han SW, Lee SK: Free radicals as triggers of brain edema formation after stroke. Free Radical Biology and Medicine 2005, 39(1):51-70.
  • Hattori Y, Kitamura A, Nagatsuka K, Ihara M: A novel mouse model of ischemic carotid artery disease. PloS one 2014, 9(6):e100257.
  • Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Nagatsuka K, Iida H, Ihara M: Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis. Sci Rep 2016, 6:32179.
  • H jos N, Paulsen O: Network mechanisms of gamma oscillations in the CA3 region of the hippocampus. Neural Networks 2009, 22(8):1113-1119.
  • Guo C, Yang M, Jing L, Wang J, Yu Y, Li Y, Duan J, Zhou X, Li Y, Sun Z: Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling. International Journal of Nanomedicine 2016, 11:5257-5276.
  • Gui X, Cui X, Wei H, Feng G, Zhang X, He Y, Li J, Li T: cPKCgamma membrane translocation is involved in herkinorininduced neuroprotection against cerebral ischemia/reperfusion injury in mice. Molecular medicine reports 2017, 15(1):221-227.
  • Gross RE: Arterial embolism and thrombosis in infancy. American Journal of Diseases of Children 1945, 70(2):61-73.
  • Green AR, Hainsworth AH, Jackson DM: GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology 2000, 39(9):1483-1494.
  • Graham NL, Emery T, Hodges JR: Distinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementia. Journal of neurology, neurosurgery, and psychiatry 2004, 75(1):61-71.
  • Goodenowe DB, Cook LL, Liu J, Lu Y, Jayasinghe DA, Ahiahonu PW, Heath D, Yamazaki Y, Flax J, Krenitsky KF et al: Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. Journal of lipid research 2007, 48(11):2485-2498.
  • Gonz lez RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR et al: The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. Journal of NeuroInterventional Surgery 2013, 5(suppl 1):i7-i12.
  • Gillardon F, Lenz C, Waschke KF, Krajewski S, Reed JC, Zimmermann M, Kuschinsky W: Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Molecular Brain Research 1996, 40(2):254-260.
  • Futrell N: An improved photochemical model of embolic cerebral infarction in rats. Stroke 1991, 22(2):225-232.
  • Fukuda AM, Badaut J: Aquaporin 4: a player in cerebral edema and neuroinflammation. Journal of Neuroinflammation 2012, 9(1):279.
  • Forster MJ, Lal H: Animal models of age-related dementia: neurobehavioral dysfunctions in autoimmune mice. Brain Research Bulletin 1990, 25(3):503-516.
  • Forchetti CM, Katsamakis G, Garron DC: Autoimmune thyroiditis and a rapidly progressive dementia: Global hypoperfusion on SPECT scanning suggests a possible mechanism. Neurology 1997, 49(2):623-626.
  • Fan X, Jin WY, Lu J, Wang J, Wang YT: Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation. Nature neuroscience 2014, 17(3):471- 480.
  • Ebrahim S, Nouri F, Barer D: COGNITIVE IMPAIRMENT AFTER STROKE. Age and Ageing 1985, 14(6):345-350.
  • Cui J, Holmes EH, Greene TG, Liu PK: Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. The FASEB journal 2000, 14(7):955- 967.
  • Craft S: The role of metabolic disorders in alzheimer disease and vascular dementia: Two roads converged. Archives of Neurology 2009, 66(3):300-305.
  • Clark RK, Lee EV, White RF, Jonak ZL, Feuerstein GZ, Barone FC: Reperfusion following focal stroke hastens inflammation and resolution of ischemic injured tissue. Brain Research Bulletin 1994, 35(4):387-392.
  • Chuang SM, Wang IC, Yang JL: Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 2000, 21(7):1423-1432.
  • Chuang SM, Liou GY, Yang JL: Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity. Carcinogenesis 2000, 21(8):1491-1500.
  • Choi I-j, Min K, Oh S, Song G-y, Kang D: Effect of Decursin on the Expression of β- Catenin and Matrix Metalloproteinase-7 in Prostate Cancer Cell Lines. Korean Journal of Urology 2009, 50(1):81-88.
  • Choi HS, Cho S-G, Kim MK, Kim MS, Moon SH, Kim IH, Ko S-G: Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression. Phytotherapy Research 2016, 30(12):2020-2026.
  • Cho JH, Kwon JE, Cho Y, Kim I, Kang SC: Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression. Nutrients 2015, 7(6):4862-4874.
  • Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC: Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways. The Journal of Immunology 1999, 163(7):3963-3968.
  • Caplan LR, Hennerici M: Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Archives of Neurology 1998, 55(11):1475-1482.
  • Cao G, Pei W, Lan J, Stetler RA, Luo Y, Nagayama T, Graham SH, Yin XM, Simon RP, Chen J: Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. The Journal of neuroscience 2001, 21(13):4678-4690.
  • Cacabelos R, Takeda M, Winblad B: The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease. International Journal of Geriatric Psychiatry 1999, 14(1):3-47.
  • Bu e L, Bussi re T, Bu e-Scherrer V, Delacourte A, Hof PR: Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work. Brain Research Reviews 2000, 33(1):95-130.
  • Bowler JV, Hachinski V: Vascular cognitive impairment: a new approach to vascular dementia. Bailliere's clinical neurology 1995, 4(2):357-376.
  • Bose AK, Mocanu MM, Carr RD, Yellon DM: Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovascular drugs and therapy 2005, 19(1):9-11.
  • Birks J, Harvey RJ: Donepezil for dementia due to Alzheimer's disease. The Cochrane database of systematic reviews 2006(1):Cd001190.
  • Beckett EAH, Sanders KM, Ward SM: Inhibitory responses mediated by vagal nerve stimulation are diminished in stomachs of mice with reduced intramuscular interstitial cells of Cajal. Scientific Reports 2017, 7:44759.
  • Baskaya MK, Rao AM, Dogan A, Donaldson D, Dempsey RJ: The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neuroscience letters 1997, 226(1):33-36.
  • Ball MJ: Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta neuropathologica 1977, 37(2):111-118.
  • Au - Llovera G, Au - Roth S, Au - Plesnila N, Au - Veltkamp R, Au - Liesz A: Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery. Journal of Visualized Experiments : JoVE 2014(89):e51729.
  • Anuncibay-Soto B, Perez-Rodriguez D, Santos-Galdiano M, Font-Belmonte E, Ugidos IF, Gonzalez-Rodriguez P, Regueiro-Purrinos M, Fernandez-Lopez A: Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation. Biochemical pharmacology 2018, 151:26-37.
  • Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP: Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal of Visualized Experiments : JoVE 2013(72).
  • Andreasen N, Vanmechelen E, Van de Voorde A, Davidsson P, Hesse C, Tarvonen S, R ih I, Sourander L, Winblad B, J. Blennow K: Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: A community based follow up study. Journal of Neurology, Neurosurgery, and Psychiatry 1998, 64:298-305.
  • Akinyemi RO, Mukaetova-Ladinska EB, Attems J, Ihara M, Kalaria RN: Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia. Current Alzheimer research 2013, 10(6):642-653.