연구동향 분석
박사

Effect of connective tissue growth factor (CTGF) gene editing using Adeno-associated virus (AAV) mediated CRISPR/Cas9 on rabbit glaucoma filtering surgery outcome

이은정 2019년

논문상세정보
인용/피인용
' Effect of connective tissue growth factor (CTGF) gene editing using Adeno-associated virus (AAV) mediated CRISPR/Cas9 on rabbit glaucoma filtering surgery outcome' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Fibrosis
  • Wound healing
  • crispr
  • ctgf
  • glaucomafilteringsurgery
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
292 0

0.0%

' Effect of connective tissue growth factor (CTGF) gene editing using Adeno-associated virus (AAV) mediated CRISPR/Cas9 on rabbit glaucoma filtering surgery outcome' 의 참고문헌

  • Zhong, H., G. Sun, X. Lin, K. Wu and M. Yu (2011). "Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgery." Invest Ophthalmol Vis Sci 52(6): 3136-3142.
  • Zada, M., U. Pattamatta and A. White (2018). "Modulation of Fibroblasts in Conjunctival Wound Healing." Ophthalmology 125(2): 179-192.
  • Yuan, H. P., X. H. Li, B. B. Yang, Z. B. Shao and L. P. Yan (2009). "[Expression of connective tissue growth factor after trabeculectomy in rabbits]." Zhonghua Yan Ke Za Zhi 45(2): 168-174.
  • Yamanaka, O., S. Saika, K. Ikeda, K. Miyazaki, A. Kitano and Y. Ohnishi (2008). "Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro." Jpn J Ophthalmol 52(1): 8-15.
  • Yamanaka, O., A. Kitano-Izutani, K. Tomoyose and P. S. Reinach (2015). "Pathobiology of wound healing after glaucoma filtration surgery." BMC Ophthalmol 15 Suppl 1: 157.
  • Yamamoto, T., J. Varani, H. K. Soong and P. R. Lichter (1990). "Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts." Ophthalmology 97(9): 1204-1210.
  • Yamamoto, K., R. Morishita, N. Tomita, T. Shimozato, H. Nakagami, A. Kikuchi, M. Aoki, J. Higaki, Y. Kaneda and T. Ogihara (2000). "Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease." Circulation 102(11): 1308-1314.
  • Yablonski, M. E., D. J. Cook and J. Gray (1985). "A fluorophotometric study of the effect of argon laser trabeculoplasty on aqueous humor dynamics." Am J Ophthalmol 99(5): 579-582.
  • Xiao, Y. Q., K. Liu, J. F. Shen, G. T. Xu and W. Ye (2009). "SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism." Invest Ophthalmol Vis Sci 50(4): 1698-1706.
  • Wong, T. T., A. L. Mead and P. T. Khaw (2005). "Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery." Invest Ophthalmol Vis Sci 46(6): 2018-2022.
  • Wolner, B., J. M. Liebmann, J. W. Sassani, R. Ritch, M. Speaker and M. Marmor (1991). "Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil." Ophthalmology 98(7): 1053-1060.
  • Weinreb, R. N. and P. T. Khaw (2004). "Primary open-angle glaucoma." Lancet 363(9422): 1711-1720.
  • Wang, J. M., N. Hui, Y. Z. Fan, L. Xiong and N. X. Sun (2011). "Filtering bleb area and intraocular pressure following subconjunctival injection of CTGF antibody after glaucoma filtration surgery in rabbits." Int J Ophthalmol 4(5): 480-483.
  • Wallace, D. M., J. E. Murphy-Ullrich, J. C. Downs and C. J. O'Brien (2014). "The role of matricellular proteins in glaucoma." Matrix Biol 37: 174-182.
  • Tovar-Vidales, T., A. F. Clark and R. J. Wordinger (2011). "Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells." Exp Eye Res 93(4): 442-451.
  • Toris, C. B., M. E. Yablonski, Y. L. Wang and C. B. Camras (1999). "Aqueous humor dynamics in the aging human eye." Am J Ophthalmol 127(4): 407-412.
  • Toris, C. B., G. L. Zhan, Y. L. Wang, J. Zhao, M. A. McLaughlin, C. B. Camras and M. E. Yablonski (2000). "Aqueous humor dynamics in monkeys with laser-induced glaucoma." J Ocul Pharmacol Ther 16(1): 19-27.
  • Toris, C. B. and J. E. Pederson (1985). "Effect of intraocular pressure on uveoscleral outflow following cyclodialysis in the monkey eye." Invest Ophthalmol Vis Sci 26(12): 1745-1749.
  • Thrasher, A. J., H. B. Gaspar, C. Baum, U. Modlich, A. Schambach, F. Candotti, M. Otsu, B. Sorrentino, L. Scobie, E. Cameron, K. Blyth, J. Neil, S. H. Abina, M. Cavazzana-Calvo and A. Fischer (2006). "Gene therapy: X-SCID transgene leukaemogenicity." Nature 443(7109): E5-6; discussion E6-7.
  • Tham, C. C., F. C. Li, D. Y. Leung, Y. Y. Kwong, D. W. Yick, C. C. Chi and D. S. Lam (2006). "Intrableb triamcinolone acetonide injection after bleb-forming filtration surgery (trabeculectomy, phacotrabeculectomy, and trabeculectomy revision by needling): a pilot study." Eye (Lond) 20(12): 1484-1486.
  • Takai, Y., M. Tanito and A. Ohira (2012). "Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract." Invest Ophthalmol Vis Sci 53(1): 241-247.
  • Stein, C. A. (2001). "The experimental use of antisense oligonucleotides: a guide for the perplexed." J Clin Invest 108(5): 641-644.
  • Stamper, R. L., M. G. McMenemy and M. F. Lieberman (1992). "Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil." Am J Ophthalmol 114(5): 544-553.
  • Stahnke, T., M. Lobler, C. Kastner, O. Stachs, A. Wree, K. Sternberg, K. P. Schmitz and R. Guthoff (2012). "Different fibroblast subpopulations of the eye: a therapeutic target to prevent postoperative fibrosis in glaucoma therapy." Exp Eye Res 100: 88-97.
  • Souchier, M., N. Buron, P. O. Lafontaine, A. M. Bron, C. Baudouin and C. Creuzot-Garcher (2006). "Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?" Br J Ophthalmol 90(11): 1366-1369.
  • SooHoo, J. R., L. K. Seibold, A. E. Laing and M. Y. Kahook (2012). "Bleb morphology and histology in a rabbit model of glaucoma filtration surgery using Ozurdex(R) or mitomycin-C." Mol Vis 18: 714-719.
  • Skuta, G. L. and R. K. Parrish, 2nd (1987). "Wound healing in glaucoma filtering surgery." Surv Ophthalmol 32(3): 149-170.
  • Siriwardena, D., P. T. Khaw, A. J. King, M. L. Donaldson, B. M. Overton, C. Migdal and M. F. Cordeiro (2002). "Human antitransforming growth factor beta(2) monoclonal antibody--a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study." Ophthalmology 109(3): 427-431.
  • Shaarawy, T. M., R. A. Hitchings, M. B. Sherwood and J. G. Crowston (2009). Glaucoma, Elsevier Health Sciences.
  • Seibold, L. K., M. B. Sherwood and M. Y. Kahook (2012). "Wound modulation after filtration surgery." Surv Ophthalmol 57(6): 530-550.
  • Seher, A., J. Nickel, T. D. Mueller, S. Kneitz, S. Gebhardt, T. M. ter Vehn, G. Schlunck and W. Sebald (2011). "Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro." Mol Vis 17: 53-62.
  • Seetner, A. and J. D. Morin (1979). "Healing of trabeculectomies in rabbits." Can J Ophthalmol 14(2): 121-125.
  • Seah, S. K., J. A. Prata, Jr., D. S. Minckler, G. Baerveldt, P. P. Lee and D. K. Heuer (1995). "Hypotony following trabeculectomy." J Glaucoma 4(2): 73-79.
  • Schulzer, M., S. M. Drance and G. R. Douglas (1991). "A comparison of treated and untreated glaucoma suspects." Ophthalmology 98(3): 301-307.
  • Sapitro, J., J. J. Dunmire, S. E. Scott, V. Sutariya, W. J. Geldenhuys, M. Hewit, B. Y. Yue and H. Nakamura (2010). "Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptorlike kinase 5 inhibitor." Mol Vis 16: 1880-1892.
  • Salmon, S. E. and A. C. Scatorelli (1987). Cancer chemotherapy. In: Katzung BG, ed. Basic and clinical pharmacology. . California, Lange Medical Publications.
  • Saika, S., O. Yamanaka, Y. Baba, Y. Kawashima, K. Shirai, T. Miyamoto, Y. Okada, Y. Ohnishi and A. Ooshima (2001). "Accumulation of latent transforming growth factor-beta binding protein-1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts." Graefes Arch Clin Exp Ophthalmol 239(3): 234-241.
  • Saika, S., A. Ooshima, O. Yamanaka, M. Kimura, Y. Okada, O. Tonoe, S. Tanaka and Y. Ohnishi (1997). "In vitro effects of doxorubicin and mitomycin C on human Tenon's capsule fibroblasts." Ophthalmic Res 29(2): 91-102.
  • Ross, R. and G. Odland (1968). "Human wound repair. II. Inflammatory cells, epithelial-mesenchymal interrelations, and fibrogenesis." J Cell Biol 39(1): 152-168.
  • Robin, A. L., R. Ramakrishnan, R. Krishnadas, S. D. Smith, J. D. Katz, S. Selvaraj, G. L. Skuta and R. Bhatnagar (1997). "A long-term dose-response study of mitomycin in glaucoma filtration surgery." Arch Ophthalmol 115(8): 969-974.
  • Resnikoff, S., D. Pascolini, D. Etya'ale, I. Kocur, R. Pararajasegaram, G. P. Pokharel and S. P. Mariotti (2004). "Global data on visual impairment in the year 2002." Bull World Health Organ 82(11): 844-851.
  • Reddick, R., J. C. Merritt, G. Ross, A. Avery and R. L. Peiffer (1985). "Myofibroblasts in filtration operations." Ann Ophthalmol 17(3): 200-203.
  • Ran, F. A., L. Cong, W. X. Yan, D. A. Scott, J. S. Gootenberg, A. J. Kriz, B. Zetsche, O. Shalem, X. Wu, K. S. Makarova, E. V. Koonin, P. A. Sharp and F. Zhang (2015). "In vivo genome editing using Staphylococcus aureus Cas9." Nature 520(7546): 186-191.
  • Quigley, H. A. and A. T. Broman (2006). "The number of people with glaucoma worldwide in 2010 and 2020." Br J Ophthalmol 90(3): 262-267.
  • Prata, J. A., Jr., S. K. Seah, D. S. Minckler, G. Baerveldt, P. P. Lee and D. K. Heuer (1995). "Postoperative complications and short-term outcome after 5-Fluorouracil or mitomycin-C trabeculectomy." J Glaucoma 4(1): 25-31.
  • Prata, J. A., Jr., R. A. Neves, D. S. Minckler, A. Mermoud and D. K. Heuer (1994). "Trabeculectomy with mitomycin C in glaucoma associated with uveitis." Ophthalmic Surg 25(9): 616-620.
  • Perkins, T. W., B. Faha, M. Ni, J. A. Kiland, G. L. Poulsen, D. Antelman, I. Atencio, J. Shinoda, D. Sinha, L. Brumback, D. Maneval, P. L. Kaufman and R. W. Nickells (2002). "Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery." Arch Ophthalmol 120(7): 941-949.
  • Nickells, R. W., G. R. Howell, I. Soto and S. W. John (2012). "Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy." Annu Rev Neurosci 35: 153-179.
  • Na, J. H., K. R. Sung, J. A. Shin and J. I. Moon (2015). "Antifibrotic effects of pirfenidone on Tenon's fibroblasts in glaucomatous eyes: comparison with mitomycin C and 5-fluorouracil." Graefes Arch Clin Exp Ophthalmol 253(9): 1537-1545.
  • Moses, R. A., W. J. Grodzki, Jr., E. L. Etheridge and C. D. Wilson (1981). "Schlemm's canal: the effect of intraocular pressure." Invest Ophthalmol Vis Sci 20(1): 61-68.
  • Miller, M. H., I. Grierson, W. I. Unger and R. A. Hitchings (1989). "Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit." Ophthalmic Surg 20(5): 350-357.
  • Mietz, H., P. Chevez-Barrios and M. W. Lieberman (1998). "A mouse model to study the wound healing response following filtration surgery." Graefes Arch Clin Exp Ophthalmol 236(6): 467-475.
  • Mietz, H., K. Addicks, W. Bloch and G. K. Krieglstein (1996). "Long-term intraocular toxic effects of topical mitomycin C in rabbits." J Glaucoma 5(5): 325-333.
  • Meyer-Ter-Vehn, T., F. Grehn and G. Schlunck (2008). "Localization of TGF-beta type II receptor and ED-A fibronectin in normal conjunctiva and failed filtering blebs." Mol Vis 14: 136-141.
  • McCarty, D. M., S. M. Young, Jr. and R. J. Samulski (2004). "Integration of adeno-associated virus (AAV) and recombinant AAV vectors." Annu Rev Genet 38: 819-845.
  • Makarova, K. S., Y. I. Wolf and E. V. Koonin (2013). "Comparative genomics of defense systems in archaea and bacteria." Nucleic Acids Res 41(8): 4360-4377.
  • Makarova, K. S., D. H. Haft, R. Barrangou, S. J. Brouns, E. Charpentier, P. Horvath, S. Moineau, F. J. Mojica, Y. I. Wolf, A. F. Yakunin, J. van der Oost and E. V. Koonin (2011). "Evolution and classification of the CRISPR-Cas systems." Nat Rev Microbiol 9(6): 467-477.
  • Makarova, K. S. and E. V. Koonin (2015). "Annotation and Classification of CRISPR-Cas Systems." Methods Mol Biol 1311: 47-75.
  • Ma, Y., L. Zhang and X. Huang (2014). "Genome modification by CRISPR/Cas9." FEBS J 281(23): 5186-5193.
  • Lutjen-Drecoll, E., T. Shimizu, M. Rohrbach and J. W. Rohen (1986). "Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes." Exp Eye Res 42(5): 443-455.
  • Lockwood, A., S. Brocchini and P. T. Khaw (2013). "New developments in the pharmacological modulation of wound healing after glaucoma filtration surgery." Curr Opin Pharmacol 13(1): 65-71.
  • Liu, X., L. Du and N. Li (2016). "The Effects of Bevacizumab in Augmenting Trabeculectomy for Glaucoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Medicine (Baltimore) 95(15): e3223.
  • Lim, D. H., T. E. Kim and C. Kee (2016). "Evaluation of Adenovirus-Mediated Down-Regulation of Connective Tissue Growth Factor on Postoperative Wound Healing After Experimental Glaucoma Surgery." Curr Eye Res 41(7): 951-956.
  • Li, N., J. Cui, X. Duan, H. Chen and F. Fan (2012). "Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts." Invest Ophthalmol Vis Sci 53(3): 1670-1678.
  • Lee, D. A., T. C. Lee, A. E. Cortes and S. Kitada (1990). "Effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation." Invest Ophthalmol Vis Sci 31(10): 2136-2144.
  • Ledford, H. (2015). "CRISPR, the disruptor." Nature 522(7554): 20-24.
  • Leask, A. and D. J. Abraham (2003). "The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology." Biochem Cell Biol 81(6): 355-363.
  • Larsson, L. I., E. S. Rettig and R. F. Brubaker (1995). "Aqueous flow in open-angle glaucoma." Arch Ophthalmol 113(3): 283-286.
  • Lama, P. J. and R. D. Fechtner (2003). "Antifibrotics and wound healing in glaucoma surgery." Surv Ophthalmol 48(3): 314-346.
  • Kupin, T. H., M. S. Juzych, D. H. Shin, A. K. Khatana and M. M. Olivier (1995). "Adjunctive mitomycin C in primary trabeculectomy in phakic eyes." Am J Ophthalmol 119(1): 30-39.
  • Knorr, M., M. Volker, P. O. Denk, K. Wunderlich and H. J. Thiel (1997). "Proliferative response of cultured human tenon's capsule fibroblasts to platelet-derived growth factor isoforms." Graefes Arch Clin Exp Ophthalmol 235(10): 667-671.
  • Khaw, P. T., N. L. Occleston, G. Schultz, I. Grierson, M. B. Sherwood and G. Larkin (1994). "Activation and suppression of fibroblast function." Eye (Lond) 8 ( Pt 2): 188-195.
  • Khaw, P. T., J. W. Doyle, M. B. Sherwood, M. F. Smith and S. McGorray (1993). "Effects of intraoperative 5- fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit." Ophthalmology 100(3): 367-372.
  • Kent, A. R., H. B. Dubiner, R. Whitaker, T. K. Mundorf, J. A. Stewart, E. A. Cate and W. C. Stewart (1998). "The efficacy and safety of diclofenac 0.1% versus prednisolone acetate 1% following trabeculectomy with adjunctive mitomycin-C." Ophthalmic Surg Lasers 29(7): 562-569.
  • Kee, C., S. Sohn and J. M. Hwang (2001). "Stromelysin gene transfer into cultured human trabecular cells and rat trabecular meshwork in vivo." Invest Ophthalmol Vis Sci 42(12): 2856-2860.
  • Kay, E. P., H. K. Lee, K. S. Park and S. C. Lee (1998). "Indirect mitogenic effect of transforming growth factorbeta on cell proliferation of subconjunctival fibroblasts." Invest Ophthalmol Vis Sci 39(3): 481-486.
  • Katz, G. J., E. J. Higginbotham, P. R. Lichter, G. L. Skuta, D. C. Musch, T. J. Bergstrom and A. T. Johnson (1995). "Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up." Ophthalmology 102(9): 1263-1269.
  • Kass, M. A., M. O. Gordon, M. R. Hoff, J. M. Parkinson, A. E. Kolker, W. M. Hart, Jr. and B. Becker (1989). "Topical timolol administration reduces the incidence of glaucomatous damage in ocular hypertensive individuals. A randomized, double-masked, long-term clinical trial." Arch Ophthalmol 107(11): 1590-1598.
  • Kass, M. A., D. K. Heuer, E. J. Higginbotham, C. A. Johnson, J. L. Keltner, J. P. Miller, R. K. Parrish, 2nd, M. R. Wilson and M. O. Gordon (2002). "The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma." Arch Ophthalmol 120(6): 701-713; discussion 829-730.
  • Kahook, M. Y. and R. Noecker (2008). "Quantitative analysis of conjunctival goblet cells after chronic application of topical drops." Adv Ther 25(8): 743-751.
  • Joseph, J. P., M. H. Miller and R. A. Hitchings (1988). "Wound healing as a barrier to successful filtration surgery." Eye (Lond) 2 Suppl: S113-123.
  • Jones, E., J. Clarke and P. T. Khaw (2005). "Recent advances in trabeculectomy technique." Curr Opin Ophthalmol 16(2): 107-113.
  • Johnson, M. (2006). "'What controls aqueous humour outflow resistance?'." Exp Eye Res 82(4): 545-557.
  • Jinek, M., K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna and E. Charpentier (2012). "A programmable dual- RNA-guided DNA endonuclease in adaptive bacterial immunity." Science 337(6096): 816-821.
  • Jinek, M. and J. A. Doudna (2009). "A three-dimensional view of the molecular machinery of RNA interference." Nature 457(7228): 405-412.
  • Jiang, W. and L. A. Marraffini (2015). "CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems." Annu Rev Microbiol 69: 209-228.
  • Iwase, A., Y. Suzuki, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa and J. G. S. Tajimi Study Group (2004). "The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study." Ophthalmology 111(9): 1641-1648.
  • Ihn, H. (2002). "Pathogenesis of fibrosis: role of TGF-beta and CTGF." Curr Opin Rheumatol 14(6): 681-685.
  • Horbelt, D., A. Denkis and P. Knaus (2012). "A portrait of Transforming Growth Factor beta superfamily signalling: Background matters." Int J Biochem Cell Biol 44(3): 469-474.
  • Hollo, G. (2017). "Wound Healing and Glaucoma Surgery: Modulating the Scarring Process with Conventional Antimetabolites and New Molecules." Dev Ophthalmol 59: 80-89.
  • Hickey-Dwyer, M. and P. K. Wishart (1993). "Serious corneal complication of 5-fluorouracil." Br J Ophthalmol 77(4): 250-251.
  • Heijl, A., M. C. Leske, B. Bengtsson, L. Hyman, B. Bengtsson, M. Hussein and G. Early Manifest Glaucoma Trial (2002). "Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial." Arch Ophthalmol 120(10): 1268-1279.
  • Gwynn, D. R., W. C. Stewart, R. A. Pitts, T. A. McMillan and H. L. Hennis (1993). "Conjunctival structure and cell counts and the results of filtering surgery." Am J Ophthalmol 116(4): 464-468.
  • Guzman-Aranguez, A., P. Loma and J. Pintor (2013). "Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy." Br J Pharmacol 170(4): 730-747.
  • Group, C. A. T. T. S., P. Khaw, F. Grehn, G. Hollo, B. Overton, R. Wilson, R. Vogel and Z. Smith (2007). "A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy." Ophthalmology 114(10): 1822-1830.
  • Gross, R. L. (2000). "Collagen type I and III synthesis by Tenon's capsule fibroblasts in culture: individual patient characteristics and response to mitomycin C, 5-fluorouracil, and ascorbic acid. Trans Am ophthalmol soc 1999;97: 513-543." Am J Ophthalmol 129(6): 833-834.
  • Grimm, D., J. S. Lee, L. Wang, T. Desai, B. Akache, T. A. Storm and M. A. Kay (2008). "In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses." J Virol 82(12): 5887-5911.
  • Grieshaber, M. C., A. Pienaar, J. Olivier and R. Stegmann (2010). "Clinical evaluation of the aqueous outflow system in primary open-angle glaucoma for canaloplasty." Invest Ophthalmol Vis Sci 51(3): 1498-1504.
  • Grierson, I., A. Swalem, H. Davies, P. Hogg, M. Batterbury and P. Watson (1997). "Pathological dilemmas in the outflow system in primary open-angle glaucoma." Acta Ophthalmol Scand Suppl(220): 7-12; discussion 13-14.
  • Gressner, O. A. and A. M. Gressner (2008). "Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases." Liver Int 28(8): 1065-1079.
  • Grant, W. M. (1958). "Further studies on facility of flow through the trabecular meshwork." AMA Arch Ophthalmol 60(4 Part 1): 523-533.
  • Grant, W. M. (1951). "Clinical measurements of aqueous outflow." AMA Arch Ophthalmol 46(2): 113-131.
  • Gordon, M. O., J. A. Beiser, J. D. Brandt, D. K. Heuer, E. J. Higginbotham, C. A. Johnson, J. L. Keltner, J. P. Miller, R. K. Parrish, 2nd, M. R. Wilson and M. A. Kass (2002). "The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma." Arch Ophthalmol 120(6): 714-720; discussion 829-730.
  • Gedde, S. J., L. W. Herndon, J. D. Brandt, D. L. Budenz, W. J. Feuer, J. C. Schiffman and G. Tube Versus Trabeculectomy Study (2012). "Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up." Am J Ophthalmol 153(5): 804-814 e801.
  • Gabelt, B. T. and P. L. Kaufman (2005). "Changes in aqueous humor dynamics with age and glaucoma." Prog Retin Eye Res 24(5): 612-637.
  • Gabbiani, G. (2003). "The myofibroblast in wound healing and fibrocontractive diseases." J Pathol 200(4): 500- 503.
  • Friedman, D. S., R. C. Wolfs, B. J. O'Colmain, B. E. Klein, H. R. Taylor, S. West, M. C. Leske, P. Mitchell, N. Congdon, J. Kempen and G. Eye Diseases Prevalence Research (2004). "Prevalence of open-angle glaucoma among adults in the United States." Arch Ophthalmol 122(4): 532-538.
  • Frazier, K., S. Williams, D. Kothapalli, H. Klapper and G. R. Grotendorst (1996). "Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor." J Invest Dermatol 107(3): 404-411.
  • Foster, P. J., R. Buhrmann, H. A. Quigley and G. J. Johnson (2002). "The definition and classification of glaucoma in prevalence surveys." Br J Ophthalmol 86(2): 238-242.
  • Foster, P. J., D. Machin, T. Y. Wong, T. P. Ng, J. F. Kirwan, G. J. Johnson, P. T. Khaw and S. K. Seah (2003). "Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study." Invest Ophthalmol Vis Sci 44(9): 3885-3891.
  • Esson, D. W., A. Neelakantan, S. A. Iyer, T. D. Blalock, L. Balasubramanian, G. R. Grotendorst, G. S. Schultz and M. B. Sherwood (2004). "Expression of connective tissue growth factor after glaucoma filtration surgery in a rabbit model." Invest Ophthalmol Vis Sci 45(2): 485-491.
  • Ekinci, M., H. H. Cagatay, E. Ceylan, S. Keles, Y. Koban, G. Gokce, U. Huseyinoglu, E. Ozcan and M. E. Oba (2014). "Reduction of conjunctival fibrosis after trabeculectomy using topical alpha-lipoic acid in rabbit eyes." J Glaucoma 23(6): 372-379.
  • Duncan, M. R., K. S. Frazier, S. Abramson, S. Williams, H. Klapper, X. Huang and G. R. Grotendorst (1999). "Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: downregulation by cAMP." FASEB J 13(13): 1774-1786.
  • Doyle, J. W., M. B. Sherwood, P. T. Khaw, S. McGrory and M. F. Smith (1993). "Intraoperative 5-fluorouracil for filtration surgery in the rabbit." Invest Ophthalmol Vis Sci 34(12): 3313-3319.
  • Deyle, D. R. and D. W. Russell (2009). "Adeno-associated virus vector integration." Curr Opin Mol Ther 11(4): 442-447.
  • Desjardins, D. C., R. K. Parrish, 2nd, R. Folberg, J. Nevarez, D. K. Heuer and M. G. Gressel (1986). "Wound healing after filtering surgery in owl monkeys." Arch Ophthalmol 104(12): 1835-1839.
  • Denk, P. O., J. Hoppe, V. Hoppe and M. Knorr (2003). "Effect of growth factors on the activation of human Tenon's capsule fibroblasts." Curr Eye Res 27(1): 35-44.
  • Day, A. C., G. Baio, G. Gazzard, C. Bunce, A. Azuara-Blanco, B. Munoz, D. S. Friedman and P. J. Foster (2012). "The prevalence of primary angle closure glaucoma in European derived populations: a systematic review." Br J Ophthalmol 96(9): 1162-1167.
  • Daniels, J. T., G. S. Schultz, T. D. Blalock, Q. Garrett, G. R. Grotendorst, N. M. Dean and P. T. Khaw (2003). "Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring." Am J Pathol 163(5): 2043-2052.
  • Cunliffe, I. A., R. C. Rees and I. G. Rennie (1996). "The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon's capsule fibroblasts in tissue culture." Acta Ophthalmol Scand 74(1): 31-35.
  • Crowston, J. G., A. N. Akbar, P. H. Constable, N. L. Occleston, J. T. Daniels and P. T. Khaw (1998). "Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts." Invest Ophthalmol Vis Sci 39(2): 449-454.
  • Costa, V. P., G. L. Spaeth, R. A. Eiferman and S. Orengo-Nania (1993). "Wound healing modulation in glaucoma filtration surgery." Ophthalmic Surg 24(3): 152-170.
  • Cordeiro, M. F., S. S. Bhattacharya, G. S. Schultz and P. T. Khaw (2000). "TGF-beta1, -beta2, and -beta3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration." Invest Ophthalmol Vis Sci 41(3): 756-763.
  • Cordeiro, M. F., P. H. Constable, R. A. Alexander, S. S. Bhattacharya and P. T. Khaw (1997). "Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit." Invest Ophthalmol Vis Sci 38(8): 1639-1646.
  • Cordeiro, M. F., J. A. Gay and P. T. Khaw (1999). "Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent." Invest Ophthalmol Vis Sci 40(10): 2225-2234.
  • Cordeiro, M. F., A. Mead, R. R. Ali, R. A. Alexander, S. Murray, C. Chen, C. York-Defalco, N. M. Dean, G. S. Schultz and P. T. Khaw (2003). "Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome." Gene Ther 10(1): 59-71.
  • Colella, P., G. Ronzitti and F. Mingozzi (2018). "Emerging Issues in AAV-Mediated In Vivo Gene Therapy." Mol Ther Methods Clin Dev 8: 87-104.
  • Cheng, J. W., J. P. Cai, Y. Li and R. L. Wei (2011). "Intraoperative mitomycin C for nonpenetrating glaucoma surgery: a systematic review and meta-analysis." J Glaucoma 20(5): 322-326.
  • Chen, C. W., H. T. Huang, J. S. Bair and C. C. Lee (1990). "Trabeculectomy with simultaneous topical application of mitomycin-C in refractory glaucoma." J Ocul Pharmacol 6(3): 175-182.
  • Cairns, J. E. (1968). "Trabeculectomy. Preliminary report of a new method." Am J Ophthalmol 66(4): 673-679.
  • Bresson-Dumont, H., A. Lehoux, C. Baroux, J. Foucher and P. Y. Santiago (2008). "[Clinical factors favoring excessive subconjunctival fibroblastic proliferation after glaucoma surgery]." J Fr Ophtalmol 31(6 Pt 2): 2S74- 77.
  • Boettcher, M. and M. T. McManus (2015). "Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR." Mol Cell 58(4): 575-585.
  • Birchenough, G. M., M. E. Johansson, J. K. Gustafsson, J. H. Bergstrom and G. C. Hansson (2015). "New developments in goblet cell mucus secretion and function." Mucosal Immunol 8(4): 712-719.
  • Bill, A. and K. Hellsing (1965). "Production and drainage of aqueous humor in the cynomolgus monkey (Macaca irus)." Invest Ophthalmol 4(5): 920-926.
  • Bill, A. (1966). "Conventional and uveo-scleral drainage of aqueous humour in the cynomolgus monkey (Macaca irus) at normal and high intraocular pressures." Exp Eye Res 5(1): 45-54.
  • Bill, A. (1965). "The aqueous humor drainage mechanism in the cynomolgus monkey (Macaca irus) with evidence for unconventional routes." Invest Ophthalmol 4(5): 911-919.
  • Bernauer, W., P. Wright, J. K. Dart, J. N. Leonard and S. Lightman (1993). "The conjunctiva in acute and chronic mucous membrane pemphigoid. An immunohistochemical analysis." Ophthalmology 100(3): 339-346.
  • Bengtsson, B., M. C. Leske, L. Hyman, A. Heijl and G. Early Manifest Glaucoma Trial (2007). "Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial." Ophthalmology 114(2): 205- 209.
  • Benedikt, O. (1976). "[Demonstration of aqueous outflow patterns of normal and glaucomatous human eyes through the injection of fluorescein solution in the anterior chamber (author's transl)]." Albrecht Von Graefes Arch Klin Exp Ophthalmol 199(1): 45-67.
  • Becker, B. (1961). "Tonography in the diagnosis of simple (open angle) glaucoma." Trans Am Acad Ophthalmol Otolaryngol 65: 156-162.
  • Barrangou, R. and P. Horvath (2012). "CRISPR: new horizons in phage resistance and strain identification." Annu Rev Food Sci Technol 3: 143-162.
  • Bardak, Y., M. H. Cuypers, M. A. Tilanus and C. A. Eggink (1997). "Ocular hypotony after laser suture lysis following trabeculectomy with mitomycin C." Int Ophthalmol 21(6): 325-330.
  • Babizhayev, M. A. and M. W. Brodskaya (1989). "Fibronectin detection in drainage outflow system of human eyes in ageing and progression of open-angle glaucoma." Mech Ageing Dev 47(2): 145-157.
  • Amar, N., A. Labbe, P. Hamard, B. Dupas and C. Baudouin (2008). "Filtering blebs and aqueous pathway an immunocytological and in vivo confocal microscopy study." Ophthalmology 115(7): 1154-1161 e1154.
  • Alvarado, J., C. Murphy and R. Juster (1984). "Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals." Ophthalmology 91(6): 564-579.
  • Addicks, E. M., H. A. Quigley, W. R. Green and A. L. Robin (1983). "Histologic characteristics of filtering blebs in glaucomatous eyes." Arch Ophthalmol 101(5): 795-798.
  • . "Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group." Am J Ophthalmol 121(4): 349-366.