연구동향 분석
박사

Studies on circadian rhythm and mood disorder in Parkinson’s disease mouse model = 파킨슨병 생쥐 모델에서 일주기 리듬과 정서장애에 대한 연구

김정아 2018년

논문상세정보
    • 저자 김정아
    • 형태사항 26 cm
    • 일반주기 지도교수: 이건수
    • 학위논문사항 서울대학교 대학원, 학위논문(박사)-, 생명과학부, 2018. 8
    • DDC 570
    • 발행지 서울
    • 언어 eng
    • 출판년 2018
    • 발행사항 서울대학교 대학원
    유사주제 논문( 1,530)
인용/피인용
' Studies on circadian rhythm and mood disorder in Parkinson’s disease mouse model = 파킨슨병 생쥐 모델에서 일주기 리듬과 정서장애에 대한 연구' 의 주제별 논문영향력
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  • 생활과학
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' Studies on circadian rhythm and mood disorder in Parkinson’s disease mouse model = 파킨슨병 생쥐 모델에서 일주기 리듬과 정서장애에 대한 연구' 의 참고문헌

  • Zheng, B., Larkin, D.W., Albrecht, U., Sun, Z.S., Sage, M., Eichele, G., Lee, C.C., and Bradley, A. (1999) The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature. 400, 169-173.
  • Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z.S., Eichele, G., and Bradley, A. (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell. 105, 683-694.
  • Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L.-W., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., and Liddle, C. (2016) Circadian amplitude regulation via FBXW7-targeted REV-ERBα degradation. Cell. 165, 1644-1657.
  • Zhang, R., Lahens, N.F., Ballance, H.I., Hughes, M.E., and Hogenesch, J.B. (2014) A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A. 111, 16219-16224.
  • Yoo, S.-H., Yamazaki, S., Lowrey, P.L., Shimomura, K., Ko, C.H., Buhr, E.D., Siepka, S.M., Hong, H.-K., Oh, W.J., and Yoo, O.J. (2004) PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A. 101, 5339-5346.
  • Yin, L., and Lazar, M.A. (2005) The orphan nuclear receptor Rev-erbα recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol. 19, 1452-1459.
  • Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-i., Ueda, M., Block, G.D., Sakaki, Y., Menaker, M., and Tei, H. (2000) Resetting central and peripheral circadian oscillators in transgenic rats. Science. 288, 682-685.
  • Wulff, K., Gatti, S., Wettstein, J.G., and Foster, R.G. (2010) Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci. 11, 589-599.
  • Wu, D.-C., Teismann, P., Tieu, K., Vila, M., Jackson-Lewis, V., Ischiropoulos, H., and Przedborski, S. (2003) NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A. 100, 6145-6150.
  • Woldt, E., Sebti, Y., Solt, L.A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M.K., Paquet, C., Delhaye, S., and Shin, Y. (2013) Rev-erb-[alpha] modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 19, 1039-1046.
  • Wise, R.A. (2009) Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction. Trends Neurosci. 32, 517-524.
  • Wirz-Justice, A. (2006) Biological rhythm disturbances in mood disorders. Int Clin Psychopharmacol. 21, S11-S15.
  • Wilhelmsson, U., Bushong, E.A., Price, D.L., Smarr, B.L., Phung, V., Terada, M., Ellisman, M.H., and Pekny, M. (2006) Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc Natl Acad Sci U S A. 103, 17513-17518.
  • Weintraub, D., Morales, K.H., Moberg, P.J., Bilker, W.B., Balderston, C., Duda, J.E., Katz, I.R., and Stern, M.B. (2005) Antidepressant studies in Parkinson's disease: a review and meta‐analysis. Mov Disord. 20, 1161- 1169.
  • Weber, M., Lauterburg, T., Tobler, I., and Burgunder, J.-M. (2004) Circadian patterns of neurotransmitter related gene expression in motor regions of the rat brain. Neurosci Lett. 358, 17-20.
  • Webb, I.C., Baltazar, R.M., Wang, X., Pitchers, K.K., Coolen, L.M., and Lehman, M.N. (2009) Diurnal variations in natural and drug reward, mesolimbic tyrosine hydroxylase, and clock gene expression in the male rat. J Biol Rhythms. 24, 465-476.
  • Watabe-Uchida, M., Zhu, L., Ogawa, S.K., Vamanrao, A., and Uchida, N. (2012) Whole-brain mapping of direct inputs to midbrain dopamine neurons. Neuron. 74, 858-873.
  • Warner, T.T., and Schapira, A.H. (2003) Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol. 53, S16-S23.
  • Walsh, S., Finn, D., and Dowd, E. (2011) Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamineinduced axonal and terminal lesion models of Parkinson's disease in the rat. Neuroscience. 175, 251-261.
  • Videnovic, A., Lazar, A.S., Barker, R.A., and Overeem, S. (2014) 'The clocks that time us'[mdash] circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 10, 683-693.
  • Teismann, P., Tieu, K., Choi, D.-K., Wu, D.-C., Naini, A., Hunot, S., Vila, M., Jackson-Lewis, V., and Przedborski, S. (2003) Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A. 100, 5473-5478.
  • Taylor, T.N., Caudle, W.M., Shepherd, K.R., Noorian, A., Jackson, C.R., Iuvone, P.M., Weinshenker, D., Greene, J.G., and Miller, G.W. (2009) Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. J Neurosci. 29, 8103-8113.
  • Tansey, M.G., and Goldberg, M.S. (2010) Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis. 37, 510-518.
  • Takahashi, J.S. (2017) Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 18, 164-179.
  • Tadaiesky, M., Dombrowski, P., Figueiredo, C., Cargnin-Ferreira, E., Da Cunha, C., and Takahashi, R. (2008) Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience. 156, 830-840.
  • Suzuki, K., Miyamoto, T., Miyamoto, M., Kaji, Y., Takekawa, H., and Hirata, K. (2007) Circadian variation of core body temperature in Parkinson disease patients with depression: a potential biological marker for depression in Parkinson disease. Neuropsychobiology. 56, 172-179.
  • Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F.C., Wong, W.H., and Weitz, C.J. (2002) Extensive and divergent circadian gene expression in liver and heart. Nature. 417, 78-83.
  • Sołtys, Z., Ziaja, M., Pawliński, R., Setkowicz, Z., and Janeczko, K. (2001) Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods. J Neurosci Res. 63, 90- 97.
  • Soria, V., Mart nez-Amor s, ., Escaram s, G., Valero, J., P rez-Egea, R., Garc a, C., Guti rrez-Zotes, A., Puigdemont, D., Bay s, M., and Crespo, J.M. (2010) Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology. 35, 1279-1289.
  • Shearman, L.P., Sriram, S., Weaver, D.R., Maywood, E.S., Chaves, I., Zheng, B., Kume, K., Lee, C.C., Hastings, M.H., and Reppert, S.M. (2000) Interacting molecular loops in the mammalian circadian clock. Science. 288, 1013-1019.
  • Sengupta, S., Yang, G., O’Donnell, J.C., Hinson, M.D., McCormack, S.E., Falk, M.J., La, P., Robinson, M.B., Williams, M.L., and Yohannes, M.T. (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med. 93, 177-189.
  • Sauer, H., and Oertel, W. (1994) Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6- hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience. 59, 401-415.
  • Santiago, R.M., Barbiero, J., Gradowski, R.W., Bochen, S., Lima, M.M., Da Cunha, C., Andreatini, R., and Vital, M.A. (2014) Induction of depressivelike behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin. Behav Brain Res. 259, 70-77.
  • Roybal, K., Theobold, D., Graham, A., DiNieri, J.A., Russo, S.J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., and Birnbaum, S. (2007) Manialike behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 104, 6406-6411.
  • Richard, I.H., Schiffer, R.B., and Kurlan, R. (1996) Anxiety and Parkinson's disease. J Neuropsychiatry Clin Neurosci. 8, 383-392.
  • Remy, P., Doder, M., Lees, A., Turjanski, N., and Brooks, D. (2005) Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 128, 1314-1322.
  • Przedbroski, S., Leviver, M., Jiang, H., Ferreira, M., Jackson-Lewis, V., Donaldson, D., and Togasaki, D. (1995) Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6- hydroxydopamine. Neuroscience. 67, 631-647.
  • Preitner, N., Damiola, F., Zakany, J., Duboule, D., Albrecht, U., and Schibler, U. (2002) The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110, 251-260.
  • Panda, S., Antoch, M.P., Miller, B.H., Su, A.I., Schook, A.B., Straume, M., Schultz, P.G., Kay, S.A., Takahashi, J.S., and Hogenesch, J.B. (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109, 307-320.
  • Musiek, E.S., Lim, M.M., Yang, G., Bauer, A.Q., Qi, L., Lee, Y., Roh, J.H., OrtizGonzalez, X., Dearborn, J.T., Culver, J.P., et al. (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 123, 5389-5400.
  • Musiek, E.S. (2015) Circadian clock disruption in neurodegenerative diseases: cause and effect? Front Pharmacol. 6, 29.
  • Meiser, J., Weindl, D., and Hiller, K. (2013) Complexity of dopamine metabolism. Cell Commun Signal. 11, 34.
  • McDearmon, E.L., Patel, K.N., Ko, C.H., Walisser, J.A., Schook, A.C., Chong, J.L., Wilsbacher, L.D., Song, E.J., Hong, H.-K., and Bradfield, C.A. (2006) Dissecting the functions of the mammalian clock protein BMAL1 by tissuespecific rescue in mice. Science. 314, 1304-1308.
  • McClung, C.A., Sidiropoulou, K., Vitaterna, M., Takahashi, J.S., White, F.J., Cooper, D.C., and Nestler, E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A. 102, 9377-9381.
  • McCarthy, M.J., and Welsh, D.K. (2012) Cellular circadian clocks in mood disorders. J Biol Rhythms. 27, 339-352.
  • Matsumoto, M., and Hikosaka, O. (2009) Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature. 459, 837-841.
  • Massano, J., and Bhatia, K.P. (2012) Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med. 2, a008870.
  • Marinova‐Mutafchieva, L., Sadeghian, M., Broom, L., Davis, J.B., Medhurst, A.D., and Dexter, D.T. (2009) Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6‐hydroxydopamine model of Parkinson’s disease. J Neurochem. 110, 966- 975.
  • Mansour, H., Wood, J., Logue, T., Chowdari, K., Dayal, M., Kupfer, D., Monk, T., Devlin, B., and Nimgaonkar, V. (2006). Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav. 5, 150-157.
  • Mang, G.M., La Spada, F., Emmenegger, Y., Chappuis, S., Ripperger, J.A., Albrecht, U., and Franken, P. (2016) Altered Sleep Homeostasis in Rev-erb α Knockout Mice. Sleep. 39, 589-601.
  • Luo, A.H., and Aston‐Jones, G. (2009) Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathway. Eur J Neurosci. 29, 748-760.
  • Lieberman, A. (2006) Depression in Parkinson's disease–a review. Acta Neurol Scand. 113, 1-8.
  • Li, J.Z., Bunney, B.G., Meng, F., Hagenauer, M.H., Walsh, D.M., Vawter, M.P., Evans, S.J., Choudary, P.V., Cartagena, P., and Barchas, J.D. (2013) Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A. 110, 9950-9955.
  • Lerner, T.N., Shilyansky, C., Davidson, T.J., Evans, K.E., Beier, K.T., Zalocusky, K.A., Crow, A.K., Malenka, R.C., Luo, L., and Tomer, R. (2015) Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits. Cell. 162, 635-647.
  • Leentjens, A.F., Scholtissen, B., Vreeling, F.W., and Verhey, F.R. (2006) The serotonergic hypothesis for depression in Parkinson's disease: an experimental approach. Neuropsychopharmacology. 31, 1009-1015.
  • Lauretti, E., Di Meco, A., Merali, S., and Pratico, D. (2017) Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson's disease. Mol Psychiatry. 22, 280-286.
  • Langston, J.W., and Ballard Jr, P.A. (1983) Parkinson's disease in a chemist working with l-methyl-4-phenyl-l, 2, 5, 6-tetrahydropyridine. N Engl J Med. 309, 310.
  • Lam, M.T., Cho, H., Lesch, H.P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M.U., Kim, A.S., Kosaka, M., et al. (2013) Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 498, 511-515.
  • Kume, K., Zylka, M.J., Sriram, S., Shearman, L.P., Weaver, D.R., Jin, X., Maywood, E.S., Hastings, M.H., and Reppert, S.M. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98, 193-205.
  • Kumar, R., Agarwal, A.K., and Seth, P.K. (1995) Free radical‐generated neurotoxicity of 6‐hydroxydopamine. J Neurochem. 64, 1703-1707.
  • Kripke, D.F., Nievergelt, C.M., Joo, E., Shekhtman, T., and Kelsoe, J.R. (2009) Circadian polymorphisms associated with affective disorders. J Circadian Rhythms. 7, 2.
  • Kondratova, A.A., and Kondratov, R.V. (2012) Circadian clock and pathology of the ageing brain. Nat Rev Neurosci. 13, 325-335.
  • Klein, C., and Westenberger, A. (2012) Genetics of Parkinson’s disease. Cold Spring Harb Perspect Med. 2, a008888.
  • King, D.P., Zhao, Y., Sangoram, A.M., Wilsbacher, L.D., Tanaka, M., Antoch, M.P., Steeves, T.D., Vitaterna, M.H., Kornhauser, J.M., and Lowrey, P.L. (1997) Positional cloning of the mouse circadian clockgene. Cell. 89, 641-653.
  • Kim, H.-J., Park, S.-Y., Cho, Y.-J., Hong, K.-S., Cho, J.-Y., Seo, S.-Y., Lee, D.-H., and Jeon, B.S. (2009) Nonmotor symptoms in de novo Parkinson disease before and after dopaminergic treatment. J Neurol Sci. 287, 200-204.
  • Jenner, P. (2003) Oxidative stress in Parkinson's disease. Ann Neurol. 53, S26- S36.
  • Hunot, S., Boissiere, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y., and Hirsch, E. (1996) Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience. 72, 355-363.
  • Hirsch, E.C., and Hunot, S. (2009) Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8, 382-397.
  • Hayashi, A., Matsunaga, N., Okazaki, H., Kakimoto, K., Kimura, Y., Azuma, H., Ikeda, E., Shiba, T., Yamato, M., and Yamada, K.-i. (2013) A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson’s disease. Neuromolecular Med. 15, 238-251.
  • Hampp, G., Ripperger, J.A., Houben, T., Schmutz, I., Blex, C., Perreau-Lenz, S., Brunk, I., Spanagel, R., Ahnert-Hilger, G., and Meijer, J.H. (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol. 18, 678-683.
  • Haavik, J., Alm s, B., and Flatmark, T. (1997) Generation of reactive oxygen species by tyrosine hydroxylase: a possible contribution to the degeneration of dopaminergic neurons? J Neurochem. 68, 328-332.
  • Haas, S.J., Zhou, X., Machado, V., Wree, A., Krieglstein, K., and Spittau, B. (2016) Expression of Tgfbeta1 and Inflammatory Markers in the 6- hydroxydopamine Mouse Model of Parkinson's Disease. Front Mol Neurosci. 9, 7.
  • Guillaumond, F., Dardente, H., Gigu re, V., and Cermakian, N. (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms. 20, 391-403.
  • Gu, Z., Wang, B., Zhang, Y.-B., Ding, H., Zhang, Y., Yu, J., Gu, M., Chan, P., and Cai, Y. (2015) Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese. Sci Rep. 5, 15891.
  • Gibbs, J.E., Blaikley, J., Beesley, S., Matthews, L., Simpson, K.D., Boyce, S.H., Farrow, S.N., Else, K.J., Singh, D., and Ray, D.W. (2012) The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A. 109, 582-587.
  • Gekakis, N., Staknis, D., Nguyen, H.B., Davis, F.C., Wilsbacher, L.D., King, D.P., Takahashi, J.S., and Weitz, C.J. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280, 1564-1569.
  • Gallego, M., and Virshup, D.M. (2007) Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol. 8, 139-148.
  • Fifel, K., Vezoli, J., Dzahini, K., Claustrat, B., Leviel, V., Kennedy, H., Procyk, E., Dkhissi-Benyahya, O., Gronfier, C., and Cooper, H.M. (2014) Alteration of daily and circadian rhythms following dopamine depletion in MPTP treated non-human primates. PLoS One. 9, e86240.
  • Everett, L.J., and Lazar, M.A. (2014) Nuclear receptor Rev-erbα: up, down, and all around. Trends Endocrinol Metab. 25, 586-592.
  • Easton, A., Arbuzova, J., and Turek, F. (2003) The circadian Clock mutation increases exploratory activity and escape‐seeking behavior. Genes Brain Behav. 2, 11-19.
  • Drui, G., Carnicella, S., Carcenac, C., Favier, M., Bertrand, A., Boulet, S., and Savasta, M. (2014) Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease. Mol Psychiatry. 19, 358-367.
  • Dom nguez‐L pez, S., Howell, R.D., L pez‐Can l, M.G., Leyton, M., and Gobbi, G. (2014) Electrophysiological characterization of dopamine neuronal activity in the ventral tegmental area across the light–dark cycle. Synapse. 68, 454-467.
  • Dibner, C., Schibler, U., and Albrecht, U. (2010) The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 72, 517-549.
  • Deusser, J., Schmidt, S., Ettle, B., Pl tz, S., Huber, S., M ller, C.P., Masliah, E., Winkler, J., and Kohl, Z. (2015) Serotonergic dysfunction in the A53T alpha‐ synuclein mouse model of Parkinson's disease. J Neurochem. 135, 589- 597.
  • Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Sch fer, H., B tzel, K., Daniels, C., Deutschl nder, A., Dillmann, U., and Eisner, W. (2006) A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 355, 896-908.
  • Dauer, W., and Przedborski, S. (2003) Parkinson's disease: mechanisms and models. Neuron. 39, 889-909.
  • Cummings JL. (1992). Depression and Parkinson's disease: A review. Am J Psychiatry. 149:443–454.
  • Comella, C. (2006) Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview. J Neural Transm Suppl. 70, 349-355.
  • Chung, S., Lee, E.J., Yun, S., Choe, H.K., Park, S.B., Son, H.J., Kim, K.S., Dluzen, D.E., Lee, I., Hwang, O., et al. (2014) Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation. Cell. 157, 858-868.
  • Chaudhuri, K.R., and Schapira, A.H. (2009) Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. The Lancet Neurol. 8, 464-474.
  • Byrnes, K.R., Loane, D.J., Stoica, B.A., Zhang, J., and Faden, A.I. (2012) Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation. 9, 43.
  • Bunger, M.K., Wilsbacher, L.D., Moran, S.M., Clendenin, C., Radcliffe, L.A., Hogenesch, J.B., Simon, M.C., Takahashi, J.S., and Bradfield, C.A. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 103, 1009-1017.
  • Brown, R.G., Landau, S., Hindle, J.V., Playfer, J., Samuel, M., Wilson, K.C., Hurt, C.S., Anderson, R.J., Carnell, J., and Dickinson, L. (2011) Depression and anxiety related subtypes in Parkinson's disease. J Neurol Neurosurg Psychiatry. 82, 803-809.
  • Bonito-Oliva, A., Masini, D., and Fisone, G. (2014) A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. Front Behav Neurosci. 8, 290.
  • Bj rklund A and Dunnett SB. (2007) Dopamine neuron systems in the brain: an update. Trends Neurosci. 30, 194-202.
  • Beppe, G.J., Dongmo, A.B., Foyet, H.S., Dimo, T., Mihasan, M., and Hritcu, L. (2015) The aqueous extract of Albizia adianthifolia leaves attenuates 6- hydroxydopamine-induced anxiety, depression and oxidative stress in rat amygdala. BMC Complement Altern Med. 15, 374.
  • Bedrosian, T.A., and Nelson, R.J. (2013) Sundowning syndrome in aging and dementia: research in mouse models. Exp Neurol. 243, 67-73.
  • Bechtold, D.A., Gibbs, J.E., and Loudon, A.S. (2010) Circadian dysfunction in disease. Trends Pharmacol Sci. 31, 191-198.
  • Balsalobre, A., Damiola, F., and Schibler, U. (1998) A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 93, 929- 937.
  • Albrecht, U. (2013) Circadian clocks and mood-related behaviors. In Circadian Clocks (Springer), pp. 227-239.
  • Akhtar, R.A., Reddy, A.B., Maywood, E.S., Clayton, J.D., King, V.M., Smith, A.G., Gant, T.W., Hastings, M.H., and Kyriacou, C.P. (2002) Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol. 12, 540-550.
  • Abbott, R., Ross, G., White, L., Tanner, C., Masaki, K., Nelson, J., Curb, J., and Petrovitch, H. (2005) Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. 65, 1442-1446.
  • Abarca, C., Albrecht, U., and Spanagel, R. (2002) Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc Natl Acad Sci U S A. 99, 9026-9030.
  • Aarsland, D., P hlhagen, S., Ballard, C.G., Ehrt, U., and Svenningsson, P. (2012) Depression in Parkinson disease—epidemiology, mechanisms and management. Nat Rev Neurol. 8, 35-47.