박사

Role of LIM-kinase2 inhibition in Improvement of erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury = 해면체 신경 손상 발기부전 백서 모델에서 LIMK2 억제제의 음경해면체 섬유화 차단 효과를 통한 발기력의 호전

박주현 2018년
논문상세정보
    • 저자 박주현
    • 형태사항 26 cm
    • 일반주기 지도교수: 김수웅
    • 학위논문사항 서울대학교 대학원, 2018. 8, 의학과 비뇨의학, 학위논문(박사)-
    • DDC 610
    • 발행지 서울
    • 언어 eng
    • 출판년 2018
    • 발행사항 서울대학교 대학원
    유사주제 논문( 4,049)
' Role of LIM-kinase2 inhibition in Improvement of erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury = 해면체 신경 손상 발기부전 백서 모델에서 LIMK2 억제제의 음경해면체 섬유화 차단 효과를 통한 발기력의 호전' 의 주제별 논문영향력
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' Role of LIM-kinase2 inhibition in Improvement of erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury = 해면체 신경 손상 발기부전 백서 모델에서 LIMK2 억제제의 음경해면체 섬유화 차단 효과를 통한 발기력의 호전' 의 참고문헌

  • Weyne E, Castiglione F, Van der Aa F, Bivalacqua TJ, Albersen M. Landmarks in erectile function recovery after radical prostatectomy. Nature reviews. Urology 2015; 12: 289-97.
  • Vignozzi L, Morelli A, Filippi S, Vannelli GB, Mungai S et al. Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat. Intern ational journal of impotence research 2008; 20: 60-7.
  • Tavukcu HH, Aytac O, Atug F. Nerve-sparing techniques and results in robot-assiste d radical prostatectomy. Investigative and clinical urology 2016; 57: S172-S84.
  • Tal R, Alphs HH, Krebs P, Nelson CJ, Mulhall JP. Erectile function recovery rate after radical prostatectomy: a meta-analysis. The journal of sexual medicine 2009; 6: 2538-46.
  • Surma M, Wei L, Shi J. Rho kinase as a therapeutic target in cardiovascular diseas e. Future Cardiology 2011; 7: 657-71.
  • Song SH, Park K, Kim SW, Paick JS, Cho MC. Involvement of Rho-Kinase/LIM Kinase/Cofilin Signaling Pathway in Corporal Fibrosis after Cavernous Nerve Injury in Male Rats. The journal of sexual medicine 2015; 12: 1522-32.
  • Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T et al. Effect of AT877 on cereb ral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective p lacebo-controlled double-blind trial. Journal of neurosurgery 1992; 76: 571-7.
  • Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E. Effects of fasudil in acute ische mic stroke: results of a prospective placebo-controlled double-blind trial. Journal of the neurological sciences 2005; 238: 31-9.
  • Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. Journal of molecular medicine 2007; 85: 555-68.
  • Satoh S, Ikegaki I, Kawasaki K, Asano T, Shibuya M. Pleiotropic effects of the rh o-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. Current vascular pharmacology 2014; 12: 758-65.
  • Rockey DC, Bell PD, Hill JA. Fibrosis--A Common Pathway to Organ Injury and Failure. New England Journal of Medcine 2015; 373: 96.
  • Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M et al. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulatio n 2005; 112: 2959-65.
  • Mullerad M, Donohue JF, Li PS, Scardino PT, Mulhall JP. Functional sequelae of c avernous nerve injury in the rat: is there model dependency. The journal of sexual medicine 2006; 3: 77-83.
  • Morin P, Wickman G, Munro J, Inman GJ, Olson MF. Differing contributions of L IMK and ROCK to TGFbeta-induced transcription, motility and invasion. European journal of cell biology 2011; 90: 13-25.
  • Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. The EMBO journal 1996; 15: 2208-16.
  • Li R, Doherty J, Antonipillai J, Chen S, Devlin M et al, LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition dose not reduce metastasis in mice. Clinical and Experimental Metastasis 2013; 30: 483-95
  • Leungwattanakij S, Bivalacqua TJ, Usta MF, Yang DY, Hyun JS et al. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. Journal of androl ogy 2003; 24: 239-45.
  • Kovanecz I, Rambhatla A, Ferrini M, Vernet D, Sanchez S et al. Long-term contin uous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) in duced by cavernosal nerve resection in rats. International journal of impotence rese arch 2008; 20: 202-12.
  • Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C. Control of transform ing growth factor beta signal transduction by small GTPases. FEBS Journal 2009; 276: 2947-65.
  • Jung G, Kim BS, Song WH, Park J, Park K et al. 886 Improvement of erectile fu nction by suppression of corporal fibrosis with LIM-kinase2 inhibitors in a rat mod el of cavernous nerve injury. European Urology Supplements; 2016; 15: e886.
  • Hu WL, Hu LQ, Song J, Li SW, Zheng XM et al. Fibrosis of corpus cavernosum in animals following cavernous nerve ablation. Asian journal of andrology 2004; 6: 111-6.
  • Haudek SB, Gupta D, Dewald O, Schwartz RJ, Wei L et al. Rho kinase-1 mediate s cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovascul ar research 2009; 83: 511-8.
  • Harrison BA, Almstead ZY, Burgoon H, Gardyan M, Goodwin NC et al. Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Trea tment of Glaucoma. ACS medicinal chemistry letters 2015; 6: 84-8.
  • Hannan JL, Kutlu O, Stopak BL, Liu X, Castiglione F et al. Valproic acid prevent s penile fibrosis and erectile dysfunction in cavernous nerve-injured rats. The journa l of sexual medicine 2014; 11: 1442-51.
  • Gratzke C, Strong TD, Gebska MA, Champion HC, Stief CG et al. Activated Rho A/Rho kinase impairs erectile function after cavernous nerve injury in rats. The Jou rnal of urology 2010; 184: 2197-204.
  • Gorovoy M, Koga T, Shen X, Jia Z, Yue BY et al. Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis. Molecular Vision 2008; 14: 1951-9.
  • Garnock-Jones KP. Ripasudil: first global approval. Drugs 2014; 74: 2211-5.
  • Gallina A, Ferrari M, Suardi N, Capitanio U, Abdollah F et al. Erectile function o utcome after bilateral nerve sparing radical prostatectomy: which patients may be le ft untreated? The journal of sexual medicine 2012; 9: 903-8.
  • Freiman J. Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in S ubjects With Primary Open-angle Glaucoma or Ocular Hypertension Available from: http://clinicaltrials.gov/ct2/show/NCT01528111. NLM identifier: NCT01528111. . Acce ssed October 15, 2017.
  • Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J et al. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunctio n (CVOD) induced by experimental cavernosal nerve damage in the rat. The journa l of sexual medicine 2009; 6: 415-28.
  • El-Sakka AI. Alleviation of post-radical prostatectomy cavernosal fibrosis: future dir ections and potential utility for PDE5 inhibitors. Expert opinion on investigational d rugs 2011; 20: 1305-9.
  • Defert O, Boland S. Rho kinase inhibitors: a patent review (2014 - 2016). Expert opinion on therapeutic patents 2017; 27: 507-15.
  • Cho MC, Park K, Kim SW, Paick JS. Restoration of erectile function by suppressi on of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rhokinase inhibitors in a rat model of cavernous nerve injury. The Journal of urology 2015; 193: 1716-23.
  • Cho MC, Park K, Chai JS, Lee SH, Kim SW et al. Involvement of sphingosine-1- phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following caverno us nerve injury in male rats. The journal of sexual medicine 2011; 8: 712-21.
  • Capogrosso P, Salonia A, Briganti A, Montorsi F. Postprostatectomy Erectile Dysfun ction: A Review. The world journal of men's health 2016; 34: 73-88.
  • Canguven O, Lagoda G, Sezen SF, Burnett AL. Losartan preserves erectile function after bilateral cavernous nerve injury via antifibrotic mechanisms in male rats. The Journal of urology 2009; 181: 2816-22.
  • Boland S, Bourin A, Alen J, Geraets J, Schroeders P et al. Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorganic & medicinal che mistry letters 2015; 25: 4005-10.