박사

Anti-obesity and anti-diabetic effects of seapolynol and dieckol from Ecklonia cava in vitro and in vivo = 감태 추출물의 항비만 및 항당뇨 효능 연구

전희전 2018년
논문상세정보
' Anti-obesity and anti-diabetic effects of seapolynol and dieckol from Ecklonia cava in vitro and in vivo = 감태 추출물의 항비만 및 항당뇨 효능 연구' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • 3t3-l1 cells
  • Diet induced obesity mouse
  • Seapolynol
  • adipogenesis
  • db/db mouse
  • diabetes
  • dieckol
  • ecklonia cava
  • obesity
  • zebrafish
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
1,100 0

0.0%

' Anti-obesity and anti-diabetic effects of seapolynol and dieckol from Ecklonia cava in vitro and in vivo = 감태 추출물의 항비만 및 항당뇨 효능 연구' 의 참고문헌

  • Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782-87.
  • Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell metabolism. 2009,9:407-16.
  • Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, et al. Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. Journal of Pharmacology and Experimental Therapeutics. 1998;284:751-9.
  • Yoon NY, Kim HR, Chung HY, Choi JS. Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Archives of pharmacological research. 2008;31:1564-71.
  • Yoon JS, Kasin Yadunandam A, Kim SJ, Woo HC, Kim HR, Kim GD. Dieckol, isolated from Ecklonia stolonifera, induces apoptosis in human hepatocellular carcinoma Hep3B cells. Journal of natural medicines. 2013;67:519-27.
  • Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A. Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation. Marine drugs. 2011;9:2793-808.
  • Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC. Anti-hyperlipidemic Effect of Polyphenol Extract (Seapolynol) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models. Preventive Nutritional Food Science. 2012;17:1-7.
  • Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: A systematic and clinical review. Journal of the American Medical Association. 2014;311:74-86.
  • Wu J, Srinivasan SV, Neumann JC, Lingrel JB. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry. 2005;44:11098-105.
  • Wijesekara I, Yoon NY, Kim SK. Phlorotannins from Ecklonia cava (phaeophyceae): Biological activities and potential health benefits. BioFactors. 2010;36:408-14.
  • Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F: Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. Journal of Biological Chemistry. 2007;282:7991-6.
  • Turner RC, Ward EA, Phillips MA, Dornan TL, Ward GM, Hockaday TD. Continuous subcutaneous insulin infusion or subcutaneous insulin injections. Lancet. 1979;2:481.
  • Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine. 2001;344:1343-50.
  • Tang QQ, Otto TC, & Lane MD. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:44-9.
  • Takeuchi K, Reue K. Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. American journal of physiology. Endocrinology and metabolism. 2009;296:E1195-209.
  • Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A. Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats. Biochimical Biophysics Acta. 2012;1820:978-88.
  • Srivastava G, Aprovian CM. Current pharmacotherapy for obesity. Nature Reviews Endocrinology. 2018;14:12-24.
  • Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. The Journal of biological chemistry. 1993;268:6823-6.
  • Spiegel K, Tasali E, Leproult R, Cauter EV. Effects of poor and short sleep on glucose metabolism and obesity risk. Nature Reviews Endocrinology. 2009;5:253-61.
  • Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007,445:881-85.
  • Shin HC, Hwang HJ, Kang KJ, Lee BH. An antioxidative and anti-inflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Archives of pharmacal research. 2006;29:165-71.
  • Shibata T, Nagayama K, Tanaka R, Yamaguchi K, Naka-mura T. Inhibitory effects of brown algal phlorotannins on secretory phospholipase A2s, lipoxygenases and cyclooxygenases. Journal of applied phycology. 2002;15:61-6.
  • Shepherd PR, Kahn BB. Glucose transporters and insulin action implications for insulin resistance and diabetes mellitus. New england journal of medicine. 1999;341:248-57.
  • Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J. Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care. 2008;31:S262-8.
  • Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. The Journal of nutrition. 2000;130:2073S-85S.
  • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001,414:799-806.
  • Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes & development. 2000;14:1293-307.
  • Rea S, James DE. Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles. Diabetes. 1997; 46:1667-77.
  • Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI: Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. Jouranl of biological chemistry. 1994;269:27920-24.
  • Peyrollier K, Hajduch E, Blair AS, Hyde R, Hundal HS: L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport. Biochemical Journal. 2000;350:361-68.
  • Park JY, Kim JH, Kwon JM, Kwon HJ, Jeong HJ, Kim YM et al. Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava. Bioorganic & medicinal chemistry. 2013;21:3730-7.
  • Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N, Tanaka T. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC physiology. 2010;10:21.
  • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. The New England Journal of Medicine. 2007;356:2457-71.
  • Neyrinck AM, Van Hee VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. British journal of medicine. 2013;109:802-9.
  • Nelson LR, Bulun SE. Estrogen production and action. Journal of the American Academy of Dermatology. 2001;45:S116-24.
  • National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obesity research. 1998;6:51S-209S.
  • Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS. Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Archives of pharmacal research 2005;28: 691-8.
  • Moreno-Navarrete J, Fern ndez-Real J. Adipocyte Differentiation. In: Symonds ME (ed) Adipose Tissue Biology. Springer New York, 2012;pp 17-38.
  • Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000;404: 652-60.
  • Lowe CE, O'Rahilly S, Rochford JJ. Adipogenesis at a glance. Journal of cell science. 2011;124:2681-86.
  • Lim CT, Kola B, Korbonits M. AMPK as a mediator of hormonal signaling. Journal of molecular endocrinology. 2010;44: 87-97.
  • Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell metabolism. 2011;13:376-88.
  • Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, Kim SK. Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava. Bioorganic & Medicinal Chemistry. 2009;17:1963-73.
  • Lee SH, Kim JY, Yoo SY, Kwon SM. Cytoprotective effect of dieckol on human endothelial progenitor cells (hEPCs) from oxidative stress-induced apoptosis. Free radical research. 2013;47:526-34.
  • Lee SH, Han JS, Heo SJ, Hwang JY, Jeon YJ. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2010; 24:375-81.
  • Lauro D, Kido Y, Castle AL, Zarnowski MJ, Hayashi H, Ebina Y, Accili D. Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nature Genetics. 1998;20:294-298.
  • Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Current Biology. 2009;19:1046-52.
  • Kopelman PG. Obesity as a medical problem. Nature. 2000;404:635-43.
  • Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK. 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trih ydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts. Marine biotechnology. 2010;12:299-307.
  • Kohjima M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada R, Harada N, Enjoji M, Takayanagi R, Nakamuta M. SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. International journal of molecular medicine. 2008;21:507-11.
  • Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS. Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. The Journal of biological chemistry. 2008;283:34896-906.
  • Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ. Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes. Environmental toxicology and pharmacology 2013;36:1253-60.
  • Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2007;8:21-34.
  • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. Journal of clinical investigation. 1999;104:733-41.
  • Kim TH, Ku SK, Bae JS. Antithrombotic and profibrinolytic activities of eckol and dieckol. Journal of Cellular Biochemistry. 2012;113:2877-83.
  • Kim SK, Kong CS. Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes. Chemico-biological interactions 2010;186:24-9.
  • Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG et al. Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life sciences 2006;79:1436-43.
  • Kim JH, Lee NS, Jeong YG, Lee JH, Kim EJ, Han SY. Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain. Anatomy & Cell Biology. 2012;45:103-13.
  • Kim H, Sakamoto K. (e)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways. Cell biology international. 2012;36:147-53.
  • Kim CY, Le TT, Chen C, Cheng JX, Kim KH. Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. The Journal of nutritional biochemistry 2011;22:910-20.
  • Kersten S. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO reports. 2001;2:282-86
  • Kendall C, Wooltorton E. Rosiglitazone (Avandia) and macular edema. Canadian Medical Association Journal. 2006;174:623.
  • Katz AI, Rubenstein AH. Metabolism of proinsulin, insulin, and C-peptide in the rat. The Journal of Clinical Investigation. 1973;52:1113-21.
  • Kang NJ, Koo DH, Kang GJ, Han SC, Lee BW, Koh YS, Hyun JW, Lee NH, Ko MH, Kang HK, Yoo ES. Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes. Biomedical & Therapeutics. 2015;23:238-44.
  • Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ. Dieckol isolated from brown seaweed Ecklonia cava attenuates type capital I, Ukrainiancapital I, Ukrainian diabetes in db/db mouse model. Food Chemical Toxicology. 2013;53:294-8.
  • Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, et al. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice. Food Chemical Toxicology. 2012;50:1986-91.
  • Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC. Antioxidative properties of brown algae polyphenolic and their perspectives as chemopreventive agents against vascular risk factors. Archives of pharmacal research. 2003;26:286-93.
  • Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK: Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth. Internationl Journal of Molecular Science. 2012;13:6407-23.
  • Kang JG, Park CY. Anti-Obesity Drug: A Review about Their Effects and Safety. Diabetes & metabolism journal. 2012;36: 13-25,
  • Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, et al. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food and Chemical Toxicology. 2010;48:509-16.
  • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444:840-46.
  • Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW: Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells. Journal of Agricultural Food Chemistry. 2009;57:4439-46.
  • Jang ZH, Chung HC, Ahn YG, Kwon YK, Kim JS, Ryu JH, Ryu DH, Kim CH, Hwang GS. Metabolic profiling of an alcoholic fatty liver in zebrafish (Danio rerio). Molecular bioSystems. 2009;8:2001-9.
  • Investigators DT, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, Hanefeld M, Hoogwerf B, Laakso M, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368:1096-105.
  • Hollander PA, Elbein SC, Hirsch IB, Kelley D, McGill J, Taylor T, Weiss SR, Crockett SE, Kaplan RA, Comstock J, et al. Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study. Diabetes Care 1998, 21:1288-94.
  • Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicology in vitro : an international journal published in association with BIBRA. 2009;23:1123-30.
  • Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. Journal of cellular biochemisty. 2004; 166:213-23.
  • H ltt -Vuori M, Salo VT, Nyberg L, Brackmann C, Enejder A, Panula P, Ikonen E. Zebrafish: gaining popularity in lipid research. The Biochemical journal. 2010;429:235-42.
  • Gilde A, Van Bilsen M. Peroxisome proliferator‐activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle. Acta physiologica scandinavica. 2003;178:425-34.
  • Gale, SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. The Journal of biological chemistry. 2006;281:11082-89.
  • Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry. 1957;226:497-509.
  • Faber OK, Hagen C, Binder C, Markussen J, Naithani VK, Blix PM, Kuzuya H, Horwitz DL, Rubenstein AH, Rossing N: Kinetics of human connecting peptide in normal and diabetic subjects. The Journal of Clinical Investigation. 1978;62:197-203.
  • Esposito DL, Li Y, Cama A, Quon MJ. Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulinstimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology. 2001,142:2833-40.
  • Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice. The Journal of nutrition. 2009;139:919-25.
  • Ducluzeau PH, Perretti N, Laville M, Andreelli F, Vega N, Riou JP, Vidal H. Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes. 2001;50:1134-42.
  • Choi Y, Um SJ, Park T. Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation. International journal of obesity : journal of the International Association for the Study of Obesity. 2013;37:881-4.
  • Choi KM, Lee YS, Sin DM, Lee S, Lee MK, Lee YM, Hong JT, Yun YP, Yoo HS. Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. Obesity. 2012;20:1365-71.
  • Choi JG, Kang OH, Brice OO, Lee YS, Chae HS, Oh YC, Sohn DH, Park H, Choi HG, Kim SG, Shin DW, Kwon DY. Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp. Foodborne pathogens and disease. 2010;7:435-41.
  • Choi HS, Jeon HJ, Lee OK, Lee BY. Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrestand AMPKα activation. Molecular nutrition & food research. 2015;59:1458-71.
  • Canto C, Auwerx J. PGC-1 alpha, SIRT1 and AMPK, an energy-sensing network that controls energy expenditure. Current opinion in lipidology. 2009;20:98-105.
  • Cakir I, Perello M, Lansari O, Messier NJ, Vaslet CA, Nillni EA. Hypothalamic Sirt1 regulates food intake a rodent model system. PLoS one. 2009;15,4:e8322.
  • Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development. 2011;138:4709-19.
  • Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. Journal of the American Medical Association. 2002;287:2570-81.
  • Baba S, Osakabe N, Kato Y, Natsume M, Yasuda A, Kido T, Fukuda K, Muto Y, Kondo K. Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. American Journal of Clinical Nutrtion. 2007;85:709-17.
  • Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chemical Toxicology. 2006;44:1065-74.
  • Arner P, Pollare T, Lithell H, Livingston JN. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1987; 30:437-40.
  • Ae PS, Choi MS, Cho SY, Seo JS, Jung UJ, Kim MJ, Sung MK, Park YB, Lee MK. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Science. 2006;79:1207-13.