박사

Nuclear S6K1 induces Wnt transcription complex formation and promotes tumorigenesis

Lee, Min Gyu 2018년
논문상세정보
' Nuclear S6K1 induces Wnt transcription complex formation and promotes tumorigenesis' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Pygo2 phosphorylation
  • S6K1
  • nuclear translocation
  • wntsignalingpathway
  • β-catenin
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
100 0

0.0%

' Nuclear S6K1 induces Wnt transcription complex formation and promotes tumorigenesis' 의 참고문헌

  • Yi S.A., Um S.H., Lee J., Yoo J.H., Bang S.Y., Park E.K., Lee M.G., Nam K.H., Jeon Y.J., Park J.W., You J.S., Lee S-J., Bae G-U., Rhie J.W., Kozma S.C., Thomas G., Han J-W. (2016) S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis. Mol. Cell 62, 443-452.
  • Yi S.A., Han J., Han J-W. (2016), Epigenetic role of nuclear S6K1 in early adipogenesis. BMB Rep. 49, 401-402.
  • Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Alfred Yung, W.K., and Lu, Z. (2012). PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685-696.
  • Yamnik, R.L., Digilova, A., Davis, D.C., Brodt, Z.N., Murphy, C.J., Holz, M.K. (2009). S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation. J. Biol. Chem. 284, 6361-6369.
  • Willert K., Jones K.A. (2006). Wnt signaling: is the party in the nucleus? Genes & Dev. 20, 1394-1404.
  • Wang Y., Ding Q., Xia W., Izzo J.G., Lang J-Y. Wu T-T., Buttar N.S., Wang K.K., Wu Y, Wang H, Ajani J., Hung M.C. (2012). The Crosstalk of mTOR/S6K1 and Hedgehog Pathways. Cancer Cell. 21, 374-387.
  • Wang L., Jin Q., Lee J-E., Su I-H., Ge K. (2010) Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc. Natl. Acad. Sci. U.S.A., 1-6.
  • Valenta T., Hausmann G. Basler K. (2012). The many faces and functions of β -catenin. The EMBO Journal. 31, 2714-2736.
  • Um, S.H., Sticker-Jantscheff, M., Chau, G.C., Vintersten, K., Mueller, M., Gangloff, Y.G., Adams, R.H., Spetz, J.F., Elghazi, L., Pfluger, P.T., et al. (2015). S6K1 controls pancreatic β-cell size independently of intrauterine growth restriction. J. Clin. Invest. 125, 2736-2747.
  • Um, S.H., D'Alessio, D., and Thomas, G. (2006). Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3, 393-402.
  • Tewari R., Bailes E. Bunting K.A., Coates J.C. (2010) Armadillo-repeat protein functions: questions for little creatures. Trends in Cell Biology. 20, 470-481.
  • Shilatifard, A. (2006). Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 75, 243-269.
  • Selman, C. Tullet, J.M., Wieser, D., Irvine, E., Lingard, S.J., Choudhury, A.I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009). Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144.
  • Saxton R.A., Sabatini D.M. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell 168, 960-976.
  • Ruvinsky, I., and Meyuhas, O. (2006). Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem. Sci. 31, 342-348.
  • Rosner, M., and Hengstschl ger, M. (2011). Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene 30, 4509-4522.
  • Rosner, M., Schipany, K., and Hengstschl ger, M. (2012). p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6. Amino Acids 42, 2251-2256.
  • Rosenbluh J., Wang X., Hahn W.C. (2014). Genomic Insights into WNT/β -catenin Signaling. Trends in Pharmacological Sciences 35, 103-109.
  • Rodr guez-Paredes, M., and Esteller, M. (2011). Cancer epigenetics reaches mainstream oncology. Nat. Med. 17, 330-339.
  • Robitaille, A.M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L.L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenoe, P., and Hall, M.N. (2013). Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-1323.
  • Prestwich T. and MacDougald O.A. (2007) Wnt/β-catenin signaling in adipogenesis and metabolism. Curr. Opi. in Cell Biol. 19, 612-617.
  • Portela, A., and Esteller, M. (2010). Epigenetic modifications and human disease. Nat. Biotechnol. 28, 1057-1068.
  • Pearson, R.B., Dennis, P.B., Han, J.W., Williamson, N.A., Kozma, S.C., Wettenhall, R.E., and Thomas, G. (1995). The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 14, 5279-5287.
  • Panashuk G., Nemazanyy I., Zhyvoloup A., Bretner M., Litchfield D.W., Filonenko V., Gout I.T. (2006). Nuclear Export of S6K1 II Is Regulated by Protein Kinase CK2 Phosphorylation at Ser-17. J. of Biol. Chem. 281, 31188-31201.
  • Owen, J.L., Zhang, Y., Bae, S.H., Farooqi, M.S., Liang, G., Hammer, R.E., Goldstein, J.L., and Brown, M.S. (2012). Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc Natl Acad Sci U S A 109, 16184-16189.
  • Ohanna, M., Sobering, A.K., Lapointe, T., Lorenzo, L., Praud, C., Petroulakis, E., Sonenberg, N., Kelly, P.A., Sotiropoulos, A., and Pende, M. (2005). Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat. Cell Biol. 7, 286-294.
  • Mosimann C., Hausmann G., Basler K. (2009). β-Catenin hits chromatin: regulation of Wnt target gene activation. Nat. Rev. Mol. Biol. 10, 276-286.
  • Montagne, J., Stewart, M.J., Stocker, H., Hafen, E., Kozma, S.C., and Thomas, G. (1999). Drosophila S6 kinase: a regulator of cell size. Science 285, 2126-2129.
  • Mahmoudi T., Boj S.F., Hatzis P., Li V.S.W., Taouatas N., Vries R.G.J., Teunissen H., Begthel H., Korving J., Mohammed S., Heck A.J.R., Clevers H. (2010) The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis. PLoS Biol. 8, 1-19.
  • Magnuson, B., Ekim, B., and Fingar, D.C. (2012). Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signaling networks. Biochem. J. 441, 1-21.
  • MacDonald B., Tamai K., He X. (2009) Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases. Dev. Cell. 17, 9-26.
  • Ma, X.M., Blenis, J. (2009). Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell. Biol. 10, 307-318.
  • Lipton, J.O., Yuan, E.D., Boyle, L.M., Ebrahimi-Fakhari, D., Kwiatkowski, E., Nathan, A., G ttler, T., Davis, F., Asara, J.M., and Sahin, M. (2015). The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell 161, 1138-1151.
  • Lien W-H., Fuchs E. (2014) Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes & Dev. 28, 1517-1532
  • Li V.S.W., Ng S.S., Boersema P.J., Low T.Y., Karthaus W.R., Gerlach J.P., Mohammed S., Heck A.J.R., Maurice M.M., Mahmoudi T., Clevers H. (2012) Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex. Cell 149, 1245-1256.
  • Lee G., Zheng Y., Cho S., Jang C., England C., Dempsey J.M., Yu Y., Liu X., He L., Paola M.C., Chavez A., Zhang E., Isik M., Couvillon A., Dephoure N.E., Blackwell T.K., Yu J.J., Rabinowitz J.D., Cantley L.C., Blenis J. (2017) Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell 171, 1-14.
  • Laplante M., Sabatini D.M. (2012). mTOR Signaling. Cold Spring Harb. Perspect. Biol., 1-4.
  • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149: 274-293
  • Lamming, D.W., Ye, L., Katajisto, P., Goncalves, M.D., Saitoh, M., Stevens, D.M., Davis, J.G., Salmon, A.B., Richardson, A., Ahima, R.S., et al. (2012). Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643.
  • Khandekar, M.J., Cohen, P., and Spiegelman, B.M. (2011). Molecular mechanisms of cancer development in obesity. Nat. Rev. Cancer 11, 886-895.
  • Kane S., Sano H., Liu S.C.H., Asara J.M., Lane W.S., Garner C.C., Lienhard G.E. (2002) A Method to Identify Serine Kinase Substrates. J. Biol. Chem. 25, 22115-22118.
  • Jung H-Y., Jun S., Lee M., Kim H-C., Wang X., Ji H., McCrea P.D., Park J-I. (2013) PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation Mol. Cell. 52, 193-205.
  • Johnson S.M., Gulhati P., Rampy B.A., Han Y., Rychahou P.G., Doan H.Q., Weiss H.L., Evers B.M. (2009). Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer. J. Am. Coli. Surg. 12, 767-776.
  • Jamieson C., Sharma M., Henderson B.R. (2014) Targeting the β-catenin nuclear transport pathway in cancer. Sem. in Can. Biol. 27, 20-29.
  • Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., Yang Q., Bennett C., Harada Y., Stankunas K., Wang C., He X., MacDougald O., You M., Williams B.O., Guan K-L., TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth. Cell 126, 955-968.
  • Inestrosa N.C., Varela-Nallar L. (2013) Wnt Signaling Roles on the Structure and Function of the Central Synapses: Involvement in Alzheimer’s Disease. Tre. Cell Sig. Path. Neu. Fate Dec., 115-139.
  • Hsu H-T., Liu P-C., Ku S-Y., Jung K-C., Hong Y-R., Kao C., Wang C. (2006) β-Catenin control of T-cell transcription factor 4 (Tcf4) importation from the cytoplasm to the nucleus contributes to Tcf4-mediated transcription in 293 cells. Biochem. and Biop. Res. Comm. 343, 893-898.
  • Hoffmeyer K., Junghans D., Kanzler B., Kemler R. (2017) Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency. Cell Rep. 18, 2815-2824.
  • Hayward P., Kalmar T., Arias A.M. (2008). Wnt/Notch signaling and information processing during development. Development 135, 411-424.
  • Groot, R.P., Ballou, L.M., Sassone-Corsi, P. (1994). Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 79, 81-91.
  • Gregorieff A., Clevers H. (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes & Dev. 19, 877-890.
  • Gao C., Cao W., Bao L., Zuo W., Xie G., Cai T., Fu W., Zhang J., Wu W., Zhang X., Chen Y-G. (2010). Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell. Biol. 12, 781-800.
  • Francipane M.G., Lagasse E. (2013) mTOR pathway in colorectal cancer: an update. Oncotarget 5, 49-66
  • Fenton, T.R., and Gout, I.T. (2011). Functions and regulation of the 70kDa ribosomal S6 kinases. Int. J. Biochem. Cell Biol. 43, 47-59.
  • Dennis, P.B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S.C., and Thomas, G. (2001). Mammalian TOR: a homeostatic ATP sensor. Science 294, 1102-1105.
  • D vel, K., Yecies, J.L., Menon, S., Raman, P., Lipovsky, A.I., Souza, A.L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010). Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183.
  • Csibi A., Lee G., Yoon S-O., Tong H., Ilter D., Elia I., Fendt S-M., Roberts T.M., Blenis J. (2014) The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B Dependent Control of c-Myc Translation. Curr. Biol. 24, 2274-2280.
  • Christodoulides, C., Lagathu, C., Sethi, J.K., and Vidal-Puig, A. (2009). Adipogenesis and WNT signaling. Trends Endocrinol. Metab. 20, 16-24.
  • Chen, J.K., Chen, J., Thomas, G., Kozma, S.C., and Harris, R.C. (2009). S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am. J. Physiol. Renal Physiol. 297, F585-593.
  • Carnevalli, L.S., Masuda, K., Frigerio, F., Le Bacquer, O., Um, S.H., Gandin, V., Topisirovic, I., Sonenberg, N., Thomas, G., and Kozma, S.C. (2010). S6K1 plays a critical role in early adipocyte differentiation. Dev. Cell 18, 763-774.
  • Blouet, C., Ono, H., and Schwartz, G.J. (2008). Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab. 8, 459-467.
  • Ben-Sahra, I., Howell, J.J., Asara, J.M., and Manning, B.D. (2013). Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339, 1323-1328.
  • Baron R., Kneissel M. (2013). WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat. Med. 19, 179-192.
  • Bae, E.J., Xu, J., Oh, D.Y., Bandyopadhyay, G., Lagakos, W.S., Keshwani, M., and Olefsky, J.M. (2012). Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance. J. Biol. Chem. 287, 18769-18780.
  • Asally M., Yoneda Y. (2005) β-Catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1). Exp. Cell Res. 308, 357-363.
  • Arif A., Terenzi F., Potdar A.A., Jia J., Sacks J., China A., Halawani D., Vasu K., Li X., Brown J.M., Chen J., Kozma S.C., Thomas G., Fox P.L. (2017). EPRS is a critical mTORC1/S6K1 effector that influences adiposity in mice. Nature 542, 357-375.