박사

Effects and Possible Mechanisms of Some Phytochemicals on Drosophila Models of Alzheimer’s Disease = 식물유래 화합물의 알츠하이머 초파리 모델에 대한 효과 및 작용메카니즘

왕설 2016년
논문상세정보
' Effects and Possible Mechanisms of Some Phytochemicals on Drosophila Models of Alzheimer’s Disease = 식물유래 화합물의 알츠하이머 초파리 모델에 대한 효과 및 작용메카니즘' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • 농학과 관계공학
  • acacetin
  • agastache rugosa
  • alzheimer’s disease
  • bace1
  • curcumalonga
  • curcuminoid
  • drosophila melanogaster
  • mechanismsofaction
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
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' Effects and Possible Mechanisms of Some Phytochemicals on Drosophila Models of Alzheimer’s Disease = 식물유래 화합물의 알츠하이머 초파리 모델에 대한 효과 및 작용메카니즘' 의 참고문헌

  • ıkrık ı, S., E. Mozioğlu, and H. Yılmaz. 2008. Biological activity of curcuminoids isolated from Curcuma longa. Rec. Nat. Prod. 2, 19–24.
  • de Paula, V. J. R., F. M. Guimar es, B. S. Diniz, and O.V. Forlenza. 2009. Neurobiological pathways to Alzheimer's disease Amyloid-beta, Tau protein or both? Dement. Neuropsychol. 3, 188–194.
  • Zhu, Z., J. Yan, W. Jiang, X. G. Yao, J. Chen, L. Chen, C. Li, L. Hu, H. Jiang, and X. Shen. 2013. Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J. Neurosci. 33, 13138–13149.
  • Zheng, H., C. Quan, C. Y. Hyeon, S. C. Kang, D. U. Lee, O. P. Zee, and J. H. Kwak. 2013. Terpenes and phenolic compounds from Agastache rugosa and their inhibitory effect on the release of β-hexosaminidase in RBL-2H3 cells. Planta Med. 79–PN93.
  • Zhang, Y. W., R. Thompson, H. Zhang, and H. Xu. 2011. APP processing in Alzheimer’s disease. Mol. Brain 4, 3.
  • Zhang, L., C. Shen, J. Chu, R. Zhang, Y. Li, and L. Li. 2014. Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's disease. Int. J. Biol. Sci. 10, 181–191.
  • Zhang, H., Q. Ma, Y.W. Zhang, and H. Xu. 2012. Proteolytic processing of Alzheimer's β-amyloid precursor protein. J. Neurochem. 1, 9–21.
  • Zhang C. 2012. Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease. Discov. Med. 14, 189–197.
  • Youn, K., and M. Jun. 2013. In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii. Planta Med. 79, 1038–1042.
  • Youn, K., and M. Jun. 2012. Inhibitory effects of key compounds isolated from Corni fructus on BACE1 activity. Phytother. Res. 26, 1714–1718.
  • Yankner, B. A., L. R. Dawes, S. Fisher, L. Villa-Komaroff, M. L. Oster-Granite, and R. L. Neve. 1989. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417–420.
  • Yagi, Y., S. Tomita, M. Nakamura, and T. Suzuki. 2000. Overexpression of human amyloid precursor protein in Drosophila. Mol. Cell Biol. Res. Commun. 4, 43–49.
  • World Health Organization. 2015. Dementia Fact sheet N 362. Available at http://www.who.int/mediacentre/factsheets/fs362/en/ (Accessed: 5th March 2015).
  • Wimo, A., M. Prince, and Alzheimer’s Disease International. 2010. World Alzheimer Report. 2010: The global economic impact of dementia. Available at http://www.alz.org/documents/national/world_alzheimer_report_2010.pdf (Accessed: 25th February 2015).
  • Wimo, A., L. Jonsson, J. Bond, M. Prince, and B. Winblad. 2013. The worldwide economic impact of dementia 2010. Alzheimers Dement. 9, 1–11.
  • Wawer, I., and A. Zielinska. 2001. 13C CP/MAS NMR studies of flavonoids. Magn. Reson. Chem. 39, 374–380.
  • Wang, X., J. R. Kim, S. B. Lee, Y. J. Kim, M. Y. Jung, H. W. Kwon, and Y. J. Ahn. 2014. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement. Altern. Med. 14, 88. doi: 10.1186/1472-6882-14-88.
  • Wang, X., H. Perumalsamy, H. W. Kwon, Y. E. Na, and Y. J. Ahn. 2015. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease. Sci. Rep. 5, 16127. doi: 10.1038/srep16127.
  • Vi a, J. and A. Lloret. 2010. Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J. Alzheimers Dis. 2, S527–S533.
  • Vassar, R. 2014. BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease. Alzheimers Res. Ther. 6, 89.
  • Utsuki, T., Q. S. Yu, D. Davidson, D. Chen, H. W. Holloway, A. Brossi, K. Sambamurti, D. K. Lahiri, N. H. Greig, and T. Giordano. 2006. Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer’s disease amyloid-beta peptide. J. Pharmacol. Exp. Ther. 318, 855– 862.
  • Tian, Y., B. Bassit, D. Chau, and Y. M. Li. 2010. An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production. Nat. Struct. Mol. Biol. 17, 151–158.
  • Thompson, S., K. L. Lanct t, and N. Herrmann. 2004. The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer’s disease. Expert Opin. Drug Saf. 3, 425–440.
  • Thompson, L. A., J. J. Bronson, and F. C. Zusi. 2005. Progress in the discovery of BACE inhibitors. Curr. Pharm. Des. 11, 3383–3404.
  • Terry, A.V Jr, and J. J. Buccafusco. 2003. The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J. Pharmacol. Exp. Ther. 306, 821–827.
  • Tang, E., and G. Eisenbrand. 1992. Chinese Drugs of Plant Origin, pp. 613–619. Springer-Verlag Press, New York.
  • Tanaka, J. C. A., G. J. Vidotti, and C. C. da Silva. 2003. A new tormentic acid derivative from Luehea divaricata Mart. (Tiliaceae). J. Braz. Chem. Soc. 14, 475– 478.
  • Tamura, T., M. Sone, T. Iwatsubo, K. Tagawa, E. E. Wanker, and H. Okazawa. 2011. Ku70 alleviates neurodegeneration in Drosophila models of Huntington’s disease. PLoS ONE 6, e27408.
  • Sun, X, Y. Wang, H. Qing, M. A. Christensen, Y. Liu, W. Zhou, Y. Tong, C. Xiao, Y. Huang, S. Zhang, X. Liu, and W. Song. 2005. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes. FASEB J. 19, 739–49.
  • Stachel, S. J., C. A. Coburn, T. G. Steele, K. G. Jones, E. F. Loutzenhiser, and A. R. Gregro. 2004. Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1). J. Med. Chem. 47, 6447–6450.
  • Singh, S., and B. B. Aggarwal. 1995. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 270, 24995– 25000.
  • Silvestri, R. 2009. Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med. Res. Rev. 29, 295–338.
  • Silbert, L. C. 2007. Does statin use decrease the amount of Alzheimer disease pathology in the brain? Neurology.69, E8–11.
  • Shimmyo, Y., T. Kihara, A. Akaike, T. Niidome, and H. Sugimoto. 2008. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim. Biophys. Acta. 1780, 819–825.
  • Shimizu, H., A. Tosaki, K. Kaneko, T. Hisano, T. Sakurai, and N. Nukina. 2008. Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. Mol. Cell Biol. 28, 3663–3671.
  • Shen, K. H., S. H. Hung, L. T. Yin, C. S. Huang, C. H. Chao, C. L. Liu, and Y. W. Shih. 2010. Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway. Mol. Cell. Biochem. 333, 279–291.
  • Selkoe, D. J. 1991. The molecular pathology of Alzheimer’s disease. Neuron 6, 403–409.
  • Schneider, L. S. 2013. Alzheimer disease pharmacologic treatment and treatment research. Continuum (Minneap Minn). 19 (2 Dementia), 339–357.
  • Scarmeas, N., Y. Stern, R. Mayeux, J.J. Manly, N. Schupf, and J. A. Luchsinger. 2009. Mediterranean diet and mild cognitive impairment. Arch. Neurol. 66, 216–225.
  • Sasaki, H., K. Miki, K. Kinoshita, K. Koyama, L. D. Juliawaty, S. A. Achmad, E. H. Hakim, M. Kaneda, and K Takahashi. 2010. β-Secretase (BACE-1) inhibitory effect of biflavonoids. Bioorg. Med. Chem. Lett. 20, 4558–4560.
  • Sarantseva, S., S. Timoshenko, O. Bolshakova, E. Karaseva, D. Rodin, A. L. Schwarzman, and M. P. Vitek. 2009. Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease. PLoS One. 4, e8191.
  • Rizzi, L., I. Rosset and M. Roriz-Cruz. 2014. Global epidemiology of dementia: Alzheimer’s and vascular types. BioMed Res. Int. 2014, Article ID 908915.
  • Ringman, J. M., S. A. Frautschy, G. M. Cole, D. L. Masterman, and J. L. Cummings. 2005. A potential role of the curry spice curcumin in Alzheimer's disease. Curr. Alzheimer Res. 200, 131–136.
  • Ringman, J. M., S. A. Frautschy, E. Teng, A. N. Begum, J. Bardens, M. Beigi, K. H. Gylys, V. Badmaev, D. D. Heath, L. G. Apostolova, V. Porter, Z.a Vanek, G. A. Marshall, G. Hellemann, C. Sugar, D. L. Masterman, T. J. Montine, J. L. Cummings and G. M. Cole. 2012. Oral curcumin for Alzheimer’s disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res. Ther. 4, 43.
  • Rezai-Zadeh, K., D, Shytle, N, Sun, T, Mori, H, Hou, D, Jeanniton, J. Ehrhart, K. Townsend, J. Zeng, D. Morgan, J. Hardy, T. Town, and J. Tan. 2005. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J. Neurosci. 25, 8807–8814.
  • Ren, C., S. E. Finkel, and J. Tower. 2009. Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp. Gerontol. 44, 228–235.
  • Reitz1, C. 2012. Alzheimer's disease and the amyloid cascade hypothesis: a critical review. Int. J. Alzheimers Dis. 2012 (2012), Article ID 369808.
  • Rates, S. M. K. (2001). Plants as source of drugs. Toxicon. 39: 603–613.
  • Raskin, I., D. M. Ribnicky, S. Komarnytsky, N. Ilic, A. Poulev, N. Borisjuk, A. Brinker, D. A. Moreno, C. Ripoll, N. Yakoby, J. M. O'Neal, T. Cornwell, I. Pastor, and B. Fridlender. 2002. Plants and human health in the twenty-first century. Trends Biotechnol. 20, 522–531.
  • Qiu, C., M. Kivipelto, and E. von Strauss. 2009. Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin. Neurosci. 11, 111–128.
  • Probst, G., and Y. Z. Xu. 2012. Small-molecule BACE1 inhibitors: a patent literature review (2006–2011). Expert. Opin. Ther. Pat. 22, 511–540.
  • Prince, M., J. Jackson., and Alzheimer’s Disease International. 2009. World Alzheimer Report 2009. Available at https://www.alz.co.uk/research/files/WorldAlzheimerReport.pdf (Accessed: 20th February 2015).
  • Pr ing, K., A. Voigt, and J. B. Schulz. 2013. Drosophila melanogaster as a model organism for Alzheimer's disease. Mol. Neurodegener. 8, 35.
  • Pirooznia S. K., J. Sarthi, A. A. Johnson, M. S. Toth, K. Chiu, S. Koduri, and F. Elefant. 2012. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer’s disease model. PLoS ONE 7, e41776.
  • Phelps, C. B., and A. H. Brand. 1998. Ectopic gene expression in Drosophila using GAL4 system. Methods 14, 367–379.
  • Perumalsamy, H., J. R. Kim, S. M. Oh, J. W. Jung, Y. J. Ahn, and H. W. Kwon. 2013. Novel histopathological and molecular effects of natural compound pellitorine on larval midgut epithelium and anal gills of Aedes aegypti. PLoS ONE. 8, e80226.
  • Periz, G., and M. E. Fortini. 2004. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. J. Neurosci. Res. 77, 309–322.
  • Patel, S., L. Vuillard, A. Cleasby, C. W. Murray, and J. Yon. 2004. Apo and inhibitor complex structures of BACE (beta-secretase). J. Mol. Biol. 343, 407–416.
  • Parsons, C. G., W. Danysz, A. Dekundy, and I. Pulte. 2013. Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease. Neurotox. Res. 24, 358–369.
  • Park, Y. T., J.Y. Jeong, M. J. Lee, K. I. Kim, T. H. Kim, Y. D. Kwon, C. Lee, O. J. Kim, and H. J. An. 2013. MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance. J. Ovarian Res. 6, 18.
  • Park, J. H., J. W. Jung, Y. J. Ahn, and H. W. Kwon. 2012. Neuroprotective properties of phytochemicals against paraquat-induced oxidative stress and neurotoxicity in Drosophila melanogaster. Pestic. Biochem. Physiol. 104, 118–125.
  • Paris, D., V. Mathura, G. Ait-Ghezala, D. Beaulieu-Abdelahad, N. Patel, C. Bachmeier, and M. Mullan. 2011. Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism. Bioinformation 6, 229–236.
  • Pandey, U. B., and C. D. Nichols. 2011. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol. Rev. 63, 411–436.
  • Pan, M. H., C. S. Lai, Y. J. Wang, and C. T. Ho. 2006. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem. Pharmacol. 72, 1293–1303.
  • Orhan, I. E. 2012. Current concepts on selected plant secondary metabolites with promising inhibitory effects against enzymes linked to Alzheimer’s disease. Curr. Med. Chem. 19, 2252–2261.
  • Olivera, A., T. W. Moore, F. Hu, A. P. Brown, A. Sun, D. C. Liotta, J. P. Snyder, Y. Yoon, H. Shim, A. I. Marcus, A. H. Miller, and T. W. W. Pacea. 2012. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int. Immunopharmacol. 12, 368–377.
  • Nishina, A., H. Kimura, H. Tsukagoshi, K. Kozawa, M. Koketsu, M. Ninomiya, and S. Furukawa. 2013. Neurite outgrowth in PC12 cells stimulated by components from Dendranthema grandiflorum cv. "Mottenohoka" is enhanced by suppressing phosphorylation of p38MAPK. Evid. Based Complement Alternat. Med. 2013, 403503.
  • Nikolaev, A., T. McLaughlin, D. D. O’Leary, and M. Tessier-Lavigne. 2009. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457, 981–989.
  • Ng, C. F., C. H. Ko, C. M. Koon, J. W. Xian, P. C. Leung, K. P. Fung, H. Y. E. Chan, and C. B. Lau. 2013. The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity. Evidence-Based Complementary and Alternative Medicine. 2013, Article ID 516741.
  • Mukherjee, P. K., V. Kumar, M. Mal, and P. J. Houghton. 2007. Acetylcholinesterase inhibitors from plants. Phytomedicine 14, 289–300.
  • Morgan, T. H. 1910. Sex limited inheritance in Drosophila. Science 32, 120–122.
  • Molinuevo, J. L., A. Llad , and L. Rami. 2005. Memantine: targeting glutamate excitotoxicity in Alzheimer’s disease and other dementias. Am. J. Alzheimers Dis. Other. Demen. 20, 77–85.
  • Mohandas, E., V. Rajmohan, and B. Raghunath. 2009. Neurobiology of Alzheimer’s disease. Indian J. Psychiatry 51, 56–61.
  • Miyazawa, M., and M. Hisama. 2003. Antimutagenic activity of flavonoids from Chrysanthemum morifolium. Biosci. Biotechnol. Biochem. 67, 2091–2099.
  • Mishra, S., and K. Palanivelu. 2008. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann. Indian. Acad. Neurol. 11, 13–19.
  • Min, K. J., and M. Tatar. 2006. Drosophila diet restriction in practice: do flies consume fewer nutrients? Mech. Ageing Dev. 127, 93–96.
  • Mhatre, S. D., B. E. Paddock, A. J. Saunders, and D. R. Marenda. 2013. Invertebrate models of Alzheimer's disease. J. Alzheimers Dis. 1, 3–16.
  • McGeer, E. G., and P. L. McGeer. 1998. The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33, 371–378.
  • Marumoto, S., and M. Miyazawa. 2010. beta-secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica. Phytother. Res. 24, 510–513.
  • Marques, F., J. C. Sousa, N. Sousa, and J. A. Palha. 2013. Blood–brain-barriers in aging and in Alzheimer’s disease. Mol. Neurodegener. 8, 38.
  • Mancini, F., A. De Simone, and V. Andrisano. 2011. Bata-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors. Anal. Bioanal. Chem. 400, 1979–1996.
  • Mahoney, M. B., C. M. Singh, L. T. Diggins, D. Keefe, E. Lund, P. O'Neil, E. Sigel, J. Symonds, A. Villaluz, M. K. Ahlijanian., and M. G. Palfreyman. 2009. Compound screening in a Drosophila melanogaster Alzheimer's disease model using a behavioral readout. Alzheimer. Dement. 5, e11–e12.
  • Lv, L., Q. Y. Yang, Y. Zhao, C. S. Yao, Y. Sun, E. J. Yang, K. S. Song, I. Mook-Jung, and W. S. Fang. 2008. BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis. Planta Med. 74, 540–545.
  • Luo, L., T. Tully, and K. White. 1992. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9, 595–605.
  • Liu, Y., Y. W. Zhang, X. Wang, H. Zhang, X. You, F. F. Liao, and H. Xu. 2009. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J. Biol. Chem. 284, 12145–12152.
  • Liu, H., Z. Li, D. Qiu, Q. Gu, Q. Lei, and L. Mao. 2010. The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swap HEK293 cells. Nuerosci. Lett. 485, 83–88.
  • Lin, T. Y., W. J. Huang, C. C. Wu, C. W. Lu, and S. J. Wang. 2014. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PLoS ONE. 9, e88644.
  • Lim, G. P, T. Chu, F. Yang, W. Beech, S. A. Frautschy, and G. M. Cole. 2001. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21, 8370–8377.
  • Li, H., B. Wang, Z. Wang, Q. Guo, K. Tabuchi, R. E. Hammer, T. C. Sudhof, and H. Zheng. 2010. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc. Natl. Acad. Sci. USA. 107, 17362–17367.
  • Levites, Y., T. Amit, S. Mandel, and M. B. Youdim. 2003. Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J. 17, 952–974.
  • Lemaitre, B., M. Meister, S. Govind, P. Georgel, R. Steward, J. M. Reichhart, and J. A. Hoffmann. 1995. Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 14, 536–545.
  • Lee, K. S., B. S. Lee, S. Semnari, A. Avanesian, C. Y. Um, H. J. Jeon, K. M. Seong, K. Yu, K. J. Min, and M. Jafari. 2010. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res. 13, 561–570.
  • Kwak. Y. D., R. Wang, J. J. Li, Y. W. Zhang, H. Xu, and F. F. Liao. 2011. Differential regulation of BACE1 expression by oxidative and nitrosative signals. Mol. Neurodegener. 6, 17.
  • Kuhn, M. A., and D. Winston. 2001. Herbal Therapy and Supplements: A Scientific & Traditional Approach, pp. 330–335. Lippincott Williams & Wilkins Press, New York.
  • Kramer, J. M., and B. E. Staveley. 2003. GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster. Genet. Mol. Res. 2, 43–47.
  • Kolarova, M., F. Garc a-Sierra, A. Bartos, J. Ricny, and D. Ripova. 2012. Structure and pathology of tau protein in Alzheimer disease. Int. J. Alzheimers Dis. 2012, Article ID 731526.
  • Kim, N. Y., D. S. Park., and H. Y. Lee. 2015. Effect of anti-skin wrinkle and antioxidant of Agastache rugosa Kentz through fermentation process of the lactic acid. Korean J. Med. Crop Sci. 23, 37–42.
  • Kim, J., H. J. Lee, and K. W. Lee. 2010. Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J. Neurochem. 112, 1415–1430.
  • Kim, H. G., M. S. Ju, S. K. Ha, H. Lee, H. Lee, S. Y. Kim, and M. S. Oh. 2012. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biol. Pharm. Bull. 35, 1287–1294.
  • Karran, E., M. Mercken, and B. De Strooper. 2011. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698–712.
  • Kandalepas, P. C, K. R. Sadleir, W. A. Eimer, J. Zhao, D. A. Nicholson, and R. Vassar. 2013. The Alzheimer’s beta-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 126, 329–352
  • Kalaria, R., G. E. Maestre, R. Arizaga, R. P. Friedland, D. Galasko, K. Hall, J. A. Luchsinger, A. Ogunniyi, E. K. Perry, F. Potocnik, M. Prince, R. Stewart, A. Wimo, Z. X. Zhang, and P. Antuono. 2008. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 7, 812–826.
  • Jung, J. I., S. Premraj, P. E. Cruz, T. B. Ladd, Y. Kwak, E. H. Koo, K. M. Felsenstein, T. E. Golde, and Y Ran. 2014. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. PLoS ONE 9, e111553.
  • Jung, H. A., T. Yokozawa, B. W. Kim, J. H. Jung, and J. S. Choi. 2010. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. AM. J. Chin. Med. 38, 415–429.
  • Jung, H. A., E. J. Lee, J. S. Kim, S. S. Kang, J. H. Lee, B. S. Min, and J. S. Choi. 2009b. Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata. Arch. Pharm. Res. 32, 1399–1408.
  • Jung, H. A., B. S. Min, T. Yokozawa, J. H. Lee, Y. S. Kim, and J. S. Choi. 2009a. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol. Pharm. Bull. 32, 1433–1438.
  • John, V., J. P. Beck, M. J. Bienkowski, S. Sinha, and R. L. Heinrikson. 2003. Human β-secretase (BACE) and BACE inhibitors. J. Med. Chem. 46, 4625–4630.
  • John, V. 2006. Human beta-secretase (BACE) and BACE inhibitors: progress report. Curr. Top. Med. Chem. 6, 569–578.
  • Ji, H., and H. Zhang. 2008. Multipotent natural agents to combat Alzheimer’s disease. Functional spectrum and structural features. Acta Pharmacol. Sin. 29, 143–151.
  • Jeon, S. Y., K. Bae, Y. H. Seong, and K. S. Song. 2003. Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg. Med. Chem. Lett. 13, 3905–3908.
  • Jayaprakasha, G. K., L. J. M. Rao, and K. K. Sakariah. 2002. Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. J. Agric. Food Chem. 50, 3668–3672.
  • J ger, A. K., and L. Saaby. 2011. Flavonoids and the CNS. Molecules 16, 1471–1485.
  • Itokawa, H., Q. Shi, T. Akiyama, S. L. Morris-Natschke, and K. H. Lee. 2008. Recent advances in the investigation of curcuminoids. Chinese Med. 3, 11.
  • Iijima-Ando, K., and K. Iijima. 2010. Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct. Funct. 214, 245–262.
  • Iijima, K., H. P. Liu, A. S. Chiang, S. A. Hearn, M. Konsolaki, and Y. Zhong. 2004. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 6623–6628.
  • Howes, M. J., and E. Perry. 2011. The role of phytochemicals in the treatment and prevention of dementia. Drugs Aging 28, 439–468.
  • Hossain, M. A., and Z. Ismail. 2013. Isolation and characterization of triterpenes from the leaves of Orthosiphon stamineus. Arabian J. Chem. 6, 295–298.
  • Hong, Y. K., S. H. Park, S. Lee, S. Hwang, M. J. Lee, D. Kim, J. H. Lee, S. Y. Han, S. T. Kim, Y. K. Kim, S. Jeon, B. S. Koo, and K. S. Cho. 2011. Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease. J. Ethnopharmacol. 134, 1028–1032.
  • Hong, L., G. Koelsch, X. Lin, S. Wu, S. Terzyan, A. K. Ghosh, X. C. Zhang, and J. Tang. 2000. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 290, 150–153.
  • Hippius, H. 2003. The discovery of Alzheimer’s disease. Dialogues Clin. Neurosci. 5, 101–108.
  • Herrup, K. 2010. Reimagining Alzheimer's Disease–an age-based hypothesis. J. Neurosci. 30, 16755–16762.
  • Hartman, H., and T. L. Hayes. 1971. Scanning electron microscopy of Drosophila. J. Hered. 62, 41–44.
  • Hardy, J., and D. J. Selkoe. 2002. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297, 353–356.
  • Hardy, J., and D. Allsop. 1991. Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol. Sci. 12, 383–388.
  • Haass, C. 2004. Take five—BACE and the gamma-secretase quartet conduct Alzheimer’s amyloid beta-peptide generation. EMBO J. 23, 483–488.
  • Guzior, N., A. Wieckowska, D. Panek, and B. Malawska. 2015. Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease. Curr. Med. Chem. 22, 373–404.
  • Groth, C., W. G. Alvord, O. A. Qui ones, and M. E. Fortini. 2010. Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of Notch and APP. Mol. Pharmacol. 77, 567–574.
  • Greeve, I., D. Kretzschmar, J. A. Tsch pe, A. Beyn, C. Brellinger, M. Schweizer, R. M. Nitsch, and R. Reifegerste. 2004. Age-dependent neurodegeneration and Alzheimer amyloid plaque formation in transgenic Drosophila. J. Neurosci. 24, 3899– 3906.
  • Goodson H.V., C. Valetti, and T. E. Kreis. 1997. Motors and membrane traffic. Curr. Opin. Cell Biol. 9, 18–28.
  • Ghosh, A. K., S. Gemma, and J. Tang. 2008. beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics 5, 399–408.
  • Gao, J., Y. Inagaki, X. Li, N. Kokudo, and W. Tang. 2013. Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer's disease. Drug Discov. Ther. 7, 46–57.
  • Gangwal, A., S. K. Parmar, and N. R. Sheth. 2010. Triterpenoid, flavonoids and sterols from Lagenaria siceraria fruits. Der Pharmacia Lettre 2, 307–317.
  • Furukawa, K., B. L. Sopher, R. E. Rydel, J. G. Begley, D. G. Pham, G. M. Martin, M. Fox, and M. P. Mattson. 1996. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J. Neurochem. 67, 1882–1896.
  • Francis, P. T. A. M. Palmer, M. Snape, and G. K. Wilcock. 1999. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J. Neurol. Neurosurg. Psychiatry 66, 137–147.
  • Finelli, A., A. Kelkar, H. J. Song, H. Yang, and M. Konsolaki. 2004. A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol. Cell Neurosci. 26, 365–375.
  • Finder, V. H. 2010. Alzheimer’s disease: a general introduction and pathomechanism, J. Alzheimers Dis. 22, S5–S19.
  • Ferri, C., M. Prince, C. Brayne, H. Brodaty, L. Flatiglioni, M. Ganguli, K. Hall, K. Hasegawa, H. Hendrie, Y. Huang, A. Jorm, C. Mathers, P. Menezes, E. Rimmer, and M Scazufca. 2005. Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112–2117.
  • Faria, A., M. Meireles, I. Fernandes, C. Santos-Buelga, S. Gonzalez-Manzano, M. Due as, V. de Freitas, N. Mateus, and C. Calhau. 2014. Flavonoid metabolites transport across a human BBB model. Food Chem. 149, 190–196.
  • Fabry, W., P. Okemo, and R. Ansborg. 1996. Activity of East African medicinal plants against Helicobacter pylori. Chemotherapy 42, 315–317.
  • Evin, G., and Q. X. Li. 2012. Platelets and Alzheimer’s disease: potential of APP as a biomarker. World J. Psychiatr. 2, 102–113.
  • Evin, G., G. Lessene, and S. Wilkins. 2011. BACE inhibitors as potential drugs for the treatment of Alzheimer’s disease: focus on bioactivity. Recent Pat. CNS Drug Discov. 6, 91–106.
  • Duthey, B. 2013. Background paper 6.11: Alzheimer disease and other dementias. A Public Health Approach to Innovation; Update on 2004 Background Paper. 2013, 1– 74. Available online: http://www.who.int/medicines/areas/priority medicines/BP6 11Alzheimer.pdf (Accessed: 8th March 2014).
  • Duffy, J. B. 2002. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 34, 1–15.
  • Drubin, D. G., and W. J. Nelson. 1996. Origins of cell polarity. Cell 84, 335–344.
  • Deshpande S. A., G. B. Carvalho, A. Amador, A. M. Phillips, S. Hoxha, K. J. Lizotte, and W. W. Ja. 2014. Quantifying Drosophila food intake: comparative analysis of current methodology. Nat. Methods 11, 535–540.
  • De Strooper, B., R. Vassar, and T. Golde. 2010. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99–107.
  • Danysz, W., and C. G. Parsons. 2012. Alzheimer’s disease, β-amyloid, glutamate, NMDA receptors and memantine – searching for the connections. Br. J. Pharmacol. 167, 324–352.
  • Dam, N. P., T. D. Dung, L. H. Van Long, and N. K. Phi Phung. 2010. Four triterpenoids from Hedyotis tenelliflora (Rubiaceae) growing in Vietnam. J. Chem. 48 (4B), 250–254.
  • Crowther D. C., K. J. Kinghorn, E. Miranda, R. Page, J. A. Curry, F. A. Duthie, D. C. Gubb, and D. A. Lomas. 2005. Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease. Neuroscience 132, 123–135.
  • Cox, C. J., F. Choudhry, E. Peacey, M. S. Perkinton, J. C. Richardson, D. R. Howlett, S. F. Lichtenthaler, P. T. Francis, and R. J. Williams. 2015. Dietary (–)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiol. Aging 36, 178–187.
  • Cole, S. L., and R. Vassar. 2007. The Alzheimer’s disease β-secretase enzyme, BACE 1. Mol. Neurodegener 2, 22.
  • Cleveland, D. W., S. Y. Hwo, and M. W. Kirschner. 1977. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J. Mol. Biol. 116, 227–247.
  • Citron, M. 2004b. β-secretase inhibition for the treatment of Alzheimer’s disease — promise and challenge. Trends Pharmacol. Sci. 25, 92-97.
  • Citron, M. 2004a. Strategies for disease modification in Alzheimer's disease. Nat. Rev. Neurosci. 5, 677–685.
  • Cholbi, M. R., M. Paya, and M. J. Alcaraz. 1991. Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation. Experientia 47, 195– 199.
  • Choi, Y. H., M. Y. Yoo, C. W. Choi, M. R. Cha, G. H. Yon, D. Y. Kwon, Y. S. Kim, W. K. Park, and S. Y. Ryu. 2009. A new specific BACE-1 inhibitor from the stembark extract of Vitis vinifera. Planta Med. 75, 537–540.
  • Choi, Y. H., G. H. Yon, K. S. Hong, D. S. Yoo, C. W. Choi, W. K. Park, J. Y. Kong, Y. S. Kim, and S. Y. Ryu. 2008. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med. 74, 1405–1408.
  • Choi, C. W., Y. H. Choi, M. R. Cha, Y. S. Kim, G. H. Yon, K. S. Hong, W. K. Park, Y. H. Kim, and S. Y. Ryu. 2011. In vitro BACE1 inhibitory activity of resveratrol oligomers from the seed extract of Paeonia lactiflora. Planta Med. 77, 374–376.
  • Cheon, M. S., M. Dierssen, S. H. Kim, and G. Lubec. 2008. Protein expression of BACE1, BACE2 and APP in Down syndrome brains. Amino Acids 35, 339–43.
  • Chen, Y., K. Zhou, R. Wang, Y. Liu, Y. D. Kwak, T. Ma, R. C. Thompson, Y. Zhao, L. Smith, L. Gasparini, Z. Luo, H. Xu, and F. F. Liao. 2009. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc. Natl. Acad. Sci. USA. 106, 3907–3912.
  • Chakraborty, R., V. Vepuri, S. D. Mhatre, B. E. Paddock, S. Miller, S. J. Michelson, R. Delvadia, A. Desai, M. Vinokur, D. J. Melicharek, S. Utreja, P. Khandelwal, S. Ansaloni, L. E. Goldstein, R. D. Moir, J. C. Lee, L. P. Tabb, A. J. Saunders, and D. R. Marenda. 2011. Characterization of a Drosophila Alzheimer’s disease model: pharmacological rescue of cognitive defects. PLoS ONE. 6, e20799.
  • Castro, D. M., C. Dillon, G. Machnicki, and R. F. Allegr. 2010. The economic cost of Alzheimer’s disease. Family or public-health burden? Dement. Neuropsychol. 4, 262– 267.
  • Carvalho, G. B., P. Kapahi, and S. Benzer. 2005. Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat. Methods. 2, 813–815.
  • Carmine-Simmen, K., T. Proctor, J. Tschape, B. Poeck, T. Triphan, R. Strauss, and D. Kretzschmar. 2009. Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol. Dis. 33, 274–281.
  • Caill , I., B. Allinquant, E. Dupont, C. Bouillot, A. Langer, U. Muller, and A. Prochiantz. 2004. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131, 2173–2181.
  • Caesar, I., M. Jonson, K. P. R. Nilsson, S. Thor, and P. Hammarstr m. 2012. Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PLoS ONE. 7, e31424.
  • Butterfield, D. A., A. Castegna, J. Drake, G. Scapagnini, and V. Calabrese. 2002. Vitamin E and neurodegenerative disorders associated with oxidative stress. Nutr. Neurosci. 5, 229–239.
  • Burock, J., and L. Naqvi. 2014. Practical management of Alzheimer's dementia. R. I. Med .J. 97, 36–40.
  • Burns, A., and S. Iliffe. 2009. Alzheimer's disease. BMJ. 338, b158.
  • Branca, C., I. Sarnico, R. Ruotolo, A. Lanzillotta, A. R. Viscomi, M. Benarese, V. Porrini, L. Lorenzini, L. Calz , B. P. Imbimbo, S. Ottonello, and M. Pizzi. 2014. Pharmacological targeting of the β-amyloid precursor protein intracellular domain. Sci. Rep. 4, 4618.
  • Bollag, D. M., M. D. Rozycki, and S. J. Edelstein. 1996. Protein Methods; Wiley-Liss Press: New York, US.
  • Birks, J. 2006. Cholinesterase inhibitors for Alzheimer’s disease (review). Cochrane Database of Systematic Reviews. Art. No.: CD005593. doi:10.1002/14651858.CD005593. Issue 1.
  • Binetti, G. 2009. Familial Alzheimer’s Disease. Alzheimer Europe. tinyurl.com/lr5ojvy (Accessed: 15th February 2015).
  • Begum, A. N., M. R. Jones, G. P. Lim, T. Morihara, P. Kim, D. D. Heath, C. L. Rock, M. A. Pruitt, F. Yang, B. Hudspeth, S. Hu, K. F. Faull, B. Teter, G. M. Cole, and S. A. Frautschy. 2008. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J. Pharmacol. Exp. Ther. 326, 196–208.
  • Baptista, F. I., A. G. Henriques, A. M. S. Silva, J. Wiltfang, and O. A. B. da Cruze Silva. 2014. Flavonoids as therapeutic compounds targeting key protein involved in Alzheimer’s disease. ACS Chem. Neurosci. 5, 83–92.
  • Bahadorani, S., P. Bahadorani, J. P. Phillips, and A. J. Hilliker. 2008. The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress. J. Gerontol. A Biol. Sci. Med. Sci. 63, 35–42.
  • Augustin, S., G. Rimbach, K. Augustin, R. Schliebs, S. Wolffram, and R. Cermak. 2009. Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease. Arch. Biochem. Biophys. 481, 177–182.
  • Ara jo, C. A. C., and L. L. Leon. 2001. Biological Activities of Curcuma longa L. Mem. Inst. Oswaldo Cruz. 96, 723–728.
  • Alzheimer's Association. 2014. 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 10, e47–e92.
  • Ali, Y. O., W. Escala, K. Ruan, and R. G. Zhai. 2011. Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration. J. Vis. Exp. 49, e2504.
  • Adams, M. D., S. E. Celniker, R. A. Holt, C. A. Evans, J. D. Gocayne, et al. 2000. The genome sequence of Drosophila melanogaster. Science 287, 2185–2195.