연구동향 분석
박사

폐경기 한국여성의 렙틴과 아디포넥틴 다형성과 비만-대사증후군의 연관성

홍승권 2016년

논문상세정보
인용/피인용
' 폐경기 한국여성의 렙틴과 아디포넥틴 다형성과 비만-대사증후군의 연관성' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • 의료과학 약
  • ADIPOQ
  • LEPR
  • ppar-γ
  • 단일 염기 다형성
  • 대립유전자
  • 대사증후군
  • 폐경
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
4,411 0

0.0%

' 폐경기 한국여성의 렙틴과 아디포넥틴 다형성과 비만-대사증후군의 연관성' 의 참고문헌

  • ZhaoX,XuK,ShiH,Cheng J,MaJ,GaoY,etal.Application ofthe back-errorpropagation artificialneuralnetwork (BPANN)on genetic variants in the PPAR-γ and RXR-α gene and risk of metabolicsyndromeinaChineseHanpopulation.JBiomedRes.2014; 28:114-22.
  • ZhangW,WeiD,SunX,LiJ,YuX,ShiY etal.Family-based analysisofadiponectingenepolymorphismsinchinesehanpolysystic ovariansyndrome.Fertandstert.2014;101(5):1419-23.
  • ZhangR,WangJ,YangR,SunJ,ChenR,LuoH,etal.Effects of Pro12Ala polymorphism in peroxisome proliferator-activated receptor-γ2geneon metabolicsyndromerisk:ameta-analysis.Gene. 2014;535(1):79-87.
  • Zhang Y,Proenca R,MaffeiM,BaroneM,Leopold L,Friedman JM.Positional cloning of the mouse obese gene and its human homologue.Nature.1994;372:425-32.
  • Zhang S,LiuX,YuY,Hong X,ChristoffelKK,Wang B,etal. Geneticand environmentalcontributionstophenotypiccomponentsof metabolicsyndrome:twinstudy.Obesity.2009;17:1581-7.
  • Zhang D,Ma J,Brismar K,Efendic S,Gu HF.A single nucleotide polymorphism alters the sequence ofSP1 binding site in the adiponectin promoter region and is associated with diabetic nephropathy among type 1 diabetic patients in the Genetics of KidneysinDiabetesStudy.JDiabetesComplications.2009;23:265–72
  • Zhang A,Zhang M,Zhang J,YuY,XieJ.Theinfluenceofthe Pro12Ala mutation of PPARgamma2 receptor gene on beta-cells restoration and insulin resistance in type 2 diabetes with hypertension. J Huazhong Univ Sci Technolog Med Sci. 2005;25:648-50
  • ZamboniM,MazzaliG,Fantin F,RossiA,DiFrancesco V. Sarcopenic obesity:a new category ofobesity in the elderly.Nutr MetabCardiovascDis.2008;8(5):388-95.
  • Zamboni M,Mazzali G,Zoico E,Harris TB,Meigs JB,Di FrancescoV,etal.Health consequencesofobesity in theelderly:a review offourunresolved questions.IntJ Obes (Lond).2005;29(9): 1011-29.
  • Zacharova J,Chiasson JL,Laakso M; STOP-NIDDM Study Group.Thecommon polymorphisms(SingleNucleotidePolymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes:the STOP-NIDDM trial.Diabetes.2005;54:893–9
  • Yu Z,Li W,Hou D,Zhou L,Deng Y,Tian M,et al. Relationship between Adiponectin Gene Polymorphisms and Late-OnsetAlzheimer'sDisease.PLoS One. 2015;10(4):e0130521.
  • YangJ,BakshiA,ZhuZ,HemaniG,VinkhuyzenAAE,LeeSH, et al. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.NatGenet.2015;47:1114-20.
  • Yang M, Qiu CC, Chen W, Xu LL, Yu M, Xiang HD. Identification ofa regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality.BiomedEnvironSci.2008;21:454–9.
  • YamauchiT,KamonJ,ItoY,Tsuchida A,YokomizoT,KitaS, et al. Cloning of adiponectin receptors that mediate antidiabetic metaboliceffects.Nature.2003;423:762-9.
  • Xu H,Barnes GT,Yang Q,Tan G,Yang D,Chou CJ,etal. Chronicinflammationinfatplaysacrucialroleinthedevelopmentof obesity-relatedinsulinresistance.JClinInvest.2003;112:940-5.
  • WooJG,DolanLM,DekaR,KaushalRD,ShenY,PalP,etal. Interactionsbetweennoncontiguoushaplotypesintheadiponectingene ACDC areassociatedwithplasmaadiponectin.Diabetes.2006;55:523–9.
  • WhiteDW,KuropatwinskiKK,Devos R,Baumann H,Tartaglia LA.Leptinreceptor(OB-R)signaling.Cytoplasmicdomainmutational analysisandevidenceforreceptorhomo-oligomerization.JBiolChem. 1997;272:4065-71.
  • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-808.
  • WautersM.MertensI.Chagnon M.Rankinen T,ConsidineRV, ChagnonYC, etal.Polymorphismsintheleptinreceptorgene,body composition and fatdistribution in overweightandobesewomen.Int JObes.2001;25(5):714–20.
  • Wauters M,Mertens I,Rankinen T,Chagnon M,Bouchard C, Van GaalL.Leptin receptorgenepolymorphismsareassociatedwith insulin in obese women with impaired glucose tolerance. J Clin EndocrinolMetab.2001;86:3227–32.
  • Warburton DE,NicolCW,Bredin SS.Health benefitsofphysical activity:Theevidence.CMAJ.2006;74(6):801-9.
  • Wang ZL,XiaB,ShresthaU,Jiang L,MaCW,Chen Q,etal. Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or withoutmetabolic syndrome in Chinese population.JEndocrinolInvest.2008;31:1086–91.
  • WHO. Global status report on noncommunicable diseases. 2014:1-298.
  • VozarovaDeCourten B, Hanson RL,FunahashiT,Lindsay RS, MatsuzawaY,etal.Common polymorphismsintheadiponectin gene ACDC are notassociated with diabetes in Pima Indians.Diabetes. 2005;54(1):284–9
  • Vozarova B,Weyer C,Lindsay RS,Pratley RE,Bogardus C, TataranniPA.High white blood cellcount is associated with a worsening ofinsulin sensitivity andpredictsthedevelopmentoftype 2diabetes.Diabetes.2002;51:455–61.
  • VionnetN,HaniEH, DupontS, GallinaS,FranckeS,DotteS, etal.Genomewidesearch fortype2diabetes-susceptibility genesin French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosiome 3q27-qter and independent replicationofatype2-diabeteslocusonchromosome1q21-q24.Am J Hum Genet.2000;67(6):1470-80.
  • Vidal-Puig AJ,Considine RV,Jimenez-Linan M,Werman A, PoriesWJ,Caro JF,etal.Peroxisome proliferator-activated receptor geneexpressioninhumantissues.Effectsofobesity,weightloss,and regulation by insulin and glucocorticoids. J Clin Invest. 1997;99:2416-22.
  • VerduciE,ScaglioniS,AgostoniC,RadaelliG,BiondiM,Manso AS,etal.TherelationshipofinsulinresistancewithSNP 276G>T at adiponectingeneandplasmalong-chainpolyunsaturatedfattyacidsin obesechildren.PediatrRes.2009;66:346–9.
  • VattikukiS,GuoJ,Chow CC.Heritability andgeneticcorrelations explained by common SNPsmetabolicsyndrometraits.PLoS Genet. 2012;8(3):1-8.
  • VasseurF,HelbecqueN,LobbensS,Vasseur-Delannoy V,Dina C,Cl mentK,etal.Hypoadiponectinaemia and high risk oftype 2 diabetes are associated with adiponectin-encoding (ACDC) gene promotervariantsin morbidobesity:evidenceforaroleofACDC in diabesity.Diabetologia.2005;48:892–9.
  • VasseurF,HelbecqueN, DinaC,LobbensS,DelannoyV,Gaget S, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.Hum Mol Genet.2002;11(21):2607–14
  • Tucholski K,Otto-Buczkowska E.The role of leptin in the regulation ofcarbohydrate metabolism.EndokrynolPol.2011;62:258–62.
  • Tsuzaki K, Kotani K, Naga N. Adiponectin gene single-nucleotide polymorphisms and treatmentresponse to obesity. JournalofEndocrinologicalInvestigation.2009;32(5):395–400.
  • TsaiMK,Wang HM,Shiang JC,ChenIH,Wang CC,ShiaoYF et al.Squence variants of ADIPOQ and association with type 2 diabetes mellitus in Taiwan Chinese Han population.SciWorld J. 2014;2014:650393.
  • Tontonoz P,Hu E,Graves RA,BudavariAI,Spiegelman BM. mPPAR gamma2:tissue-specificregulatorofan adipocyteenhancer. GenesDev.1994;8:1224-34.
  • Tonjes A,Scholz M,Loeffler M,StumvollM.Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gammawith Pre-diabeticphenotypes:meta-analysisof57studieson nondiabeticindividuals.DiabetesCare. 2006;29:2489-97.
  • TartagliaLA,DembskiM,Weng X,Deng N,CulpepperJ,Devos R,etal.Identification and expression cloning ofa leptin receptor, OB-R.Cell.1995;83:1263-71.
  • Suh YS, Kim DH, Kim SK, Lee IK, Kim HS. Pro12Ala polymorphisms ofthe PPARγ2 gene and fatdistribution in korean obesepatients.KoreanJObes.2001;10(2):182-9.
  • Simkin-Silverman LR,Wing RR,BorazMA,KullerLH.Lifestyle intervention can preventweightgain during menopause:resultsfrom a5-yearrandomizedclinicaltrial.AnnBehavMed.2003;26(3):212-20.
  • Semple RK, Chatterjee VK, O'Rahilly S. PPAR gamma and human metabolic disease. J Clin Invest 2006;116:581-9.
  • SchererPE,Williams S,Fogliano M,BaldiniG,Lodish HF.A novel serum protein similar to C1q, produced exclusively in adipocytes.JBiolChem.1995;270:26746–9.
  • SchafflerA,Schomerich J.Innate immunity and adipose tissue biology.TrendsImmunol,2010;30:228-35.
  • SavinoF,LiguoriSA. Updateon breastmilk hormones:leptin, ghrelinandadiponectin.ClinNutr.2008;27(1):42-7.
  • SamatA,Rahim A,BarnettA.Pharmacotherapy forobesity in menopausalwomen.MenopauseInt.2008;14(2):57-62.
  • S ezME, GriloA, Mor nFJ, ManzanoL, Mart nez-LarradMT, Gonzalez-PerezA,etal.Interaction between Calpain 5, peroxisome proliferator-activated receptor-gamma and peroxisome proliferator-activated receptor-delta genes:a poligenic approach to obesity.CardiovascDiabetol.2008;25:7-23
  • Roszkowska-GancarzM,KurylowiczA,Polosak J,Mossakowska, M,FranekE,Puzianowska-KuźnickaM.Functionalpolymorphismsof theleptinandleptinreceptorgenesareassociatedwithlongevityand withtheriskofmyocardialinfarctionandoftype2diabetesmellitus. EndokrynologiaPolska.2014;65(1):11-6
  • RosmondR,ChagnonYC,Holm G,etal.Hypertensioninobesity and the leptin receptor gene locus. J Clin Endocrinol Metab. 2000;85(9):3126–31.
  • Rosano GM,VitaleC,MarazziG,VolterraniM.Menopauseand cardiovascular disease: the evidence. Climacteric. 2007; 10 (Suppl 1):19-24.
  • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulatorofmacrophageactivation.Nature.1998;391(6662):79-82.
  • Richter V, Purschwitz K, Rassoul F, Thiery J, Zunft HJ, Leitzmann C.Effects of diet modification on cardiovascular risk: resultsfrom theLeipzigWholesomeNutritionStudy.AsiaPacJClin Nutr.2004;13(Suppl):S106.
  • RheeEJ,Oh KW,Yun EJ,Jung CH,Park CY,LeeWY,etal. The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-g gene with serum osteoprotegerin levelsinhealthyKoreanwomen.ExpMolMed.2007;39:696-704.
  • RheeEJ,Oh KW,LeeWY,Kim SY,Oh ES,Baek KH,etal. The effects ofC161―>T polymorphisms in exon 6 ofperoxisome proliferator-activated receptor-gamma gene on bone mineral metabolism and serum osteoprotegerin levels in healthy middle-aged women.Am JObstetGynecol.2005;192:1087-93.
  • RheeEJ,Oh KW,LeeWY,Kim SY,Oh ES,Baek KH,etal. Effects of two common polymorphisms of peroxisome proliferator-activated receptor-γ gene on metabolic syndrome. Arch MedRes.2006;37:86–94.
  • Reddy NL,Tan BK,BarberTM.Randeva HS.Brown adipose tissue: endocrine determinants of function and therapeutic manipulationasanoveltreatmentstrategy forobesity.BMC Obesity 2014;1:13
  • QiLU.LiT.Rimm E.Zhang C,RafaiN,HunterD.The+276 polymorphism ofthe APM1 gene,plasma adiponectin concentration, andcardiovascularriskindiabeticmen. Diabetes.2005;54(5)1607-10.
  • QiL,DoriaA,Manson JE,MeigsJB,HunterD,MantzorosCS, et al. Adiponectin genetic variability, plasma adiponectin, and cardiovascularrisk in patients with type 2 diabetes.Diabetes.2006; 55:1512–6.
  • PovelCM,BoerJMA,ReilingE,FeskensJM.Geneticvariantsand the metabolic syndrome:a systematic review.Obes Rev.2011;12: 952-67.
  • Poehlman ET, Toth MJ, Ades PA, Rosen CJ. Menopause-associated changes in plasma lipids,insulin-like growth factorIand blood pressure:a longitudinalstudy.EurJClin Invest. 1997;27:322–6.
  • Pietilainen KH,Kannisto K,Korsheninnikova E,Rissanen A, Kaprio J,Ehrenborg E,etal.Acquired obesity increase CD68 and tumornecrosisfactor-alphaanddecreasesadiponectingeneexpression in adipose tissue:a study in monozygotic twins.J Clin Endocrinol Metab.2006;91(7):2776-81.
  • Park KS,Shin HD,Park BL,Cheong HS,ChoYM,LeeHK,et al.Polymorphismsin theleptin receptor(LEPR)―putativeassociation withobesityandT2DM.JHum Genet.2005;51:85-91.
  • Park E,ChoiSJ,LeeHY.ThePrevalenceofMetabolicSyndrome and Related Risk FactorsBased on theKNHANES V 2010.JAgric MedCommunityHealth.2013;38(1):1-13.
  • Palou A,S nchezJ,Pic C. Nutrient-geneinteractionsin early life programming:leptin in breastmilk prevents obesity lateron in life.AdvExpMedBiol.2009;646:95-104.
  • OreopoulosA,Kalantar-ZadehK,SharmaAM,Fonarow GC.The obesity paradox in the elderly: potential mechanisms and clinical implications.ClinGeriatrMed. 2009;25(4):643-59
  • Ong KL,LiM,Tso AW,Xu A,Cherny SS,Sham PC,etal. adiponectin leveland hypertension in Hong Kong Chinese.Eur J Endocrinol.2010;163:251–7.
  • Olswang Y,CohenH,PapoO,CassutoH,CronigerCM,Hakimi P etal.A mutation in theperoxisomeproliferator-activated receptor gamma-bindingsite in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fatcontentinmice.ProcNatlAcadSci.U S A.2002;99:625-30.
  • Oliveira Rd,Cerda A,GenvigirFD,Sampaio MF,Armaganijan D, Bernik MM, et al. Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals.ArqBrasEndocrinolMetabol.2013;57(9):677-84.
  • Olefsky JM,Glass CK.Macrophage,Inflammation,and Insulin resistance.AnnuRevPhysilol.2010;72:219-46.
  • Odegaard JI Ricardo-Gonzalez RR,Goforth MH,Morel CR, Subramanian V, Mukundan L, et al. Macrophage-specific PPARgamma controls alterenative activation and improves insulin resistance.Nature.2007;447(7148):1116-20.
  • NakataniK,NomaK,NishiokaJ,KasaiY,MoriokaK,Katsuki A,etal.Adiponectin gene variation associates with the increasing risk oftype2diabetesin non-diabeticJapanesesubjects.IntJMol Med.2005;15:173–7.
  • NagataniS,GuthikondaP,Thompson RC,Tsukamura H,Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced LH secretion during fasting. Neuroendocrinology.1998;67:370-6.
  • Nadal-Casellas A,Proenza AM,Llad I,GianottiM.Effects of ovariectomy and 17-β estradiolreplacement on rat brown adipose tissuemitochondrialfunction.Steroids.2011;76:1051-6.
  • Musso G,Gambino R,De MichieliF,Durazzo M,Pagano G, Cassader M. Adiponectin Gene Polymorphisms Modulate Acute Adiponectin Responseto Dietary Fat:PossiblePathogeneticRolein NASH.Hepatology.2008;47:1167-77
  • MuellerE,DroriS,AiyerA,Yie J,SarrafP,Chen H,etal. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem. 2002;277:41925-30.
  • Mousavinasab F,T htinen T,Jokelainen J,Koskela P,Vanhala M,Oikarinen J, et al.Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in youngFinnishmen.MolGenetMetab.2006;87:147–51.
  • MorandiA,Maffeis C,Lobbens S,Bouatia-NajiN,Heude B, PinelliL,etal.Earlydetrimentalmetabolicoutcomesofrs17300539-A AlleleofADIPOQ genedespitehigheradiponectinemia.Obesity.2010; 18:1469–73.
  • Montagnana M,Fava C,Nilsson PM,Engstrom G,Hedblad B, Lippi,G etal.ThePro12Alapolymorphism ofthePPARG geneisnot associated with the metabolic syndrome in an urban population of middle-agedSwedishindividuals.DiabetMed.2008;25(8):902-8
  • Mohammadzadeh G, Zarghami N. Associations between single-nucleotide polymorphisms of the adiponectin gene, serum adiponectin levels and increased risk oftype 2 diabetes mellitus in Iranianobeseindividuals.ScandJClinLabInvest.2009;69:764–71.
  • MinistryofHealthandWelfare,KoreaCentersforDiseaseControl andPrevention(2013),KoreaHealthStatistics. KoreaNationalHealth and Nutrition Examination Survey (KNHANES V-3).Korea Centers forDiseaseControlandPrevention(Cheongwon):ROK.2012.
  • MenzaghiC,ErcolinoT,SalveminiL,CocoA,Kim SH,FiniG, etal.Multigeniccontrolofserum adiponectin levels:evidencefora role ofthe APM1 gene and a locus on 14q13.PhysiolGenomics. 2005;19:170–4.
  • MenzaghiC,Ercolino T,DiPaola R,Berg AH,Warram JH, SchererPE,etal.A haplotypeattheadiponectin locusisassociated with obesity and otherfeatures ofthe insulin resistance syndrome. Diabetes.2002;51:2306–12.
  • Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance,type2 diabetes,and cardiovascular disease.Diabetes.2007;56(5):1198-209.
  • Melistas L,Mantzoros CS,KontogianniM,Antonopoulou S, Ordovas JM, Yiannakouris N. Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistanceinnondiabeticGreekwomen.EurJEndocrinol.2009;161:845–52.
  • MeirhaegheA ,CottelD,AmouyelP,DallongevilleJ.Association between peroxisome proliferator-activated receptorγ haplotypes and the metabolic syndrome in French men and women. Diabetes. 2005;54:3043-8.
  • McGorrianC,YusufS,Islam S,JungH,RangarajanS ,Avezum A.Estimating modifiable coronary heart disease risk in multiple regionsoftheworld:theINTERHEART ModifiableRiskScore.Eur HeartJ.2011;32:581–90
  • Matsushita M,Yoneshiro T,Aita S,Kamiya T,Kusaba N, Yamaguchi K, et al. Kaempferia parviflora extract increases whole-body energy expenditure in humans:Roles ofbrown adipose tissue.JNutrSciVitaminol. 2015;61(1):79-83.
  • Martinez FO,Helming L,Gordon S.Alternative activation of macrophage: an immunologic functional perspective. Ann Rev Immunol.2009;17:451-83.
  • Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activationandpolarization.FrontBiosci.2008;13:453–61
  • Markelic M, Velickovic K, Golic I, Otasevic V, Stancic A, JankovicA.Endothelialcellapoptosisinbrownadiposetissueofrats induced by hyperinsulinaemia:the possible role of TNF-α.Eur J Histochem.2011;55(4):e34.
  • MansooriA,AminiM,KolahdoozF,Seyedrezazadeh E.Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-GammaGenein Healthy Adults:A SystematicReview and Meta-Analysis.AnnNutrMetab.2015;67:104-18
  • Mackevics V,Heid IM,Wagner SA,Cip P,Doppelmayr H, LejnieksA,etal.Theadiponectingeneisassociatedwithadiponectin levelsbutnotwith characteristicsoftheinsulin resistancesyndrome inhealthyCaucasians.EurJHum Genet.2006;14:349–56.
  • Ma XH,MuzumdarR,Yang XM,Gabriely I,BergerR,Barzilai N.Aging is associated with resistance to effects ofleptin on fat distribution and insulin action.JGerontolA BiolSciMed Sci.2002; 57:B225–31.
  • Lydia F, Suliya M, Laurent L, Segho H, Jacqueline D, Marie-OdileJ,etal. Adiponectin genevariants,adiponectinisoforms and cardiometabolic risk in type 2 diabetic patients. J Diabetes Investig.2014;5(2):192-8.
  • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175-84.
  • Low CF,Mohd Tohit ER,Chong PP,Idris F.Adiponectin SNP45TG is associated with gestational diabetes mellitus. Arch GynecolObstet.2011;283(6):1255-60.
  • Lovejoy JC,Champagne Cm,Jonge L de,Xie H,Smith SR. Increased visceralfatand decreased energy expenditure during the menopausaltransition.IntJObes.2008;32:949-58.
  • LockeAE,KahaliB,BerndtSI,JusticeAE,PersTH,Day FR, etal.Genetic studies ofbody mass index yield new insights for obesitybiology.Nature.2015;518(7538):197-205.
  • Liu YJ,Rocha-SanchezSMS ,Liu PY, Long JR,Lu Y,ElzeL, et al. Tests of linkage and/or association of the LEPR gene polymorphismswithobesityphenotypesinCaucasiannuclearfamilies. PhysiolGenomics.2004;17:101–6.
  • Lindsay RS,UnahashiT.Krakoff FJ,MatsuzawaY,TanakaS, KobesS,etal. Genome-widelinkageanalysisofserum adiponectin inthePimaIndianpopulation.Diabetes.2003;52(9):2419–25.
  • LinHF,Boden-AlbalaB,JuoSH,ParkN,RundekT,SaccoRL. etal.Heritabilitiesofthemetabolicsyndromeand itscomponentsin theNorthernManhattanFamilyStudy.Diabetologia.2005;48:2006-12.
  • Lim S,Shin H,Jung HS,Kwak SH,Kang SM,Yoon JW,etal. Increasing Prevalence ofMetabolic Syndrome in Korea The Korean NationalHealth and Nutrition Examination Survey for 1998–2007. DiabetesCare.2011;34(6):1323-8.
  • LiS,Chen W,Srinivasan SR,BoerwinkleE,Berenson GS.The peroxisomeproliferator-activatedreceptor-gamma2genepolymorphism (Pro12Ala)beneficially influences insulin resistance and its tracking from childhood to adulthood:the Bogalusa Heart Study.Diabetes. 2003;52:1265-9.
  • LiP,JiangR,LiL,LiuC,YangF,QiuY.Correlationofserum adiponectin and adiponectin gene polymorphism with metabolic syndromeinChineseadolescents.EurJClinNutr. 2015;69(1):62-7.
  • LiLL,Kang XL,Ran XJ,Wang Y,Wang CH,Huang L,etal. Associations between 45T/G polymorphism ofthe adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp PharmacolPhysiol.2007;34:1287–90.
  • LeeYY,LeeNS,ChoYM,MoonMK,JungHS,ParkYJ,etal. Genetic association study ofadiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population.Diabetic Medicine. 2005;22:569–75.
  • LeeJY,ChoJK,HongHR,JinYY,KangHS.Geneticeffectsof adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults.EurJ ApplPhysiol. 2012;112(2):623-9
  • LapiceE,VaccaroO.InteractionbetweenPro12Alapolymorphism ofPPARγ2 and dieton adiposity phenotypes.CurrAtherosclerRep. 2014;16(12):462.
  • Lamarche B,MoorjaniS,Cantin B,Dagenais GR,Lupien PJ, Despres JP. Associations of HDL2 and HDL3 subfractions with ischemic heartdisease in men.Prospective results from the Quebec CardiovascularStudy.ArteriosclerThrombVascBiol. 1997;17:1098– 105.
  • L pez-JaramilloP,G mez-Arbel ezD,L pez-L pezJ,L pez-L pez C, Mart nez-Ortega J, G mez-Rodr guez A, et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes.Horm Mol BiolClinInvestig.2014;18(1):37-45.
  • KyriakouT,CollinsLJ,Spencer-JonesNJ,Malcolm C,Wang X, SniederH, etal.Adiponectin geneADIPOQ SNP associationswith serum adiponectin in twofemalepopulationsandeffectsofSNPson promoteractivity.JHum Genet.2008;53:718–27.
  • Kurokaw J,NaganoH,AraiS,MiyazakiT,OharaO,KubotaN. Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adiposetissue.ProcNatlAcadSci.2011;108(29):12072-7
  • KosteliA,SugaruE,HaemmerleG,MartinJF,LeiJ,ZechnerR, etal.Weightlossandlipolysispromoteadynamicimmuneresponse inmurineadiposetissue.JclinInvest.2010;120(10):3466-79.
  • Koleva DI, Orbetzova MM, Atanassova PK. Adipose tissue hormones and appetite and body weight regulators in insulin resistance.FoliaMed(Plovdiv).2013;55:25-32.
  • Kolehmainen M,Uusitupa MI,Alhava E,Laakso M,VidalH. Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massivelyobesesubjects.JClinEndocrinolMetab.2003;88:1717-22.
  • KolaczynskiJW,Ohanneisian J,Considine RV,Marco CC,Caro JF.Response ofleptin to short-term and prolonged overfedding in humans.JClinEndocrinolMetab.1996;81:4162-5.
  • Kim MH, Kim MK, Choi BY, Shin YJ. Prevalence of the metabolic syndrome and its association with cardiovascular diseases in Korea. J Korean Med Sci 2004;19(2):195-201.
  • Kim M,Kim J,BaeW,Kim S,LeeY,NaW,etal.Relationship between Nutrientsintakes,dietary quality,and serum concentrations ofinflammatory markers in metabolic syndrome patients.Korean J CommunityNutr.2011;16(1):51-61.
  • Kim KS,ChoiSM,Shin SU,Yang HS,Yoon Y.Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects. Metabolism. 2004;53:1538-43.
  • Kim JY,LeeHB,Lim SH,LeeBW,Baik HW,Kim YO etal. Association between Polymorphisms of Leptin Receptor and Hypercholesterolemia,Hypertension,andObesityinKoreanPopulation. JournalofKoreanSocietyofStressMedicine.2011;19(2):155-63.
  • Kim HM,Park J,Ryu SY,Kim J.Theeffectsofmenopauseon themetabolicsyndromeamong Korean Women:theKorean National Health and Nutrition Examination Survey. Diabetes Care. 2007;30(3):701-6.
  • Kang K, Reilly SM,Karabacak V,GanglMR,Fitzgerald K, Hatano B, et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. CellMetab.2008;7(6):485-95.
  • KaklamaniVG,WisinskiKB,Sadim M,GuldenC,DoA,OffitK, etal.Variantsoftheadiponectin (ADIPOQ)andadiponectin receptor 1(ADIPOR1)genesandcolorectalcancerrisk.JAMA.2008;300:1523– 31.
  • Juhan VI, Alessi MC. Regulation of fibrinolysis in the development of atherothrombosis: role of adipose tissue. Thromb Haemost.1999;82:832-6.
  • Joo JK,Son JB,Jung JE,Kim SC,Lee KS.Differences of prevalence and components of metabolic syndrome according to menopausalstatus.JKoreanSocMenopause.2012;18(3):155-62.
  • Janssen I,PowellLH,Crawford S,Lasley B,Sutton-tyrrelS. Menopause and the metabolic syndrome? - The study ofwomen's healthacrossthenation.ArchInternMed.2008;168(14):1568-75.
  • Jang Y,Lee JH,Chae JS,Kim OY,Koh SJ,Kim JY,etal. Association ofthe 276G→T polymorphism ofthe adiponectin gene withcardiovasculardiseaseriskfactorsinnondiabeticKoreans.Am J ClinNutr.2005;82:760–7.
  • JananiC,RanjithaKumariBD.PPAR gammagene– A review. DiabetesMetabSyndr.2015;9(1):46-50
  • Iwashima Y,Katsuya T,Ishikawa K,Ouchi N,Ohishi M, SugimotoK,etal.Hypoadiponectinemiaisanindependentriskfactor forhypertension.Hypertension.2004;43:1318–23.
  • IppeiS,YohkoY,TaroK,TohruM.Adiposetissueinflammation indiabetesandheartfailure.MicrobesInfect.2013;15(1):11-7
  • Huang MC,Wang TN,LeeKT,Wu YJ,Tu HP,Liu CS,etal. AdiponectingeneSNP276variantsandcentralobesityconferrisksfor hyperglycemia in indigenous Taiwanese. Kaohsiung J Med Sci. 2010;26:227–36.
  • Huang JT, Welch JS,RicoteM,BinderCJ,Willson TM,Kelly CW, et al. Interleukin-4-dependent PPARgamma ligands in macrophagesby12/15-lipoxygenase.Nature.1999;400(6742):378-82.
  • Hu E,Liang P,Spiegelman BM.AdipoQ is a noveladiposespecific gene dysregulated in obesity.JBiolChem.1996;271:10697– 703.
  • Hotta K,Funahashi T,Arita Y,Takahashi M,Matsuda M, Okamoto Y. Plasma concentrations of a novel, adipose-specific protein,adiponectin in type 2 diabetic patients.ArteriosclerThromb VascBiol.2000;20:1595-9.
  • HoefleG,Muendlein A,Saely CH,Risch L,Rein P,Koch L,et al. The -11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular eventsinmen.ThrombHaemost.2007:97;451–7.
  • HivertMF,Manning AK,McAteerJB,FlorezJC,DupuisJ,Fox CS.Common variants in the adiponectin gene (ADIPOQ)associated with plasma adiponectin levels,type2 diabetes,and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008;57(12):3353-9.
  • HindorffLA,Sethupathy P,JunkinsHA,RamosEM,MehtaJP, Collins FS,etal.Potentialetiologic and functionalimplications of genome-wide association locifor human diseases and traits.Proc NatlAcadSciUSA.2009;106(23):9362-7.
  • HesslinkRL,D'AlesandroMM,ArmstrongDW,ReedHL.Human cold air habituation is independentofthyroxine and thyrotropin.J ApplPhysiol.1992;72(6):2134-9.
  • HennemanP,AulchenkoYS,FrantsRR,ZorkoltsevaIV,Zillikens MC,Frolich M,et al.Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits. DiabetesCare.2010;33(4):908-13.
  • Harman-Boehm I,Bl herM,RedelH,Sion-Vardy N,Ovadia S, Avinoach E, et al. Macrophage infiltration into omental versus subcuteneous fat across different populations: effect of regional adiposity and the comorbidities ofobesity.JClin EndocrinolMetab. 2007;92(6):2240-7.
  • HaraK,OkadaT,TobeK,YasudaK,MoriY,KadowakiH, et al.The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun. 2000;271:212-6.
  • HaraK,Boutin P,MoriY,TobeK,DinaC,YasudaK, etal. Geneticvariation in thegeneencoding adiponectin isassociatedwith an increased risk of type 2 diabetes in the Japanese population. Diabetes.2002;51:536–40.
  • Han TS,TajarA,Lean ME. Obesity and weightmanagement intheelderly.BrMedBull.2011;97:169-96.
  • Han MS. Metabolic syndrome emerging from menopause. J KoreanSocMenopause.2011;17(3):127-35.
  • Han HR,Ryu H-J,Cha HS, Go MJ,Ahn Y,Koo BK,etal. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Koreanfemalepopulation.ClinGenet.2008;74:105-15.
  • Guo X,Saad MF,Langefeld CD,WilliamsAH,CuiJ,Taylor KD,et al.Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structuralgene:theIRAS Family Study. Diabetes.2006;55(6)1723–30.
  • Gu zar-Mendoza JM, Amador-Licona N,Flores-Mart nez SE, L pez-Cardona MG, Ahuatzin-Tr mary R, S nchez-Corona J. Association analysis ofthe Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents.JHum Hypertens.2005;19(5)341–6.
  • Gu HF.Biomarkersofadiponectin:plasmaprotein variation and genomicDNA polymorphisms.BiomarkInsights.2009;4:123–33.
  • Gu HF,AbulaitiA,Ostenson CG,HumphreysK,WahlestedtC, Brookes AJ,etal.Single nucleotide polymorphisms in the proximal promoterregion oftheadiponectin (APM1)geneareassociated with type2diabetesinSwedishCaucasians.Diabetes2004;53:S31–5
  • Gorska E, Popko K, Stelmaszczyk-Emmel A, Ciepiela O, Kucharska A, Wasik M. Leptin receptors. Eur. J. Med. Res. 2010;15(Suppl2):50-4.
  • Gonzalez Sanchez JL,Serrano Rios M,Fernandez Perez C, LaaksoM,MartinezLarradMT.EffectofthePro12Alapolymorphism ofthe peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population.EurJEndocrinol.2002;147:495-501.
  • Gonz lez-S nchez JL1, Zabena CA, Mart nez-Larrad MT, Fern ndez-P rezC,P rez-BarbaM,LaaksoM,etal.AnSNP inthe adiponectin gene is associated with decreased serum adiponectin levelsand risk forimpaired glucosetolerance.ObesRes.2005;13:807–12.
  • Gonz lez-S nchez JL, Zabena CA, Mart nez-Larrad MT, Fern ndez-P rezC,P rez-BarbaM,LaaksoM,etal.AnSNP inthe adiponectin gene is associated with decreased serum adiponectin levelsand risk forimpaired glucosetolerance.ObesRes.2005;13:807–12.
  • Gibson F.Froguel P.Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes.2004;53(11):2977–83.
  • Ghanim H,AljadaA,HofmeyerD,SyedT,Mohanty P,Dandona P. Circulating mononuclear cells in the obese are in a proinflammatorystate.Circulation.2004;110:1564–71.
  • Garofalo C,SurmaczE.Leptin and cancer.JCellPhysiol.2006; 207:12–22.
  • Fumeron F,AubertR,SiddiqA,BetoulleD,P anF,HadjadjS, et al.Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistancesyndromeprospectivestudy.Diabetes.2004;53:1150–7.
  • Frederiksen L, Br dbaek K, Fenger M, J rgensen T, Borch-Johnsen K, Madsbad S, et al. Comment: studies of the Pro12Alapolymorphism ofthePPAR-γ geneintheDanish MONICA cohort:homozygosityoftheAlaalleleconfersadecreasedriskofthe insulin resistance syndrome.JClin EndocrinolMetab.2002;87:3989–92.
  • Francke S,ManrajM.LacquemantC,Lecoeur C,Lepr tre F, Passa P,et al.A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum MolGenet.2001;10(24):2751–65.
  • Fornage M,Jacobs DR,Steffes MW,Gross MD,Bray MS, Schreiner PJ. Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA study. Metabolism. 2005;54:910-7.
  • FordES.Risksforall-causemortality,cardiovasculardisease,and diabetesassociated with themetabolicsyndrome:a summary ofthe evidence.DiabetesCare.2005;28(7):1769-78.
  • FilippiE,SentinelliF,RomeoS,ArcaM,BerniA,TibertiC, et al.The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age ≤50 years).J Mol Med.2005;83:711–9.
  • Ferguson JF, Phillips CM, Tierney AC, P rez-Mart nez P, DefoortC,HelalO,etal.Gene-nutrientinteractionsin themetabolic syndrome:singlenucleotidepolymorphismsinADIPOQ andADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.Am JClinNutr.2010;91:794–801.
  • FeiH,Okano HJ,LiC,Lee GH,Zhao C,DarnellR,et al. Anatomic localization ofalternatively spliced leptin receptors (Ob-R) inmousebrainandothertissues.ProcNatlAcadSci.1997;94:7001-5.
  • Fantuzzi G. Adipose tissue,adipokines,and inflammation.J AllergyClinImmunol. 2015;115(5):911-20.
  • Fantuzzi G. Adipose tissue, adipokines and inflammation. J Allergy Clin Immunol. 2005;115:911-9.
  • F veB,BastardJP.Theroleofinterleukinsin insulin resistance andtype2diabetesmellitus.NatRevEndocrinol.2009;5:305–11.
  • EspositoK,NappoF,GiuglianoF,DiPaloC,CiotolaM,Barbieri M, et al. Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type2diabetesmellitus.Am JClinNutr.2003;78(6):1135-40
  • DuggalPS,VanDerHoekKH,MilnerCR,RyanNK,Armstrong DT, Magoffin DA, et al. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat.Endocrinology.2000;141: 1971-6.
  • Dubnov-Raz G, Pines A. Berry EM. Diet and lifestyle in managingpostmenopausalobesity.Climacteric.2007;10(Suppl2):38-41.
  • Dubnov G,BrzezinskiA,Berry EM.Weight controland the managementofobesity aftermenopause:theroleofphysicalactivity. Maturitas.2003;44(2):89-101
  • DomeniciFA,Brochado MJ,MartinelliAde L,Zucoloto S,da Cunha SF,VannucchiH.Peroxisome proliferator-activated receptors alphaandgamma2polymorphismsin nonalcoholicfatty liverdisease: astudyinBrazilianpatients.Gene.2013;529:326-31.
  • Deeb SS,Fajas L,Nemoto M,PihlajamakiJ,Mykkanen L, KuusistoJ,etal.A Pro12AlasubstitutioninPPARgamma2associated with decreased receptor activity, lower body mass index and improvedinsulinsensitivity.NatGenet.1998;20:284-87
  • Dan L,Lin T,Yanping W,ChaoC,ZaichunD.Leptin andleptin receptor gene polymorphisms in obstructive sleep apnea:a HuGE review andmeta-analysis.SleepBreath.2015;19:1073-8
  • Cypess AM,Lehman S,WilliamsG,TalI,Rodman D,Goldfine AB,etal.Identification and importance ofbrown adipose tissue in adulthumans.N EnglJMed.2009;360:1509-17
  • CorsonelloA,MalaraA,DeDomenicoD, PerticoneF,ValentiA, BuemiM,etal.Identifying pathways involved in leptin-dependent aggregationofhumanplatelets.IntJObesRelatMetabDisord.2004; 28:979–84.
  • ConsidineRV,ConsidineEL,WilliamsCJ,NyceMR,MagosinSA, BauerTL,etal.Evidenceagainsteithera prematurestop codon or the absence ofobese gene mRNA in human obesity.JClin Invest. 1995;95:2986-8.
  • ComuzzieAG,FunahashiT,SonnenbergG, MartinLJ,JacobHJ, BlackAE,etal.Thegeneticbasisofplasmavariationinadiponectin, a globalendophenotype for obesity and the metabolic syndrome.J ClinEndocrinolMetab.2001;86(9)4321-5.
  • Coelho M,Oliveira T,Fernandes R. Biochemistry ofadipose tissue:anendocrineorgan.ArchMedSci.2013;9(2):191-200.
  • Chung HK,Chae JS,Hyun Y.Influence ofadiponectin gene polymorphisms on adiponectin leveland insulin resistance index in response to dietary intervention in overweight-obese patients with impairedfastingglucoseornewlydiagnosedtype2diabetes.Diabetes Care.2009;32(4):552–8.
  • Chuang LM,Chiu YF,W.Sheu HH,Hung YJ,HoLT,GroveJ, etal. Biethniccomparisonsofautosomalgenomicscanforlocilinked toplasmaadiponectininpopulationsofchineseandJapaneseorigin.J ClinEndocrinolMetab.2004;89(11):5772-8.
  • Chinetti G, GriglioS,AntonucciM,TorraIP,DeleriveP,Majd Z, et al. Activation of proliferator-activated receptors alpha and gammainducesapoptosisofhumanmonocyte-derivedmacrophages.J BiolChem.1998;273(40):255573-80.
  • Chen Y,Copeland WK,Vedanthan R,GrantE,LeeJE,Gu D,et al. Associationbetweenbody massindex andcardiovasculardisease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium. BMJ. 2013; 347:f5446
  • Chen L,Velasco Mondrag n HE,Lazcano-Ponce E,Collins A, ShugartYY.Effectoftheperoxisomeproliferators-activated receptor (PPAR) gamma 3 gene on BMI in 1,210 school students from Morelos,Mexico.PacSympBiocomput.2006:467-77.
  • ChehaibiK,NouiraS,MahdouaniK,HamdiS,RouisM,Slimane MN.Effectofthe PPARγ C161T gene varianton serum lipids in ischemicstrokepatientswith andwithouttype2diabetesmellitus.J MolNeurosci2014;54:730-8.
  • CharriereG,CousinB,ArnaudE,AndreM,BacouF,PenicaudL, etal.Preadipocyteconversiontomacrophage,Evidenceofplasticity.J BiolChem.2003;278:9850-5.
  • Carroll S, Borkoles E, Polman R. Short-term effects of a non-dieting lifestyle intervention program on weight management, fitness, metabolic risk, and psychological wellbeing in obese premenopausalfemales with the metabolic syndrome.ApplPhysiol NutrMetab.2007;32(1):125-42.
  • Caro JF,Sinha MK,KolaczynskiJW,Zhang PL,Considine RV. Leptin:thetaleofanobesitygene.Diabetes.1996;45:1455-62.
  • Bruun JM,Helge JW,Richelsen B,Stallknecht B.Diet and exercisereducelow-gradeinflammationandmacrophageinfiltrationin adiposetissuebutnotin skleletalmusclein severely obesesubjects. Am JPhysiolEndocrinolMetab.2006;290(5):E961-7.
  • BrownJB.fat:areview.Metabolism.1959;8:221-40.
  • Bouret SG. Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutrition Workshop Series: PediatricProgram.2010;65:25-39.
  • Bouatia-NajiN,Meyre D,Lobbens S,S ron K,Fumeron F, BalkauB,etal.ACDC/adiponectinpolymorphismsareassociatedwith severechildhoodandadultobesity.Diabetes2006;55:545–50.
  • Bouatia-NajiN,Meyre D,Lobbens S, S ron K,Fumeron F, Balkau B,et al. ACDC/adiponectin polymorphisms are associated withseverechildhoodandadultobesity.Diabetes.2006;55(2):545–50.
  • Bosy-WestphalA,OnurS,GeislerC,WolfA,Korth O,etal. Commonfamilialinfluencesonclusteringofmetabolicsyndrometraits withcentralobesityandinsulinresistance:theKielobesityprevention study.IntJObesity.2007;31:784-90.
  • BohlerH Jr,Mokshagundam S,Winters SJ.Adipose tissue and reproductioninwomen.FertilSteril.2010;94:795-825.
  • Boes E, Coassin S, Kollerits B, Heid IM, Kronenberg F. Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Exp Gerontol. 2009;44(3):136-60.
  • Bj rbaek C. Central leptin receptor action and resistance in obesity.JInvestigMed.2009;57:789-94.
  • Berg AH,Combs TP,Du X,Brownlee M,Scherer PE.The adipocyte-secretedprotein Acrp30 enhances hepatic insulin action. NatMed.2001;7:947-53.
  • Beebe-DimmerJL,ZuhlkeKA,RayAM,LangeEM,CooneyKA. Genetic variation in adiponectin (ADIPOQ)and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. ProstateCancerProstaticDis.2012;13(4):362-8.
  • BarakY,Nelson MC,Ong ES,JonesYZ,Ruiz-LozanoP,Chien KR etal.PPAR gammaisrequiredforplacental,cardiac,andadipose tissuedevelopment.MolCell.1999;4:585-95.
  • BacciS,MenzaghiC,ErcolinoT,MaX,RauseoA,SalveminiL, et al. The +276 G/T single nucleotide polymorphism of the adiponectingeneisassociatedwithcoronary artery diseasein type2 diabeticpatients.DiabetesCare.2004;27:2015–20.
  • Arnaiz-Villena A, Fernandez-Honrado M, Rey D, Enriquez-de-Salamanca M,Abd-El-Fatah-KhalilS,ArribasI,Coca C,etal.Amerindians show association to obesity with adiponectin geneSNP45andSNP276:populationgeneticsofafoodintakecontrol and‘‘thrifty’’gene. MolBiolRep.2013;40:1819-26.
  • AnthonyRM,RutitzkyLI,UrbanJF Jr,StadeckerMJ,GauseWC. Protective immune mechanisms in helminth infection. Nat Rev Immunol.2007;7:975–87.
  • Angel-ChavezLI,Tene-PerezCE,CastroE.Leptinreceptorgene K656N polymorphism isassociatedwithlow bodyfatlevelsand elevatedhigh-densitycholesterollevelsinMexicanchildrenand adolescents.EndocrRes.2012;37(3):124-34
  • AltshulerD,Hirschhorn JN,Klannemark M,Lindgren CM,Vohl MC, Nemesh J et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk oftype 2 diabetes. NatGenet.2000;26:76-80.
  • Alberti KG,Eckel RH,Grundy SM,Zimmet PZ,Cleeman JI, Donato KA,et al.Harmonizing the metabolic syndrome: a joint interim statementoftheInternationalDiabetesFederationTaskForce on Epidemiology and Prevention;NationalHeart,Lung,and Blood Institute; American Heart Association; World Heart Federation; InternationalAtherosclerosisSociety and InternationalAssociation for theStudyofObesity.Circulation.2009;120(16):1640-5.
  • AbbasiF,Chu JW,Lamendola C,McLaughlin T,Hayden J, Reaven GM, et al. Discrimination between obesity and insulin resistanceintherelationshipwithadiponectin.Diabetes.2004;53(3):585–90.
  • 177．PechlivanisS,BermejoJL,PardiniB,NaccaratiA,VodickovaL, Novotny J,etal.Genetic variation in adipokine genes and risk of colorectalcancer.EurJEndocrinol.2009;160:933–40.