연구동향 분석
박사

비만과 당뇨병 바이오마커 발굴: SPARC의 새로운 기능연구를 중심으로 : Discovery of biomarkers in diabesity: focusing on the novel functional role of SPARC

라자 2015년

논문상세정보
인용/피인용
' 비만과 당뇨병 바이오마커 발굴: SPARC의 새로운 기능연구를 중심으로 : Discovery of biomarkers in diabesity: focusing on the novel functional role of SPARC' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • apoptosis
  • autophagy
  • diabetes
  • obestiy
  • oxidative stress
  • sparc
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
1,428 0

0.0%

' 비만과 당뇨병 바이오마커 발굴: SPARC의 새로운 기능연구를 중심으로 : Discovery of biomarkers in diabesity: focusing on the novel functional role of SPARC' 의 참고문헌

  • de Cavanagh, E.M., Inserra, F., Toblli, J., Stella, I., Fraga, C.G., and Ferder, L. (2001). Enalapril attenuates oxidative stress in diabetic rats. Hypertension, 38,1130-1136.
  • Zitzmann, M. (2009). Testosterone deficiency, insulin resistance and themetabolic syndrome. Nature Reviews Endocrinology, 5, 673-681.
  • Zimmermann, K.C., Bonzon, C., and Green, D.R. (2001). The machinery ofprogrammed cell death. Pharmacology and Therapeutics, 92, 57-70.
  • Zierath, J.R., and Hawley, J.A. (2004). Skeletal muscle fiber type: influence oncontractile and metabolic properties. PLoS Biology, 2, e348.
  • Zhi, W., Purohit, S., Carey, C., Wang, M., and She, J.X. (2010). Proteomictechnologies for the discovery of type 1 diabetes biomarkers. Journal of DiabetesScience and Technology, 4, 993-1002.
  • Zheng, D., MacLean, P.S., Pohnert, S.C., Knight, J.B., Olson, A.L., Winder,W.W., and Dohm, G.L. (2001). Regulation of muscle GLUT-4 transcription byAMP-activated protein kinase. Journal of Applied Physiology, 91, 1073-1083.
  • Zhang, L., Pang, S., Deng, B., Qian, L., Chen, J., Zou, J., Zheng, J., Yang, L.,Zhang, C., Chen, X., Liu, Z., and Le, Y. (2012). High glucose induces renalmesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. International Journal of Biochemistry and Cell Biology, 44, 629-638.
  • Zhang, D., Christianson, J., Liu, Z.X., Tian, L., Choi, C.S., Neschen, S., Dong, J.,Wood, P.A., and Shulman, G.I. (2010). Resistance to high-fat diet-inducedobesity and insulin resistance in mice with very long-chain acyl CoAdehydrogenase deficiency. Cell Metabolism, 11, 402-411.
  • Yu, T., Robotham, J.L., and Yoon, Y. (2006). Increased production of reactiveoxygen species in hyperglycemic conditions requires dynamic change ofmitochondrial morphology. Proceedings of the National Academy of Sciences ofthe United States of America, 103, 2653-2658.
  • Yu, T., Jhun, B.S., and Yoon, Y. (2011). High-glucose stimulation increasesreactive oxygen species production through the calcium and mitogen-activatedprotein kinase-mediated activation of mitochondrial fission. Antioxidants andRedox Signaling, 14, 425-437.
  • Yoshioka, M., Boivin, A., Bolduc, C., and St-Amand, J. (2007). Genderdifference of androgen actions on skeletal muscle transcriptome. Journal ofMolecular Endocrinology, 39, 119-133.
  • Yoshimura, A., and Muto, G. (2011). TGF-β function in immune suppression. Current Topics in Microbiology and Immunology, 350, 127-147.
  • Yang, M., Liu, W., Wang, C.Y., Liu, T., Zhou, F., Tao, J., Wang, Y., and Li M.T. (2006). Proteomic analysis of differential protein expression in early process ofpancreatic regeneration in pancreatectomized rats. Acta Pharmacologica Sinica,27, 568-578.
  • Yang, C.M., Lee, I.T., Hsu, R.C., Chi, P.L., and Hsiao, L.D. (2013). NADPHoxidase/ROS-dependent PYK2 activation is involved in TNF-α-induced matrixmetalloproteinase-9 expression in rat heart-derived H9c2 cells. Toxicology andApplied Pharmacology, 272, 431-442.
  • Xu, L., Ping, F., Yin, J., Xiao, X., Xiang, H., Ballantyne, C.M., Wu, H., and Li,M. (2013). Elevated plasma SPARC levels are associated with insulin resistance,dyslipidemia, and inflammation in gestational diabetes mellitus. PLoS One, 8,e81615.
  • Xie, X., Li, S., Liu, S., Lu, Y., Shen, P., and Ji, J. (2008). Proteomic analysis ofmouse islets after multiple low-dose streptozotocin injection. Biochimica etBiophysica Acta, 1784, 276-284.
  • Xie, X., Chang, X., Chen, L., Huang, K., Huang, J., Wang, S., Shen, X., Liu, P.,and Huang, H. (2013). Berberine ameliorates experimental diabetes-inducedrenal inflammation and fibronectin by inhibiting the activation of RhoA/ROCKsignaling. Molecular and Cellular Endocrinology, 381, 56-65.
  • Wu, D., Li, L., Yang, M., Liu, H., and Yang, G. (2011). Elevated Plasma Levelsof SPARC in Patients with Newly Diagnosed Type 2 Diabetes Mellitus. European Journal of Endocrinology, 165, 597-601.
  • Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004). Globalprevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 27, 1047-1053.
  • Wikk, A. (2008). Estrogen receptors in skeletal muscle, expression and activation(PhD diss., Karolinska Institute, Sweden), 1-49.
  • Wiersma, J.J., Meuwese, M.C., van Miert, J.N., Kastelein, A., Tijssen, J.G., Piek,J.J., and Trip, M.D. (2008). Diabetes mellitus type 2 is associated with higherlevels of myeloperoxidase. Medical Science Monitor, 14, CR406-410.
  • Wells, C.C., Riazi, S., Mankhey, R.W., Bhatti, F., Ecelbarger, C., and Maric, C. (2005). Diabetic nephropathy is associated with decreased circulating estradiollevels and imbalance in the expression of renal estrogen receptors. GenderMedicine, 2, 227-237.
  • Weaver, M.S., Workman, G., and Sage, E.H. (2008). The copper binding domainof SPARC mediates cell survival in vitro via interaction with integrin beta1 andactivation of integrin-linked kinase. Journal of Biological Chemistry, 283,22826-22837.
  • Watanabe, T., Yonemura, Y., Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama,K., Moriizumi, S., Unno, M., Tanaka, O., and Kondo, H. (1994). Pancreatic betacellreplication and amelioration of surgical diabetes by Reg protein. Proceedingsof the National Academy of Sciences of the United States of America, 91, 3589-3592.
  • Watanabe, K., Okamoto, F., Yokoo, T., Iida, K.T., Suzuki, H., Shimano, H.,Oshika, T., Yamada, N., and Toyoshima, H. (2009). SPARC is a major secretorygene expressed and involved in the development of proliferative diabeticretinopathy. Journal of atherosclerosis and thrombosis, 16, 69-76.
  • Wang, Z., Jiang, L., Huang, C., Li, Z., Chen, L., Gou, L., Chen, P., Tong, A.,Tang, M., Gao, F., Shen, J., Zhang, Y., Bai, J., Zhou, M., Miao, D., and Chen, Q. (2008). Comparative proteomics approach to screening of potential diagnosticand therapeutic targets for oral squamous cell carcinoma. Molecular and CellularProteomics, 7, 1639-1650.
  • Wang, Y.X., Zhang, C.L., Yu, R.T., Cho, H.K., Nelson, M.C., Bayuga-Ocampo,C.R., Ham, J., Kang, H., and Evans, R.M. (2004). Regulation of muscle fibertype and running endurance by PPAR-delta. PLoS Biology, 2, e294.
  • Wang, K. (2014). Molecular mechanisms of hepatic apoptosis. Cell Death andDisease, 5, e996.
  • Wang, C., Zou., S., Cui, Z., Guo, P., Meng, Q., Shi, X., Gao, Y., Yang, G., andHan, Z., (2015). Zerumbone protects INS-1 rat pancreatic beta cells from highglucose-induced apoptosis through generation of reactive oxygen species. Biochemical and Biophysical Research Communications, 460, 205-209.
  • Wandell, P.E., and Carlsson, A.C. (2013). Time trends and gender differences inincidence and prevalence of type 1 diabetes in Sweden. Current DiabetesReviews, 9, 342-349.
  • Wagener, F.A., Dekker, D., Berden, J.H., Scharstuhl, A., and van der Vlag, J. (2009). The role of reactive oxygen species in apoptosis of the diabetic kidney. Apoptosis, 14, 1451-1458.
  • Vital, P., Larrieta, E., and Hiriart, M. (2006). Sexual dimorphism in insulinsensitivity and susceptibility to develop diabetes in rats. Journal ofEndocrinology, 190, 425-432.
  • Verrecchia, F., Pessah, M., Atfi, A., and Mauviel, A. (2000). Tumor necrosisfactor-alpha inhibits transforming growth factor-beta/Smad signaling in humandermal fibroblasts via AP-1 activation. Journal of Biological Chemistry, 275,30226-30231.
  • Venojarvi, M., Korkmaz, A., Aunola, S., Hallsten, K., Virtanen, K., Marniemi, J.,Halonen, J.P., Hanninen, O., Nuutila, P., and Atalay, M. (2014). Decreasedthioredoxin-1 and increased HSP90 expression in skeletal muscle in subjectswith type 2 diabetes or impaired glucose tolerance. BioMed ResearchInternational, 2014, 386351.
  • Vantyghem, M.C., Haye, S., Balduyck, M., Hober, C., Degand, P.M., andLefebvre, J. (1999). Changes in serum amylase, lipase and leukocyte elastaseduring diabetic ketoacidosis and poorly controlled diabetes. Acta Diabetologica,36, 39-44.
  • Vacek, T.P., Vacek, J.C., and Tyagi, S.C. (2012). Mitochondrial mitophagicmechanisms of myocardial matrix metabolism and remodelling. Archives ofPhysiology and Biochemistry, 118, 31-42.
  • Turner, M.D., Nedjai, B., Hurst, T., and Pennington, D.J. (2014). Cytokines andchemokines: At the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta, 1843, 2563-2582.
  • Trejo-Solis, C., Jimenez-Farfan, D., Rodriguez-Enriquez, S., Fernandez-Valverde,F., Cruz-Salgado, A., Ruiz-Azuara, L., and Sotelo, J. (2012). Copper compoundinduces autophagy and apoptosis of glioma cells by reactive oxygen species andJNK activation. BMC Cancer, 12, 156.
  • Tiwari, B.K., Pandey, K.B., Abidi, A.B., and Rizvi, S.I. (2013). Markers ofoxidative stress during diabetes mellitus. Journal of Biomarkers, 378790, 1-8.
  • Tessari, P., Puricelli, L., Iori, E., Arrigoni, G., Vedovato, M., James, P., Coracina,A., and Millioni, R. (2007). Altered chaperone and protein turnover regulatorsexpression in cultured skin fibroblasts from type 1 diabetes mellitus withnephropathy. Journal of Proteome Research, 6, 976-986.
  • Tartare-Deckert, S., Chavey, C., Monthouel, M.N., Gautier, N., and VanObberghen, E. (2001). The matricellular protein SPARC/osteonectin as a newlyidentified factor up-regulated in obesity. Journal of Biological Chemistry, 276,22231-22237.
  • Tang, M.J., and Tai, I.T. (2007). A novel interaction between procaspase 8 andSPARC enhances apoptosis and potentiates chemotherapy sensitivity incolorectal cancers. Journal of Biological Chemistry, 282, 34457-34467.
  • Taneda, S., Pippin, J.W., Sage, E.H., Hudkins, K.L., Takeuchi, Y., Couser, W.G.,and Alpers, C.E. (2003). Amelioration of diabetic nephropathy in SPARC-nullmice. Journal of the American Society of Nephrology, 14, 968-980.
  • Tan, M.H., Sata, T., and Havel, R.J. (1977). The significance of lipoprotein lipasein rat skeletal muscles. Journal of Lipid Research, 18, 363-370.
  • Takahashi, M., Higuchi, M., Matsuki, H., Yoshita, M., Ohsawa, T., Oie, M., andFujii, M. (2013). Stress granules inhibit apoptosis by reducing reactive oxygenspecies production. Molecular and Cellular Biology, 33, 815-829.
  • Szkudelski, T. (2001). The mechanism of alloxan and streptozotocin action in Bcells of the rat pancreas. Physiological Research, 50, 537-546.
  • Szalat, A., and Raz, I. (2008). Gender-specific care of diabetes mellitus:particular considerations in the management of diabetic women. Diabetes,Obesity and Metabolism, 10, 1135-1156.
  • Szabo, C., Zanchi, A., Komjati, K., Pacher, P., Krolewski, A.S., Quist, W.C.,LoGerfo, F.W., Horton, E.S., and Veves, A. (2002). Poly (ADP-Ribose)polymerase is activated in subjects at risk of developing type 2 diabetes and isassociated with impaired vascular reactivity. Circulation, 106, 2680-2686.
  • Szabo, A., and Sahin-Toth, M. (2012). Increased activation of hereditarypancreatitis-associated human cationic trypsinogen mutants in presence ofchymotrypsin C. Journal of Biological Chemistry, 287, 20701-20710.
  • Sugiura, M., Ohshima, M., Ogawa, K., Yano, M. (2006). Chronic administrationof Satsuma mandarin fruit (Citrus unshiu Marc.) improves oxidative stress instreptozotocin-induced diabetic rat liver. Biological and Pharmaceutical Bulletin,29, 588-591.
  • Strehlow, K., Rotter, S., Wassmann, S., Adam, O., Grohe, C., Laufs, K., Bohm,M., and Nickenig, G. (2003). Modulation of antioxidant enzyme expression andfunction by estrogen. Circulation Research, 93, 170-177.
  • Straub, R.H. (2007). The complex role of estrogens in inflammation. EndocrineReviews, 28, 521-574.
  • St John, L.C., Rule, D.C., Knabe, D.A., Mersmann, H.J., and Smith, S.B. (1987). Fatty acid-binding protein activity in tissues from pigs fed diets containing 0 and20% high oleate oil. Journal of Nutrition, 117, 2021-2026.
  • Sparre, T., Larsen, M.R., Heding, P.E., Karlsen, A.E., Jensen, O.N., and Pociot, F. (2005). Unraveling the pathogenesis of type 1 diabetes with proteomics: presentand future directions. Molecular and Cellular Proteomics, 4, 441-457.
  • Sparre, T., Christensen, U.B., Mose Larsen, P., Fey, S.J., Wrzesinski, K.,Roepstorff, P., Mandrup-Poulsen, T., Pociot, F., Karlsen, A.E., and Nerup, J. (2002). IL-1beta induced protein changes in diabetes prone BB rat islets ofLangerhans identified by proteome analysis. Diabetologia, 45, 1550-1561.
  • Sowers, M., Gonzalez Villalpando, C., Stern, M.P., Fox, C., and Mitchell, B.D.,(1995). Relationships between physical activity, insulin levels and lipids in nondiabeticlow income residents of Mexico City: the Mexico City Diabetes Study. Archives of Medical Research, 26, 133-140.
  • Soupene, E., and Kuypers, F.A. (2008). Mammalian long-chain acyl-CoAsynthetases. Experimental Biology and Medicine (Maywood), 233, 507-521.
  • Socha, M.J., Manhiani, M., Said, N., Imig, J.D., Motamed, K. (2007). Secretedprotein acidic and rich in cysteine deficiency ameliorates renal inflammation andfibrosis in angiotensin hypertension. American Journal of Pathology, 171, 1104-1112.
  • Skeletal muscle pathways of contraction-enhanced glucose uptake. InternationalJournal of Sports Medicine, 29, 785-794.
  • Simoneau, J.A. and Bouchard, C. (1989). Human variation in skeletal musclefiber-type proportion and enzyme activities. American Journal of Physiology,257, E567-572.
  • Shillabeer, G., Hornford, J., Forden, J.M., Wong, N.C., and Lau, D.C. (1990).
  • Shibata, S., and Ishiyama, J. (2013). Secreted protein acidic and rich in cysteine(SPARC) is upregulated by transforming growth factor (TGF)-β and is requiredfor TGF-β-induced hydrogen peroxide production in fibroblasts. Fibrogenesisand Tissue Repair, 6, 1-11.
  • Shi, Q., Bao, S., Maxwell, J.A., Reese, E.D., Friedman, H.S., Bigner, D.D, Wang,X. F., and Rich, J.N. (2004). Secreted protein acidic, rich in cysteine (SPARC),mediates cellular survival of gliomas through AKT activation. Journal ofBiological Chemistry, 279, 52200-52209.
  • Shi, H., Seeley, R.J., and Clegg, D.J. (2009). Sexual differences in the control ofenergy homeostasis. Frontiers in Neuroendocrinology, 30, 396-404.
  • Shevchenko, A., Wilm, M., Vorm, O., and Mann M. (1996). Mass spectrometricsequencing of proteins silver-stained polyacrylamide gels. Analytical Chemistry,68, 850-858.
  • Shen, Y., Zhao, Y., Yuan, L., Yi, W., Zhao, R., Yi, Q., and Yong, T. (2014). SPARC is over-expressed in adipose tissues of diet-induced obese rats and causesinsulin resistance in 3T3-L1 adipocytes. Acta Histochemica, 116,158-166.
  • Shah, A., Xia, L., Goldberg, H., Lee, K.W., Quaggin, S.E., and Fantus, I.G. (2013). Thioredoxin-interacting protein mediates high glucose-induced reactiveoxygen species generation by mitochondria and the NADPH oxidase, Nox4, inmesangial cells. Journal of Biological Chemistry, 288, 6835-6848.
  • Schweikl, H., Petzel, C., Bolay, C., Hiller, K.A., Buchalla, W., and Krifka, S. (2014). 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- andp53-dependent intrinsic mitochondrial pathway. Biomaterials, 35, 2890-2904.
  • Schneikert, J., Grohmann, A., and Behrens, J. (2007). Truncated APC regulatesthe transcriptional activity of beta-catenin in a cell cycle dependent manner. Human Molecular Genetics, 16, 199-209.
  • Schiemann, B.J., Neil, J.R., and Schiemann, W.P. (2003). SPARC inhibitsepithelial cell proliferation in part through stimulation of the transforminggrowth factor-beta-signaling system. Molecular Biology of the Cell, 14, 3977-3988.
  • Sauk, J.J., Smith, T., Silbergeld, E.K., Fowler, B.A., and Somerman, M.J. (1992). Lead inhibits secretion of osteonectin/SPARC without significantly alteringcollagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells. Toxicologyand Applied Pharmacology, 116, 240-247.
  • Sato, H., Sugai, H., Kurosaki, H., Ishikawa, M., Funaki, A., Kimura, Y., andUeno, K. (2013). The effect of sex hormones on peroxisome proliferatoractivatedreceptor gamma expression and activity in mature adipocytes. Biological and Pharmaceutical Bulletin, 36, 564-573.
  • Santos, J.M., Ribeiro, S.B., Gaya, A.R., Appell, H.J., and Duarte, J.A. (2008).
  • Sangaletti, S., Tripodo, C., Cappetti, B., Casalini, P., Chiodoni, C., Piconese, S.,Santangelo, A., Parenza, M., Arioli, I., Miotti, S., and Colombo, M.P. (2011).
  • Saluja, A.K., Bhagat, L., Lee, H.S., Bhatia, M., Frossard, J.L., and Steer, M.L. (1999). Secretagogue-induced digestive enzyme activation and cell injury in ratpancreatic acini. American Journal of Physiology, 276, G835-842.
  • Sailaja, G.S., Bhoopathi, P., Gorantla, B., Chetty, C., Gogineni, V.R., Velpula,K.K., Gondi, C.S., and Rao, J.S. (2013). The secreted protein acidic and rich incysteine (SPARC) induces endoplasmic reticulum stress leading to autophagymediatedapoptosis in neuroblastoma. International Journal of Oncology, 42,188-196.
  • SPARC oppositely regulates inflammation and fibrosis in bleomycin-inducedlung damage. American Journal of Pathology, 179, 3000-3010.
  • Ryall, C.L., Viloria, K., Lhaf, F., Walker, A.J., King, A., Jones, P., Mackintosh,D., McNeice, R., Kocher, H., Flodstrom-Tullberg, M., Edling, C., and Hill, N.J. (2014). Novel role for matricellular proteins in the regulation of islet β cellsurvival: the effect of SPARC on survival, proliferation and signalling. Journalof Biological Chemistry, 289: 30614-30624.
  • Roth, S.M., Ferrell, R.E., Peters, D.G., Metter, E.J., Hurley, B.F., and Rogers,M.A. (2002). Influence of age, sex, and strength training on human muscle geneexpression determined by microarray. Physiological Genomics, 10, 181-190.
  • Rosendahl, J., Witt, H., Szmola, R., Bhatia, E., Ozsvari, B., Landt, O., Schulz, H. U., Gress, T. M., Pfutzer, R., Lohr, M., Kovacs, P., Bluher, M., Stumvoll, M.,Choudhuri, G., Hegyi, P., te Morsche, R.H., Drenth, J.P., Truninger, K., Macek,M. Jr., Puhl, G., Witt, U., Schmidt, H., Buning, C., Ockenga, J., Kage, A.,Groneberg, D.A., Nickel, R., Berg, T., Wiedenmann, B., Bodeker, H., Keim, V.,Mossner, J., Teich, N., and Sahin-Toth, M. (2008). Chymotrypsin C (CTRC)variants that diminish activity or secretion are associated with chronicpancreatitis. Nature Genetics, 40, 78-82.
  • Rodriguez-Cuenca, S., Pujol, E., Justo, R., Frontera, M., Oliver, J., Gianotti, M.,and Roca, P. (2002). Sex-dependent thermogenesis, differences in mitochondrialmorphology and function, and adrenergic response in brown adipose tissue. Journal of Biological Chemistry, 277, 42958-42963.
  • Rippe, C., Berger, K., Mei, J., Lowe, M.E., and Erlanson-Albertsson, C. (2003). Effect of long-term high-fat feeding on the expression of pancreatic lipases andadipose tissue uncoupling proteins in mice. Pancreas, 26, e36-42.
  • Riento, K., and Ridley, A.J. (2003). Rocks: multifunctional kinases in cellbehaviour. Nature Reviews Molecular Cell Biology, 4, 446-456.
  • Resjo, S., Berger, K., Fex, M., and Hansson, O. (2008). Proteomic studies inanimal models of diabetes. Proteomics. Clinical applications, 2, 654-669.
  • Reding, T., Wagner, U., Silva, A.B., Sun, L.K., Bain, M., Kim, S.Y., Bimmler, D.,and Graf, R. (2009). Inflammation-dependent expression of SPARC duringdevelopment of chronic pancreatitis in WBN/Kob rats and a microarray geneexpression analysis. Physiological Genomics, 38, 196-204.
  • Rebours, V., Levy, P., and Ruszniewski, P. (2012). An overview of hereditarypancreatitis. Digestive and Liver Disease, 44, 8-15.
  • Ratnam, S., Wijekoon, E.P., Hall, B., Garrow, T.A., Brosnan, M.E., and Brosnan,J.T. (2006). Effects of diabetes and insulin on betaine-homocysteine Smethyltransferaseexpression in rat liver. American Journal of Physiology -Endocrinology and Metabolism, 290, E933-E939.
  • Quintana, F.J., Rotem, A., Carmi, P., and Cohen, I.R. (2000). Vaccination withempty plasmid DNA or CpG oligonucleotide inhibits diabetes in non-obesediabetic mice: modulation of spontaneous 60-kDa heat shock proteinautoimmunity. Journal of Immunology, 165, 6148-6155.
  • Quan, Y., Jiang, C.T., Xue, B., Zhu, S.G., and Wang, X. (2011). High glucosestimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κBpathways. Acta Pharmacologica Sinica, 32, 188-193.
  • Qiu, Y., Mao, T., Zhang, Y., Shao, M., You, J., Ding, Q., Chen, Y., Wu, D., Xie,D., Lin, X., Gao, X., Kaufman, R.J., Li, W., and Liu, Y. (2010). A crucial role forRACK1 in the regulation of glucose-stimulated IRE1 alpha activation inpancreatic beta cells. Science Signaling, 3, ra7.
  • Qiu, L., List, E.O., and Kopchick, J.J. (2005). Differentially expressed proteinsin the pancreas of diet-induced diabetic mice. Molecular and CellularProteomics, 4, 1311-1318.
  • Pullen, T.J., Khan, A.M., Barton, G., Butcher, S.A., Sun, G. and Rutter, G.A. (2010). Identification of genes selectively disallowed in the pancreatic islet. Islets, 2, 89-95.
  • Pradhan, A.D., Manson, J.E, Rifai, N., Buring, J.E., and Ridker, P.M. (2001). Creactiveprotein, interleukin 6, and risk of developing type 2 diabetes mellitus. The Journal of the American Medical Association, 286, 327-334.
  • Ploug, T., Galbo, H., and Richter, E.A. (1984). Increased muscle glucose uptakeduring contractions: no need for insulin. American Journal of Physiology, 247,E726-731.
  • Ploug, T., Galbo, H., Vinten, J., Jorgensen, M., and Richter, E.A. (1987). Kineticsof glucose transport in rat muscle: effects of insulin and contractions. AmericanJournal of Physiology, 253, E12-20.
  • Petridou, A., Tsalouhidou, S., Tsalis, G., Schulz, T., Michna, H., and Mougios, V. (2007). Long-term exercise increases the DNA binding activity of peroxisomeproliferator-activated receptor gamma in rat adipose tissue. Metabolism, 56,1029-1036.
  • Peng, C., Ma, J., Gao, X., Tian, P., Li, W., and Zhang, L. (2013). High GlucoseInduced Oxidative Stress and Apoptosis in Cardiac Microvascular EndothelialCells Are Regulated by FoxO3a. PLoS One, 8, e79739.
  • Peng J., Li, X., Zhang, D., Chen, J.K., Su, Y., Smith, S.B., and Dong, Z. (2015). Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in thesusceptibility of diabetic models to ischemic acute kidney injury. KidneyInternational, 87, 137-150.
  • Peixoto, E., Atorrasagasti, C., Aquino, J.B., Militello, R., Bayo, J., Fiore, E.,Piccioni, F., Salvatierra, E., Alaniz, L., Garcia, M.G., Bataller, R., Corrales, F.,Gidekel, M., Podhajcer, O., Colombo, M.I., and Mazzolini, G. (2015). SPARC(secreted protein acidic and rich in cysteine) knockdown protects mice fromacute liver injury by reducing vascular endothelial cell damage. Gene Therapy,22, 9-19.
  • Pei, Z., Fraisl, P., Berger, J., Jia, Z., Forss-Petter, S., and Watkins, P.A. (2004). Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Journalof Biological Chemistry, 279, 54454-54462.
  • Pedersen, S.B., Kristensen, K., Hermann, P.A., Katzenellenbogen, J.A., andRichelsen, B. (2004). Estrogen controls lipolysis by up-regulating alpha2Aadrenergicreceptors directly in human adipose tissue through the estrogenreceptor alpha. Implications for the female fat distribution. The Journal ofClinical Endocrinology and Metabolism, 89, 1869-1878.
  • Patel, R., Shervington, A., Pariente, J.A., Martinez-Burgos, M.A., Salido, G.M.,Adeghate, E., and Singh, J. (2006). Mechanism of exocrine pancreaticinsufficiency in streptozotocin-induced type 1 diabetes mellitus. Annals of theNew York Academy of Sciences, 1084, 71-88.
  • Park, S.Y., Kim, H.J., Wang, S., Higashimori, T., Dong, J., Kim, Y.J., Cline, G.,Li, H., Prentki, M., Shulman, G.I., Mitchell, G.A., and Kim, J.K. (2005). Hormone-sensitive lipase knockout mice have increased hepatic insulinsensitivity and are protected from short-term diet-induced insulin resistance inskeletal muscle and heart. American Journal of Physiology-Endocrinology andMetabolism, 289, E30-39.
  • Park, K.J., Lee, S.H., Lee, C.H., Jang, J.Y., Chung, J., Kwon, M.H., and Kim, Y.S. (2009). Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 andp53 are involved in the JNK-mediated autophagic cell death. Biochemical andBiophysical Research Communications, 382, 726-729.
  • Pan, Y., Wang, Y., Zhao, Y., Peng, K., Li, W., Wang, Y., Zhang, J., Zhou, S., Liu,Q., Li, X., Cai, L., and Liang, G. (2014). Inhibition of JNK phosphorylation by anovel curcumin analog prevents high glucose-induced inflammation andapoptosis in cardiomyocytes and the development of diabetic cardiomyopathy. Diabetes, 63, 3497-3511.
  • Paik, Y.H., Kim, J., Aoyama, T., De Minicis, S., Bataller, R., and Brenner, D.A. (2014). Role of NADPH oxidases in liver fibrosis. Antioxidants and RedoxSignaling, 20, 2854-2872.
  • Ozveri, E.S., Bozkurt, A., Haklar, G., Cetinel, S., Arbak, S., Yegen, C., and Yegen,B.C. (2001). Estrogens ameliorate remote organ inflammation induced by burninjury in rats. Inflammation Research, 50, 585-591.
  • Ordonez, P., Moreno, M., Alonso, A., Llaneza, P., Diaz, F., and Gonzalez, C. (2008). 17-beta-Estradiol and/or progesterone protect from insulin resistance inSTZ-induced diabetic rats. Journal of Steroid Biochemistry and MolecularBiology, 111, 287-294.
  • Olson, E.N., and Williams R.S. (2000). Remodeling muscles with calcineurin. Bioessays, 22, 510-519.
  • Okamoto, H. (1999). The Reg gene family and Reg proteins: with specialattention to the regeneration of pancreatic beta-cells. Journal of Hepato-Biliary-Pancreatic Surgery, 6, 254-262.
  • Ohno, T., Ishii, C., Kato, N., Ito, Y., Shimizu, M., Tomono, S., Murata, K., andKawazu, S. (1995). Increased expression of a regenerating (reg) gene protein inneonatal rat pancreas treated with streptozotocin. Endocrine Journal, 42, 649-653.
  • Nishita, T., Igarashi, S., and Asari, M. (1995). Determination of carbonicanhydrase-III by enzyme-immunoassay in liver, muscle and serum of male ratswith streptozotocin-induced diabetes mellitus. The International Journal ofBiochemistry and Cell Biology, 27, 359-364.
  • Nie, J., and Sage, E.H. (2009). SPARC inhibits adipogenesis by its enhancementof beta-catenin signaling. Journal of Biological Chemistry, 284, 1279-1290.
  • Nie, J., Chang, B., Traktuev, D.O., Sun, J., March, K., Chan, L., Sage, E.H.,Pasqualini, R., Arap, W., Kolonin, M.G. (2008). IFATS collection: Combinatorialpeptides identify alpha5beta1 integrin as a receptor for the matricellular proteinSPARC on adipose stromal cells. Stem Cells, 26, 2735-2745.
  • Ng, Y.L., Klopcic, B., Lloyd, F., Forrest, C., Greene, W., and Lawrance, I.C. (2013). Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonicinflammatory symptoms in dextran sodium sulphate-induced murine colitis. PLoS One, 8, e77575.
  • Newsholme, P., Morgan, D., Rebelato, E., Oliveira-Emilio, H.C., Procopio, J.,Curi, R., and Carpinelli, A. (2009). Insights into the critical role of NADPHoxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia, 52,2489-2498.
  • Neri, M., Descalzi-Cancedda, F., and Cancedda, R. (1992). Heat-shock responsein cultured chick embryo chondrocytes. Osteonectin is a secreted heat-shockprotein. European Journal of Biochemistry, 205, 569-574.
  • Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E.,Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J., andEvans, R.M. (2008). AMPK and PPAR-delta agonists are exercise mimetics. Cell,134, 405-415.
  • Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J.H., Xue, X., andOkumura, K. (2006). Reactive oxygen species mediate crosstalk between NFkappaBand JNK. Cell Death and Differentiation, 13, 730-737.
  • Nakamura, S., Kamihagi, K., Satakeda, H., Katayama, M., Pan, H., Okamoto, H.,Noshiro, M., Takahashi, K., Yoshihara, Y., Shimmei, M., Okada, Y., and Kato, Y. (1996). Enhancement of SPARC (osteonectin) synthesis in arthritic cartilage. Increased levels in synovial fluids from patients with rheumatoid arthritis andregulation by growth factors and cytokines in chondrocyte cultures. Arthritis andRheumatology, 39, 539-551.
  • Nakagawa, T., Lomb, D.J., Haigis, M.C., and Guarente, L. (2009). SIRT5Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell,137, 560-570.
  • Nair, S., Yadav, D., and Pitchumoni, C.S., (2000). Association of diabeticketoacidosis and acute pancreatitis: observations in 100 consecutive episodes ofDKA. American Journal of Gastroenterology, 95, 2795-2800.
  • Nagaraju, G.P., and Sharma, D. (2011). Anti-cancer role of SPARC, an inhibitorof adipogenesis. Cancer Treatment Reviews, 37, 559-566.
  • Misu, H., Takamura, T., Matsuzawa, N., Shimizu, A., Ota, T., Sakurai, M., Ando,H., Arai, K., Yamashita, T., Honda, M., Yamashita, T., and Kaneko, S. (2007). Genes involved in oxidative phosphorylation are coordinately upregulated withfasting hyperglycaemia in livers of patients with type 2 diabetes. Diabetologia,50,268-277.
  • Mirza S., Hossain, M., Mathews, C., Martinez, P., Pino, P., Gay, J.L., Rentfro, A.,McCormick, J.B., and Fisher-Hoch, S.P. (2012). Type 2-diabetes is associatedwith elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptinin a population of Mexican Americans: a cross-sectional study. Cytokine, 57,136-142.
  • Miller, W.C., Hickson, R.C., and Bass, N.M. (1988). Fatty acid binding proteinsin the three types of rat skeletal muscle. Proceedings of The Society forExperimental Biology and Medicine, 189, 183-188.
  • Miller, W.C., Bryce, G.R., and Conlee, R.K. (1984). Adaptations to a high-fat dietthat increase exercise endurance in male rats. Journal of applied physiology:respiratory, environmental and exercise physiology, 56, 78-83.
  • Mikael, L.G., and Rozen, R. (2008). Homocysteine modulates the effect ofsimvastatin on expression of ApoA-I and NF-kappaB/iNOS. CardiovascularResearch, 80, 151-158.
  • McCormick, K.M., Burns, K.L., Piccone, C.M., Gosselin, L.E., and Brazeau,G.A. (2004). Effects of ovariectomy and estrogen on skeletal muscle functionin growing rats. Journal of Muscle Research and Cell Motility. 25: 21-27Melloul, D. (2008). Role of NF-kappaB in beta-cell death. Biochemical SocietyTransactions, 36, 334-339.
  • Mauvais-Jarvis, F., Clegg, D.J., and Hevener, A.L. (2013). The role of estrogensin control of energy balance and glucose homeostasis. Endocrine Reviews, 34,309-338.
  • Mauvais-Jarvis, F. (2011). Estrogen and androgen receptors: regulators of fuelhomeostasis and emerging targets for diabetes and obesity. Trends inEndocrinology and Metabolism, 22, 24-33.
  • Matsuda, T., Kido, Y., Asahara, S., Kaisho, T., Tanaka, T., Hashimoto, N.,Shigeyama, Y., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Hosooka, T.,Matsumoto, M., Inoue, H., Uchida, T., Koike, M., Uchiyama, Y., Akira, S., andKasuga, M. (2010). Ablation of C/EBPβ alleviates ER stress and pancreatic betacell failure through the GRP78 chaperone in mice. Journal of ClinicalInvestigation, 120, 115-126.
  • Marette, A., Richardson, J.M., Ramlal, T., Balon, T.W., Vranic, M., Pessin, J.E.,and Klip, A. (1992). Abundance, localization, and insulin-induced translocationof glucose transporters in red and white muscle. American Journal of Physiology,263, C443-452.
  • Marchetti, P., Del Guerra, S., Marselli, L., Lupi, R., Masini, M., Pollera, M.,Bugliani, M., Boggi, U., Vistoli, F., Mosca, F., and Del Prato, S. (2004). Pancreatic islets from type 2 diabetic patients have functional defects andincreased apoptosis that are ameliorated by metformin. Journal of Endocrinologyand Metabolism, 89, 5535-5541.
  • Manna, P., Das, J., Ghosh, J., and Sil, P.C. (2010). Contribution of type 1diabetes to rat liver dysfunction and cellular damage via activation of NOS,PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependentpathways: Prophylactic role of arjunolic acid. Free Radical Biology andMedicine, 48, 1465-1484.
  • Mandrup-Poulsen, T., Pickersgill, L., and Donath, M.Y. (2010). Blockade ofinterleukin 1 in type 1 diabetes mellitus. Nature Reviews Endocrinology, 6, 158-166.
  • Maltin, C.A. (2008). Muscle development and obesity: Is there a relationship?Organogenesis, 4, 158-169.
  • Maher, A.C., Akhtar, M., Vockley, J., and Tarnopolsky, M.A. (2010). Womenhave higher protein content of beta-oxidation enzymes in skeletal muscle thanmen. PLoS One, 5, e12025.
  • Macedo, C.S., Capelletti, S.M., Mercadante, M.C.S., Padovani, C.R., andSpadella, C.T. (2002). Role of metabolic control on diabetic nephropathy. ActaCirurgica Brasileira, 17, 370-376.
  • Ma, Z.A., Zhao, Z., and Turk, J. (2012). Mitochondrial dysfunction and B-cellfailure in type 2 diabetes mellitus. Experimental Diabetes Research, 2012,703538.
  • Lv, P., Huang, J., Yang, J., Deng, Y., Xu, J., Zhang, X., Li, W., Zhang, H., Yang,Y. (2014). Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats andStreptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TORor FoxO3. PLoS One, 9, e87254.
  • Lupu, R., and Menendez, J.A. (2006). Targeting fatty acid synthase in breast andendometrial cancer: An alternative to selective estrogen receptor modulators?Endocrinology, 147, 4056-4066.
  • Lukic, M.L., Pejnovic, N., and Lukic, A. (2014). New insight into early events intype 1 diabetes: role for islet stem cell exosomes. Diabetes, 63, 835-857.
  • Lowe, M.E., Kaplan, M.H., Jackson-Grusby, L., D'Agostino, D., and Grusby,M.J. (1998). Decreased neonatal dietary fat absorption and T cell cytotoxicity inpancreatic lipase-related protein 2-deficient mice. Journal of BiologicalChemistry, 273, 31215-31221.
  • Los, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg,Z., Wang, Z.Q., and Schulze-Osthoff, K. (2002). Activation and caspasemediatedinhibition of PARP: a molecular switch between fibroblast necrosis andapoptosis in death receptor signaling. Molecular Biology of the Cell, 13, 978-988.
  • Lomas-Soria, C., Ramos-Gomez, M., Guevara-Olvera, L., Guevara-Gonzalez, R.,Torres-Pacheco, I., Gallegos-Corona, M.A., and Reynoso-Camacho, R. (2011). Transcriptomic analysis in diabetic nephropathy of streptozotocin-induceddiabetic rats. International Journal of Molecular Sciences, 12, 8431-8448.
  • Logan, C.Y., and Nusse, R. (2004). The Wnt signaling pathway in developmentand disease. Annual Review of Cell and Developmental Biology, 20, 781-810.
  • Liu, B., Chen, Y., and St Clair, D.K. (2008). ROS and p53: a versatile partnership. Free Radical Biology and Medicine, 44, 1529-35.
  • Lipson, K.L., Fonseca, S.G., Ishigaki, S., Nguyen, Foss, L.X., Bortell, R., Rossini,A.A., and Urano, F. (2006). Regulation of insulin biosynthesis in pancreatic betacells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metabolism,4, 245-254.
  • Liochev, S.I., and Fridovich, I. (1994). The role of O2. - in the production of HO.:in vitro and in vivo. Free Radical Biology and Medicine, 16, 29-33.
  • Lin, H.Y., Xu, Q., Yeh, S., Wang, R.S., Sparks, J.D., and Chang, C. (2005). Insulin and leptin resistance with hyperleptinemia in mice lacking androgenreceptor. Diabetes, 54, 1717-1725.
  • Lenzen, S., Drinkgern, J., and Tiedge M., (1996). Low antioxidant enzyme geneexpression in pancreatic islets compared with various other mouse tissues. FreeRadical Biology and Medicine, 20, 463-466.
  • Leney, S.E., and Tavare, J.M. (2009). The molecular basis of insulin-stimulatedglucose uptake: signalling, trafficking and potential drug targets. Journal ofEndocrinology, 203, 1-18.
  • Lei, Z.B., Fu, X.J., Lu, Z.T., Wang, B.C., Liu, X.L., and You, N.Z. (2003). Effectof estradiol on chemokine receptor CXCR2 expression in rats: implications foratherosclerosis. Acta Pharmacologica Sinica, 24, 670-674.
  • Le May, C., Chu, K., Hu, M., Ortega, C.S., Simpson, E.R., Korach, K.S., TsaiM.J., and Mauvais-Jarvis, F. (2006). Estrogens protect pancreatic beta-cells fromapoptosis and prevent insulin-deficient diabetes mellitus in mice. Proceedings ofthe National Academy of Sciences of the United States of America, 103, 9232-9237.
  • Larsen, P.M., Fey, S.J., Larsen, M.R., Nawrocki, A., Andersen, H.U., Kahler, H.,Heilmann, C., Voss, M.C., Roepstorff, P., Pociot, F., Karlsen, A.E., and Nerup, J. (2001). Proteome analysis of interleukin-1 beta-induced changes in proteinexpression in rat islets of Langerhans. Diabetes, 50, 105610-105663.
  • Langfort, J., Donsmark, M., Ploug, T., Holm, C., and Galbo, H. (2003). Hormone-sensitive lipase in skeletal muscle: regulatory mechanisms. ActaPhysiologica Scandinavica, 178, 397-403.
  • Kyriakis, J.M., and Avruch, J. (2012). Mammalian MAPK signal transductionpathways activated by stress and inflammation: a 10-year update. PhysiologicalReviews, 92, 689-737.
  • Krook, A., Kawano, Y., Song, X.M., Efendi?, S., Roth, R.A., Wallberg-Henriksson, H., and Zierath, J.R. (1997). Improved glucose tolerance restoresinsulin-stimulated Akt kinase activity and glucose transport in skeletal musclefrom diabetic Goto-Kakizaki rats. Diabetes, 46, 2110-2114.
  • Krause, K.H. (2007). Aging: a revisited theory based on free radicals generatedby NOX family NADPH oxidases. Experimental Gerontology, 42, 256-262.
  • Koukourakis, M.I., Giatromanolaki, A., Brekken, R.A., Sivridis, E., Gatter, K.C.,Harris, A.L., and Sage, E.H. (2003). Enhanced expression of SPARC/osteonectinin the tumor-associated stroma of non-small cell lung cancer is correlated withmarkers of hypoxia/acidity and with poor prognosis of patients. Cancer Research,63, 5376-5380.
  • Kos, K., and Wilding, J.P. (2010). SPARC: a key player in the pathologiesassociated with obesity and diabetes. Nature Reviews Endocrinology, 6, 225-235.
  • Kos, K., Wong, S., Tan, B., Gummesson, A., Jernas, M., Franck, N., Kerrigan, D.,Nystrom, F.H., Carlsson, L.M., Randeva, H.S., Pinkney, J.H., and Wilding, J.P. (2009). Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectinin human adipose tissue by weight change, leptin, insulin, and glucose. Diabetes,58, 1780-1788.
  • Komi, P.V., and Karlsson, J. (1978). Skeletal muscle fibre types, enzymeactivities and physical performance in young males and females. ActaPhysiologica Scandinavica, 103, 210-218.
  • King, H., Aubert, R.E., and Herman, W.H. (1998). Global burden of diabetes1995-2025: prevalence, numerical estimates, and projections. Diabetes Care, 21,1414-1431.
  • Kim, S.W., Hwang, H.J., Kim, H.M., Lee, M.C., Shik Lee, M., Choi, J.W., andYun, J.W. (2006b). Effect of fungal polysaccharides on the modulation of plasmaproteins in streptozotocin-induced diabetic rats. Proteomics, 6, 5291-5302.
  • Kim, S.W., Hwang, H.J., Cho, E.J., Oh, J.Y., Baek, Y.M., Choi, J.W., and Yun,J.W. (2006a). Time-dependent plasma protein changes in streptozotocin-induceddiabetic rats before and after fungal polysaccharide treatments. Journal ofProteome Research, 5, 2966-2976.
  • Kim, S.W., Hwang, H.J., Baek, Y.M., Lee, S.H., Hwang, H.S., and Yun, J.W. (2008). Proteomic and transcriptomic analysis for streptozotocin-induceddiabetic rat pancreas in response to fungal polysaccharide treatments. Proteomics,8, 2344-2361.
  • Kim, S.K., Woodcroft, K.J., and Novak, R.F., (2003). Insulin and glucagonregulation of glutathione S-transferase expression in primary cultured rathepatocytes. Journal of Pharmacology and Experimental Therapeutics, 305,353-361.
  • Kim, S.I., Kim, H.J., Han, D.C., and Lee, H.B. (2000). Effect of lovastatin onsmall GTP binding proteins and on TGF-beta1 and fibronectin expression. Kidney International Supplements, 77, S88-S92.
  • Kim, J.J., Lee, S.B., Park, J.K., and Yoo, Y.D. (2010). TNF-alpha-induced ROSproduction triggering apoptosis is directly linked to Romo1 and Bcl-X(L). CellDeath and Differentiation, 17, 1420-1434.
  • Ki, Y.W., Park, J.H., Lee, J.E., Shin, I.C., and Koh, H.C. (2013). JNK and p38MAPK regulate oxidative stress and the inflammatory response in chlorpyrifosinducedapoptosis. Toxicology Letters, 218, 235-245.
  • Ketterer, B. (1998). Glutathione S-transferases and prevention of cellular freeradical damage. Free Radical Biology and Medicine, 28, 647-658.
  • Kern, M., Wells, J.A., Stephens, J.M., Elton, C.W., Friedman, J.E., Tapscott, E. B., Pekala, P.H., and Dohm, G.L. (1990). Insulin responsiveness in skeletalmuscle is determined by glucose transporter (Glut4) protein level. BiochemicalJournal, 270, 397-400.
  • Kelly, K.J., Plotkin, Z., Vulgamott, S.L., and Dagher, P.C. (2003). P53 mediatesthe apoptotic response to GTP depletion after renal ischemia-reperfusion:protective role of a p53 inhibitor. Journal of the American Society of Nephrology,14, 128-138.
  • Kawelke, N., Vasel, M., Sens, C., Au Av., Dooley, S., and Nakchbandi, I.A. (2011). Fibronectin protects from excessive liver fibrosis by modulating theavailability of and responsiveness of stellate cells to active TGF-β. PLoS One, 6,e28181.
  • Kawamura, T., Yoshida, K., Sugawara, A., Nagasaka, M., Mori, N., Takeuchi, K.,and Kohzuki, M. (2004). Regulation of skeletal muscle peroxisome proliferatoractivatedreceptor gamma expression by exercise and angiotensin-convertingenzyme inhibition in fructose-fed hypertensive rats. Hypertension Research, 27,61-70.
  • Kavanagh, K., Zhang, L., and Wagner, J.D. (2009). Tissue-specific regulationand expression of heat shock proteins in type 2 diabetic monkeys. Cell StressChaperones, 14, 291-299.
  • Karna, P., Zughaier, S., Pannu, V., Simmons, R., Narayan, S., and Aneja, R. (2010). Induction of reactive oxygen species-mediated autophagy by a novelmicrotubule-modulating agent. Journal of Biological Chemistry, 285, 18737-18748.
  • Kanters, S.D., Banga, J.D., Algra, A., Frijns, R.C, Beutler, J.J., and Fijnheer, R. (2001). Plasma levels of cellular fibronectin in diabetes. Diabetes Care, 24, 323-337.
  • Kaneto, H., Katakami, N., Matsuhisa, M., and Matsuoka, T.A. (2010). Role ofreactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators of Inflammation, 2010, 453892.
  • Kanellis, J., Watanabe, S., Li, J.H., Kang, D.H., Li, P., Nakagawa, T., Wamsley,A., Sheikh-Hamad, D., Lan, H.Y., Feng, L., and Johnson, R.J. (2003). Uric acidstimulates monocyte chemoattractant protein-1 production in vascular smoothmuscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension, 41, 1287-1293.
  • Kanauchi, M., Nishioka, M., and Dohi, K. (2000). Secreted protein acidic andrich in cysteine (SPARC) in patients with diabetic nephropathy andtubulointerstitial injury. Diabetologia, 43, 1076-1077.
  • Kakkar, R., Mantha, S.V., Radhi, J., Prasad, K., and Kalra, J. (1998). Increasedoxidative stress in rat liver and pancreas during progression of streptozotocininduceddiabetes. Clinical Science, 94, 623-632.
  • Justo, R., Boada, J., Frontera, M., Oliver, J., Bermudez, J., and Gianotti, M. (2005). Gender dimorphism in rat liver mitochondrial oxidative metabolism andbiogenesis. American Journal of Physiology - Cell Physiology, 289, C372-378.
  • Joo, J.I., Oh, T.S., Kim, D.H., Choi, D.K., Wang, X., Choi, J.W., and Yun, J.W. (2011). Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet. Proteomics, 11, 1429-1448.
  • Jonsson, D. (2007). The biological role of the female sex hormone estrogen inthe periodontium-studies on human periodontal ligament cells. Swedish dentaljournal. Supplement, 11-54.
  • Johnson, R.J., Nakagawa, T., Sanchez-Lozada, L.G., Shafiu, M., Sundaram, S.,Le, M., Ishimoto, T., Sautin, Y.Y., and Lanaspa, M.A. (2013). Sugar, uric acid,and the etiology of diabetes and obesity. Diabetes, 62, 3307-3315.
  • Jiang, Y.L., Ning, Y., Ma, X.L., Liu, Y.Y., Wang, Y., Zhang, Z., Shan, C.X., Xu,Y.D., Yin, L.M., and Yang, Y.Q. (2011). Alteration of the proteome profile of thepancreas in diabetic rats induced by streptozotocin. International Journal ofMolecular Medicine, 28, 153-160.
  • Jensen, M.D., Martin, M.L., Cryer, P.E., and Roust, L.R. (1994). Effects ofestrogen on free fatty acid metabolism in humans. American Journal ofPhysiology, 266, E914-920.
  • Jennens, M.L., and Lowe, M.E. (1995). Rat GP-3 is a pancreatic lipase withkinetic properties that differ from colipase-dependent pancreatic lipase. Journalof Lipid Research, 36, 2374-2382.
  • Jansen, F., Yang, X., Franklin, B.S., Hoelscher, M., Schmitz, T., Bedorf, J.,Nickenig, G., and Werner, N. (2013). High glucose condition increases NADPHoxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovascular Research, 98, 94-106.
  • Jang, Y.Y., Song, J.H., Shin, Y.K., Han, E.S., and Lee, C.S. (2000). Protectiveeffect of boldine on oxidative mitochondrial damage in streptozotocin-induceddiabetic rats. Pharmacological Research, 42, 361-371.
  • Jandeleit-Dahm, K., Rumble, J., Cox, A.J., Kelly, D.J., Dziadek, M., Cooper,M.E., and Gilbert, R.E. (2000). SPARC gene expression is increased in diabetesrelatedmesenteric vascular hypertrophy. Microvascular Research, 59, 61-71.
  • Jain, S.K., Rains, J., Croad, J., Larson, B., and Jones, K. (2009). Curcuminsupplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in highglucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1,glucose, and glycosylated hemoglobin in diabetic rats. Antioxidants and RedoxSignaling, 11, 241-249.
  • Insenser, M., Montes-Nieto, R., Vilarrasa, N., Lecube, A., Simo, R., Vendrell, J.,and Escobar-Morreale, H.F. (2012). A nontargeted proteomic approach to thestudy of visceral and subcutaneous adipose tissue in human obesity. Molecularand Cellular Endocrinology, 363, 10-19.
  • Inoguchi, T., Li, P., Umeda, F., Yu, H.Y., Kakimoto, M., Imamura, M., Aoki, T.,Etoh, T., Hashimoto, T., Naruse, M., Sano, H., Utsumi, H., and Nawata, H. (2000). High glucose level and free fatty acid stimulate reactive oxygen speciesproduction through protein kinase C-dependent activation of NAD(P)H oxidasein cultured vascular cells. Diabetes, 49, 1939-1945.
  • Inada, S., Ikeda, Y., Suehiro, T., Takata, H., Osaki, F., Arii, K., Kumon, Y., andHashimoto K. (2007). Glucose enhances protein tyrosine phosphatase 1B genetranscription in hepatocytes. Molecular and Cellular Endocrinology, 271, 64-70.
  • Huxley, H., and Hanson, J. (1954). Changes in the cross-striations of muscleduring contraction and stretch and their structural interpretation. Nature, 173,973-976.
  • Huang, W., Bansode, R., Mehta, M., and Mehta, K.D. (2009). Loss of proteinkinase C beta function protects mice against diet-induced obesity anddevelopment of hepatic steatosis and insulin resistance. Hepatology, 49, 1525-1536.
  • Holm, C., Osterlund, T., Laurell, H., and Contreras, J.A. (2000). Molecularmechanisms regulating hormone-sensitive lipase and lipolysis. Annual Review ofNutrition, 20, 365-393.
  • Hojlund, K., Wrzesinski, K., Larsen, P.M., Fey, S.J., Roepstorff, P., Handberg, A.,Dela, F., Vinten, J., McCormack, J.G., Reynet, C., and Beck-Nielsen, H. (2003). Proteome analysis reveals phosphorylation of ATP synthase beta-subunit inhuman skeletal muscle and proteins with potential roles in type 2 diabetes. Journal of Biological Chemistry, 278, 10436-10442.
  • Hisamoto, K., Ohmichi, M., Kurachi, H., Hayakawa, J., Kanda, Y., Nishio, Y.,Adachi, K., Tasaka, K., Miyoshi, E., Fujiwara, N., Taniguchi, N., and Murata, Y. (2001). Estrogen induces the Akt-dependent activation of endothelial nitric-oxidesynthase in vascular endothelial cells. Journal of Biological Chemistry, 276,3459-3467.
  • Hill, J.W., Elmquist, J.K., and Elias, C.F. (2008). Hypothalamic pathways linkingenergy balance and reproduction. American Journal of Physiology -Endocrinology and Metabolism, 294, E827-832.
  • Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed byhigh fat diets in the rat. Journal of Lipid Research, 31, 623-631.
  • Heine, P.A., Taylor, J.A., Iwamoto, G.A., Lubahn, D.B., and Cooke, P.S. (2000). Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 97, 12729-12734.
  • Heikkinen, J., Kyllonen, E., Kurttila-Matero, E., Wilen-Rosenqvist, G., Lankinen,K.S., Rita, H., and Vaananen, H.K. (1997). HRT and exercise: effects on bonedensity, muscle strength and lipid metabolism. A placebo controlled 2-yearprospective trial on two estrogen-progestin regimens in healthy postmenopausalwomen. Maturitas, 26, 139-149.
  • Hartl, F.U. (1996). Molecular chaperones in cellular protein folding. Nature, 381,571-579.
  • Harries, L.W., McCulloch, L.J., Holley, J.E, Rawling, T.J., Welters, H.J., and Kos,K. (2013). A role for SPARC in the moderation of human insulin secretion. PlosOne, 8, e68253.
  • Hardt, P.D., Killinger, A., Nalop, J., Schnell-Kretschmer, H., Zekorn, T., and Klor,H.U. (2002). Chronic pancreatitis and diabetes mellitus. A retrospective analysisof 156 ERCP investigations in patients with insulin-dependent and non-insulindependentdiabetes mellitus. Pancreatology, 2, 30-33.
  • Halliwell, B. (1994). Free radicals, antioxidants, and human disease: curiosity,cause, or consequence? The Lancet, 344, 721-724.
  • Guichard, C., Moreau, R., Pessayre, D., Epperson, T.K., and Krause, K.H. (2008). NOX family NADPH oxidases in liver and in pancreatic islets: a role in themetabolic syndrome and diabetes? Biochemical Society Transactions, 36(Pt 5),920-929.
  • Greenwel, P., Tanaka, S., Penkov, D., Zhang, W., Olive, M., Moll, J., Vinson, C.,Di Liberto, M., and Ramirez, F. (2000). Tumor necrosis factor alpha inhibits typeI collagen synthesis through repressive CCAAT/enhancer-binding proteins. Molecular and Cellular Biology, 20, 912-918.
  • Green, H.J., Fraser, I.G., and Ranney, D.A. (1984). Male and female differencesin enzyme activities of energy metabolism in vastus lateralis muscle. Journal ofthe Neurological Sciences, 65, 323-331.
  • Gojo, A., Utsunomiya, K., Taniguchi, K., Yokota, T., Ishizawa, S., Kanazawa, Y.,Kurata, H., and Tajima, N. (2007). The rho-kinase inhibitor, fasudil, attenuatesdiabetic nephropathy in streptozotocin-induced diabetic rats. European Journalof Pharmacology, 568, 242-247.
  • Gilbert, R.E., McNally, P.G., Cox, A., Dziadek, M., Rumble, J., Cooper, M.E.,and Jerums, G. (1995). SPARC gene expression is reduced in early diabetesrelatedkidney growth. Kidney International, 48, 1216-1225.
  • Giacco, F., and Brownlee, M. (2010). Oxidative stress and diabetic complications. Circulation Research, 107, 1058?1070.
  • Gayan-Ramirez, G., van de Casteele, M., Rollier, H., Fevery, J., Vanderhoydonc,F., Verhoeven, G., and Decramer, M. (1998). Biliary cirrhosis induces type IIx/bfiber atrophy in rat diaphragm and skeletal muscle, and decreases IGF-I mRNAin the liver but not in muscle. Journal of Hepatology, 29, 241-249.
  • Gao, J., Wang, F., Wang, W., Su, Z., Guo, C., and Cao, S. (2014). Emodinsuppresses hyperglycemia-induced proliferation and fibronectin expression inmesangial cells via inhibiting cFLIP. PLoS One, 9, e93588.
  • Fridman, J.S., and Lowe, S.W. (2003). Control of apoptosis by p53. Oncogene,22, 9030-9040.
  • Franceschini, A., Szklarczyk, D., Frankild, S., Kuhn, M., Simonovic, M., Roth,A., Lin, J., Minguez, P., Bork, P., von Mering, C., and Jensen, L.J. (2013). STRING v9.1: protein-protein interaction networks, with increased coverage andintegration. Nucleic Acids Research, 41, D808-D815.
  • Finocchiaro, G., Ito, M., Ikeda, Y., and Tanaka, K. (1988). Molecular cloning andnucleotide sequence of cDNAs encoding the alpha-subunit of human electrontransfer flavoprotein. Journal of Biological Chemistry, 263, 15773-15780.
  • Fernandez, J., Gharahdaghi, F., and Mische, S.M. (1998). Routine identificationof proteins from sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) gels or polyvinyl difluoride membranes using matrix assisted laserdesorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS)Electrophoresis, 19, 1036-1045.
  • Fenouille, N., Puissant, A., Tichet, M., Zimniak, G., Abbe, P., Mallavialle, A.,Rocchi, S., Ortonne, J.P, Deckert, M., Ballotti, R., and Tartare-Deckert, S. (2011). SPARC functions as an anti-stress factor by inactivating p53 through AktmediatedMDM2 phosphorylation to promote melanoma cell survival. Oncogene,30, 4887-4900.
  • Fatma, N., Singh, P., Chhunchha, B., Kubo, E., Shinohara, T., Bhargavan, B., andSingh, D.P., (2011). De ficiency of Prdx6 in lens epithelial cells induces ER stressresponse-mediated impaired homeostasis and apoptosis. American Journal ofPhysiology - Cell Physiology, 301, C954-C967.
  • Eskes, T., and Haanen, C. (2007). Why do women live longer than men?European Journal of Obstetrics and Gynecology and Reproductive Biology, 133,126-133.
  • Elghazi, L., Gould, A.P., Weiss, A.J., Barker, D.J., Callaghan, J., Opland, D.,Myers, M., Cras-Meneur, C., and Bernal-Mizrachi, E. (2012). Importance of β-Catenin in glucose and energy homeostasis. Scientific Reports, 2, 693.
  • Douen, A.G., Ramlal, T., Rastogi, S., Bilan, P.J., Cartee, G.D., Vranic, M.,Holloszy, J.O., and Klip, A. (1990). Exercise induces recruitment of the "insulin-193-responsive glucose transporter". Evidence for distinct intracellular insulin- andexercise-recruitable transporter pools in skeletal muscle. Journal of BiologicalChemistry, 265, 13427-13430.
  • Dominguez-Munoz, J.E., Pieramico, O., Buchler, M., and Malfertheiner, P. (1993). Ratios of different serum pancreatic enzymes in the diagnosis andstaging of chronic pancreatitis. Digestion, 54, 231-236.
  • Dolan, P.L., Tapscott, E.B., Dorton, P.J., and Dohm, G.L. (1993). Contractileactivity restores insulin responsiveness in skeletal muscle of obese Zucker rats. Biochemical Journal, 289 (Pt 2), 423-426.
  • Dodgson, S.J., and Watford, M. (1990). Differential regulation of hepaticcarbonic anhydrase isozymes in the streptozotocin-diabetic rat. Archives ofBiochemistry and Biophysics, 277, 410-414.
  • Diana, J., and Lehuen, A. (2014). Macrophages and β-cells are responsible forCXCR2-mediated neutrophil infiltration of the pancreas during autoimmunediabetes. EMBO Molecular Medicine, 6, 1090-1104.
  • Demonacos C.V., Karayanni, N., Hatzoglou, E., Tsiriyiotis, C., Spandidos, D.A.,and Sekeris, C.E. (1996), Mitochondrial genes as sites of primary action ofsteroid hormones. Steroids, 61, 226-232.
  • Dejeans, N., Auclair, S., Chauvet, S., Milenkovic, D., and Mazur, A. (2009). Transcriptomic analysis of aorta from a short-term high-fat diet fed mousereveals changes in the expression of vessel structure genes. Journal of physiologyand pharmacology, 60 Suppl 1, 37-45.
  • De Reggi, M., and Gharib, B. (2001). Protein-X, pancreatic stone-, pancreaticthread-, reg-protein, P19, lithostathine, and now what? characterization,structural analysis and putative function(s) of the major nonenzymatic protein ofpancreatic secretions. Current Protein and Peptide Science, 2, 19-42.
  • Dandona, P., Freedman, D.B., Foo, Y., Perkins, J., Katrak, A., Mikhailidis, D.P.,Rosalki, S.B., and Beckett, A.G. (1984). Exocrine pancreatic function in diabetesmellitus. Journal of Clinical Pathology, 37, 302-306.
  • D'Eon, T.M., Souza, S.C., Aronovitz, M., Obin, M.S., Fried, S.K., and Greenberg,A.S. (2005). Estrogen regulation of adiposity and fuel partitioning. Evidence ofgenomic and non-genomic regulation of lipogenic and oxidative pathways. Journal of Biological Chemistry, 280, 35983-35991.
  • D'Autreaux, B., and Toledano, M.B. (2007). ROS as signalling molecules:mechanisms that generate specificity in ROS homeostasis. Nature reviewsMolecular cell biology 8, 813-824.
  • Czaja, M.J., (2010). JNK regulation of hepatic manifestations of the metabolicsyndrome. Trends in Endocrinology and Metabolism, 21, 707-713.
  • Coort, S.L., Coumans, W.A., Bonen, A., van der Vusse, G.J., Glatz, J.F., andLuiken, J.J. (2005). Divergent effects of rosiglitazone on protein-mediated fattyacid uptake in adipose and in muscle tissues of Zucker rats. Journal of LipidResearch, 46, 1295-1302.
  • Clifford, A.J., Chen, K., McWade, L., Rincon, G., Kim, S.H., Holstege, D.M.,Owens, J.E., Liu, B., Muller, H.G., Medrano, J.F., Fadel, J.G., Moshfegh, A.J.,Baer, D.J., and Novotny, J.A. (2012). Gender and single nucleotidepolymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 aresignificant predictors of plasma homocysteine normalized by RBC folate inhealthy adults. Journal of Nutrition, 142, 1764-1771.
  • Christofilis, M.A., Carrere, J., Atlan-Gepner, C., Zevaco- Mattei, C., Thivolet, C.,Baeza, N., Figarella, C., and Vialettes, B. (1999). Serum reg protein level is notrelated to the beta cell destruction/regeneration process during early phases ofdiabetogenesis in type I diabetes. European Journal of Endocrinology, 141, 368-373.
  • Christensen, U.B., Larsen, P.M., Fey, S.J., Andersen, H.U., Nawrocki, A., Sparre,T., Mandrup-Poulsen, T., and Nerup, J. (2000). Islet protein expression changesduring diabetes development in islet syngrafts in BB-DP rats and during rejectionof BB-DP islet allografts. Autoimmunity, 32, 1-15.
  • Choi, S.K., Galan, M., Kassan, M., Partyka, M., Trebak, M., and Matrougui, K. (2012). Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriolefunction in type 2 diabetes mellitus. Hypertension, 59, 1060-1068.
  • Choi, M., Choi, J.W., Chaudhari, H.N., Aseer, K.R., Mukherjee, R., and Yun, J.W. (2013b). Gender-dimorphic regulation of skeletal muscle proteins instreptozotocin-induced diabetic rats. Cellular Physiology and Biochemistry, 31,408-420.
  • Choi, J.W., Wang, X., Joo, J.I., Kim, D.H., Oh, T.S., Choi, D.K., and Yun, J.W. (2010). Plasma proteome analysis in dietinduced obesity-prone and obesity-resistant rats. Proteomics, 10, 4386-4400.
  • Choi, J.W., Aseer, K.R., Chaudhari, H.N., Mukherjee, R., Choi, M., and Yun, J.W. (2013a). Gender dimorphism in regulation of plasma proteins in streptozotocininduceddiabetic rats. Proteomics, 13, 2482-2494.
  • Chen, Y., Hu, Y., Zhou, T., Zhou, K.K., Mott, R., Wu, M., Boulton, M., Lyons,T.J., Gao, G., and Ma, J.X. (2009). Activation of the Wnt pathway plays apathogenic role in diabetic retinopathy in humans and animal models. AmericanJournal of Pathology, 175, 2676-2685.
  • Chen, J.Y., Chou, H.C., Chen, Y.H., and Chan, H.L. (2013). High glucoseinducedproteome alterations in hepatocytes and its possible relevance to diabeticliver disease. Journal of Nutritional Biochemistry, 24, 1889-910.
  • Chang, T.C., Hsu, M.F., and Wu, K.K. (2015). High glucose induces bonemarrow-derived mesenchymal stem cell senescence by upregulating autophagy. PLoS One, 10, e0126537.
  • Chamorro-Jorganes, A., Calleros, L., Griera, M., Saura, M., Luengo, A.,Rodriguez-Puyol, D., and Rodriguez-Puyol, M. (2011). Fibronectin upregulatescGMP-dependent protein kinase type Iβ through C/EBP transcription factoractivation in contractile cells. American Journal of Physiology -Cell Physiology,300, C683-C691.
  • Catalan, V., Gomez-Ambrosi, J., Rodriguez, A., Perez-Hernandez, A.I., Gurbindo,J., Ramirez, B., Mendez-Gimenez, L., Rotellar, F., Valenti, V., Moncada, R.,Marti, P., Sola, I., Silva, C., Salvador, J., and Fruhbeck, G. (2014). Activation ofnoncanonical Wnt signaling through WNT5A in visceral adipose tissue of obesesubjects is related to inflammation. The Journal of Clinical Endocrinology andMetabolism, 99, E1407-E1417.
  • Carr, M.C. (2003). The emergence of the metabolic syndrome with menopause. The Journal of Clinical Endocrinology and Metabolism, 88, 2404-2411.
  • Camino, A.M, Atorrasagasti, C., Maccio, D., Prada, F., Salvatierra, E., Rizzo, M.,Alaniz, L., Aquino, J.B., Podhajcer, O.L., Silva, M., and Mazzolini, G. (2008). Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. Journal of Gene Medicine, 10, 993-1004.
  • Brotto, M.A., Biesiadecki, B.J., Brotto, L.S., Nosek, T.M., and Jin, J.P. (2006). Coupled expression of troponin T and troponin I isoforms in single skeletalmuscle fibers correlates with contractility. American Journal of Physiology - CellPhysiology, 290, C567-576.
  • Brekken, R.A., and Sage, E.H. (2001). SPARC, a matricellular protein: at thecrossroads of cell-matrix communication. Matrix Biology, 19, 816-827.
  • Bradford M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry, 72, 248-254
  • Booth, F.W., and Thomason, D.B. (1991). Molecular and cellular adaptation ofmuscle in response to exercise: perspectives of various models. PhysiologicalReviews. 71, 541-585.
  • Blazejewski, S., Le Bail, B., Boussarie, L., Blanc, J.F., Malaval, L., Okubo, K.,Saric, J., Bioulac-Sage, P., and Rosenbaum, J. (1997). Osteonectin (SPARC)expression in human liver and in cultured human liver myofibroblasts. AmericanJournal of Pathology, 151, 651-657.
  • Bjorntorp, P. (1985). Regional patterns of fat distribution. Annals of InternalMedicine, 103, 994-995.
  • Bienert, G.P., Schjoerring, J.K., and Jahn, T.P. (2006). Membrane transport ofhydrogen peroxide. Biochimica et Biophysica Acta, 1758, 994-1003.
  • Bhoopathi, P., Gorantla, B., Sailaja, G.S., Gondi, C.S, Gujrati, M., Klopfenstein,J.D., and Rao, J.S. (2012). SPARC overexpression inhibits cell proliferation inneuroblastoma and is partly mediated by tumor suppressor protein PTEN andAKT. PLoS One, 7, e36093.
  • Bhoopathi, P., Chetty, C., Gujrati, M., Dinh, D.H., Rao, J.S., and Lakka, S. (2010). Cathepsin B facilitates autophagy-mediated apoptosis in SPARCoverexpressed primitive neuroectodermal tumor cells. Cell Death andDifferentiation, 17, 1529-1539.
  • Bhoopathi, P., Chetty, C., Dontula, R., Gujrati, M., Dinh, D.H., Rao, J.S., andLakka, S.S. (2011). SPARC stimulates neuronal differentiation ofmedulloblastoma cells via the Notch1/STAT3 pathway. Cancer Research, 71,4908-4919.
  • Berke, B.M., and Kaplan, M.L. (1983). Effects of high fat and high carbohydratediets on development of hepatic and adipose lipogenesis in fa/fa and non-fa/farats. Journal of Nutrition, 113, 820-834.
  • Berchtold, M.W., Brinkmeier, H., and Muntener, M. (2000). Calcium ion inskeletal muscle: its crucial role for muscle function, plasticity, and disease. Physiological Reviews, 80, 1215-1265.
  • Bence, K.K. (ed.). (2013). Protein Tyrosine Phosphatase Control of Metabolism,Springer Science+Business Media, New York, pp. 239-262.
  • Barros, R.P., Machado, U.F., Warner, M., and Gustafsson, J.A. (2006). MuscleGLUT4 regulation by estrogen receptors ER-beta and ER-alpha. Proceedings ofthe National Academy of Sciences of the United States of America, 103, 1605-1608.
  • Barclay, C.J., Woledge, R.C., and Curtin, N.A. (2007). Energy turnover for Ca2+cycling in skeletal muscle. Journal of Muscle Research and Cell Motility, 28,259-274.
  • Aughsteen, A.A., Abu-Umair, M.S., and Mahmoud, S.A. (2005). Biochemicalanalysis of serum pancreatic amylase and lipase enzymes in patients with type 1and type 2 diabetes mellitus. Saudi Medical Journal, 26, 73-77.
  • Atorrasagasti, C., Peixoto, E., Aquino, J.B., Kippes, N., Malvicini, M., Alaniz, L.,Garcia, M., Piccioni, F., Fiore, E.J., Bayo, J., Bataller, R., Guruceaga, E.,Corrales, F., Podhajcer, O., and Mazzolini, G. (2013). Lack of the matricellularprotein SPARC (secreted protein, acidic and rich in cysteine) attenuates liverfibrogenesis in mice. PLoS One, 8, e54962.
  • Ashmarina, L.I., Rusnak, N., Miziorko, H.M., and Mitchell, G.A. (1994). 3-Hydroxy-3-methylglutaryl-CoA lyase is present in mouse and human liverperoxisomes. Journal Biological Chemistry, 269, 31929-31932.
  • Aseer, K.R., and Yun, J.W. (2013). Gender-dependent expression of pancreaticproteins in streptozotocin-induced diabetic rats. Biotechnology and BioprocessEngineering, 18, 1122-1134.
  • Aseer, K.R., Kim, S.W., Choi, M.S., and Yun, J.W. (2015). Opposite Expressionof SPARC between the Liver and Pancreas in Streptozotocin-Induced DiabeticRats. PLoS One, 10, e0131189.
  • Arnold, S.A., and Brekken, R.A. (2009). SPARC: a matricellular regulator oftumorigenesis. Journal of Cell Communication and Signaling, 3, 255-273.
  • Aram, G., Potter, J.J., Liu, X., Torbenson, M.S., and Mezey, E. (2008). Lack ofinducible nitric oxide synthase leads to increased hepatic apoptosis anddecreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology, 47, 2051-2058.
  • Andersen, H.U., Fey, S.J., Larsen, P.M., Nawrocki, A., Hejnaes, K.R., Mandrup-Poulsen, T., and Nerup J. (1997). Interleukin-1beta induced changes in theprotein expression of rat islets: a computerized database. Electrophoresis, 18,2091-2103.
  • Anastasi, E., Ponte, E., Gradini, R., Bulotta, A., Sale, P., Tiberti, C., Okamoto, H.,Dotta, F., and Di Mario, U. (1999). Expression of Reg and cytokeratin 20 duringductal cell differentiation and proliferation in a mouse model of autoimmunediabetes. European Journal of Endocrinology, 141, 644-652.
  • Amin, R.H., Mathews, S.T., Camp, H.S., Ding, L., and Leff, T. (2010). Selectiveactivation of PPAR-gamma in skeletal muscle induces endogenous production ofadiponectin and protects mice from diet-induced insulin resistance. AmericanJournal of Physiology-Endocrinology and Metabolism, 298, E28-37.
  • Alberti, K.G., Zimmet, P., and Shaw, J. (2006). Metabolic syndrome-a newworld-wide definition. A Consensus Statement from the International DiabetesFederation. Diabetic Medicine, 23, 469-480.
  • Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S., Nishio, Y., Nakajima,T., Hirano, T., and Kishimoto, T. (1990). A nuclear factor for IL-6 expression(NF-IL6) is a member of a C/EBP family. The EMBO Journal, 9, 1897-1906.
  • Ahmed, M. (2010). Proteomics and islet research. Advances in ExperimentalMedicine and Biology, 654, 363-390.
  • Afzali, A., Weiss, N.S., Boyko, E.J., and Ioannou, G.N. (2010). Associationbetween serum uric acid level and chronic liver disease in the United States. Hepatology, 52, 578-589.
  • Adrogue, H.J., Wilson, H., Boyd, A.E. 3rd., Suki, W.N., and Eknoyan, G. (1982). Plasma acid base patterns in diabetic ketoacidosis. The New England Journal ofMedicine, 307, 1603-1610.
  • Abou Mrad, J., Yakubu, F., Lin, D., Peters, J.C., Atkinson, J.B., and Hill, J.O. (1992). Skeletal muscle composition in dietary obesity-susceptible and dietaryobesity-resistant rats. American Journal of Physiology, 262, R684-688.