박사

The protective effect of bee venom against Porphyromonas gingivalis LPS-induced inflammation in human keratinocytes : 각질세포에서 Porphyromonas gingivalis LPS로 유도된 실험적 치주염 모델에서 봉독의 항염증 효과

권용철 2016년
논문상세정보
' The protective effect of bee venom against Porphyromonas gingivalis LPS-induced inflammation in human keratinocytes : 각질세포에서 Porphyromonas gingivalis LPS로 유도된 실험적 치주염 모델에서 봉독의 항염증 효과' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • Akt/Erk activation
  • Effects of bee venom
  • bee venom
  • hacat
  • human keratinocytes
  • inflammation
  • keratinocytes
  • lps
  • porphyromonas gingivalis
  • tnfα
  • 실험적 치주염
  • 항염증
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
1,204 0

0.0%

' The protective effect of bee venom against Porphyromonas gingivalis LPS-induced inflammation in human keratinocytes : 각질세포에서 Porphyromonas gingivalis LPS로 유도된 실험적 치주염 모델에서 봉독의 항염증 효과' 의 참고문헌

  • Zhang W, Ju J, Rigney T, Tribble G. Integrin alpha5beta1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway. BMC microbiology.2013;13:5.
  • Yee M, Kim S, Sethi P, Duzgunes N, Konopka K. Porphyromonas gingivalis stimulates IL-6 and IL-8 secretion in GMSM-K, HSC-3 and H413 oral epithelial cells. Anaerobe. 2014;28:62-7.
  • Yaron A,HatzubaiA,DavisM,Lavon I,AmitS,Manning AM, et al. Identification of the receptor component of the IkappaBalpha-ubiquitinligase.Nature.1998;396:590-4.
  • Yanti,LeeM,Kim D,Hwang JK.Inhibitory effectofpanduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells. Biological & pharmaceutical bulletin.2009;32:1770-5.
  • Yang HW,Huang YF,Chou MY.Occurrence ofPorphyromonas gingivalis and Tannerella forsythensis in periodontally diseased and healthy subjects. Journal of periodontology. 2004;75:1077- 83.
  • WebsterGF.Acnevulgaris.BMJ.2002;325:475-9.
  • Wang PL,Ohura K.Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2002;13:132-42.
  • Vowels BR,Yang S,Leyden JJ.Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infection and immunity.1995;63:3158-65.
  • Trinchieri G,Sher A.Cooperation of Toll-like receptor signals in innate immune defence. Nature reviews Immunology. 2007;7:179-90.
  • Tribble GD,Kerr JE,Wang BY.Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biologicalconsequences.Futuremicrobiology.2013;8:607-20.
  • TonettiMS,Imboden MA,Lang NP.Neutrophilmigration into the gingivalsulcus is associated with transepithelialgradients of interleukin-8 and ICAM-1. Journal of periodontology. 1998;69:1139-47.
  • Teng YT. Protective and destructive immunity in the periodontium: Part 1--innate and humoral immunity and the periodontium.Journalofdentalresearch.2006;85:198-208.
  • Teles R, Sakellari D, Teles F, Konstantinidis A, Kent R, Socransky S,etal.Relationships among gingivalcrevicularfluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota. Journal of periodontology. 2010;81: 89-98.
  • Taylor JJ. Cytokine regulation of immune responses to Porphyromonasgingivalis.Periodontology2000.2010;54:160-94.
  • Tang X,Pan Y,Zhao Y.Vitamin D inhibits the expression of interleukin-8 in human periodontalligamentcells stimulated with Porphyromonas gingivalis. Archives of oral biology. 2013;58:397-407.
  • Takeuchi H,Hirano T,Whitmore SE,Morisaki I,Amano A, Lamont RJ. The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-kappaB RelA/p65.PLoS pathogens.2013;9:e1003326.
  • Stuhlmeier KM.Apis mellifera venom and melittin block neither NF-kappa B-p50-DNA interactions nor the activation of NF-kappa B, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates.JImmunol.2007;179:655-64.
  • StiegerM,Wuthrich B,Wyss S,KopperE.[Clinicalpicture and diagnosis of bee-venom allergy. A comparison between skin tests and RAST determinations]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 1978;29: 632-7.
  • Spencer E,Jiang J,Chen ZJ.Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.Genes & development.1999;13:284-94.
  • Socransky SS,Haffajee AD,CuginiMA,Smith C,KentRL,Jr. Microbial complexes in subgingival plaque. Journal of clinical periodontology.1998;25:134-44.
  • ShibataM,Katsuyama M,Onodera T,Ehama R,HosoiJ,Tagami H. Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with Propionibacterium acnes or proinflammatory cytokines. The Journal of investigative dermatology.2009;129:375-82.
  • SeymourGJ,GemmellE,Kjeldsen M,YamazakiK,Nakajima T, Hara K.Cellular immunity and hypersensitivity as components ofperiodontaldestruction.Oraldiseases.1996;2:96-101.
  • Schmidt N, Gans EH. Tretinoin: A Review of Its Anti-inflammatory Properties in the Treatment of Acne.The Journalofclinicalandaestheticdermatology.2011;4:22-9.
  • Scheres N,Laine ML,de Vries TJ,Everts V,van Winkelhoff AJ.Gingivaland periodontalligament fibroblasts differ in their inflammatory response to viable Porphyromonas gingivalis. Journalofperiodontalresearch.2010;45:262-70.
  • Scheres N,Laine ML,Sipos PM,Bosch-TijhofCJ,Crielaard W, de Vries TJ,etal.Periodontalligamentand gingivalfibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis. Journal of periodontal research. 2011;46:407-16.
  • Sanz M,Lau L,Herrera D,Morillo JM,Silva A.Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontalmicrobiology, with special emphasis on advanced molecular techniques: a review.Journalofclinicalperiodontology.2004;31:1034-47.
  • Roberts FA,McCaffery KA,Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. Journal of dentalresearch.1997;76:1833-9.
  • Roberts FA, Hockett RD, Jr., Bucy RP, Michalek SM. Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontitis.Oral microbiology and immunology.1997;12:336-44.
  • Raingeaud J, Pierre J. Interleukin-4 downregulates TNFalphainduced IL-8 production in keratinocytes. FEBS letters. 2005;579:3953-9.
  • Rahman MM,McFadden G.Modulation ofNF-kappaB signalling by microbial pathogens. Nature reviews Microbiology. 2011;9: 291-306.
  • Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding ofperiodontitis? Journalofclinical periodontology.2011;38Suppl11:60-84.
  • PivarcsiA,BodaiL,RethiB,Kenderessy-Szabo A,Koreck A, SzellM,etal.Expression and function ofToll-like receptors 2 and 4 in human keratinocytes. International immunology. 2003;15:721-30.
  • Perlman H,Bradley K,Liu H,Cole S,Shamiyeh E,Smith RC, et al. IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts.JImmunol.2003;170:838-45.
  • Pathirana RD,O'Brien-Simpson NM,Reynolds EC.Hostimmune responses to Porphyromonas gingivalis antigens. Periodontology 2000.2010;52:218-37.
  • Park HJ,Lee SH,Son DJ,Oh KW,Kim KH,Song HS,etal. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis and rheumatism. 2004;50:3504-15.
  • Palm NW,Medzhitov R.Role of the inflammasome in defense against venoms. Proceedings of the National Academy of SciencesoftheUnitedStatesofAmerica.2013;110:1809-14.
  • Netea MG,van der GraafC,Van der Meer JW,Kullberg BJ. Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. Journalofleukocytebiology.2004;75:749-55.
  • Neish AS,Naumann M.Microbial-induced immunomodulation by targeting the NF-kappaB system. Trends in microbiology. 2011;19:596-605.
  • Nagy I,PivarcsiA,Koreck A,SzellM,Urban E,Kemeny L. Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. The Journal of investigativedermatology.2005;124:931-8.
  • Mysak J,Podzimek S,Sommerova P,Lyuya-MiY,Bartova J, Janatova T, et al. Porphyromonas gingivalis: major periodontopathic pathogen overview. Journal of immunology research.2014;2014:476068.
  • MurakamiJ,Kato T,KawaiS,AkiyamaS,Amano A,MorisakiI. Cellular motility of Down syndrome gingival fibroblasts is susceptible to impairment by Porphyromonas gingivalis invasion. Journalofperiodontology.2008;79:721-7.
  • Morandini AC, Chaves Souza PP, Ramos-Junior ES, Brozoski DT, Sipert CR, Souza Costa CA, et al. Toll-like receptor 2 knockdown modulates interleukin (IL)-6 and IL-8 but not stromal derived factor-1 (SDF-1/CXCL12) in human periodontal ligament and gingival fibroblasts. Journal of periodontology. 2013;84:535-44.
  • Miggin SM,O'Neill LA.New insights into the regulation of TLR signaling.Journalofleukocytebiology.2006;80:220-6.
  • Mans JJ,Hendrickson EL,Hackett M,Lamont RJ.Cellular and bacterial profiles associated with oral epithelium-microbiota interactions.Periodontology2000.2010;52:207-17.
  • Liu YC, Lerner UH, Teng YT. Cytokine responses against periodontal infection: protective and destructive roles. Periodontology2000.2010;52:163-206.
  • Liu J,Tang X,LiC,Pan C,LiQ,Geng F,etal.Porphyromonas gingivalis promotes the cell cycle and inflammatory cytokine production in periodontal ligament fibroblasts. Archives of oral biology.2015;60:1153-61.
  • Liu J, Wang Y, Ouyang X. Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-kappaB and ERK signaling pathways in periodontal fibroblasts. Inflammation. 2014;37:522-33.
  • Listgarten MA, Loomer PM. Microbial identification in the management of periodontal diseases. A systematic review. Annals of periodontology / the American Academy of Periodontology.2003;8:182-92.
  • Lin SJ,Chen YL,Kuo MY,LiCL,Lu HK.Measurement of gp130 cytokines oncostatin M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis. Cytokine. 2005;30: 160-7.
  • Li C, Liu J, Tan L, Yu N, Lin L, Geng F, et al. The sociodemographic characteristics, periodontal health status, and subgingivalmicrobiota of patients with chronic periodontitis and type 2 diabetes mellitus: a case-control study in a Chinese population.Journalofperiodontology.2013;84:1058-66.
  • Lee WR,Kim KH,An HJ,Kim JY,Chang YC,Chung H,etal. The protective effects of melittin on Propionibacterium acnes-induced inflammatory responses in vitro and in vivo.The Journalofinvestigativedermatology.2014;134:1922-30.
  • LamontRJ,Jenkinson HF.Subgingivalcolonization by Porphyromonas gingivalis.Oralmicrobiologyandimmunology.2000;15:341-9.
  • Lamont RJ, Yilmaz O. In or out: the invasiveness of oral bacteria.Periodontology2000.2002;30:61-9.
  • Kwon YB,LeeHJ,Han HJ,MarWC,Kang SK,Yoon OB,etal. The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritisinrats.Lifesciences.2002;71:191-204.
  • Kwon YB,Lee JD,Lee HJ,Han HJ,MarWC,Kang SK,etal. bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain. 2001; 90:271-80.
  • Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB:its role in health and disease.J MolMed (Berl). 2004;82:434-48.
  • Kuboniwa M,Hasegawa Y,Mao S,Shizukuishi S,Amano A, LamontRJ,etal.P.gingivalis accelerates gingivalepithelialcell progression through the cell cycle. Microbes and infection / InstitutPasteur.2008;10:122-8.
  • Kuboniwa M, Lamont RJ. Subgingival biofilm formation. Periodontology2000.2010;52:38-52.
  • Kornman KS, Holt SC, Robertson PB. The microbiology of ligature-induced periodontitis in the cynomolgus monkey.Journal ofperiodontalresearch.1981;16:363-71.
  • Kollisch G,KalaliBN,VoelckerV,Wallich R,BehrendtH,Ring J, et al. Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes.Immunology.2005;114:531-41.
  • Kock A,Schwarz T,Kirnbauer R,UrbanskiA,Perry P,Ansel JC, et al. Human keratinocytes are a source for tumor necrosis factor alpha:evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.The Journalof experimentalmedicine.1990;172:1609-14.
  • Kinane DF,Galicia JC,Gorr SU,Stathopoulou PG,Benakanakere M. P. gingivalis interactions with epithelial cells. Frontiers in bioscience:ajournalandvirtuallibrary.2008;13:966-84.
  • Kim JY,Lee WR,Kim KH,An HJ,Chang YC,Han SM,etal. Effects of bee venom against Propionibacterium acnes-induced inflammation in human keratinocytes and monocytes. Internationaljournalofmolecularmedicine.2015;35:1651-6.
  • Kim JH,Kim DH,Baek SH,Lee HJ,Kim MR,Kwon HJ,etal. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells.Biochemicalpharmacology.2006;71:1198-205.
  • Kim J.Review ofthe innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokineresponses.Dermatology.2005;211:193-8.
  • Kim J,Ochoa MT,Krutzik SR,TakeuchiO,Uematsu S,Legaspi AJ, et al. Activation of toll-like receptor 2 in acne triggers inflammatorycytokineresponses.JImmunol.2002;169:1535-41.
  • Kawa K,TsutsuiH,UchiyamaR,Kato J,MatsuiK,IwakuraY, et al.IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes.Internationalimmunology.2010;22:157-66.
  • Katz J,Sambandam V,Wu JH,Michalek SM,Balkovetz DF. Characterization of Porphyromonas gingivalis-induced degradation of epithelialcelljunctionalcomplexes.Infection and immunity.2000;68:1441-9.
  • KatoT,KawaiS,NakanoK,InabaH,KuboniwaM,NakagawaI, et al. Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Cellular microbiology.2007;9:753-65.
  • Kato H, Taguchi Y, Tominaga K, Umeda M, Tanaka A. Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells. Archives of oral biology. 2014;59:167-75.
  • Kang S,Cho S,Chung JH,Hammerberg C,FisherGJ,Voorhees JJ. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo. The Americanjournalofpathology.2005;166:1691-9.
  • Jugeau S, Tenaud I, Knol AC, Jarrousse V, Quereux G, Khammari A, et al. Induction of toll-like receptors by Propionibacterium acnes. The British journal of dermatology. 2005;153:1105-13.
  • Jain A, Basal E. Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2003;10:34-8.
  • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptiveimmuneresponses.Natureimmunology.2004;5:987-95.
  • Inaba H,Kuboniwa M,BainbridgeB,YilmazO,KatzJ,Shiverick KT,etal.Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis. Cellularmicrobiology.2009;11:1517-32.
  • Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontology2000.2005;38:72-122.
  • Holt SC, Ebersole J, Felton J, Brunsvold M, Kornman KS. Implantation of Bacteroides gingivalis in nonhuman primates initiatesprogressionofperiodontitis.Science.1988;239:55-7.
  • Hider RC.HoneyBV: a rich source of pharmacologically active peptides.Endeavour.1988;12:60-5. [83] Habermann E. Bee and wasp venoms. Science. 1972;177:314- 22.
  • Heymann WR.Toll-like receptors in acne vulgaris. Journal of theAmericanAcademyofDermatology.2006;55:691-2.
  • HariA,Flach TL,ShiY,MydlarskiPR.Toll-like receptors:role in dermatological disease. Mediators of inflammation. 2010;2010:437246.
  • HajishengallisG.Periodontitis:from microbialimmunesubversion to systemicinflammation.NaturereviewsImmunology.2015;15:30-44.
  • Hajishengallis G. The inflammophilic character of the periodontitis-associated microbiota. Molecular oral microbiology. 2014;29:248-57.
  • Hajishengallis G,Liang S,Payne MA,Hashim A,Jotwani R, Eskan MA, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell host & microbe. 2011;10:497- 506.
  • Haffajee AD,CuginiMA,Tanner A,Pollack RP,Smith C,Kent RL,Jr.,etal.Subgingivalmicrobiota in healthy,well-maintained elder and periodontitis subjects. Journal of clinical periodontology.1998;25:346-53.
  • Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontology 2000. 1994;5:78-111.
  • Gursoy UK,Kononen E,Uitto VJ.Stimulation of epithelialcell matrix metalloproteinase (MMP-2, -9, -13) and interleukin-8 secretion by fusobacteria. Oral microbiology and immunology. 2008;23:432-4.
  • Groeger S, Doman E, Chakraborty T, Meyle J. Effects of Porphyromonas gingivalis infection on human gingival epithelial barrier function in vitro. European journal of oral sciences. 2010;118:582-9.
  • Grange PA, Raingeaud J, Calvez V, Dupin N. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappaB and MAPK pathways. Journalofdermatologicalscience.2009;56:106-12.
  • Garlet GP,Avila-Campos MJ,MilaneziCM,Ferreira BR,Silva JS. Actinobacillus actinomycetemcomitans-induced periodontal disease in mice: patterns of cytokine, chemokine, and chemokine receptor expression and leukocyte migration. Microbesandinfection/InstitutPasteur.2005;7:738-47.
  • Garaj-Vrhovac V,GajskiG.Evaluation ofthe cytogenetic status ofhuman lymphocytes afterexposure to a high concentration of bee venom in vitro. Arhiv za higijenu rada i toksikologiju. 2009;60:27-34.
  • Feliciani C, Gupta AK, Sauder DN. Keratinocytes and cytokine/growth factors. Critical reviews in oral biology and medicine :an officialpublication ofthe American Association of OralBiologists.1996;7:300-18.
  • Engebretson SP,Grbic JT,SingerR,LamsterIB.GCF IL-1beta profiles in periodontal disease. Journal of clinical periodontology.2002;29:48-53.
  • Dzemileva T,Popova H.[Chemicalcontrolof dentalplaque via rinsing solution "Antiplaque C".2.Cytologicaland bacterioscopic studies].StomatologiiaStomatology.1989;71:21-5.
  • Duesbery NS,Webb CP,Leppla SH,Gordon VM,KlimpelKR, Copeland TD, et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 1998;280:734-7.
  • Dosseva-Panova VT, Popova CL, Panov VE. Subgingival microbialprofile and production of proinflammatory cytokines in chronicperiodontitis.FoliaMed(Plovdiv).2014;56:152-60.
  • DombrowskiY,Peric M,Koglin S,Kaymakanov N,SchmezerV, Reinholz M, et al. Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes.Allergy. 2012;67:1400-7.
  • Diaz-Zuniga J, Monasterio G, Alvarez C, Melgar-Rodriguez S, Benitez A, Ciuchi P, et al. Variability of the dendritic cell response triggered by different serotypes of Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis is toll-like receptor 2 (TLR2) or TLR4 dependent. Journal of periodontology.2015;86:108-19.
  • DewhirstFE,Chen T,Izard J,PasterBJ,TannerAC,Yu WH,et al. The human oral microbiome. Journal of bacteriology. 2010;192:5002-17.
  • Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis.NaturereviewsMicrobiology.2010;8:481-90.
  • Darveau RP,Belton CM,Reife RA,LamontRJ.Localchemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis.Infectionandimmunity.1998;66:1660-5.
  • Dahlen G. Role of suspected periodontopathogens in microbiological monitoring of periodontitis. Advances in dental research.1993;7:163-74.
  • Colombo AV, da Silva CM, Haffajee A, Colombo AP. Identification of intracellular oral species within human crevicular epithelial cells from subjects with chronic periodontitis by fluorescence in situ hybridization. Journal of periodontalresearch.2007;42:236-43.
  • Colombo AP, Bennet S, Cotton SL, Goodson JM, Kent R, Haffajee AD, et al. Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray.Journalofperiodontology.2012;83:1279-87.
  • Chen Q,Koga T,UchiH,Hara H,Terao H,MoroiY,etal. Propionibacterium acnes-induced IL-8 production may be mediated by NF-kappaB activation in human monocytes. Journalofdermatologicalscience.2002;29:97-103.
  • Brummer E, Maqbool A,Stevens DA.Protection of peritoneal macrophages by granulocyte/macrophage colony-stimulating factor (GM-CSF) against dexamethasone suppression of killing ofAspergillus,and the effectofhuman GM-CSF.Microbes and infection/InstitutPasteur.2002;4:133-8.
  • Brecx MC,Nalbandian J,Ooya K,Kornman KS,Robertson PB. Morphologicalstudies on periodontaldisease in the cynomolgus monkey. II. Light microscopic observations on ligature-induced periodontitis.Journalofperiodontalresearch.1985;20:165-75.
  • BostanciN,Belibasakis GN.Porphyromonas gingivalis:an invasive and evasive opportunistic oralpathogen.FEMS microbiology letters. 2012;333:1-9.
  • Beljaards RC,Van Beek P,NieboerC,StoofTJ,Boorsma DM. The expression of interleukin-8 receptor in untreated and treated psoriasis. Archives of dermatological research. 1997;289:440-3.
  • BasalE,Jain A,KaushalGP.Antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthysubjects.JMicrobiol.2004;42:117-25.
  • Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.Periodontology2000.2013;62:203-17.
  • Bainbridge B, Verma RK, Eastman C, Yehia B, Rivera M, Moffatt C, et al. Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response,and induction ofalveolar bone resorption in rats.Infectionandimmunity.2010;78:4560-9.
  • Assuma R,Oates T,Cochran D,AmarS,Graves DT.IL-1 and TNF antagonists inhibit the inflammatory response and bone lossinexperimentalperiodontitis.JImmunol.1998;160:403-9.
  • Armitage GC. Classifying periodontal diseases--a long-standing dilemma.Periodontology2000.2002;30:9-23.
  • Ara T,Kurata K,HiraiK,UchihashiT,Uematsu T,Imamura Y, et al. Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. Journal of periodontal research.2009;44:21-7.
  • Andrian E, Grenier D, Rouabhia M. Porphyromonas gingivalisepithelial cell interactions in periodontitis. Journal of dental research.2006;85:392-403.
  • Amano A.Disruption ofepithelialbarrierand impairmentofcellular function by Porphyromonas gingivalis.Frontiers in bioscience :a journalandvirtuallibrary.2007;12:3965-74.
  • Amano A,Furuta N,Tsuda K.Host membrane trafficking for conveyance of intracellular oral pathogens. Periodontology 2000. 2010;52:84-93.
  • Al Batran R,Al-Bayaty FH,Al-Obaidi MM.In-vivo effect of andrographolide on alveolar bone resorption induced by Porphyromonas gingivalis and its relation with antioxidantenzymes. BioMedresearchinternational.2013;2013:276329.
  • Aderem A,Ulevitch RJ.Toll-like receptors in the induction of theinnateimmuneresponse.Nature.2000;406:782-7.
  • Abu-Amer Y. NF-kappaB signaling and bone resorption. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2013;24:2377-86.