el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, and Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH and Levine AJ. Anlaysis of p53-regulated gene expression patterns using oligonucleotidea arrays. Genes Dev., 14: 981-993, 2000.
Yaar M and Gilchrest BA. Photoageing: mechanism, prevention and therapy. Br. J. Dermatol., 157: 874-887, 2007.
Xu H, Yan Y, Li L,Peng S, Qu T and Wang B. Ultraviolet B-induced apoptosis of human skin fibroblassts involves activation of caspase-8 and-3 with increased expression of vimentin. Photodermatol. Photoimmunol. Photomed., 26: 198-204, 2010.
Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, Luo HB, Yang DP, Chen YL, Shen JG and Chen JP. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res. Treat., 134: 943-955, 2012.
Vogelstein B and Kinzler KW. function and dysfunction. Cell, 70: 523-526, 1992.
Vile GF and, Tyrrell RM. Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem., 268: 14678-14681, 1993.
Tyrrell RM and Pidoux M. Singlet oxygen involvement in the inactivation of cultured human fibroblasts by UVA (334 nm, 365 nm) and near-visible (405 nm) radiations. Photochem. Photobiol., 49: 407-412, 1989.
Tr eb RM. Is androgenetic alopecia a photoaggravated dermatosis? Dermatology, 207: 343-348, 2003.
Torres M. and Forman HJ. Redox signaling and the MAP kinase pathways. Biofactors, 17: 287-296, 2003.
T.C. Pappas, A.G. Bader, B.F, Andruss, D. Brown, and L.P. Ford. Applying small RNA 451 molecules to the directed treatment of human diseases: realizing the potential. Expert Opin. Ther. Targets, 12: 115-2, 2008.
Shih RS, Wong SH, Schoene NW, Zhang JJ and Lei KY. Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells. Exp. Biol. Med. (Maywood), 235: 932-940, 2010.
Shao HJ, Lou Z, Jeong JB, Kim KJ, Lee J and Lee SH. Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-κB Signaling. Biomol. Ther., 23: 39-44, 2015.
Scherer SJ, Maier SM, Seifert M, Hanselmann RG, Zang KD, Muller-Hermelink HK, Angel P, Welter C and Schartl M. p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J. Biol. Chem., 275: 37469-37473, 2000.
Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE and Chumakov PM. The antioxidant function of p53 tumor suppressor. Nat. Med., 11: 1306-1313, 2005.
Ryan RD, Carlos C, Michale R and Fiona MW. Hair follicle dermal papilla cells at a glance. J. Cell Sci., 124 (Pt 8): 1179-1182, 2011.
Reinhardt HC and Schumacher B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet., 28: 128-136, 2012.
Pustisek N and Situm M. UV-radiation, apoptosis and skin. Coll Antropol., 35 (Suppl 2): 339-341, 2011.
Philpott MP, Green MR and Kealey T. Human hair growth in vitro. J. Cell Sci., 97 (Pt 3): 463-471, 1990.
Paus and Cotsarelis G. The biology of hair follicles. N. Engl. J. Med., 341: 491-497, 1999.
Park JG, Yuk Y, Rhim H, Yi SY and Yoo YS. Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells. J. Biochem. Mol. Biol., 35: 267-272, 2002.
Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, Singh TS, Ha JH, Lee MG, Kim JE, Hyun MC, Kwon TK, Kim YH and Kim SH. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res., 31: 1303-1311, 2008.
Oren M. Decision making by p53: life, death and cancer. Cell Death Differ., 10: 431-442, 2003.
Napoli C, de Nigris F and Palinski W. Multiple role of reactive oxygen species in the arterial wall. J. Cell Biochem., 82: 674-682, 2001.
Mo J, Panichayupakaranant P, Kaewnopparat N, Songkro S and Reanmongkol W. Topical anti-inflammatory potential of standardized pomegranate rind extract and ellagic acid in contact dermatitis. Phytother. Res., 28: 629-632, 2014.
Menendez D, Inga A and Resnick MA. The expanding universe of p53 targets. Nat. Rev. Cancer, 9: 724-737, 2009.
Mendoza-Rodriguez CA and Cerbon MA. Tumor suppressor gene p53: mechanisms of action in cell proliferation and death. Rev. Inves.t Clin.., 53: 266-273, 2001.
Matsuzka T and Yoshizato K. Role of hair papilla cells on induction and regeneration prosess of hair follicles. Wound Repair Regen., 6: 524-530, 1998.
Matsugo S, Bito T and Konishi T. Photochemical stability of lipoic acid and its impact on skin ageing. Free Radic. Res., 45: 918-924, 2011.
Marrot L and Meunier JR. Skin DNA photodamage and its biological consequences. J. Am. Acad. Dermatol., 58(5 Suppl 2): 139-148, 2008.
Liebermann DA and Hoffman B. Gadd45 in the response of hematopoietic cells to genotoxic stress. Blood Cells Mol. Dis., 39: 329-335, 2007.
Levine AJ. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
Lee YK, Cha HJ, Hong M, Yoon Y, Lee H and An S. Role of NF-κB -p53 crosstalk in ultraviolet A-induced cell death and G1 arrest in human dermal fibroblasts. Arch. Dermatol. Res., 304: 73-79, 2012.
Lee YJ, Kang IJ, B nger R and Kang YH. Enhanced survival effect of pyruvate correlates MAPK and NF-kappaB activation in hydrogen peroxide-treated human endothelial cells. J. Appl. Physiol., 96: 793-801, 2004.
Kubbutat MH, Jones SN and Vousden KH. Regulation of p53 stability by Mdm 2. Nature, 387: 299-303, 1997.
Krause K, Wasner M, Reinhard W, Haugwitz U, Dohna CL, M ssner J and Engeland K. The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res., 28: 4410-4418, 2000.
Krause K and Foitzik K. Biology of the hair follicle: the basics. Semin Cutan. Med. Surg., 25: 2-10, 2006.
Kasai K1, Yoshimura M, Koga T, Arii M and Kawasaki S. Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin. J. Nutr. Sci. Vitaminol., 52: 383-388, 2006.
Kaidbey KH and Kligman AM. The acute effects of long-wave ultraviolet radiation on human skin. J. Invest. Dermatol., 72: 253-256, 1979.
Jin S, Antinore MJ, Lung FD, Dong X, Zhao H, Fan F, Colchagie AB, Blanck P, Roller PP, Fornace AJ Jr and Zhan Q. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J. Biol. Chem., 275: 16602-16608, 2000.
Jiang H, Yamamoto S and Kato R. Induction of anagen in telogen mouse skin by topical application of FK506, a poent immunosuppressant. J. Investing. Dermatol., 104: 523-525, 1995.
Jahoda CA, Horne KA and Oliver RF. Induction of hair growth by implantation of cultured dermal papilla cells. Nature, 311(5986): 560-562, 1984.
Hseu YC, Chou CW, Senthil Kumar KJ, Fu KT, Wang HM, Hsu LS, Kuo YH, Wu CR, Chen SC and Yang HL. Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food. Chem. Toxicol., 50: 1245-1255, 2012.
Hoffmann R, Eicheler W, Huth A, Wenzel B and Happle R. Cytokines and growth factors influence hair growth I vitro. Possible implications for the pathogenesis and treatment of alopecia areata. Arch. Dermatol. Res., 288: 153-156, 1996.
Hermeking H, Lengauer C, Polyak K, He T, Zhang L, Thiagalingam S, Kinzler KW and Vogelstein B. 14-3-3 sigma Is a p53-regulated Inhibitor of G2/M Progression. Mol Cell, 1: 3-11, 1997.
Haupt Y, Maya R, Kazaz A and Oren M. Mdm2 promotes the rapid degradation of p53. Nature, 387: 296-299, 1997.
Hardy MH. The secret life of the hair follicle. Trends Genet., 8: 55-61, 1992.
Hall PA, Kearsey JM, Coates PJ, Norman DG, Warbrick E and Cox LS. Characterisation of the interaction between PCNA and Gadd45. Oncogene, 10: 2427-2433, 1995.
Grether-Beck S, Olaizola-Horn S, Schmitt H, Grewe M, Jahnke A, Johnson JP, Briviba K, Sies H and Krutmann J. Activation of transcription factor AP-2 mediates UVA radiation-and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc. Natl. Acad. Sci. USA., 93: 14586-14591, 1996.
Gloire G, Legrand-Poels S and Piette J. NF-κB activation by reactive oxygan species: fifteen years latter. Biochem. Pharmacol., 72: 1493-1505, 2006.
Ghosh S, May MJ, and Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol., 16: 225-260, 1998.
Gao M, Guo N, Huang C and Song L. Diverse roles of GADD45alpha in stress signaling. Curr. Protein Pept. Sci., 10: 388-394, 2009.
Galli SJ, Nakae S and Tsai M. Mast cells in the development of adaptive immune responses. Nat. Immunol., 6: 135-142, 2005.
Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M and Rapp UR. Regulation of RAF Activity by 14-3-3 Proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. J. Biol. Chem., 284: 3183-3194, 2009.
Dumay O, Karam A, Vian L, Moyal D, Hourseau C, Stoebner P, Peyron JL, Meynadier J, Cano JP and Meunier L. Ultraviolet AI exposure of human skin results in Langerhans cell depletion and reduction of epidermal antigen-presenting cell function: partial protection by abroad-spectrum sunscreen. Br. J. Dermatol., 144: 1161-1168, 2001.
Devasagayam TP and Kamat JP. Biological significance of singlet oxygen. Indian J. Exp. Biol., 40: 680-692, 2002.
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y anh Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997.
Cropo JD, Qury T, Rabouille C, Slot JW and Chang LY. Cooper, zine superoxide dismutase is primarily a cytosolic protein human cells. Proc. Natl. Acad. Sci. U S A, 89: 10405-10459, 1992.
Corn lio Favarin D, Martins Teixeira M, Lemos de Andrade E, de Freitas Alves C, Lazo Chica JE, Art rio Sorgi C, Faccioli LH and Paula Rogerio A. Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediators Inflamm., 2013: 164202, 2013.
Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am. J. Pathol., 147: 545-560, 1995.
Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, Rivas C, Burgering BM, Serrano M and Lam EW. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J. Biol. Chem., 275: 21960-21968, 2000.
Chen IT, Smith ML, O'Connor PM and Fornace AJ Jr. Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. Oncogene, 11: 1931-1937, 1995.
Chan TA, Hwang PM, Hermeking H, Kinzler KW and Vogelstein B. Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev., 14: 1584-1588, 2000.
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96: 857-868, 1999.
Bruls WA, Slaper H, van der Leun JC and Berrens L. Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet visible wavelengths. Photochem. Photobiol., 40: 485-494, 1984.
Botchkarev VA and Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J. Invest. Dermatol. Symp. Proc., 8: 46-55, 2003.
Bates S and Vousden KH. p53 in signaling check-pointarrestor apoptosis. Curr. Opin. Genet. Dev., 6: 12-18, 1996.
Bae JY, Choi JS, Kang SW, Lee YJ, Park J and Kang YH. Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Exp. Dermatol., 19: 182-190, 2010.
Arck PC, Overall R, Spatz K, Liezman C, Handjiski B, Klapp BF, Birch-Machin MA and Peters EM. Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 20: 1567-1569, 2006.
Agar NS, Halliday GM, Barnetson RS, Ananthaswamy HN, Wheeler M and Jones AM. The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc. Natl. Acad. Sci., 101: 4954-4959, 2004.