연구동향 분석
박사

MicroRNA 발현분석을 활용한 인간 모유두 세포에서 Dihydrotestosterone이 세포에 미치는 영향 및 Epigallocatechin gallate의 세포보호효과 분석 = Study on Protective Effects of Epigallocatechin Gallate on Dihydrotestosterone-induced Damage by Using the MicroRNA Expression Profiles in Human Dermal Papilla Cells

이명주 2015년

논문상세정보
인용/피인용
' MicroRNA 발현분석을 활용한 인간 모유두 세포에서 Dihydrotestosterone이 세포에 미치는 영향 및 Epigallocatechin gallate의 세포보호효과 분석 = Study on Protective Effects of Epigallocatechin Gallate on Dihydrotestosterone-induced Damage by Using the MicroRNA Expression Profiles in Human Dermal Papilla Cells' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • dihydrotestosterone (dht)
  • epigallocatechin gallate (egcg)
  • human dermal papilla cells (hdpcs)
  • microarray
  • microrna
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
203 0

0.0%

' MicroRNA 발현분석을 활용한 인간 모유두 세포에서 Dihydrotestosterone이 세포에 미치는 영향 및 Epigallocatechin gallate의 세포보호효과 분석 = Study on Protective Effects of Epigallocatechin Gallate on Dihydrotestosterone-induced Damage by Using the MicroRNA Expression Profiles in Human Dermal Papilla Cells' 의 참고문헌

  • 호르몬 비의존성 전립선암 세포에서 Glucocorticoid Receptor를통한 Dihydrotestosterone의 Signal Transducer and Activators ofTranscription 5 활성화와 세포 생존의 향상에 대한 연구
    민경은 울산대학교석사학위논문 [2011]
  • 초병렬시퀀싱 방법을 이용한 인간 별아교세포의 microRNA 프로파일링
    김대용 가천의과대학교 박사학위논문 [2010]
  • 인체 두피 모낭의 장기간 배양을 위한 기관 배양배지의 개발. Kor. Chem. Eng
    신연호 유보영 윤희훈 Res., 44: 58-64 [2006]
  • 인간 모유두세포주와 각질형성세포주에서 파라페닐렌디아민에 의한 세포독성 관여 마이크로RNA 발현 분석
    이옥규 건국대학교 박사학위논문 [2014]
  • 유도체 화합물 CT-126에 의한 면역세포의 apoptosis,cell cycle arrest 및 tubulin assembly 분석에 대한 연구
    조상민 대진대학교석사학위논문 [2007]
  • 배양된 흰 쥐 대뇌피질 신경세포에서 산소 결핍과 포도당 결핍간의 유전자 발현 차이에 대한 Microarray 분석
    한규홍 충북대학교 박사학위논문 [2013]
  • 배양 피지세포에서 염증성 사이토카인의 발현에 대한Dihydrotestosterone의 영향
    정홍대 경북대학교 석사학위논문 [2008]
  • 거대핵세포 분화관련 microRNA 탐색 연구
    김수진 한양대학교 석사학위논문 [2014]
  • Zhu C, Shao P, Bao M, Li P, Zhou H, Cai H, Cao Q, Tao L, Meng X,Ju X, Qin C, Li J, Yin C. miR-154 inhibits prostate cancer cellproliferation by targeting CCND2. Urol. Oncol., 32: 31, 2014.
  • Zhang Y, Chao T, Li R, Liu W, Chen Y, Yan X, Gong Y, Yin B, LiuW, Qiang B, Zhao J, Yuan J, Peng X. MicroRNA-128 inhibitsglioma cells proliferation by targeting transcription factor E2F3a. J . Mol. Med., 87: 43-51, 2009.
  • Yoganathan N, Yee A, Zhang Z, Leung D, Yan J, Fazli L, Kojic DL,Costello PC, Jabali M, Dedhar S, Sanghera J. Intergrin-linkedkinase, a promising cancer therapeutic target: biochemical andbiological properties. Pharmacol. Ther., 93: 233-242, 2002.
  • Yin F, Zhang JN, Wang SW, Zhou CH, Zhao MM, Fan WH, Fan M,Liu S. MiR-125a-3p regulates glioma apoptosis and invasion byregulating Nrg1. PLoS One, 10: 1-15, 2015.
  • Yayabe F, Kinugasa H, Takeo T. A simple preparativechromatographic separation of green tea catechins. J . AgriculturalChemical, 63: 845, 1989.
  • Yang YC, Fu HC, Wu CY, Wei KT, Huang KE, Kang HY. Androgenreceptor accelerates premature senescence of human dermal papillacells in association with DNA damage. PLoS One, 8: 1-10, 2013.
  • Yang TT, Koo MW. Chinese green tea lowers cholesterol levelthrough an increase in fecal lip idexcretion. Life Sci., 66:411-423, 2000.
  • Xiong S, Zheng Y, Jiang P, Liu R, Liu X, Chu Y. MicroRNA-7inhibits the growth of human non-small cell lung cancer A549cells through targeting BCL-2. Int. J . Bio. Sci., 7: 805-814, 2011.
  • Xin C, Zhang H, Liu Z. miR-154 suppresses colorectal cancer cellgrowth and motility by targeting TLR2. Mol. Cell Biochem., 387:271-277, 2014.
  • Wu Z, Sun H, Zeng W, He J, Mao X. Upregulation of MircoRNA-370induces proliferation in human prostate cancer cells bydownregulating the transcription factor FOXO1. PLoS One, 27:2012.
  • Wightman B, Ha I, Ruvkun G, Posttransciptional regulation of theheterochronic gene Lin-14 by Lin-4 mediates temporal patternformation in C. elegans. Cell, 75: 855-862, 1993.
  • Wester RC, Maibach HI, Guy RH, Novak E. Minoxidil stimulatescutaneous blood flow in human balding scalps: pharmacodynamicsmeasured by laser Doppler velocimetry and photopulseplethysmography. J . Invest. Dermatol., 82: 515-517, 1984.
  • Wang Y, Liu J, Liu C, Naji A, Stoffers DA. MicroRNA-7 regulatesthe mTOR pathway and proliferation in adult pancreatic β-cells. Diabetes, 62: 887-895, 2013.
  • Wang XF, Shi ZM, Wang XR, Cao L, Wang YY, Zhang JX, Yin Y,Luo H, Kang CS, Liu N, Jiang T, You YP. MiR-181d acts as atumor suppressor in glioma by targeting K-ras and Bcl-2. J . Cancer Res. Clin. Oncol., 138: 573-584, 2012.
  • Veltri R, Rodriguez R. Molecular biology, endocrinology, andphysiology of the prostate and seminal vesicles. Saunders, 9: 2677?2726, 2007.
  • Van het Hof KH, Wiseman SA, Yang CS, Tijiburg LB. Plasma and lipoprotein levels of tea catechins following repeated teaconsumption. Proc. Soc. Exp. Biol. Med., 220: 203-209, 1999.
  • Van Neste D, Tobin DJ. Hair cycle and hair pigmentation: dynamicinteractions and changes associated with aging. Micron, 35:193-200, 2004.
  • Van Leathem A, Claerhout S, Garmyn M, Agostinins P. The sunburncell: regulation of death and survival of the keratinocyte. Int. J . Biochem. Cell Biol., 37: 1547-1553, 2005.
  • Valentina G, Ting C, Michael R, Markus S, Amalia P, Nicole S, JuneDCR, Elaine F. A two-step mechanism for stem cell activationduring hair regeneration. Cell Stem Cell, 4: 155-169, 2009.
  • Trub RM. The value of hair cosmetics and pharmaceuticals. Dermatology, 202: 38-45, 2001.
  • Toshihiko H, Toshio N. Role of TGF-β2 in the human hair cycle. J . Dermatol. Sci., 35: 9-18, 2004.
  • Tobin DJ, Paus R. Graying. gerontobiology of the hair folliclepigmentraryunit. Exp. Gerontol., 36: 29-54, 2001.
  • Thigpen AE, Silver RI, Guileyardo JM, et al. Tissue distribution andontogeny of steroid 5α-reductase isoenzyme expression. J . Clin. Invest., 92: 903-910, 1993.
  • Surh YJ. Cancer chemopreventive effects of dietary phytochemicals. J . Korean Assoc. Cancer Prev., 9: 68-83, 2004.
  • Sun X, Li Y, Yu J, Pei H, Luo P, Zhang J. miR-128 modulateschemosensitivity and invasion of prostate cancer cells throughtargeting ZEB1. Jpn. J . Clin. Oncol., 45: 474-482, 2015.
  • Stapleton PD, Shah S, Anderson JC, Hara Y, Hamilton-Miller JM,Taylor PW. Modulation of beta-lactam resistance inStaphylococcus aureus by catechins and gallates. Int. J . Antimicrob. Agents, 23: 462-467, 2004.
  • Shang C, Hong Y, Guo Y, Liu YH, Xue YX. MiR-210 up-regulationinhibits proliferation and induces apoptosis in glioma cells bytargeting SIN3A. Med. Sci. Monit., 20: 2571-2577, 2014.
  • Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell,115: 199-208, 2003.
  • Santosh KK, Rajesh A, Susan E, Gray SW, Hasan M. Protectionagainst 12-O-tetradecanoyl-phorbol-13-acetate-caused inflaction inSENCAR mouse ear skin by polyphenolic fraction isolated fromgreen tea. Carcinogenesis, 14: 361, 1993.
  • Ryan RD, Adam G, Kim BJ, Klaas WM, Fiona MW. Sox2-positivedermal papilla cells specify hair follicle type in mammalianepidermis. Development, 136: 2815-2823, 2009.
  • Ruvkun G, Giusto J. The Caenorhabditis elegans heterochronicgene lin-14 encodes a nuclear protein that forms a temporaldevelopmental switch. Nature, 338: 313-319, 1989.
  • Ricquier, D. Fundamental mechanisms of thermogenesis. C. R. Biol.,329: 578-586, 2006.
  • Rho SS, Park SJ. The hair growth promoting effect of Asiasari radixextract and its molecular regulation. J . Dermatol. Sci., 2005: 38:89-97.
  • Reinhart BJ, Slack Fj, Basson M, Pasquinelli AE, Bettinger JC,Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNAregulates developmentaltiming in Caenorhabditis elegans. Nature,403: 901-906, 2000.
  • Regulatory Factors of Cellular Senescence in Human DiploidFibroblast: SA-p-Erk1/2, PP1/2A, PKCα
    김홍석 아주대학교 박사학위논문 [2008]
  • Peus D, Pittelkow MR, Growth factors in hair organ development andthe hair growth cycle. Dermatol. Clin., 14: 559-572, 1996.
  • Peters EM. Towards a “free radical theory of graying": melanocyteapoptosisin theaging human hairfollicleis an indicatorofoxidativestressinduced damage. FASEB J ., 20: 1567-1569, 2006.
  • Paus R. Principles of hair cycle control. J . Dermatol., 25: 793-802,1998.
  • Pack GY, Lee SJ, Im JG. Effect of green tea catechin on cytochromeP, xanthine oxidase activities in liver and liver damage instreptozotocin induced diabetic rats. J . Kor. Soc. Food Sci. Nutr.,26: 901-907, 1997.
  • Nixhimura EK, Granter SR, Green AC. Determination of hair graying:incomplete melanocyte stem cell maintence in the niche. Science,307: 720-724, 2005.
  • Ninio-Many L, Grossman H, Shomron N, Chuderland D and Shalgi R. microRNA-125a-3p reduces cell proliferation and migration bytargeting Fyn. J . Cell. Sci., 126: 2867-2876, 2013.
  • Naotsugu H, Hiroshi I, Koshi M, Fumiaki T, Tohru U. Analysis ofgastric cancer with cDNA microarray. Cancer Chemother. Pharmacol., 21-24, 2004.
  • Mori O, Uno H. The effect of topical minoxidil on hair follicular cyclesof rats. J . Invest. Dermatol., 17: 276-281, 1990.
  • Michael R, Lisa P, Elaine F. BMP signaling in dermal papilla cells isrequired for their hair follicle inductive properties. Genes Dev., 22:543-557, 2008.
  • Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hairgrowth. Br. J . Dermatol., 150: 186-194, 2004.
  • Meister G, Tuschl T. Mechanisms of gene silencing by doublestrandedRNA. Nature, 431: 343-349, 2004.
  • Mehraein-Ghomi F, Lee E, Church DR, Thompson TA, Basu HS,Wilding G. JunD mediates androgeninduced oxidative stress inandrogen dependent LNCaP human prostate cancer cells. Prostate,68: 924-934, 2008.
  • Mbros V. A hierarchy of regulatory genes scontrols a larva-to-adultdevelopmental switch in C. elegans. Cell , 57: 49-57, 1989.
  • Matsuzka T and Yoshizato K. Role of hair papilla cells on induction and regeneration prosess of hair follicles. Wound Repair Regen., 6: 524-530, 1998.
  • Liu S, Zhang P, Chen Z, Liu M, Li X, Tang H. MicroRNA-7downregulates XIAP expression to suppress cell growth andpromote apoptosis in cervical cancer cells. FEBS Lett., 587:2247-2253, 2013.
  • Lin X, Yang Z, Zhang P, Shao G. miR-154 suppresses non-small celllung cancer growth in vitro and in vivo. Oncol, Rep., 2015.
  • Lin L, Ranelle CS, Hongqing G, Anton B, Joy KC, Jose EG. Geneexpression profiles of laser-captured adjacent neuronal subtypes. Nature, 5: 117-122, 1999.
  • Lin J.K. Biochemical studies on the anticarcinogenesis of teapolyphenols. Proceedings of the 3rd International Symposium ongreen tea, Seoul. 1-11, 1995.
  • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J,Bartel DP, Linsley PS, Johnson JM. Microarray analysis showsthat some microRNAs down regulate large numbers of targetmRNAs. Nature. 433: 769-773, 2005.
  • Lim IK, Won Hong K, Kwak IH, Yoon G, Park SC. Cytoplasmicretention of p-Erk1/2 and nuclear accumulation of actin proteinsduring cellular senescence in human diploid fibroblasts. Mech. Ageing. Dev., 119: 113-130. 2000.
  • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic geneLin-4 encodes small RNAs with antisense complementarity toLin-14. Cell, 75: 843-854, 1993.
  • Lambert JD, Yang CS. Cancer chemopreventive activity andbioavailability of tea and tea polyphenols. Mutat. Res., 523:201-208, 2003.
  • Kuttan,R.Anti-diabeticactivityofgreenteapolyphenolsandtheirrole in reducing oxidative stress in experimental diabetes, J Ethnopharmacol83:109-116,2002.
  • Kurbel S, Kurbel B, Matanic DZ. Minoxidil and male-pattern alopecia:a potential role for a local regulator of sebum secretion withvasoconstrictive effects. Med. Hypotheses, 53: 402-406, 1999.
  • Krause K, Foitzik K. Biology of the hair follicle: the basics. Semin. Cutan. Med. Surg., 25: 2-10, 2006.
  • Kligman AM. The human hair cycle. J . Invest. Dermatol., 33: 307?316, 1959.
  • Kim MB, Tea of Korea. Tam Gu Dang, 322, 1983.
  • Kaufman KD. Androgen met abolism a s it affect s hair growth inandrogenetic alopecia. Dermatol. Clin., 14: 697-711, 1996.
  • Katiyal SK, Mukhtar H. Tea antioxidants in cancer chemoprevention. J . Cell.　Biochem., 27: 59, 1997.
  • Jiro K, Robert EB, Bruce AM. Wnt signaling maintains thehair-inducing activity of the dermal papilla. Genes Dev., 14:1181-1185, 2000.
  • Jindo T, Tsuboi R, Imai R, Takamori K, Rubin J S, Ogawa H. Theeffect of hepatocyte growth factor/scatter factor on human hairfollicle growth. J . Dermatol. Sci., 10: 229-232, 1995.
  • Jindo T, Tsuboi R, Imai R, Takamori K, Rubin J S, Ogawa H. Hepatocyte growth factor/scatter factor stimulates hair growth ofmouse vibrissae in organ culture. J . Invest. Dermatol., 103:306-309, 1994.
  • Jiang X, Xiang G, Wang Y, Zhang L, Yang X, Cao L, Peng H, Xue P,Chen D. MicroRNA-590-5p regulates proliferation and invasion inhuman hepatocellular carcinoma cells by targeting TGF-β RII. Mol. Cells, 33: 545-551, 2012.
  • Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, WangA, Dai Y, Zhou X. MicroRNA-7 targets IGF1R (insulin-likegrowth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochem. J ., 432: 199-205, 2010.
  • Jiang L, Chang J, Zhang Q, Sun L, Qiu X. MicroRNAhsa-miR-125a-3p activates p53 and induces apoptosis in lungcancer cells. Cancer Invest., 31: 538-544, 2013.
  • Jiang J, Li Z, Yu C, Chen M, Tian S, Sun C. MiR-1181 inhibits stemcell-like phenotypes and suppresses SOX2 and STAT3 in humanpancreatic cancer. Cancer Lett., 356: 962-970, 2015.
  • Jezek P. Possible physiological roles of mitochondrial uncouplingproteins-UCPn. Int. J . Biochem. Cell Biol., 34: 1190-1206, 2002.
  • Jahoda CA, Horne KA and Oliver RF. Induction of hair growth byimplantation of cultured dermal papilla cells. Nature, 311: 560-562,1984.
  • Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S. Identificationof androgen-inducible TGF-beta1 derived from dermal papilla cellsas a key mediator in androgenetic alopecia. J . Invest. Dermatol., 8:69-71, 2003.
  • Hydrogen Peroxide 스트레스에 의한 인간 모유두 세포의 유전자발현 변화 분석
    김종란 건국대학교 박사학위논문 [2012]
  • Hoffmann R, Eicheler W, Huth A, Wenzel E, Happle R. Cytokines andgrowth factors influence hair growth in vitro. Possible implicationsfor the pathogenesis and treatment of alopecia areata. Arch. Dermatol. Res., 288: 153-156, 1996.
  • Hodgson JM, Puddey IB, BurkeV, Jordan N. Effects on blood pressureof drinking green and black tea. J . Hypertens., 17: 457-463, 1999.
  • Hiipakka RA, Zhang HZ, Dai W, Dai Q, Liao S. Structure-activityrelationships for inhibition of human 5 alpha-reductases bypolyphenols. Biochem. Pharmacol., 63: 1165-1176, 2002.
  • Hell MP, Thoma CR, Fankhauser N, Christinat Y, Weber TC, Krek W. miR-28-5p promotes chromosomal instability in VHL-associatedcancers by inhibiting Mad2 translation. Cancer Res., 74: 2432-2443,2014.
  • Hayflick L. The Limited in Vitro Lifetime of Human Diploid CellStrains. Exp. Cell. Res., 37: 614-636. 1965.
  • Hauser B, Zhao Y, Pang X, Ling Z, Myers E, Wang P, Califano J, GuX. Functions of MiRNA-128 on the regulation of head and necksquamous cell carcinoma growth and apoptosis. PLoS. One, 10:2015.
  • Harris G1, Azzolina B, Baginsky W, Cimis G, Rasmusson GH, TolmanRL, Raetz CR, Ellsworth K. Identification and selective inhibitionof an isoenzyme of steroid 5α-reductase in human scalp. Proc. Natl. Acad. Sci. U S A., 89: 10787-10791, 1992.
  • Hara Y, Matsuzaki T, Suzuki T. Angiotensin converting enzymeihibiting activity of tea components. Nippon Nogeikagaku Kaishi,61: 803, 1987.
  • Han JS, Shin DH, Yun SE. Kim MS. Antimicrobial effects on listeriamonocytogenes by some edible plants extracts. Kor. J . Food. Sci. Technol., 26; 545, 1994.
  • Hamilton JB. Male hormone stimulation is prerequisite and an incitantin common baldness. Am. J . Anat., 71: 451-480, 1942.
  • Guo Q, Zhao B, Li M, Shen S, Xin W : Studies on protectivemechanisms of four components of green tea polyphenols againstlipid peroxidation in synaptosomes. Biochim. Biophys. Acta., 1304:210-222, 1996.
  • Graham HN. Green tea composition, consumption, and polyphenolchemistry. Prev. Med., 21: 334-350, 1992.
  • Gon-Allo B, Puerta E, Ramos M, Lasheras B, Jorda J, Aguirre N. Minoxidil prevents 3,4-methylenedioxymetham phetamine- inducedserotonin depletions: Role of mitochondrial ATP sensitivepotassium channels, Akt and ERK. J . Neurochem., 104: 914-925,2007.
  • Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M. Molecularclassification of cancer: class discovery and class prediction bygene expression monitoring. Science, 86: 531-537, 1999.
  • Farthing MJG, Martei AM, Edward CRW, Dawson AM. Relationbetween plasma testosterone and dihydrot estosteroneconcentrations and male facial hair growth. Br. J . Dermatol., 107:559-564, 1982.
  • Fang Y, Xue JL, Shen Q, Chen J, Tian L. MicroRNA-7 inhibits tumorgrowth and metastasis by targeting the phosphoinositide3-kinase/Akt pathway in hepatocellular carcinoma. Hepatology, 55:1852-1862, 2012.
  • Fan C, Liu S, Zhao Y, Han Y, Yang L, Tao G, Li Q, Zhang L. Upregulation of miR-370 contributes to the progression of gastriccarcinoma via suppression of FOXO1. Biomed. Pharmacother., 67:521-526, 2013.
  • Erlanson-Albertsson C. the role of uncoupling proteins in theregulation of metabolism. Acta. Physiol. Scand., 178: 405-412, 2003.
  • EGCG의 산화 및 항산화능에 관한
    김도용 전남대학교 박사학위논문 [2003]
  • Douglas TR, Uwe S, Michael BE, Charles MP, Christian R, Paul S. Systematic variation in gene expression patterns in human cancercell lines. Nature, 24: 227-235, 2000.
  • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, MedranoEE, Linskens M, Rubelj I, Pereira-Smith O. A biomarker thatidentifies senescent human cells in culture and in aging skin invivo. Proc. Natl. Acad. Sci. U. S. A., 92: 9363-9367, 1995.
  • Conney AH, Lu Y, Lou Y, Xie J, Huang M. Inhibitory effect of greenand black tea on tumor growth. Proc. Soc. Exp. Biol. Med., 220:229-233, 1999.
  • Chou FP, Chu YC, Hsu JD, Chiang HC, Wang CJ. Specific inductionof glutathionne S-Transferase GSTM2 subunit expression byepigallocatechin gallate in rat liver. Biochem. Pharmacol., 60:643-650, 2000.
  • Chen ZP, Schell JB, Ho CT, Chen KY. Green tea epigallocatechingallate shows a pronounced growth inhibitory effect on cancerouscells but not on their normal counterparts. Cancer Lett., 129:173-179, 1998.
  • Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, BeckWT. Novel regulation of nuclear factor-YB by miR-485-3p affectsthe expression of DNA topoisomerase IIα and drug responsiveness. Mol. Pharmacol., 79: 735-741, 2011.
  • Chase HB. Critical stages of hair development and pigmentation in themouse. Physiol. Zool., 24: 1-9, 1951.
  • Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y,Kandel ES, Lausch E, Christov K and Roninson IB. A senescencelikephenotypedistinguishes tumor cells that undergo terminalproliferation arrest after exposure to anticancer agents. CancerRes.. 59: 3761-3767. 1999.
  • Cha BC, Lee W, Choi MY. Antioxidative and antimicrobial effects ofnut species. Kor. J . Pharmacogn., 29: 28-34, 1998.
  • Buhl AE, Waldon DJ, Baker CA, Johnson GA. Minoxidil sulfate is theactive metabolite that stimulates hair follicles. J . Invest. Dermatol., 95: 553-557, 1990.
  • Bartel DP: Micrornas. Genomics, biogenesis, mechanism, and function. Cell. 116: 281, 2004.
  • Anaya-Ruiz M1, Bandala C, Perez-Santos JL. miR-485 acts as atumor suppressor by inhibiting cell growth and migration in breastcarcinoma T47D cells. Asian. Pac. J . Cancer Prev., 14: 3757-3760,2013.
  • Ambros V. The functions of animal microRNAs. Nature, 431: 350-355,2004.
  • Amanda KP. Timothy CH. Integrating stress-response and cell-cyclecheckpoint pathways. Trends Cell Biol., 11: 426-433, 2011.