연구동향 분석
박사

Hepatoprotective Effects of Platycodin D on the Acute Ethanol-induced Liver Damages in C57BL/6 Mice : 급성 알코올성 간 손상 유발 마우스에서 Platycodin D의 간 보호 효과 평가

김봉석 2015년

논문상세정보
인용/피인용
' Hepatoprotective Effects of Platycodin D on the Acute Ethanol-induced Liver Damages in C57BL/6 Mice : 급성 알코올성 간 손상 유발 마우스에서 Platycodin D의 간 보호 효과 평가' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • 간보호효과
  • 알코올성 간손상. platycodin d
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
4 0

0.0%

' Hepatoprotective Effects of Platycodin D on the Acute Ethanol-induced Liver Damages in C57BL/6 Mice : 급성 알코올성 간 손상 유발 마우스에서 Platycodin D의 간 보호 효과 평가' 의 참고문헌

  • Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol. 2005;166:1681-90.
  • Zhou Z, Wang L, Song Z, Lambert JC, McClain CJ, Kang YJ. A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am J Pathol. 2003;163:1137-46.
  • Zhou Z, Sun X, Kang Y. Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress. Exp Biol Med. 2002;227:214-22.
  • Zhao HL, Kim YS. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Arch Pharm Res. 2004;27:1048-52.
  • Zhao HL, Cho KH, Ha YW, Jeong TS, Lee WS, Kim YS. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. Eur J Pharmacol. 2006;537:166-73.
  • Zhang R, Hu Y, Yuan J, Wu D. Effects of Puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury. J Ethnopharmacol. 2009;126:207-14.
  • Zeng T, Xie KQ. Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. Arch Toxicol. 2009;83:1075-81.
  • Zarkovic N. 4-hydroxynonenal as a bioactive marker of pathophysiological processes. Mol Aspects Med. 2003;24:281-91.
  • Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK. Adipocyte-specific gene expressionand adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem. 2003;278:498-505.
  • Yu JS, Kim AK. Platycodin D induces apoptosis in MCF-7 human breast cancer cells. J Med Food. 2010;13:298-305.
  • You M, Crabb DW. Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. Am J Physiol Gastrointest Liver
  • You M, Crabb DW. Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol. 2004a;34:39-43.
  • Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luser MI, Thurman RG. Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice. Gastroenterology. 1999;117:942-52.
  • Yang P, Wang Z, Zhan Y, Wang T, Zhou M, Xia L, Yang X, Zhang J. Endogenous A1 adenosine receptor protects mice from acute ethanol-induced hepatotoxicity. Toxicology. 2013;309:100-6.
  • Xing WW, Zou MJ, Liu S, Xu T, Wang JX, Xu DG. Interleukin-22 protects against acute alcohol-induced hepatotoxicity in mice. Biosci Biotechnol Biochem. 2011;75:1290-4.
  • Xie Y, Sun HX, Li D. Platycodin D improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. Chem Biodivers. 2010;7:677-89.
  • Xie Y, Deng W, Sun H, Li D. Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses. Int Immunopharmacol. 2008;8:1143-50.
  • Xiang J, Zhu W, Li Z, Ling S. Effect of juice and fermented vinegar from Hovenia dulcis peduncles on chronically alcohol-induced liver damage in mice. Food Funct. 2012;3:628-34.
  • Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs. 2001;15:465-89.
  • Wang T, Yang P, Zhan Y, Xia L, Hua Z, Zhang J. Deletion of circadian gene Per1 alleviates acute ethanol-induced hepatotoxicity in mice. Toxicology. 2013;314:193-201.
  • Wang C, Schuller Levis GB, Lee EB, Levis WR, Lee DW, Kim BS, Park SY, Park E. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Int Immunopharmacol. 2004;4:1039-49.
  • Wada S, Yamazaki T, Kawano Y, Miura S, Ezaki O. Fish oil fed prior toethanol administration prevents acute ethanol-induced fatty liver in mice. J Hepatol. 2008;49:441-50.
  • Voldstedlund M, Tranum-Jensen J, Handberg A, Vinten J. Quantity of Na/K-ATPase and glucose transporters in the plasma membrane of rat adipocytes is reduced by in vivo triiodothyronine. Eur J Endocrinol. 1995;133:626-34.
  • Videla LA. Energy metabolism, thyroid calorigenesis, and oxidative stress:functional and cytotoxic consequences. Redox Rep. 2000;5:265-75.
  • Venditti P, Di Meo S. Thyroid hormone-induced oxidative stress. Cell Mol Life Sci. 2006;63:414-434.
  • Uli?n O, Greks k M, Van?ov O, Zlato? L, Galbav? ?, Bo?ek P, Nakano M. Hepatoprotective effect of rooibos tea (Aspalathus linearis) on CCl₄-induced liver damage in rats. Physiol Res. 2003;52:461-6.
  • Tada A, Kaneiwa Y, Shoji J, Shibata S. Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem Pharm Bull (Tokyo). 1975;23:2965-72.
  • Sun Y, Larry WO, Ying L. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497-500.
  • Subudhi U, Das K, Paital B, Bhanja S, Chainy GB. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem Biol Interact. 2008;173:105-14.
  • Song Z, Deaciuc I, Song M, Lee DY, Liu Y, Ji X, McClain C. Silymarin protects against acute ethanol-induced hepatotoxicity in mice. Alcohol Clin Exp Res. 2006;30:407-13.
  • Somani SM. Exercise, drugs and tissue specific antioxidant system. In: Somani SM (Ed.), Pharmacology in Exercise and Sports. Boca Raton, FL: CRC Press, pp57-95, 1996.
  • Sodikoff CH. Laboratory profiles of small animal diseases, A guide to laboratory diagnosis. St. Louise: Mosby; pp. 1-36, 1995.
  • Smathers RL, Galligan JJ, Stewart BJ, Petersen DR. Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. Chem Biol Interact. 2011;192:107-12.
  • Shi SR, Chaiwun B, Young L, Cote RJ, Taylor CR. Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections. J Histochem Cytochem. 1993;41:1599-604.
  • Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205.
  • Saravanan R, Viswanathan P, Pugalendi KV. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci. 2006;78:713-8.
  • Saravanan N, Rajasankar S, Nalini N. Antioxidant effect of 2-hydroxy-4-methoxy benzoic acid on ethanol-induced hepatotoxicity in rats. J Pharm Pharmacol. 2007;59:445-53.
  • Saravanan N, Nalini N. Inhibitory effect of Hemidesmus indicus and its active principle 2-hydroxy 4-methoxy benzoic acid on ethanol-induced liver injury. Fundam Clin Pharmacol. 2007;21:507-14.
  • Saeki T, Nikaido T. Evaluations of saponin properties of HPLC analysis of Platycodon grandiflorum A.DC. Yakugaku Zasshi. 2003;123:431-41.
  • Ruan X, Shen C, Meng Q. Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity. Food Chem Toxicol. 2010;48:1145-51.
  • Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology. 1997;25:351-5.
  • Rogers CQ, Ajmo JM, You M. Adiponectin and alcoholic fatty liver disease. IUBMB Life 2008;60:790-7.
  • Reddy JK, Mannaerts GP. Peroxisomal lipid metabolism. Annu Rev Nutr. 1994;14:343-70.
  • Rao RK, Seth A, Sheth P. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2004;286:G881-4.
  • Ponnappa BC, Rubin E. Modeling alcohol’s effects on organs in animal models. Alcohol Res Health. 2000;24:93-104.
  • Poli G, Parola M. Oxidative damage and fibrogenesis. Free Radic Biol Med. 1997;22:287-305.
  • Park JH, Kim SJ, Hwang I, Bae KC, Bae JH, Song DK. Green tea extract co-administered with a polymer effectively prevents alcoholic liver damage by prolonged inhibition of alcohol absorption in mice. Alcohol Alcohol. 2013;48:59-67.
  • Pari L, Suresh A. Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food Chem Toxicol. 2008;46:1627-34.
  • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007; 87: 315-424.
  • Ozaras R, Tahan V, Aydin S, Uzun H, Kaya S, Senturk H. N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat. World J Gastroenterol. 2003;9:125-8.
  • Odabasoglu F, Cakir A, Suleyman H, Aslan A, Bayir Y, Halici M, Kazaz C. Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol. 2006;103:59-65.
  • Noyan S, Cavusoglu I, Minbay FZ. The effect of vitamin A on EtOH-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study. Acta Histochem. 2006;107:421-34.
  • Nordmann, R. Alcohol and antioxidant systems. Alcohol. Alcohol. 1994;29:513-22.
  • Noh JR, Kim YH, Gang GT, Hwang JH, Kim SK, Ryu SY, Kim YS, Lee HS, Lee CH. Hepatoprotective effect of Platycodon grandiflorum against chronic ethanol-induced oxidative stress in C57BL/6 mice. Ann Nutr Metab. 2011;58:224-31.
  • Navasumrit P, Ward TH, Dodd NJ, O'Connor PJ. Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure. Carcinogenesis. 2000;21:93-9.
  • Nagy LE. Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury. Annu Rev Nutr. 2004;24:55-78.
  • Morgan K, French SW, Morgan TR. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology. 2002;36:122-34.
  • Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006;133:143-9.
  • Meyer SA, Kulkarni AP. Hepatotoxicity. In: Hodgson E, Smart RC (ed), Introduction to biochemical toxicology. 3rd ed. New York: John Wiley & Sons, pp487-90, 2001.
  • Messarah M, Boumendjel A, Chouabia A, Klibet F, Abdennour C, Boulakoud MS, Feki AE. Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. Exp Toxicol Pathol. 2010;62:301-310.
  • McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349-51.
  • McCarty MF. Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol. Med Hypotheses. 2001;56:8-11.
  • Maddrey WC. Alcohol-induced liver disease. Clin Liver Dis. 2000;4:115-31.
  • Ludbrook J: Update: microcomputer statistics packages. Apersonal view. Clin Exp Pharmacol Physiol 1997; 24: 294-296.
  • Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology. 2008;47:1483-94.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-75.
  • Lieber C. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev. 1997;77:517-44.
  • Li YM, Chen SH, Yu CH, Zhang Y, Xu GY. Effect of acute alcoholism on hepatic enzymes and oxidation/antioxidation in rats. Hepatobiliary Pancreat Dis Int. 2004;3:241-4.
  • Li SY, Yang D, Fu ZJ, Woo T, Wong D, Lo AC. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012;45:624-32.
  • Levene A. Pathological factors influencing excision of tumours in the head and neck. Part I. Clin Otalary. 1981;6:145-151.
  • Leung TM, Lu Y, Yan W, Mor n-Concepci n JA, Ward SC, Ge X, Conde de la Rosa L, Nieto N. Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice. Hepatology. 2012;55:1596-609.
  • Lee EJ, Kang M, Kim YS. Platycodin D inhibits lipogenesis through AMPKalpha-PPARgamma2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta Med. 2012;78:1536-42.
  • Kwon OG, Ku SK, An HD, Lee YJ. The effects of Platycodin D, a saponin purified from Platycodi Radix, on collagen-induced DBA/1j mouse rheumatoid arthritis. Evid Based Complement Alternat Med. 2014;2014:954508.
  • Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takaishi M, Horie Y, Fukuda M, Mizukami K, Ishii H. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology. 199;112:1331-43.
  • Kumar RS, Ponmozhi M, Viswanathan P, Nalini N. Effect of Cassia auriculata leaf extract on lipids in rats with alcoholic liver injury. Asia Pac J Clin Nutr. 2002;11:157-63.
  • Koch O, Farr S, De Leo ME, Palozza P, Palazzotti B, Borrelo S, Palombini G, Cravero A, Galeotti T. Regulation of manganese superoxide dismutase (MnSOD) in chronic experimental alcoholism: effects of vitamin E-supplemented and ? deficient diets. Alcohol Alcohol. 2000;35:159-63.
  • Kim YP, Lee EB, Kim SY, Li D, Ban HS, Lim SS, Shin KH, Ohuchi K. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Planta Med. 2001;67:362-4.
  • Ki SH, Yang JH, Ku SK, Kim SC, Kim YW, Cho IJ. Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis. J Ginseng Res. 2013;37:45-53.
  • Kavutcu M, Canbolat O, Ozt rk S, Olcay E, Ulutepe S, Ekinci C, G khun IH, Durak I. Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin-treated guinea pigs: effects of vitamins E and C. Nephron. 1996;72:269-74.
  • Kaviarasan S, Anuradha CV. Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis. Pharmazie. 2007;62:299-304.
  • Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, El May M, Gharbi N, Kamoun A, El-Faza S. Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci. 2007;80:1033-9.
  • Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, Kwon YS, Lee YJ, Ku SK. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutr Res. 2011;31:387-96.
  • Ji C, Chan C, Kaplowitz N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006;45:717-24.
  • Jenkins RR, Goldfarb A. Introduction: oxidant stress, aging, and exercise. Med Sci Sports Exerc. 1993;25:210-2.
  • Jamall IS, Smith JC. Effects of cadmium on glutathione peroxidase, superoxidase dismutase and lipid peroxidation in the rat heart: a possible mechanism of cadmium cardiotoxicity. Toxicol Appl Pharmacol. 1985;80:33-42.
  • Jafri MA, Jalis Subhani M, Javed K, Singh S. Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats. J Ethnopharmacol. 1999;66:355-61.
  • Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor-α attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology. 1997;26:1530-7.
  • Husain K, Scott BR, Reddy SK, Somani SM. Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol. 2001;25:89-97.
  • Hu M, Yin H, Mitra MS, Liang X, Ajmo JM, Nadra K, Chrast R, Finck BN, You M. Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice. Hepatology. 2013;58:1953-63.
  • Hu CM, Cao Q, Lv XW, Cheng WM, Li R, Li J. Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation-related protein expression. Am J Chin Med. 2012;40:599-610.
  • Hong J, Shin KH, Lim SS, Kwak JH, Zee O, Ishihara K, Hirasawa N, Seyama T, Ohuchi K. Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea. Inflamm Allergy Drug Targets. 2008;7:195-202.
  • Honchel R, Ray MB, Marsano L. Tumor necrosis factor in alcohol enhanced endotoxin liver injury. Alcohol Clin Exp Res. 1992;16:665-9.
  • Ho WY, Yeap SK, Ho CL, Abdul Rahim R, Alitheen NB. Hepatoprotective activity of Elephantopus scaber on alcohol-induced liver damage in mice. Evid Based Complement Alternat Med. 2012;2012:417953.
  • Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature. 2003;426:190-3.
  • Hartley DP, Kolaja KL, Reichard J, Petersen DR. 4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization. Toxicol Appl Pharmacol. 1999;161:23-33.
  • Han LK, Zheng YN, Xu BJ, Okuda H, Kimura Y. Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J Nutr. 2002;132:2241-5.
  • Habib-ur-Rehman M, Mahmood T, Salim T, Afzal N, Ali N, Iqbal J, Tahir M, Khan A. Affect of silymarin on serum levels of ALT and GGT in ethanol induced hepatotoxicity in albino rats. J Ayub Med Coll Abbottabad. 2009;21:73-5.
  • Gopumadhavan S, Rafiq M, Azeemuddin M, Mitra SK. Ameliorative effect of Partysmart in rat model of alcoholic liver disease. Indian J Exp Biol. 2008;46:132-7.
  • Ghoneim AI, Eldahshan OA. Anti-apoptotic effects of tamarind leaves against ethanol-induced rat liver injury. J Pharm Pharmacol. 2012;64:430-8.
  • Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem. 2003;278:27997-8004.
  • Dubinina EE, Dadali VA. Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry(Mosc). 2010;75:1069-87.
  • Donohue TM Jr. Alcohol-induced steatosis in liver cells. World J Gastroenterol. 2007;13:4974-8.
  • Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology. 2006;43:S63-74.
  • Devipariya N, Srinivasan M, Sudheer AR, Menon VP. Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study. Singapore Med J. 2007;48:311-8.
  • Dehmlow C, Erhard J, de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology. 1996;23:749-54.
  • DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991;52:287-305.
  • Das SK, Varadhan S, Gupta G, Mukherjee S, Dhanya L, Rao DN, Vasudevan DM. Time-dependent effects of ethanol on blood oxidative stress parameters and cytokines. Indian J Biochem Biophys. 2009;46:116-21.
  • Das K, Chainy GB. Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. Biochim Biophys Acta. 2001;1537:1-13.
  • Dahiru D, Obidoa O. Evaluation of the antioxidant effects of Ziziphus mauritiana Lam. Leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver. Afr J Tradit Complement Altern Med. 2007;5:39-45.
  • Crabb DW, Galli A, Fischer M, You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol. 2004;34:35-8.
  • Chung JW, Noh EJ, Zhao HL, Sim JS, Ha YW, Shin EM, Lee EB, Cheong CS, Kim YS. Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition. Biol Pharm Bull. 2008;31:2114-20.
  • Chun J, Joo EJ, Kang M, Kim YS. Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells. J Cell Biochem. 2013;114:456-70.
  • Choi SS, Han EJ, Lee TH, Han KJ, Lee HK, Suh HW. Antinociceptive profiles of platycodin D in the mouse. Am J Chin Med. 2004;32:257-68.
  • Choi JH, Yoo KY, Park OK, Lee CH, Won MH, Hwang IK, Ryu SY, Kim YS, Yi JS., Bae YS, Kang IJ. Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus. Brain Res. 2009;1279:197-208.
  • Cho JY, Kim PS, Park J, Yoo ES, Baik KU, Kim YK, Park MH. Inhibitor of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa. J Ethnopharmacol. 2000;70:127-33.
  • Chen YH, Yang CM, Chang SP, Hu ML. C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in mice. Acta Pharmacol Sin. 2009;30:1138-43.
  • Chen JH, TipoeGL, Liong EC, SoHS, Leung KM, Tom WM, Fung PC, Nanji AA. Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants. Am J Clin Nutr. 2004;80:742-51.
  • Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull. 1993;49:481-93.
  • Castilla R, Gonz lez R, Fouad D, Fraga E, Muntan J. Dual effect of ethanol on cell death in primary culture of human and rat hepatocytes. Alcohol Alcohol. 2004;39:290-6.
  • Cahill A, Cunningham CC, Adachi M, Ishii H, Bailey SM, Fromenty B, Davies A. Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol Clin Exp Res. 2002;26:907-15.
  • Butler WM, Maling HM, Horning MG, Brodie BB. The direct determination of liver triglycerides. J Lipid Res. 1961;2:95-6.
  • Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476-82.
  • Bondy SC, Orozco J. Effects of ethanol treatment upon sources of reactive oxygen species in brain and liver. Alcohol Alcohol. 1994;29:375-83.
  • Ahn YM, Kim SK, Kang JS, Lee BC. Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells. J Pharm Pharmacol. 2012;64:697-704.
  • Aebi H. Catalase. In: Bergmeyer HU (Ed.), Methods in Enzymatic Analysis. New York: Academic Press, pp 673-86, 1974.
  • ?Diehl AM. Liver disease in alcohol abusers: clinical perspective. Alcohol. 2002;27:7-11.