연구동향 분석
박사

양파와 유자 추출물의 허혈/저산소성 뇌혈관장벽 손상에 대한 보호 효과 및 기전 연구 : The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier

현수왕 2015년

논문상세정보
인용/피인용
' 양파와 유자 추출물의 허혈/저산소성 뇌혈관장벽 손상에 대한 보호 효과 및 기전 연구 : The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • blood-brain barrier
  • cerebral ischemia/hypoxia
  • foxo3a
  • hesperidin
  • onion
  • oxidative stress
  • quercetin
  • yuzu
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
782 0

0.0%

' 양파와 유자 추출물의 허혈/저산소성 뇌혈관장벽 손상에 대한 보호 효과 및 기전 연구 : The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier' 의 참고문헌

  • Zhao J, Moore AN, Redell JB, Dash PK: Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci 27: 10240-10248, 2007
  • Yu HY, Park SW, Chung IM, Jung YS: Anti-platelet effects of yuzu extract and its component. Food Chem Toxicol 49: 3018-3024, 2011
  • Yang Y, Rosenberg GA: Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 42: 3323-3328, 2011
  • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 27, 697-709 (2007).
  • Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H, You H, Dong MQ, Yuan Z: Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep 13: 371-377, 2012b
  • Xie Q, Chen J, Yuan Z: Post-translational regulation of FOXO. Acta Biochim Biophys Sin (Shanghai) 44: 897-901, 2012a
  • Witt KA, Mark KS, Sandoval KE, Davis TP: Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat. Microvasc Res 75: 91-96, 2008
  • Wang Z, Leng Y, Tsai LK, Leeds P, Chuang DM: Valproic acid attenuates bloodbrain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition. J Cereb Blood Flow Metab 31: 52-57, 2011
  • Wang Y-C, Chuang Y-C, Hsu H-W: The flavonoid, carotenoid and pectin content in peels of citrus cultivated in Taiwan. Food Chem 106: 277-284, 2008
  • Wang P, Xue Y, Shang X, Liu Y: Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro. Cell Mol Neurobiol 30: 717-725, 2010
  • Walberer M, Ritschel N, Nedelmann M, Volk K, Mueller C, Tschernatsch M, Stolz E, Blaes F, Bachmann G, Gerriets T: Aggravation of infarct formation by brain swelling in a large territorial stroke: a target for neuroprotection? J Neurosurg 109: 287-293, 2008
  • Vatsala TM, Singh M, Murugesan RG: Effects of onion in induced atherosclerosis in rabbits: I. Reduction of arterial lesions and lipid levels. Artery 7: 519-530, 1980
  • Tu XK, Yang WZ, Liang RS, Shi SS, Chen JP, Chen CM, Wang CH, Xie HS, Chen Y, Ouyang LQ: Effect of baicalin on matrix metalloproteinase-9 expression and bloodbrain barrier permeability following focal cerebral ischemia in rats. Neurochem Res 36: 2022-2028, 2011
  • Stamatovic SM, Keep RF, Andjelkovic AV: Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol 6: 179-192, 2008
  • Slimestad R, Fossen T, Vagen IM: Onions: a source of unique dietary flavonoids. J Agric Food Chem 55: 10067-10080, 2007
  • Shri R, Singh Bora K: Neuroprotective effect of methanolic extracts of Allium cepa on ischemia and reperfusion-induced cerebral injury. Fitoterapia 79: 86-96, 2008
  • Selvakumar K, Prabha RL, Saranya K, Bavithra S, Krishnamoorthy G, Arunakaran J: Polychlorinated biphenyls impair blood-brain barrier integrity via disruption of tight junction proteins in cerebrum, cerebellum and hippocampus of female Wistar rats: neuropotential role of quercetin. Hum Exp Toxicol 32: 706-720, 2013
  • Sandoval KE, Witt KA: Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 32: 200-219, 2008
  • Salih DA, Brunet A: FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20: 126-136, 2008
  • Rosenberg GA, Yang Y: Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus 22: E4, 2007
  • Rosell A, Lo EH: Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol 8: 82-89, 2008
  • Rong Z, Pan R, Xu Y, Zhang C, Cao Y, Liu D: Hesperidin pretreatment protects hypoxia-ischemic brain injury in neonatal rat. Neuroscience 255: 292-299, 2013
  • Raza SS, Khan MM, Ahmad A, Ashafaq M, Khuwaja G, Tabassum R, Javed H, Siddiqui MS, Safhi MM, Islam F: Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Brain Res 1420: 93-105, 2011
  • Qu YZ, Li M, Zhao YL, Zhao ZW, Wei XY, Liu JP, Gao L, Gao GD: Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. Eur J Pharmacol 606: 137-141, 2009
  • Pun PB, Lu J, Moochhala S: Involvement of ROS in BBB dysfunction. Free Radic Res 43: 348-364, 2009
  • Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X: Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biol Psychiatry 65: 150-159, 2009
  • Pluta R: Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury. Chemotherapy 51: 223-226, 2005
  • Pluta R, Ulamek M, Jablonski M: Alzheimer's mechanisms in ischemic brain degeneration. Anat Rec (Hoboken) 292: 1863-1881, 2009
  • Pierre S, Jamme I, Droy-Lefaix MT, Nouvelot A, Maixent JM: Ginkgo biloba extract (EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice. Neuroreport 10: 47-51, 1999
  • Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD: Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 1: 223-236, 2006
  • Park SR: Regulation mechanism of tight junction proteins during ischemia/hypoxiainduced blood-brain barrier dysfunction (Thesis). Suwon, Ajou University, 2011
  • Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, Park SW, Ko EY, Oh SR, Jung YS: Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxiainduced apoptosis in cardiomyocytes via antioxidant effect. Eur J Nutr 48: 235-242, 2009
  • Niessen CM: Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol 127: 2525-2532, 2007
  • Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR: The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine 18: 170-175, 2011
  • Maiese K, Chong ZZ, Shang YC: "Sly as a FOXO": new paths with Forkhead signaling in the brain. Curr Neurovasc Res 4: 295-302, 2007
  • Magalhaes PJ, Carvalho DO, Cruz JM, Guido LF, Barros AA: Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat Prod Commun 4: 591-610, 2009
  • Luissint AC, Federici C, Guillonneau F, Chretien F, Camoin L, Glacial F, Ganeshamoorthy K, Couraud PO: Guanine nucleotide-binding protein Galphai2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. J Cereb Blood Flow Metab 32: 860-873, 2012
  • Lochhead JJ, McCaffrey G, Quigley CE, Finch J, DeMarco KM, Nametz N, Davis TP: Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J Cereb Blood Flow Metab 30: 1625-1636, 2010
  • Liu WY, Wang ZB, Zhang LC, Wei X, Li L: Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS Neurosci Ther 18: 609-615, 2012b
  • Liu J, Jin X, Liu KJ, Liu W: Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to bloodbrain barrier damage in early ischemic stroke stage. J Neurosci 32: 3044-3057, 2012a
  • Lee JK, Kwak HJ, Piao MS, Jang JW, Kim SH, Kim HS: Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats. Acta Neurochir (Wien) 153: 1321-1329, 2011
  • Lee HY, You HJ, Won JY, Youn SW, Cho HJ, Park KW, Park WY, Seo JS, Park YB, Walsh K, Oh BH, Kim HS: Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arterioscler Thromb Vasc Biol 28: 302-308, 2008
  • Lancaster JE, Kelly KE: Quantitative analysis of the S-alk(en)yl-L-cysteine sulphoxides in onion (Allium cepa L.). J Sci Food Agric 34: 1229-1235, 1983
  • Kim YA, Park SL, Kim MY, Lee SH, Baik EJ, Moon CH, Jung YS: Role of PKCbetaII and PKCdelta in blood-brain barrier permeability during aglycemic hypoxia. Neurosci Lett 468: 254-258, 2010
  • Jin R, Song Z, Yu S, Piazza A, Nanda A, Penninger JM, Granger DN, Li G: Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Stroke 42: 2033-2044, 2011
  • Hyun SW, Jang M, Park SW, Kim EJ, Jung YS: Onion (Allium cepa) extract attenuates brain edema. Nutrition 29: 244-249, 2013
  • Hwang IK, Lee CH, Yoo KY, Choi JH, Park OK, Lim SS, Kang IJ, Kwon DY, Park J, Yi JS, Bae YS, Won MH: Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. J Med Food 12: 990- 995, 2009
  • Huber JD, Egleton RD, Davis TP: Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 24: 719-725, 2001
  • Heo JH, Han SW, Lee SK: Free radicals as triggers of brain edema formation after stroke. Free Radic Biol Med 39: 51-70, 2005
  • Fukunaga K, Shioda N: Pathophysiological relevance of forkhead transcription factors in brain ischemia. Adv Exp Med Biol 665: 130-142, 2009
  • Fischer S, Wiesnet M, Renz D, Schaper W: H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. Eur J Cell Biol 84: 687-697, 2005
  • El-Shemy HA, Aboul-Enein AM, Aboul-Enein KM, Fujita K: Willow leaves' extracts contain anti-tumor agents effective against three cell types. PLoS One 2: e178, 2007
  • Ding-Zhou L, Marchand-Verrecchia C, Croci N, Plotkine M, Margaill I: L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice. Eur J Pharmacol 457: 137-146, 2002
  • Cardoso FL, Brites D, Brito MA: Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches. Brain Res Rev 64: 328-363, 2010
  • Bianchini F, Vainio H: Allium vegetables and organosulfur compounds: do they help prevent cancer? Environ Health Perspect 109: 893-902, 2001
  • Beard RS, Jr., Haines RJ, Wu KY, Reynolds JJ, Davis SM, Elliott JE, Malinin NL, Chatterjee V, Cha BJ, Wu MH, Yuan SY: Non-muscle Mlck is required for betacatenin- and FoxO1-dependent downregulation of Cldn5 in IL-1beta-mediated barrier dysfunction in brain endothelial cells. J Cell Sci 127: 1840-1853, 2014
  • Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH: Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of bloodbrain barrier and white matter components after cerebral ischemia. J Neurosci 21: 7724-7732, 2001
  • Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ: Structure and function of the blood-brain barrier. Neurobiol Dis 37: 13-25, 2010