연구동향 분석
박사

The Evaluation of Osteogenic Property of Adipose-derived Mesenchymal Stem Cell with Platelet Rich Plasma in Canine Bone Healing Model : 개의 골치유 모델에서 지방유래 줄기세포와 혈소판 풍부 혈장이 골재생에 미치는 영향

이승진 2015년

논문상세정보
인용/피인용
' The Evaluation of Osteogenic Property of Adipose-derived Mesenchymal Stem Cell with Platelet Rich Plasma in Canine Bone Healing Model : 개의 골치유 모델에서 지방유래 줄기세포와 혈소판 풍부 혈장이 골재생에 미치는 영향' 의 주제별 논문영향력
논문영향력 선정 방법
논문영향력 요약
주제
  • adipose derived msc
  • bone
  • dog
  • platelet rich plasma
동일주제 총논문수 논문피인용 총횟수 주제별 논문영향력의 평균
538 0

0.0%

' The Evaluation of Osteogenic Property of Adipose-derived Mesenchymal Stem Cell with Platelet Rich Plasma in Canine Bone Healing Model : 개의 골치유 모델에서 지방유래 줄기세포와 혈소판 풍부 혈장이 골재생에 미치는 영향' 의 참고문헌

  • van't Hof RJ and Ralston SH: Nitric oxide and bone. Immunology2001; 103: 255-261.
  • de Wert G and Mummery C: Human embryonic stem cells:research, ethics and policy. Hum Reprod 2003; 18: 672-682.
  • Zhang ZY, Huang AW, Fan JJ, Wei KH, Jin D, Chen B, Li D, Bi L,Wang J, and Pei GX: The Potential Use of Allogeneic Platelet-Rich Plasma for Large Bone Defect Treatment: Immunogenicityand Defect Healing Efficacy. Cell Transplantation 2013; 22: 175-187.
  • Zhang N, Wu YP, Qian SJ, Teng C, Chen S, and Li H: Researchprogress in the mechanism of effect of PRP in bone deficiencyhealing. ScientificWorldJournal 2013; 2013: 134582.
  • Zhang H, Liu C-Y, Zha Z-Y, Zhao B, Yao J, Zhao S, Xiong Y, LeiQ-Y, and Guan K-L: TEAD transcription factors mediate thefunction of TAZ in cell growth and epithelial-mesenchymaltransition. Journal of biological chemistry 2009; 284: 13355-13362.
  • Zaragoza C, Lopez-Rivera E, Garcia-Rama C, Saura M,Martinez-Ruiz A, Lizarbe TR, Martin-de-Lara F, and Lamas S:Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts.Journal of Cell Science 2006; 119: 1896-1902.
  • Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K, and NagasakaT: Autogenous injectable bone for regeneration withmesenchymal stem cells and platelet-rich plasma: tissueengineeredbone regeneration. Tissue Eng 2004; 10: 955-964.92
  • Wu AC, Kidd LJ, Cowling NR, Kelly WL, and Forwood MR:Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostinare spatially and temporally associated following stress fractureinitiation. Bonekey Rep 2014; 3: 571.
  • Whittle BJR, Varga C, Berko A, Horvath K, Posa A, Riley JP,Lundeen KA, Fourie AM, and Dunford PJ: Attenuation ofinflammation and cytokine production in rat colitis by a novelselective inhibitor of leukotriene A(4) hydrolase. British Journalof Pharmacology 2008; 153: 983-991.
  • Watt FM and Hogan BL: Out of Eden: stem cells and their niches.Science 2000; 287: 1427-1430.
  • Watanabe K, Kawamori T, Nakatsugi S, and Wakabayashi K:COX-2 and iNOS, good targets for chemoprevention of coloncancer. Biofactors 2000; 12: 129-133.
  • Waselau M, Sutter WW, Genovese RL, and Bertone AL:Intralesional injection of platelet-rich plasma followed bycontrolled exercise for treatment of midbody suspensory ligamentdesmitis in Standardbred racehorses. J Am Vet Med Assoc 2008;91232: 1515-1520.
  • Wang FS, Wang CJ, Chen YJ, Chang PR, Huang YT, Sun YC,Huang HC, Yang YJ, and Yang KD: Ras induction of superoxideactivates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulatedosteoblasts. J Biol Chem 2004; 279: 10331-10337.
  • Vogel JP, Szalay K, Geiger F, Kramer M, Richter W, and Kasten P:Platelet-rich plasma improves expansion of human mesenchymalstem cells and retains differentiation capacity and in vivo boneformation in calcium phosphate ceramics. Platelets 2006; 17: 462-469.
  • Verrier S, Meury TR, Kupcsik L, Heini P, Stoll T, and Alini M:Platelet-released supernatant induces osteoblastic differentiationof human mesenchymal stem cells: potential role of BMP-2. EurCell Mater 2010; 20: 403-414.
  • Venugopal P, Balasubramanian S, Majumdar AS, and Ta M:90Isolation, characterization, and gene expression analysis ofWharton's jelly-derived mesenchymal stem cells under xeno-freeculture conditions. Stem Cells Cloning 2011; 4: 39-50.
  • Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM,Dembowy J, Yaffe MB, Zandstra PW, and Wrana JL: TAZcontrols Smad nucleocytoplasmic shuttling and regulates humanembryonic stem-cell self-renewal. Nat Cell Biol 2008; 10: 837-848.
  • Trucco C, Oliver FJ, de Murcia G, and Menissier-de Murcia J:DNA repair defect in poly(ADP-ribose) polymerase-deficient celllines. Nucleic Acids Res 1998; 26: 2644-2649.
  • Tonti GA and Mannello F: From bone marrow to therapeuticapplications: different behaviour and genetic/epigenetic stabilityduring mesenchymal stem cell expansion in autologous and foetalbovine sera? Int J Dev Biol 2008; 52: 1023-1032.
  • Tizard IR. Immunology : an introduction. 4th ed. Philadelphia:Saunders College Pub. 1995: xviii, 544 p.
  • Thomas MV and Puleo DA: Infection, inflammation, and bone89regeneration: a paradoxical relationship. J Dent Res 2011; 90:1052-1061.
  • Thanasas C, Papadimitriou G, Charalambidis C, ParaskevopoulosI, and Papanikolaou A: Platelet-rich plasma versus autologouswhole blood for the treatment of chronic lateral elbowepicondylitis: a randomized controlled clinical trial. Am J SportsMed 2011; 39: 2130-2134.
  • Textor JA and Tablin F: Activation of equine platelet-rich plasma:comparison of methods and characterization of equine autologousthrombin. Vet Surg 2011; 41: 784-794.
  • Taylor DW, Petrera M, Hendry M, and Theodoropoulos JS: ASystematic Review of the Use of Platelet-Rich Plasma in SportsMedicine as a New Treatment for Tendon and Ligament Injuries.Clinical Journal of Sport Medicine 2011; 21: 344-352.
  • Tanidir ST, Yuksel N, Altintas O, Yildiz DK, Sener E, and CaglarY: The effect of subconjunctival platelet-rich plasma on cornealepithelial wound healing. Cornea 2010; 29: 664-669.
  • Tang X, Falls DL, Li X, Lane T, and Luskin MB: Antigenretrievalprocedure for bromodeoxyuridine immunolabeling withconcurrent labeling of nuclear DNA and antigens damaged byHCl pretreatment. J Neurosci 2007; 27: 5837-5844.
  • Szabo C: Alterations in nitric oxide production in various formsof circulatory shock. New horizons (Baltimore, Md.) 1995; 3: 2-32.88
  • Syed Z and Khan A: Bone densitometry: applications andlimitations. J Obstet Gynaecol Can 2002; 24: 476-484.
  • Sung JH, Hwang MR, Kim JO, Lee JH, Il Kim Y, Kim JH, ChangSW, Jin SG, Kim JA, Lyoo WS, Han SS, Ku SK, Yong CS, andChoi HG: Gel characterisation and in vivo evaluation ofminocycline-loaded wound dressing with enhanced woundhealing using polyvinyl alcohol and chitosan. InternationalJournal of Pharmaceutics 2010; 392: 232-240.
  • Summer R, Fitzsimmons K, Dwyer D, Murphy J, and Fine A:Isolation of an adult mouse lung mesenchymal progenitor cellpopulation. Am J Respir Cell Mol Biol 2007; 37: 152-159.
  • Southan GJ and Szabo C: Selective pharmacological inhibition ofdistinct nitric oxide synthase isoforms. Biochem Pharmacol 1996;51: 383-394.
  • Smyth PG and Berman SA: Markers of apoptosis: methods forelucidating the mechanism of apoptotic cell death from the87nervous system. Biotechniques 2002; 32: 648-650, 652, 654passim.
  • Smulson ME, Pang D, Jung M, Dimtchev A, Chasovskikh S,Spoonde A, Simbulan-Rosenthal C, Rosenthal D, Yakovlev A,and Dritschilo A: Irreversible binding of poly(ADP)ribosepolymerase cleavage product to DNA ends revealed by atomicforce microscopy: possible role in apoptosis. Cancer Res 1998; 58:3495-3498.
  • Schroeder JE and Mosheiff R: Tissue engineering approaches forbone repair: concepts and evidence. Injury 2011; 42: 609-613.
  • Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurtsvan Kessel AH, Verheijen R, and Ramaekers FC: Assignment ofthe gene(s) involved in the expression of the proliferation-relatedKi-67 antigen to human chromosome 10. Hum Genet 1989; 83:297-299.
  • Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I,Koberle M, Sack U, and Lange F: Comparison of hematopoieticstem cells derived from fresh and cryopreserved whole cord bloodin the generation of humanized mice. PLoS One 2012; 7: e46772.
  • Saura M, Tarin C, and Zaragoza C: Recent Insights into theImplication of Nitric Oxide in Osteoblast Differentiation andProliferation during Bone Development.86Thescientificworldjournal 2010; 10: 624-632.
  • Sariguney Y, Yavuzer R, Elmas C, Yenicesu I, Bolay H, andAtabay K: Effect of platelet-rich plasma on peripheral nerveregeneration. J Reconstr Microsurg 2008; 24: 159-167.
  • Sampson S, Gerhardt M, and Mandelbaum B: Platelet rich plasmainjection grafts for musculoskeletal injuries: a review. Curr RevMusculoskelet Med 2008; 1: 165-174.
  • Ross M, Romrell L, and Kaye G: Histology: a text and atlas, 1995.Baltimore p318 1995;
  • Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, and GuldbergRE: Combination of platelet-rich plasma with polycaprolactonetricalciumphosphate scaffolds for segmental bone defect repair. JBiomed Mater Res A 2007; 81: 888-899.
  • Rai B, Ho KH, Lei Y, Si-Hoe KM, Jeremy Teo CM, Yacob KB,Chen F, Ng FC, and Teoh SH: Polycaprolactone-20% tricalciumphosphate scaffolds in combination with platelet-rich plasma forthe treatment of critical-sized defects of the mandible: a pilotstudy. J Oral Maxillofac Surg 2007; 65: 2195-2205.
  • Rahmanzadeh R, Huttmann G, Gerdes J, and Scholzen T:Chromophore-assisted light inactivation of pKi-67 leads toinhibition of ribosomal RNA synthesis. Cell Proliferation 2007;40: 422-430.85
  • Petite H, Viateau V, Bensaid W, Meunier A, de Pollak C,Bourguignon M, Oudina K, Sedel L, and Guillemin G: Tissueengineeredbone regeneration. Nat Biotechnol 2000; 18: 959-963.
  • Peerbooms JC, Sluimer J, Bruijn DJ, and Gosens T: Positiveeffect of an autologous platelet concentrate in lateral epicondylitisin a double-blind randomized controlled trial: platelet-rich plasmaversus corticosteroid injection with a 1-year follow-up. Am JSports Med 2010; 38: 255-262.
  • Parsons P, Butcher A, Hesselden K, Ellis K, Maughan J, Milner R,Scott M, Alley C, Watson JT, and Horner A: Platelet-richconcentrate supports human mesenchymal stem cell proliferation,bone morphogenetic protein-2 messenger RNA expression,alkaline phosphatase activity, and bone formation in vitro: a modeof action to enhance bone repair. J Orthop Trauma 2008; 22: 595-604.
  • Park EJ, Kim ES, Weber HP, Wright RF, and Mooney DJ:Improved Bone Healing by Angiogenic Factor-Enriched Platelet-Rich Plasma and Its Synergistic Enhancement by Bone84Morphogenetic Protein-2. International Journal of Oral &Maxillofacial Implants 2008; 23: 818-826.
  • Padilla F, Puts R, Vico L, and Raum K: Stimulation of bone repairwith ultrasound: a review of the possible mechanic effects.Ultrasonics 2014; 54: 1125-1145.
  • Orth P, Cucchiarini M, Zurakowski D, Menger MD, Kohn DM,and Madry H: Parathyroid hormone [1-34] improves articularcartilage surface architecture and integration and subchondralbone reconstitution in osteochondral defects in vivo.Osteoarthritis Cartilage 2013; 21: 614-624.
  • Old LJ: Tumor necrosis factor (TNF). Science 1985; 230: 630-632.
  • Nunez G, Benedict MA, Hu Y, and Inohara N: Caspases: theproteases of the apoptotic pathway. Oncogene 1998; 17: 3237-3245.
  • Murphy CM, Haugh MG, and O'Brien FJ: The effect of meanpore size on cell attachment, proliferation and migration incollagen-glycosaminoglycan scaffolds for bone tissue engineering.Biomaterials 2009; 31: 461-466.
  • Mungrue IN, Husain M, and Stewart DJ: The role of NOS in heartfailure: lessons from murine genetic models. Heart Fail Rev 2002;7: 407-422.83
  • Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS,Reardon B, and Ellsworth JL: Fibroblast growth factor-18stimulates chondrogenesis and cartilage repair in a rat model ofinjury-induced osteoarthritis. Osteoarthritis Cartilage 2005; 13:623-631.
  • Moon CH, Kwon O, Woo CH, Ahn HD, Kwon YS, Park SJ, SongCH, and Ku SK: Therapeutic effect of irradiation of magneticinfrared laser on osteoarthritis rat model. Photochem Photobiol2014; 90: 1150-1159.
  • Matsushima K and Oppenheim JJ: Interleukin 8 and MCAF:novel inflammatory cytokines inducible by IL 1 and TNF.Cytokine 1989; 1: 2-13.
  • Marx RE: Platelet-rich plasma: evidence to support its use. J OralMaxillofac Surg 2004; 62: 489-496.82
  • Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE,and Georgeff KR: Platelet-rich plasma: Growth factorenhancement for bone grafts. Oral Surg Oral Med Oral PatholOral Radiol Endod 1998; 85: 638-646.
  • Marsell R and Einhorn TA: The biology of fracture healing. Injury2011; 42: 551-555.
  • Marden LJ, Fan RS, Pierce GF, Reddi AH, and Hollinger JO:Platelet-derived growth factor inhibits bone regeneration inducedby osteogenin, a bone morphogenetic protein, in rat craniotomydefects. J Clin Invest 1993; 92: 2897-2905.
  • Malhotra A, Pelletier MH, Yu Y, and Walsh WR: Can platelet-richplasma (PRP) improve bone healing? A comparison between thetheory and experimental outcomes. Arch Orthop Trauma Surg2013; 133: 153-165.
  • Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, and Mirams M:Endochondral ossification: How cartilage is converted into bonein the developing skeleton. International Journal of Biochemistry& Cell Biology 2008; 40: 46-62.
  • Ludbrook J: Update: microcomputer statistics packages. Apersonal view. Clin Exp Pharmacol Physiol 1997; 24: 294-296.
  • Lin CY, Lin KJ, Li KC, Sung LY, Hsueh S, Lu CH, Chen GY,Chen CL, Huang SF, Yen TC, Chang YH, and Hu YC: Immuneresponses during healing of massive segmental femoral bonedefects mediated by hybrid baculovirus-engineered ASCs.81Biomaterials 2012; 33: 7422-7434.
  • Lieberman JR, Daluiski A, and Einhorn TA: The role of growthfactors in the repair of bone. Biology and clinical applications. JBone Joint Surg Am 2002; 84-A: 1032-1044.
  • Li W, Zhao GF, Xu SW, Wang JW, Zhou YF, and Liu J: Role ofdual energy X-ray absorptiometry in monitoring fracture healingin a rat femoral fracture model. Chin J Traumatol 2005; 8: 121-125.
  • Levene A: Pathological factors influencing excision of tumours inthe head and neck. Part I. Clinical Otolaryngology & AlliedSciences 1981; 6: 145-151.
  • Lee HJ, Choi BH, Min BH, and Park SR: Changes in SurfaceMarkers of Human Mesenchymal Stem Cells During theChondrogenic Differentiation and Dedifferentiation Processes InVitro. Arthritis and Rheumatism 2009; 60: 2325-2332.
  • Lee H-S, Cho H-R, Moon S-B, Shin H-D, Yang K-J, Park B-R,Jang H-J, Kim L-S, and Ku S-K: Effect of ет-glucan from80Aureobasidium pullulans on rat rib fracture healing. LaboratoryAnimal Research 2008; 24: 39-44.
  • Lee CW, Park SM, Kim YS, Jegal KH, Lee JR, Cho IJ, Ku SK,Lee JY, Ahn YT, Son Y, Ju SA, Kim SC, and An WG:Biomolecular evidence of anti-inflammatory effects by Clematismandshurica Ruprecht root extract in rodent cells. Journal ofEthnopharmacology 2014; 155: 1141-1155.
  • Lee CS, Yi EH, Kim HR, Huh SR, Sung SH, Chung MH, and YeSK: Anti-dermatitis effects of oak wood vinegar on the DNCBinducedcontact hypersensitivity via STAT3 suppression. Journalof Ethnopharmacology 2011; 135: 747-753.
  • Kraus KH and Kirker-Head C: Mesenchymal stem cells and boneregeneration. Vet Surg 2006; 35: 232-242.
  • Kon T, Cho TJ, Aizawa T, Yamazaki M, Nooh N, Graves D,Gerstenfeld LC, and Einhorn TA: Expression of osteoprotegerin,receptor activator of NF-kappa B ligand (osteoprotegerin ligand)and related proinflammatory cytokines during fracture healing.Journal of Bone and Mineral Research 2001; 16: 1004-1014.
  • Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, CenacchiA, Fornasari PM, Giannini S, and Marcacci M: Platelet-richplasma: intra-articular knee injections produced favorable results79on degenerative cartilage lesions. Knee Surg Sports TraumatolArthrosc 2010; 18: 472-479.
  • Komatsu DE and Hadjiargyrou M: Activation of the transcriptionfactor HIF-1 and its target genes, VEGF, HO-1, iNOS, duringfracture repair. Bone 2004; 34: 680-688.
  • Kocaoemer A, Kern S, Kluter H, and Bieback K: Human ABserum and thrombin-activated platelet-rich plasma are suitablealternatives to fetal calf serum for the expansion of mesenchymalstem cells from adipose tissue. Stem Cells 2007; 25: 1270-1278.
  • Knaack D, Goad ME, Aiolova M, Rey C, Tofighi A, ChakravarthyP, and Lee DD: Resorbable calcium phosphate bone substitute. JBiomed Mater Res 1998; 43: 399-409.
  • Kazakos K, Lyras DN, Thomaidis V, Agrogiannis G, Botaitis S,Drosos G, Kokka A, and Verettas D: Application of PRP gel aloneor in combination with guided bone regeneration does notenhance bone healing process: An experimental study in rabbits. JCraniomaxillofac Surg 2011; 39: 49-53.
  • Karsenty G: Minireview: transcriptional control of osteoblastdifferentiation. Endocrinology 2001; 142: 2731-2733.
  • Kang YH, Jeon SH, Park JY, Chung JH, Choung YH, ChoungHW, Kim ES, and Choung PH: Platelet-rich fibrin is a Bioscaffoldand reservoir of growth factors for tissue regeneration. Tissue EngPart A 2010; 17: 349-359.78
  • Kang SJ, Kim JW, Kim KY, Ku SK, and Lee YJ: Protectiveeffects of calcium gluconate on osteoarthritis induced by anteriorcruciate ligament transection and partial medial meniscectomy inSprague-Dawley rats. Journal of Orthopaedic Surgery andResearch 2014; 9:
  • Kang SH, Chung YG, Oh IH, Kim YS, Min KO, and Chung JY:Bone regeneration potential of allogeneic or autogeneicmesenchymal stem cells loaded onto cancellous bone granules ina rabbit radial defect model. Cell Tissue Res 2014; 355: 81-88.
  • Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA,Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, andYaffe MB: TAZ: a novel transcriptional co-activator regulated byinteractions with 14-3-3 and PDZ domain proteins. Embo Journal2000; 19: 6778-6791.
  • Joo SY, Chung YS, Choi B, Kim M, Kim JH, Jun TG, Chang J,Sprent J, Surh CD, Joh JW, and Kim SJ: Systemic Human T Cell77Developmental Processes in Humanized Mice CotransplantedWith Human Fetal Thymus/Liver Tissue and Hematopoietic StemCells. Transplantation 2012; 94: 1095-1102.
  • Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD,Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M,Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, andVerfaillie CM: Pluripotency of mesenchymal stem cells derivedfrom adult marrow. Nature 2002; 418: 41-49.
  • Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM,and Bunnell BA: Biologic properties of mesenchymal stem cellsderived from bone marrow and adipose tissue. J Cell Biochem2006; 99: 1285-1297.
  • Ito T, Mitui H, Udaka N, Hayashi H, Okudela K, Kanisawa M,and Kitamura H: Ki-67 (MIB 5) immunostaining of mouse lungtumors induced by 4-nitroquinoline 1-oxide. Histochemistry andCell Biology 1998; 110: 589-593.
  • Ishida Y, Kondo T, Kimura A, Matsushima K, and Mukaida N:Absence of IL-1 receptor antagonist impaired wound healingalong with aberrant NF-kappa B activation and a reciprocalsuppression of TGF-beta signal pathway. Journal of Immunology2006; 176: 5598-5606.
  • Intini G: The use of platelet-rich plasma in bone reconstructiontherapy. Biomaterials 2009; 30: 4956-4966.76
  • Im GI, Shin YW, and Lee KB: Do adipose tissue-derivedmesenchymal stem cells have the same osteogenic andchondrogenic potential as bone marrow-derived cells?Osteoarthritis and Cartilage 2005; 13: 845-853.
  • Hwangbo M, Jung JY, Ki SH, Park SM, Jegal KH, Cho IJ, Lee JH,Kang SH, Park SD, Ku SK, Kim SC, Zhao RJ, Jee SY, and KimYW: U-Bang-Haequi Tang: A Herbal Prescription that PreventsAcute Inflammation through Inhibition of NF-kappa B-MediatedInducible Nitric Oxide Synthase. Evidence-BasedComplementary and Alternative Medicine 2014;
  • Hwang Y, Yoo Y, and Baik S: Comparative Study of Rat ThyroidRegeneration Using PCNA and BrdU Immunohistochemistry.Korean J Anat 2000; 33: 247-254.
  • Hwang MR, Kim JO, Lee JH, Kim YI, Kim JH, Chang SW, JinSG, Kim JA, Lyoo WS, Han SS, Ku SK, Yong CS, and Choi HG:Gentamicin-loaded wound dressing with polyvinylalcohol/dextran hydrogel: gel characterization and in vivo healingevaluation. AAPS PharmSciTech 2010; 11: 1092-1103.
  • Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR,Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY,McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR,and Bender SL: Nonclinical Antiangiogenesis and AntitumorActivities of Axitinib (AG-013736), an Oral, Potent, and SelectiveInhibitor of Vascular Endothelial Growth Factor ReceptorTyrosine Kinases 1, 2, 3. Clinical Cancer Research 2008; 14:757272-7283.
  • Horcajada-Molteni MN, Crespy V, Coxam V, Davicco MJ,Remesy C, and Barlet JP: Rutin inhibits ovariectomy-inducedosteopenia in rats. Journal of Bone and Mineral Research 2000;15: 2251-2258.
  • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y,Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA,Hopkins N, and Yaffe MB: TAZ, a transcriptional modulator ofmesenchymal stem cell differentiation. Science 2005; 309: 1074-1078.
  • Hong JH and Yaffe MB: TAZ - A beta-catenin-like molecule thatregulates mesenchymal stem cell differentiation. Cell Cycle 2006;5: 176-179.
  • Heldin CH and Westermark B: Mechanism of action and in vivo74role of platelet-derived growth factor. Physiol Rev 1999; 79:1283-1316.
  • Greenwald AS, Boden SD, Goldberg VM, Khan Y, Laurencin CT,and Rosier RN: Bone-graft substitutes: facts, fictions, andapplications. J Bone Joint Surg Am 2001; 83-A Suppl 2 Pt 2: 98-103.
  • Grainger DJ, Wakefield L, Bethell HW, Farndale RW, andMetcalfe JC: Release and activation of platelet latent TGF-beta inblood clots during dissolution with plasmin. Nat Med 1995; 1:932-937.
  • Giannoudis PV, Dinopoulos H, and Tsiridis E: Bone substitutes:an update. Injury 2005; 36 Suppl 3: S20-27.
  • Gazdag AR, Lane JM, Glaser D, and Forster RA: Alternatives toAutogenous Bone Graft: Efficacy and Indications. J Am AcadOrthop Surg 1995; 3: 1-8.
  • Ganey T, Libera J, Moos V, Alasevic O, Fritsch KG, Meisel HJ,and Hutton WC: Disc chondrocyte transplantation in a caninemodel: a treatment for degenerated or damaged intervertebral disc.Spine (Phila Pa 1976) 2003; 28: 2609-2620.
  • Frechette JP, Martineau I, and Gagnon G: Platelet-rich plasmas:growth factor content and roles in wound healing. J Dent Res732005; 84: 434-439.
  • Franco D, Franco T, Schettino AM, Filho JM, and Vendramin FS:Protocol for obtaining platelet-rich plasma (PRP), platelet-poorplasma (PPP), and thrombin for autologous use. Aesthetic PlastSurg 2011; 36: 1254-1259.
  • Fortier LA and Smith RK: Regenerative medicine for tendinousand ligamentous injuries of sport horses. Vet Clin North AmEquine Pract 2008; 24: 191-201.
  • Follak N, Kloting I, and Merk H: Influence of diabetic metabolicstate on fracture healing in spontaneously diabetic rats. DiabetesMetab Res Rev 2005; 21: 288-296.
  • Everts PA, Knape JT, Weibrich G, Schonberger JP, Hoffmann J,Overdevest EP, Box HA, and van Zundert A: Platelet-rich plasmaand platelet gel: a review. J Extra Corpor Technol 2006; 38: 174-187.
  • Dugrillon A, Eichler H, Kern S, and Kluter H: Autologousconcentrated platelet-rich plasma (cPRP) for local application inbone regeneration. Int J Oral Maxillofac Surg 2002; 31: 615-619.
  • Doucet C, Ernou I, Zhang YZ, Llense JR, Begot L, Holy X, andLataillade JJ: Platelet lysates promote mesenchymal stem cellexpansion: A safety substitute for animal serum in cell-basedtherapy applications. Journal of Cellular Physiology 2005; 205:228-236.72
  • Dohan Ehrenfest DM, Rasmusson L, and Albrektsson T:Classification of platelet concentrates: from pure platelet-richplasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).Trends Biotechnol 2009; 27: 158-167.
  • Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, MouhyiJ, and Gogly B: Platelet-rich fibrin (PRF): a second-generationplatelet concentrate. Part II: platelet-related biologic features. OralSurg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: e45-50.
  • Doetsch AM, Faber J, Lynnerup N, Watjen I, Bliddal H, andDanneskiold-Samsoe B: The effect of calcium and vitamin D3supplementation on the healing of the proximal humerus fracture:a randomized placebo-controlled study. Calcif Tissue Int 2004; 75:183-188.
  • Dimitriou R, Jones E, McGonagle D, and Giannoudis PV: Boneregeneration: current concepts and future directions. BMC Med2011; 9: 66.
  • Diez F: Guidelines for the diagnosis of osteoporosis bydensitometric methods. J Manipulative Physiol Ther 2002; 25:403-415.71
  • Di Palma T, D'Andrea B, Liguori GL, Liguoro A, de Cristofaro T,Del Prete D, Pappalardo A, Mascia A, and Zannini M: TAZ is acoactivator for Pax8 and TTF-1, two transcription factorsinvolved in thyroid differentiation. Experimental Cell Research2009; 315: 162-175.
  • Czekanska EM, Ralphs JR, Alini M, and Stoddart MJ: Enhancinginflammatory and chemotactic signals to regulate boneregeneration. Eur Cell Mater 2014; 28: 320-334.
  • Cole KK and Perez-Polo JR: Poly(ADP-ribose) polymeraseinhibition prevents both apoptotic-like delayed neuronal death andnecrosis after H2O2 injury. Journal of Neurochemistry 2002; 82:19-29.
  • Choi BH, Zhu SJ, Kim BY, Huh JY, Lee SH, and Jung JH: Effectof platelet-rich plasma (PRP) concentration on the viability andproliferation of alveolar bone cells: an in vitro study. Int J OralMaxillofac Surg 2005; 34: 420-424.
  • Choi BH, Im CJ, Huh JY, Suh JJ, and Lee SH: Effect of platelet70rich plasma on bone regeneration in autogenous bone graft. Int JOral Maxillofac Surg 2004; 33: 56-59.
  • Chell S, Kadi A, Williams AC, and Paraskeva C: Mediators ofPGE(2) synthesis and signalling downstream of COX-2 representpotential targets for the prevention/treatment of colorectal cancer.Biochimica Et Biophysica Acta-Reviews on Cancer 2006; 1766:104-119.
  • Carter CA, Jolly DG, Worden CE, Sr., Hendren DG, and Kane CJ:Platelet-rich plasma gel promotes differentiation and regenerationduring equine wound healing. Exp Mol Pathol 2003; 74: 244-255.
  • Carano RA and Filvaroff EH: Angiogenesis and bone repair. DrugDiscov Today 2003; 8: 980-989.
  • Bullwinkel J, Baron-Luhr B, Ludemann A, Wohlenberg C, GerdesJ, and Scholzen T: Ki-67 protein is associated with ribosomalRNA transcription in quiescent and proliferating cells. Journal ofCellular Physiology 2006; 206: 624-635.
  • Brown KM, Saunders MM, Kirsch T, Donahue HJ, and Reid JS:Effect of COX-2-specific inhibition on fracture-healing in the ratfemur. J Bone Joint Surg Am 2004; 86-A: 116-123.69
  • Blasi A, Martino C, Balducci L, Saldarelli M, Soleti A, NavoneSE, Canzi L, Cristini S, Invernici G, Parati EA, and Alessandri G:Dermal fibroblasts display similar phenotypic and differentiationcapacity to fat-derived mesenchymal stem cells, but differ in antiinflammatoryand angiogenic potential. Vasc Cell 2011; 3: 5.
  • Bilston LE, Little DG, Smith NC, Williams P, and Briody J:Zoledronic acid improves the mechanical properties of normaland healing bone. Clin Biomech (Bristol, Avon) 2002; 17: 716-718.
  • Bianco P, Robey PG, and Simmons PJ: Mesenchymal stem cells:revisiting history, concepts, and assays. Cell Stem Cell 2008; 2:313-319.
  • Barrett KL, Willingham JM, Garvin AJ, and Willingham MC:Advances in cytochemical methods for detection of apoptosis. JHistochem Cytochem 2001; 49: 821-832.
  • Awasthi N, Zhang CH, Ruan W, Schwarz MA, and Schwarz RE:BMS-754807, a Small-Molecule Inhibitor of Insulin-like GrowthFactor-1 Receptor/Insulin Receptor, Enhances Gemcitabine68Response in Pancreatic Cancer. Molecular Cancer Therapeutics2012; 11: 2644-2653.
  • Arpornmaeklong P, Kochel M, Depprich R, Kubler NR, andWurzler KK: Influence of platelet-rich plasma (PRP) onosteogenic differentiation of rat bone marrow stromal cells. An invitro study. Int J Oral Maxillofac Surg 2004; 33: 60-70.
  • Arend WR: The balance between IL-1 and IL-1Ra in disease.Cytokine & Growth Factor Reviews 2002; 13: 323-340.
  • Alsousou J, Thompson M, Hulley P, Noble A, and Willett K: Thebiology of platelet-rich plasma and its application in trauma andorthopaedic surgery: a review of the literature. J Bone Joint SurgBr 2009; 91: 987-996.
  • Albrektsson T and Johansson C: Osteoinduction, osteoconductionand osseointegration. Eur Spine J 2001; 10 Suppl 2: S96-101.
  • ?1. Aghaloo TL, Moy PK, and Freymiller EG: Investigation ofplatelet-rich plasma in rabbit cranial defects: A pilot study. J OralMaxillofac Surg 2002; 60: 1176-1181.