Zhu YP :Harwood academicpublishers.Amsterdam,Chin.Mat.Med.146-149,1998.

Zhang Q1,Seltmann H,Zouboulis CC,KongerRL :InvolvementofPPARc in Oxidative Stress-Mediated Prostaglandin E2 Production inSZ95 Human Sebaceous Gland Cells.J InvestDermatol.126(1):42-8,2006.

Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch.. Dermatol. Res.. 300: 479-483, 2008.

WilloughbyDA :Humanarthritisappliedtoanimalmodels.Towardsabettertherapy.AnnRheum Dis34.471-478,1975.

VaneJR,Bakhle YS,Botting RM :Cyclooxygenaseand 2.Anu RevPharmacolToxicol.38:97-120,1998.

TakahashiM,Mutoh M,ShojiY,Sato H,Kamanaka Y,Naka M,MaruyamaT,SugimuraT,WakabayashiK :Suppressiveeffectofaninducible nitricoxideinhibitor,ONO-1714,on AOM-induced ratcoloncarcinogenesis.NitricOxide.14:130-136,2006.

SeoYJ:RoleofCyclooxygenase-2inCarcimogenesisandItsSelectiveInhibitionforCancerChemoprevention.Moleculesandcells.13(4):8-17,2002.

Seo JW :The anti-oxidative activities and separation ofthe Gentianascabravar.buergeriextracts.WonkwangUniversity,2008.

SatoT,NakajimaH,FujioK,MoriY :EnhancementofprostaglandinE2 production by epidermal growth factor requires the coordinateactivationofcytosolicphospholipaseA2andcyclooxygenase2inhumansquamouscarcinomaA431cells.Prostaglandins.53:355-369,1997.

PryorWA :Oxy-radicalsand related specied theirformation life-timeandreactions.AnnuRevPhysiol.48:657-667,1986.

ParkK,HanS,ShinE,Kim HJ,Kim JY :Cox-2expressionontissuemicroarrayofbreastcancer.EurJSurgOncol.32:1093-6,2006.

ParkDS,MoonSH,AnBC :EffectsofG.S.R.Aqua-acupuncturebyDensityGallstoneFormationim Mice.JKorAcupuncture& MoxibustionSoc.8(1):141-56,1991.

Park JH :An illustrated book of medicinalplants.Shinilcompany.Seoul.pp306-308,2000.

PapaS,SkulachevVP :Reactiveoxygenspecies,mitochondria,apoptosisandaging.MolCellBiol.174:305-319,1997.

NoST :StudyofSkinDepigmentingMechanism oftheEthanolExtractofFagopyrum esculentum.WonkwangUniversity,2006.

NathanC :Nitricoxideasasecretoryproductofmammaliancell.TheFASEB J.6:3051-3064,1992.

Nambara T,TakahashiH,Kamikawa Y :Studies on metabolism of3-deoxysteroids.IV.Synthesis of2,17-oxygenated 5-dehydro- and 5beta-androstanes.Chem Pharm Bull.18(9),1970.

MorenoM.IslaM.SampietroA.VattuoneM :Comparisonofthefreeradicalscavengingactivityofpropolisfrom severalregionofArgentian.JEnthrophamacol.71(1-2):109-114,2000.

Medzhitov R :Origin and physiologicalrolesofinflammation.Nature.454:428-435,2008.

Lim HW,YoonMY,ChaSB,Kim KW,ParkYK,LeeJY :EffectsofcitrusessentialoilsmelaninproductioninB16melanimacell.JYakhakHoeji.47:15-30,2003.

Levy GN :Prostaglandin H synthases,nonsteroidalanti-inflammatorydrugs,andcoloncancer.FASEB J.11:234-247,1997.

LeeYJ,Kim EO,ChoiSW.Isolation and identification ofantioxidantpolyphenolic compounsin Mulberry(morus alba L.) seeds.J Kor SocFoodSciNutr.40(4):517-524,2011.

LeeSY,Kim JM,OhHC,Im SJ,HwangCY,MunYJ,WooWH :TheeffectofCodonopsislanceolata on themelanogenesis.JKorea OrientalMedicinePrescription.10(2):199-211,2002.

LeeJG,Kim EW,LeeJH :EffectofGentianaeRadix on Neurogenesisand Apoptosis in Hippocampus of Ethanol-induced Newborn Rats.JOrientalNeuropsychiatry.21(2):29-44,2010.

Lee SJ :Novelnaturalproducts as active materialforbeauty food.FoodSciInd.40:10-18,2008.

Kubo M,Matsuda H :Developmenttudies ofcuticle and medicinaldrug from naturalsources on melanin biosynthesis.Fragrance J.8:48-55,1995.

Kim NY,Kang TH,Kim DH,Kim YC :Anitric oxide synthesisinhibitorfrom therootsofGentianascabrain RAW 264.7cells.JKorPharmacogn.30(2):173-176,1999.

Kim MS,Kim SC,Jee SY,Hwang SY,Cho WJ,Lee JR,Park SJ:Inhibitory effectofGentianaeRadix MeOH extracton pro-inflammatorymediator production in lipopolysaccharide activated Raw264.7 cells.JKoreanOrientalMedicalOphthalmology& Otolaryngology& Dermatology.21(1):28-38,2008.

Kim KH :A Study on the Application ofCosmetic Materials usingAntioxidant Activity of the Extracts from Castanea crenata Leaf.DaeguHaanyUniversity,2011.

Kelly LM,HillAD,Kennedy S,Connolly EM,Ramanath R,Teh S,etal:Lack ofprognosticeffectofCox-2 expression in primary breastcanceronshort-term follow-up.EurJSurgOncol.29:707-10,2003.

Kaliora AC,Dedousssis GVZ,SchimiditH :Dietary antioxidants inpreventingatherogenesis.Atherosclerosis.187:1-17,2006.

Jeun JA,Lee SJ :Application ofNurigenomics in the Beauty FoodsResearch.FoodSciInd.40(4):pp.27-30,2007.

Jang MJ:Studieson anti-oxidantofPinusrigida innerbark forthedevelopmentoffunctionalcosmetics.DaeguHaanyUniversity,2007.

InouyeH,NakamuraY :Studiesonmonoterpeneglucosidesandrelatednatural products. XVI. Occurrence of secoiridoid glucosides ingentianaceous plants especially in the genera Gentiana and Swertia.YakugakuZassh.91(7):755,1971.

Huh H,Kim HK,LeeHK :PAF antagonisticactivity of2-hydroxy-3-methoxybenzoicacid.glucoseesterfrom Genyianascabra.ArchPharmRes.21(4):436-439,1998.

Huh H, Kim HK, Lee HK : PAF antagonistic activity of2-hydroxy-3-methoxybenzoicacid glucoseesterfrom Genyianascabra.ArchPharm.21(4):436-439,1988.

HuangM,StolinaM,SharmaS,MaoJ.T,ZhuL.P,MillerW,WollmanJ, Her schman H, Dubinett S.M : Non-small cell lung cancercyclooxygenase-2-dependentregulationofcytokinebalanceinlymphocytesandmacrophageUp-regulationofinterleukin10anddown-regulationofinterleukin12production.CancerRes.58:1208-1216,1998.

Homebeck W :Downregulation oftissue inhibitorofmatrix metalloprotease-1(TIMP-1)inagedhumanskincontributestomatrixdegradationandimpairedcellgrowthandsurvival.JPatholBiol.51(10):569,2003.

HearingVJ,JimnezM :Mammaliantyrosinasethecriticalregula-torycontrolpointinmelanocytepigmentation.IntJBiochem.19:1141-1147,1987.

Haratake A,Uchida Y,Schmuth M :UVB-induced alterations inpermeabilitybarrierfunction:rolesforepidermalhyperprolifera-tionandthymocyte-mediatedresponse.JInvestDermatol.108:769-775,1998.

HanSW :EffectsofAqua-acupuncturewithGentianaescabraeRadixand BupleuriRadix Extracton Serum Activities ofGOT,GPT,LDH,ALP and r-GTP in Damaged Rat Liver induced by the CarbonTetracholoride(CCL4).TheAcupuncture.10(1):297-313,1993.

Green strok CL :Radiation and aging freeradicaldamage,biologicalresponseand possibleantioxidantintervention.Med Hypotheses.41(5):473-482,1993.

Do JR,Baek SY,Im SD,Kim YM,Kim IH,Han DS,Kim BS :Selection ofbeauty material from Fruits and Vegetables.J KorSocFoodSci.Nutr.10:248-248,2008.

Chung HY,CesariM,Anton S,MarzettiE,GiovanniniS,Seo AY,Carter C, Yu BP, Leeuwenburgh C : Molecular inflammation:underpinnings ofaging and age-related diseases.Ageing Res Rev 8:18-30,2009.

Chung EK,Seo EH,Park JH,Shim JH,Kim KH,Lee BR :Anti-inflammaatory and anti-allergic effect ofextracts from organicsoybean.KoreanJOrganicAgric2.245-253, 2011.

ChoiJH,LeeEY,ChoiMK,Kim JS,ChoiGB,Jung SG,Han YS :Character into biologically activated substance by cultivars of ulsanpear.ArchEnvironHealth.3:74-106,2005.

ChoiJH,Kim JS,ChoiGB,JungSG,HanYS :Physilogicalactivititiesaccording to cultivarsand partsofulsan pear.JKorSocAppl.Biol.49:43-48,2006.

Cho SY,Han YB,Shin KH :Screening forAntioxidantActivity ofEdiblePlants.JKorSocFoodSciNutr.30(1):133-137,2001.

Chang YH,Kim C,Jung M,Lim YH,LeeS,Kang S :Inhibition ofmelanogenesisbyselina-4(14),7(11)-dien-8-oneisolatedfrom AtractylodisRhizomaAlba.BiolPharm Bull.30:719-723,2007.

CabanesJ,ChazarraS,Garcia-CarmonaF :Kojicacid,acosmeticskinwhitening agent,isa slow-binding inhibitorofcatecholaseactivity oftyrosinase.JPharm Pharmacol.46:982-985,1994.

BorenfreundE,PuernerJA :Toxicitydeterminedinvitrobymorphologicalalterationsandneutralredabsorption.ToxicolLett.24(2-3):119-124,1984.

Blois MS :Antioxidantdeterminations by the use ofstable freeradical.Nature.18:1199-1120,1958.

?1.PrattDE,BiracPM :Sourceofantioxidantactivityofsoybeansandsoyproducts.JFoodSci.44:1720-1728,1979.