Turrin, N.P., and Plata-Salaman, C.R. (2000). Cytokine-cytokine interactions and the brain. Brain research bulletin 51, 3-9.

Tao, Y.X. (2010). The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocrine reviews 31, 506-543.

Tak, P.P., and Firestein, G.S. (2001). NF-kappaB: a key role in inflammatory diseases. The Journal of clinical investigation 107, 7-11.

Stroud, J.C., Lopez-Rodriguez, C., Rao, A., and Chen, L. (2002). Structure of a TonEBPDNA complex reveals DNA encircled by a transcription factor. Nature structural biology 9, 90-94.

Sternberg, E.M. (1997). Neural-immune interactions in health and disease. The Journal of clinical investigation 100, 2641-2647.

Skinner, G.W., Mitchell, D., and Harden, L.M. (2009). Avoidance of physical activity is a sensitive indicator of illness. Physiology & behavior 96, 421-427.

Shin, H.J., Kim, H., Heo, R.W., Kim, H.J., Choi, W.S., Kwon, H.M., and Roh, G.S. (2014). Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-kappaB-mediated neuroinflammation in kainic acid-induced seizures. Cell death and differentiation 21, 1095-1106.

Roth, I., Leroy, V., Kwon, H.M., Martin, P.Y., Feraille, E., and Hasler, U. (2010). Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity. Molecular biology of the cell 21, 3459-3474.

Purkayastha, S., Zhang, G., and Cai, D. (2011). Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nature medicine 17, 883- 887.

Miyakawa, H., Woo, S.K., Dahl, S.C., Handler, J.S., and Kwon, H.M. (1999). Tonicityresponsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proceedings of the National Academy of Sciences of the United States of America 96, 2538-2542.

Masuda, K., Masuda, R., Neidhart, M., Simmen, B.R., Michel, B.A., Muller-Ladner, U., Gay, R.E., and Gay, S. (2002). Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation. Arthritis research 4, R8.

Maallem, S., Berod, A., Mutin, M., Kwon, H.M., and Tappaz, M.L. (2006). Large discrepancies in cellular distribution of the tonicity-induced expression of osmoprotective genes and their regulatory transcription factor TonEBP in rat brain. Neuroscience 142, 355- 368.

Loyher, M.L., Mutin, M., Woo, S.K., Kwon, H.M., and Tappaz, M.L. (2004). Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neuroscience 124, 89-104.

Licinio, J., and Wong, M.L. (1997). Pathways and mechanisms for cytokine signaling of the central nervous system. The Journal of clinical investigation 100, 2941-2947.

Li, N., and Karin, M. (1999). Is NF-kappaB the sensor of oxidative stress? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 13, 1137-1143.

Lawrence, T. (2009). The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor perspectives in biology 1, a001651.

Kuper, C., Fraek, M.L., Muller, H.H., Beck, F.X., and Neuhofer, W. (2012). Sepsis-induced urinary concentration defect is related to nitric oxide-dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2. Critical care medicine 40, 1887-1895.

Kluger, M.J. (1991). Fever: role of pyrogens and cryogens. Physiological reviews 71, 93-127.

Kim, J.A., Jeon, U.S., Kwon, M.S., Lim, S.W., and Kwon, H.M. (2007). Transcriptional activator TonE-binding protein in cellular protection and differentiation. Methods in enzymology 428, 253-267.

Ji, R.C. (2012). Macrophages are important mediators of either tumor- or inflammationinduced lymphangiogenesis. Cellular and molecular life sciences : CMLS 69, 897-914.

Jeong, J.K., Kim, J.G., and Lee, B.J. (2014). Participation of the central melanocortin system in metabolic regulation and energy homeostasis. Cellular and molecular life sciences : CMLS 71, 3799-3809.

Jang, P.G., Namkoong, C., Kang, G.M., Hur, M.W., Kim, S.W., Kim, G.H., Kang, Y., Jeon, M.J., Kim, E.H., Lee, M.S., et al. (2010). NF-kappaB activation in hypothalamic proopiomelanocortin neurons is essential in illness- and leptin-induced anorexia. The Journal of biological chemistry 285, 9706-9715.

Hopkins, S.J., and Rothwell, N.J. (1995). Cytokines and the nervous system. I: Expression and recognition. Trends in neurosciences 18, 83-88.

Hayden, M.S., and Ghosh, S. (2004). Signaling to NF-kappaB. Genes & development 18, 2195-2224.

Hasler, U., Leroy, V., Jeon, U.S., Bouley, R., Dimitrov, M., Kim, J.A., Brown, D., Kwon, H.M., Martin, P.Y., and Feraille, E. (2008). NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. The Journal of biological chemistry 283, 28095-28105.

Halterman, J.A., Kwon, H.M., Leitinger, N., and Wamhoff, B.R. (2012). NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration. Frontiers in physiology 3, 313.

Grossberg, A.J., Scarlett, J.M., Zhu, X., Bowe, D.D., Batra, A.K., Braun, T.P., and Marks, D.L. (2010). Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130. Endocrinology 151, 606-616.

Grinspoon, S., and Mulligan, K. (2003). Weight loss and wasting in patients infected with human immunodeficiency virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 36, S69-78.

Gahring, L.C., Carlson, N.G., Kulmar, R.A., and Rogers, S.W. (1996). Neuronal expression of tumor necrosis factor alpha in the murine brain. Neuroimmunomodulation 3, 289-303.

Elmquist, J.K., Scammell, T.E., and Saper, C.B. (1997). Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends in neurosciences 20, 565-570.

Dinarello, C.A. (1991). The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. The Journal of infectious diseases 163, 1177-1184.

Cansell, C., Denis, R.G., Joly-Amado, A., Castel, J., and Luquet, S. (2012). Arcuate AgRP neurons and the regulation of energy balance. Frontiers in endocrinology 3, 169.

Bradley, J.R. (2008). TNF-mediated inflammatory disease. The Journal of pathology 214, 149-160.

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